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.
MSH- -
4-9
ACTH . MSH-
ACTH )
1-13
1-20
(ACTH
MSH-
,( , ,,
, ,
.
.
POMC-
LPH
ACTH
K-16
MSH
ACTH
LPH
N-terminal
CASH
MSH
-endorphin
LPH
-endorphin
CLIP
MSH
MSH
-endorphin
met-enk
MSH- ACTH-;
1 -.
, ACTH
ACTH ,
7-36
7-34
8
8
[Thr ]ACTH
[Thr ]ACTH -
-.
1-31
7-31
) POMC- mRNA-
7-38
, ACTH
31
-N( . , 6 . 8
[Thr ]ACTH , .
1-31
ACTH
. -,
1-39
, . -N- 6 .
.
ACTH
ACTH -
ACTH
1-39
1-38
1-37
monopeptidyl carboxypeptidase" -
ACTH
1-39
. dipeptidyl carboxypeptidase-
: ACTH-
. - 1.
- : < 2.
ACTH- < < .
, " 3-30 .
. , ACTH-
. ACTH
ACTH, - 3. . . GRP-
,
, )
).
4.
ACTH- POMC ( . ,
amygdala-.
ACTH. 5.
)GC- (NFB?).?(
- 6.
) . ACTH-
.
, , - , ACTH- 7.
ACTH- . . ,
(T ) POMC-
) (in-vitro , ,CRF ) (
, endorphin- .
1-39
ACTH
,
1-26
ACTH- - - - .
1-23
, ACTH
1-24
ACTH
. ) POMC-
(
CRF ,
CRF- endorphin- .
1-39
ACTH
. ,
. ACTH
mast endorphin- ACTH 8.
. endorphin- ACTH . ,
. POMC- 9. mRNA
, .
. POMC- mRNA ,
paraganglioma, ) ( , 10.
. ACTH
:ACTH-
1.
ACTH-
GC,
GC ACTH- . ,
.
:
).( zona fasciculata- .
cAMP- . cAMP- .
ACTH . , ACTH-
5-24
, zona fasciculata- cAMP-
.
ACTH"
ACTH 1000-10,000
-.
5-24
1-39
. ACTH-
ACTH
PLC- . -
5-24
1-39
PLC- ,
ACTH
5-24
6-24
ACTH .
ACTH " -
1-39
ACTH "
, ACTH- .
.
. RNA- ACTH- .
)( . ,
.
ACTH- . .
.
ACTH- .
.
. ,
ACTH- . ,
. , ,
, , ,
.
.
C) - . ) peroxide scavangers-,
-ACTH-. .
) (adrenal ascorbic depletion test-AAD.
, ) ( ACTH-.
. . , " ACTH-
. , ACTH,
.
. PGF - PGs-; PGE ACTH- .
1
2
PLC-. PGs
. ,
2.
ACTH .
ACTH -,
ACTH -
-
1-39
1-24
5-24
cAMP , protein kinase A ( cAMP-dependent protein kinase-
(HSL) hormone sensitive lipase- PKA- kinase A). [PKA],
ACTH- .
ACTH- .
). )
FFA- ACTH- . ,
.
. RQ- FFA- ACTH- .
3.
. .
. , ACTH- ,
. GC-
. . ,
)GC-).
. .
. - ) .
ACTH ,Myasthenia gravis
).
4-10
, ,
ACTH .
4-10
.
4.
MSH- ). . )
5.
. .
6.
NE- .
, CG- .
. ACTH-
.
.
.ACTH- , .ACTH-
ACTH ,
-50% .
. ACTH-
E-. NE- ACTH- .
Ang.II ACTH- . Ang.II- ) -( .
ACTH-.
' ,' ,' -' ) ,(
ACTH ,
. ,
7.
ACTH .
)( . -
1-24
ACTH-. "
8.
ACTH . ,
ACTH -
-
1-39
22-39
ACTH .
ACTH -
ACTH -,
, ACTH
,
1-39
1-24
1-4
4-10
.
7-38,
ACTH
18-39
, ACTH
11-24
, ACTH
1-10
ACTH
. -
4-10
, -,
ACTH . ,
1-24
ACTH -
1-39
ACTH .
)( . "
ACTH-
)( . ,
"
ACTH-.
ACTH- "
. )
ACTH-.( ,
PGF - ACTH- .
2
)( )() . ( .
). ) ACTH-
ACTH . ,
ACTH
-
1-39
1-24
) ) , in-vitro- , in-vivo
, ' -' POMC-
. ACTH-
cAMP- ACTH .
.
cAMP- . ACTH-
.
NE- ACTH- .
.
. ACTH-,
ACTH-. "
9.
ACTH-. -50%\
." B- T . "
. . "
. "
.
. T .
. .
) tumor nrcrosis factor ( TNF .
-).
1-39
ACTH )
-11
-10
ACTH- M
-9
B. 10 .
IL-5-. B 5
1-
ACTH
1-24
B. (ACTH . "
-).
39
- , ACTH- .
. GC-
10.
ACTH .
ACTH
1-39
1-24
). )
11.
CNS- ,ACTH
. POMC-
. -
1-3
ACTH .
ACTH .
-
4-9
.
). )
1-24
ACTH .
ACTH .
ACTH . -
-
4-9
1-24
" . ,
, - ,
4-9
.
