Professional Documents
Culture Documents
SESSION 2007-2012
COLLEGE OF PHARMACY
GC UNIVERSITY
FAISALABAD
Pharmaceutical unit dosage form
SUPPOSITORIES
DEFINITION
FOUR METHODS
PREPARATION
METHODS OF PREPARATION
Four methods
3. Molding by hand
4. Compression
5. Pour molding
6. Compression in a tabletting machine
● MOLDING BY HAND
STEP 1
drug
fine powder
1. MOLDING BY HAND
STEP 2
Drug (fine powder)
Base
1. MOLDING BY HAND
STEP 3
Trituration
in pestle and
mortar
1. MOLDING BY HAND
STEP 4
Mass
Rolled
Long rods
1. MOLDING BY HAND
STEP 5
Rods
STEP 1
drug
fine powder
2. COMPRESSION
MOLDING
STEP 2
Drug (fine powder)
Base
2. COMPRESSION MOLDING
STEP 3
Trituration
in pestle and
mortar
2. COMPRESSION
MOLDING
STEP 4
Compress the
mixture in the
compression mold
ADVANTAGES
1. It is a simple method
2. More elegant than hand molded
suppositories.
3. Sedimentation of solids in the base is
prevented.
DISADVANTAGES
STEP 1
drug
fine powder
3. POUR MOLDING
STEP 2
STEP 3
Drug incorporation
into melted base
3. POUR MOLDING
STEP 4
Cooling down
process
3. POUR MOLDING
STEP 5
Molds are chilled
(lubricate if
necessary)
3. POUR MOLDING
STEP 6
Molten liquid mass
chilled molds
3. POUR MOLDING
STEP 7
Warm spatula
3. POUR MOLDING
STEP 8
Removed
excessive part via
warm spatula
3. POUR
MOLDING
STEP 9
After solidification
the cone shaped
suppositories are
removed.
● AUTOMATIC MOLDING
MACHINE
In
industry all the operations in pour
molding are done by automatic
machines.
PRACTICAL
PROCEDURE
STEP 1
Given by physician
Drug quantity e.g., 400 mg zinc oxide
Total weight of suppository e.g., 2g
No of suppositories e.g., 10
Purpose e.g., For rectal use
STEP 2
Select mold
Solidification
excessive removed
STEP 4
melt
Check volume of
remelted base
Confirm average
weight of suppository
STEP 5
Check the weight by
using formula
Mass= density × volume
Homogeneous
mixture
STEP 9
pour into the mould
Solidification
Excessive removed
RESULT
Desired suppository
Note
it is normal practice to prepare for an
excess quantity of suppositories
RULES AND PREVENTIONS
SUPPOSITORY
PACKAGING
PACKAGING
Types of molds of different shapes and
volumes
Reusable
Stainless steel mold
Aluminium mold
Brass mold
Plastic
Disposable
Soft Plastic molds
PACKAGING
Suppositories manufactured in metal
moulds
Placed in container
PACKAGING
Suppositories manufactured in disposable
moulds
About Containers:
Environmental Factors:
Important due to base
SUPPOSITORY
DISCARD DATES
DISCARD DATES
Thanks
Questions?