Summary of the August 21, 2012 issue, including articles on risk for colorectal cancer after polyp detection, lead exposure and gout, a lung cancer risk model, and the effects of lipid-lowering therapy in chronic kidney disease, as well as an Update in hematology and medical oncology, an article on a new curriculum on high value, cost-conscious care, and commentaries on maintenance of licensure and the tenth anniversary of A Physician Charter.