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1916 .
1956 [Leland Clark].
1962 :
. [Leland Clark, New York Academy of Sciences Symposium].
1969 [Guilbault and Montalvo].
1972/5 :
Yellow Springs Instruments.
1980 in vivo .
1982 .

1983
(SPR).

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3.

DNA RNA


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(Evanescent wave):
(, , )


(Surface Plasmon Resonance)

(Evanescent wave)
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(Surface Plasmon Resonance)

Surface Plasmon wave

(~50nm)

q2
q1


(Surface Plasmon Resonance)

Kx(.)
a
Kz (.)
dz = 200nm

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t


(Surface Plasmon Resonance)
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CCD

CCD
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Beer-Lambert:

I 0
Absorbance log10

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2 LED, 660nm
910nm

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laser

laser


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98%

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(Lab on a Chip)








, 6.1 2004 8.2
2009.( 6.3%)
2003

2009

99%



: http://www.bccresearch.com/
: http://www.bccresearch.com/


F. S. Ligler, C. A. Rowe Taitt, Optical Biosensors:Present and Future, Elsevier, 2002
I. Willner, E. Katz, Bioelectronics: From Theory to Applications, Wiley-VCH, 2005
F. Schubert, Biosensors, Elsevier, 1992
J. Cooper, A. E. G. Cass, Biosensors: A Practical Approach, Oxford University
Press,2004
T. Vo-Dinh, Biomedical photonics handbook, CRC Press, 2003
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