ACTH
ACTH .
-
4-9
-hydroxy-dopamine. 6
ACTH .
-
4-10
.
, " "
.
CNS-.
. , -
1-10
ACTH .
ACTH .
1-39
GABA , , ,
ACTH- .
.
. frontal cortex- DA -
1-24
ACTH .
ACTH .
ACTH
ACTH
4-10
1-24,
1-10
hippocampus- ,
)CLIP-(
ACTH
4-11,
1-4
ACTH )( .
ACTH
18-39
).( hippocampus-
ACTH .
MSH -
1-24
-
4-11
ACTH
1-4
) ACTH( . ,
). )
1-24
ACTH .
)).
1-24
). )
-
1-16
ACTH -
1-24
ACTH .
). ) ,
. -
1-10
in-vitro). )
. RNA
ACTH- -70%
)).
ACTH-
ACTH-
. Rathke's pouch-,
, ACTH- ,
, ,
.
. GC ACTH-
ACTH . .
ACTH-
.
ACTH .
.
- ACTH-
) ( GC
.
ACTH ACTH-
, .
. . , 18 ACTH-
,
)).
.ACTH
CRF 7 (CRF) corticotropin releasing factor-.
14. CRF . CRF-I ,
CRF-III ,. 34-41 ,CRF-II ,
CRF-
CRF-I
FIYHSYK pig
CRF-II
SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH sheep
2
SEEPPISLDLTFHLLREVLEMARAE QLAQQAHSNRKLMEI I-NH human, rat
2
CRF-III
NRKLLD IA-NH sheep
2
AVP-
, CRF- AVP- .
,
. , CRF-
" CRF- ACTH. CRF, AVP
. AVP- CRF- AVP-,
ACTH . CRF- AVP- species-
CRF-. , ACTH AVP
ACTH CRF-
. -20% CRF- AVP AVP-
ACTH-
A
V
P
-
ANF
MSH-IF
NE
NE
somatostatin
substance P
enkephalins
5-HT
AVP CRF
ANF
ACTH
IL-1
Ang.II
, V , ACTH
1
V . ACTH V
2
1
( )PKC- (protein kinase C
V ). ,
1
AVP-. ACTH- PKC-
CRF-. ACTH-
CRF-. ACTH- PKC-
cAMP-, CRF- ,
,
CRF- .
, PKC-
. PKC AVP-
- CRF.
ACTH- CRF ,
. AVP- .
: , ACTH
. CRF
CRF )paraventricular nucleus- (PVN ,
,AVP , , AVP ,AVP , CRF
) (.
PVN- .
,
. button-
,
-
ACTH PVN- . .
. PVN-
CRF , -
. , - NE
.ACTH ,
NE
ACTH- , . , ACTH-
CRF.
ACTH-
. )( .
ACTH :
.(MIF MSH-IF) MSH inhibiting factor- ,substance-P ,
. ,
ACTH,
, . ,
, ACTH-
GC .
ACTH-.
. -N- . MIF-
.
-HT- . -HT- 5 5
,substance-P
, , CRF
.
. ACTH
CRF GABA- . ACTH-
. ACTH-
" " ACTH
CRF " CRF
CRF ACTH- ACTH, long-NFB.
, .short-NFB ,
POMC- CRF- mRNA-
ACTH .
. CRF , ,
ACTH-
.POMC- ,
ACTH- .
ACTH- GC- .
ultrashort-NFB- GC-" ACTH. (long-NFB
). ACTH-"
,POMC-
promotor- . ,POMC-
GC- .
,
. ACTH.
AVP ) GC-
( . , Ang.II-
ACTH- , GC-
.
, POMC-. GC-
.
) ,
( . " ,
ACTH- , ACTH-.
.
AVP )-( ,
, "
AVP , Ang.II- .
CRF AVP- - . CRF- ACTH Ang.II- , ACTH.
Ang.II- . ,
Ang.II- AVP-. CRF- ACTH
.ACTH- , AVP- CRF- mRNA-
) Ang.II- - captopril-
ACTH , ACTH-( ,
Ang.II- . , CRF
ACTH-.
, ,
AVP-
(ANF
)ANF-
AVP
ANF- . , ,
AVP+CRF. CRF-, AVP, ACTH-
,
POMC mRNA- ANF,
. ACTH
, , ,
GC- .ACTH .
, ACTH-,
. long-NFB
,
. ACTH
)interleukin-1- (IL-1
'
. ACTH- ,
IL-1-
IL-1- .ACTH- CRF- IL-2- IL-1-
.CRF
CRF, ,
IL , CRF-. ACTH ACTHCRF ACTH- 1 . ,
CRF- . , POMC- mRNA-
IL-1- .
. PLA .
2
( PAF- .
PLA ACTH-,( . , 2
PLA -. ACTH-, GC- .
2
VIP- . ACTH
D ,
ACTH-, .
-hydroxy-dopamine 6
). , )
ACTH-
)).
. ACTH , CRF- CRF
ACTH , CRF , , .
. ACTH- CRF GC-
- ACTH-
.- ACTH CRF
ACTH-
. ACTH
urotensin-I- ACTH
urotensin-I- -50% CRF- .urophysis-
-50% ACTH
ACTH Ang.II- .urotensin-I
isotocin- AVT- . ,
, ACTH
. ,CRF- urotensin-I-