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Table1051CausesofMegaloblasticAnemia
Cobalamindeficiencyorabnormalitiesofcobalaminmetabolism(seeTables1053and1054) Folatedeficiencyorabnormalitiesoffolatemetabolism(seeTable1055) Therapywithantifolatedrugs(e.g.,methotrexate) Independentofeithercobalaminorfolatedeficiencyandrefractorytocobalaminandfolatetherapy: Somecasesofacutemyeloidleukemia,myelodysplasia TherapywithdrugsinterferingwithsynthesisofDNA[e.g.,cytosinearabinoside,hydroxyurea,6 mercaptopurine,azidothymidine(AZT)] Oroticaciduria(respondstouridine) Thiamineresponsive

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