12/1/2015

RajGosavi,Ph.D.|LinkedIn

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RajGosavi,Ph.D.

1st

NMSUProfDoctorate
Learnanalytical,scientifically
validapproachestoeconomic
development.

ScientistI,KBIBiopharma
RaleighDurham,NorthCarolinaArea

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Research

Current

KBIBiopharma

Previous

NIEHS,DurhamTechnicalCommunityCollege,The
UniversityofToledo

Education

UniversityofToledo,Ohio

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Connected41minutesago

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ContactInfo

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NamTonthat

Email

ScientistII/ProjectLeaderatKBI
Biopharma

rajgosavi@gmail.com

LeiPeng
Linkedin

ScientistatKBIBiopharma

https://www.linkedin.com/in/rajgosaviphd57269818

MukeshMaheshwari

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ScientistIatKBIBiopharma

Background

TravisKirkpatrick
ResearchAssociateatKBI
Biopharma,Inc.

Summary

AmandaHoertz
AssociateDirectoratKBIBiopharma

Enthusiasticandmotivatedindividualwithaninterestinbiochemistryandstructuralbiology.
DeepaSingh

Researchbackgroundisinchemicalengineeringandstructuralbiology.Havefocused(graduatestudies)
onparametersthatimproveproteinsolubilityandlikelihoodofproteincrystalnucleation.Extendedsome
oftheseconceptsonstructuralbiologyprojectsinpostdoctoralstudies.Havefosteredmyteamworking
skillsthroughexperienceinacollaborativeenvironment.

PostDoctoralFellowatNational
InstituteofEnvironmentalHealth
Sciences

PrathimaAcharya
ChiefBusinessDevelopmentOfficer
atKBIBiopharmaInc.

Apartfromresearch,Ihaveexperienceorganizingandmanagingprofessional&careerdevelopment
events.Currentlycontributingasawriterfortheinstitutesmonthlynewsletter.Havebeeninvolvedin
volunteerteachingopportunitiesatlabbenchaswellasincommunitycollege.
Anotherpersonyoumay
know
Currentlyavailablefornewopportunitiesthatrequirescientificbackgroundinproteinbiochemistryand
LeiLiPostdoctoralFellowat
structuralbiology.Tocontactpleaseemailatrajgosavi@gmail.com
MississippiStateUniversity

AbhinavShukla
Sr.VicePresident,Process
DevelopmentandManufacturingat
KBIBiopharma

GeorgeBrough
ScientistIIatKBIBiopharma

Experience

AmandaRussellRibaudo,Ph.D.
ScientistIIatKBIBiopharma

ScientistI
KBIBiopharma
October2014Present(1year3months)

Guestwriter|TheEnvironmentalfactor
NIEHS

InCommonwithRaj
Raj

July2013September2014(1year3months) | RaleighDurham,NorthCarolinaArea
HavecontributedtotheNIEHSmonthlynewsletterbywritingshortarticlescoveringseminars,
departmentretreat,aregionalconferenceandintramuralpapers
Youcanfindmycontributionsinthefollowinglink.
http://tinyurl.com/GosaviArticles

ResearchFellow|Crystallography|Environmentaltoxicology|
Biochemistry
NIEHS

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12/1/2015

RajGosavi,Ph.D.|LinkedIn

April2013September2014(1year6months) | CollaborativeXrayCrystallographygroup|Raleigh
Durham,NorthCarolinaAre
Obtainedstructuralinsightsintotheinhibitorypotentialofbrominateflameretardantstowardsestrogen
hormonemetabolizingenzymeleadingtoaselectedoralpresentationandonepublication.Exposureto
ubiquitouslyfoundbrominatedflameretardantshavebeencorrelatedwithadversehealtheffectsin
humans.
Involvedinthedesign&developmentofaprojectforasummerinterninthelabaswellaswas
responsiblefortraining,guidanceandsupervisionthroughouttheinternship

7
Skills&Expertise

1
Group

3Dimagesshowflameretardantscanmimi

VolunteerTeaching|Biochemistry
DurhamTechnicalCommunityCollege
July2013July2013(1month) | RaleighDurham,NorthCarolinaArea
TaughttheBiochemistrysectionoftheChem130course
Developedandoptimizedtheinstructiontoaccommodatetheprofessionaldiversityintheclassroom

PostdoctoralFellow|Crystallography|DNArepair|Allergens
NIEHS
April2008March2013(5years) | StructureFunctionResearchgroup|RaleighDurham,NorthCarolina
Area
InvolvedinstructuralcharacterizationofallergensArah2,apeanutallergenandDerp5,adustmite
allergen.Structuralcharacterizationofallergenshelpinbetterunderstandingfordevelopmentof
immunotherapeuticstrategies.
ProvidedastructuralinsightsintoeachstepoftheDNArepairenzymescatalyticmechanismof
incorporatingaribonucleotideleadingtoaselectedoralpresentationandonepublication.

