plateletthrombocyte

20004000714

24

3
PF33

ADPATP
5-5-hydroxytryptamine
5HTCa2+

Thromboxane A25HT
5-hydroxytryptamine
PDGFplateletderivedgrowthfactor
-TGBeta-thromboglobulin
PF4
GPIIb/IIla

243

 JOURNAL OF KAOHSIUNG MEDICAL ASSOCIATION 2013. vol.21, No.3

""

(
)PFA-100

(1)(2):
(3)
PFA-100

ADP

ADP

25

MPV
MPVP

244

AA+ADP
ADPGPIIb/IIIa

ADP

IADP
II
IIIADP

21%

GPIIIa
PLA1(Leu33)PL2(Pro33)GPIa
(39bp
Thrl45Met-5T/C)
GPIa807C/TLys505Glu

PFA-100
ASA

:
1.George JN. Platelets. Lancet
2000;355:15319.
2. Michelson AD. Platelets. San Diego:
Academic Press; 2002.
3. Rodgers GM. Overview of platelet
physiology and laboratory evaluation of
platelet function. Clin Obstet Gynecol
1999;42:34959.
4. Michelson AD, Barnard MR, Krueger
LA, et al. Circulating monocyteplatelet
aggregates are a more sensitive marker of in
vivo platelet activation than platelet surface
P-selectin: studies in baboons, human
coronary intervention, and human acute
myocardial infarction. Circulation. 2001;
104: 15331537.
5. Paul H., (2005), The role of PFA-100_
testing in the investigation and management
of haemostatic defects in children and
adults,British Journal of Haematology, 130,
310.

245