: GLP-1 (-1 glucagon -like peptide-1

: GLP-1 (
-1 glucagon -like peptide-1

peptidase 4DPP-4)

(incretin)

(glucagon-like peptide 1

T2DM

GLP-1) (distal

(incretin action)

ileum) (colon)

DPP-4

(incretinmimetics)

GLP-1

DPP-4 (DPP-4

inhibitor)

( cells)

(glucagon-like peptide 1

(insulin)

agonists, GLP-1 agonists)

( cells)
(glucagon)

GLP-1

T2DM

GLP-1

(gastric emptying)

(satiety sensation)

GLP-1

-4 (dipeptidyl

-1

252

 JOURNAL OF KAOHSIUNG MEDICAL ASSOCIATION 2015. vol. 23, No.3

glucagon-like peptide-1

agonists, GLP-1 agonists

GLP-1

-4dipeptidyl

peptidase-4 inhibitors, DDP-4

inhibitors

GLP-1T2DM

GLP-1

1GLP-1

253

: GLP-1 (-1 glucagon -like peptide-1

Exendin-4Gila

GLP-1

monster

GLP-1

GLP-1

DDP-4Exenatide

exendin-4

metformin

glitazone

GLP-1

Exenatide

GLP-1

Byetta5g

60

10

Bydureon
2mg

Exenatide

T2DM

HbA1C

GLP-16

T2DM

GLP-1

exenatide

GLP-1T2DM

exenatide

Liraglutide

exenatide

GLP-1

Byetta,Bydureon,

liraglutide Victoza,

0.6

GLP-1

254

 JOURNAL OF KAOHSIUNG MEDICAL ASSOCIATION 2015. vol. 23, No.3

1.2-1.8

GLP-1

Liraglutide

T2DM

HbA1Cexenatide

T2DM

exenatide

exenatide

1. -incretin
DDP-4

137-140.(

GLP-1 2005

DPP-4

2. Henriksen JH, de Muckadell OB.

2006

S e c r e t i n , i t s d i s c o v e r y, a n d t h e

introduction of the hormone concept.

Scand J Clin Lab Invest 2000; 60: 463-

8.0%HbaA1CGLP-1

71.

HbaA1C1.5%

3. AK. Mitra Assemi Betsy AC. Diabetes

HbaA1C

Mellitus. In: Koda-Kimble Mary Anne

HbaA1CGLP-1

et al. Applied Therapeutics: The Clinical

Use Of Drugs, 9th ed. 2009, Chap. 50.

4.Diabetes Mellitus. In: Pharmacotherapy:

A Pathophysiologic Approach, 8th ed.

2009, Chap. 83.

T2DM

5.Andre J Schen. A Review of gliptins in

GLP-1

2011. Pharmacother. 2012, 13(1):81-99.

255