Chair|NIEHSTraineesAssembly|Professionalcareerdevelopment
NIEHS
July2009June2010(1year) | RaleighDurham,NorthCarolinaArea
Involvedincoordinatingprofessionaldevelopmentworkshopsandactivitiesforpostdoctoralfellowsat
theNIEHS
ProvidingaplatformforintercommunicationamongNIEHSfellowsthrougheventssuchas
PostdoctoralAppreciationDayandGeneralAssemblymeeting
InvolvedasofficialtraineesliaisontotheNIEHSadministration

CoChair|BiomedicalCareerFair|Professionalcareer
development
NIEHS
September2009April2010(8months) | RaleighDurham,NorthCarolinaArea
CareerFair,aprofessionaldevelopmenteventforpostdoctoralfellowsandgraduatestudents,provides
opportunityfortheparticipantstolearnaboutsciencecareeropportunitiesthroughworkshops,panel
discussionsandnetworking.
Responsibleforrecruitingandcoordinatingpanelofprofessionals
InvolvedinorganizationoftheCareerFairCommitteeandchartingoutgoalsforcompletingtasks
withindeadlines
Involvedindevelopmentanddesignoftheagendacomprisingofpanelsessionsandworkshops
Workedtogetherwithateamof15membersonthecommittee

TeachingAssistant|ChemicalandEnvironmentalEngineering|
SAXS/WAXS
TheUniversityofToledo
August2007December2007(5months) | Toledo,OhioArea
DepartmentofChemicalandEnvironmentalEngineering
ResponsibleforoverseeingtheuseandmaintenanceofRigakusUltimaIV(XrayDiffractionwith
SmallandWideangleXrayscattering)
Responsibleforensuringtrainingofnewusersfortheinstrument

GraduateStudent|Bioseparations|Crystallization
TheUniversityofToledo
August2002December2007(5years5months) | Toledo,OhioArea
DepartmentofChemicalandEnvironmentalEngineering

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12/1/2015

RajGosavi,Ph.D.|LinkedIn

Developedandconductedsolubilitystudiesonproteinstounderstandtheeffectofadditivesonprotein
solubilityandnucleationofproteincrystalswhichresultedinthreepublications
Responsibleforidentifyingoptimalbufferconditionstoimprovetheproteincrystalhitsinhigh
throughputcrystallizationexperiments
Supervised,trainedandguided3undergraduatestudentsinprojectdevelopment
Activities:Committeemember,EngineeringGraduateStudentAssociation(EGSA).

TeachingAssistant|ChemicalandEnvironmentalEngineering|
UndergraduateCourse
TheUniversityofToledo
August2002May2003(10months) | Toledo,OhioArea
TAfortwosemesters(Fall2002andSpring2003)
DepartmentofChemicalandEnvironmentalEngineering
Responsibleforinstructionofexperimentsforthelab
Evaluationofstudentscomprehensionoflabmaterialsandfinalreports

Languages

English

Hindi

Nativeorbilingualproficiency

Nativeorbilingualproficiency

Marathi
Nativeorbilingualproficiency

Organizations

NationalPostdoctoralAssociation
StartingFebruary2009

SigmaXI
StartingMarch2013

Publications

Mimickingofestradiolbindingbyflameretardantsandtheirmetabolites:a
crystallographicanalysis.
(
EnvironHealthPerspect
L
October2013
i
BACKGROUND:
n
k
Brominatedflameretardants(BFRs),usedinmanytypesofconsumergoods,arebeingstudiedbecause
)
ofconcernsaboutpossiblehealtheffectsrelatedtoendocrinedisruption,immunotoxicity,reproductive
toxicity,andneurotoxicity.TetrabromobisphenolA(TBBPA),themostwidelyusedBFR,andhuman
metabolitesofcertaincongenersofpolybrominateddiphenylether(e.g.,3OHBDE47)... more

ThecatalyticcycleforribonucleotideincorporationbyhumanDNAPol

(
L
i
AlthoughmostDNApolymerasesdiscriminateagainstribonucleotidetriphosphaets(rNTPs)duringDNA
n
synthesis,recentstudieshaveshownthatlargenumbersofribonucleotidesareincorporatedintothe
k
eukaryoticnucleargenome.Here,weinvestigatehowaDNApolymerasecanstablyincorporatean
)
NucleicAcidsRes
August2012

rNTP.TheXraycrystalstructureofavariantofhumanDNApolymeraserevealsthattherNTP
occupies... more

Arah2:crystalstructureandIgEbindingdistinguishtwosubpopulationsof
peanutallergicpatientsbyepitopediversity
Allergy
July2011
Background:Peanutallergyaffects1%ofthepopulationandcausesthemostfatalfoodrelated
anaphylacticreactions.TheproteinArah2isthemostpotentpeanutallergenrecognizedby8090%of
peanutallergicpatients.

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12/1/2015

RajGosavi,Ph.D.|LinkedIn

Methods:ThecrystalstructureofthemajorpeanutallergenArah2wasdeterminedforthefirsttimeat
2.7resolutionusingacustomizedmaltosebindingprotein(MBP)... more

Derp5CrystalStructureProvidesInsightintotheGroup5DustMiteAllergens
(
TheJournalofBiologicalChemistry
L
August13,2010
i

Group5allergensfromhousedustmiteselicitstrongIgEantibodybindinginmiteallergicpatients.The
n
structureofDerp5wasdeterminedbyxraycrystallographytobetterunderstandtheIgEepitopes,to
k
investigatethebiologicfunctioninmites,andtocomparewiththeconflictingpublishedBlot5
)
structures,designated2JMHand2JRKintheProteinDataBank.Derp5isathreehelical... more

Thedistributionofimpuritiesinlysozymecrystals

(
L
i
Theeffectivedistributioncoefficient,KIeff,ofturkeyeggwhitelysozymeintohostheneggwhite
n
lysozymecrystalswasmeasuredforvaryinglevelsofrelativesupersaturation,impurityconcentrations
k
andtemperatures.Turkeyeggwhitelysozymeservedasatestimpurityofhighhomologytohenegg
)
JournalofCrystalGrowth
August1,2009

whitelysozyme.KIeffincreasedwithincreasinghostproteinconcentrationandtemperature,... more

Beneficialeffectsofsolubilityenhancersonproteincrystalnucleationand
growth
Langmuir(
L
April21,2009
i
Crystallizingsolutionsofproteinsoftencontainvariousnonelectrolyteadditivesthatarisefromthe
n
purificationprocessofproteinsorfromthereagentsemployedinthescreeningkits.Currently,limited
k
knowledgeexistsabouttheinfluenceoftheseadditivesonthemechanismsunderlyingthe
)
crystallizationprocess,inparticularonthenucleationstageofcrystals.Toaddressthisneed,
we... more

Optimizationofbuffersolutionsforproteincrystallization
ActaCryst.D
May2008
Increasingthesolubilityofproteinstocksolutionstoabovethatinastandardchromatographybuffer(50
mMTrisHClpH7.5,100mMNaCl)ledtoanincreaseinthenumberofcrystallizationconditionsforten
globularproteinssubjectedtotwocrystalscreens:theIndexandPrecipitant/PrecipitantAdditive(P/PA)
Screens.Solubilityenhancementofproteinstocksolutionswasachievedthrough... more

Skills

TopSkills
28

ProteinExpression

24

Biochemistry

19

ProteinPurification

18

ProteinChemistry

12

MolecularBiology

11

WesternBlotting

11

MolecularCloning

TissueCulture

PCR

Purification

Rajalsoknowsabout...
4

FluorescenceMicroscopy

Cell

Xraycrystallography

Transfection

CellCulture
3

ConfocalMicroscopy

Biophysics

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12/1/2015

RajGosavi,Ph.D.|LinkedIn

Education

UniversityofToledo,Ohio
Ph.D.,ChemicalEngineering
20022007
ActivitiesandSocieties:EngineeringGraduateStudents'Association,Secretary(2003)IndianStudents
CulturalOrganization,PRO(2004)

Recommendations

Given(1)

Desheng,wouldyouliketorecommendRaj?
RecommendRaj

IrinaPerdivara
ResearchFellow

IinteractedwithIrinawhenwewerebothpostdoctoralfellowsattheNIEHS.Ihavehad
excitingdiscussionsaboutourprojectsduringourdepartmentalretreats.Ihavehadthe
opportunitytotrackherprogressthroughannualdepartmentalpresentationsandIcansay
thisthatshedisplayedgreatholdonpresentationskillsaswellasstrongevidenceofher
productivity.... more
May5,2013,RajworkedwithIrinaatNIEHS

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