JOURNAL OF KAGHSIUNG MEDICAL ASSOCIATION 2015. vol. 23, No.4 l0RBSFREAREREMA-WHRS BEBSARMOPNLAMK TRI EMT WED Br: K Wes BBs a — A >t Jee — M8 BEL, FF as BS SE Ld TEBSA KB ABE OS FER = 8 SUNY Aa > th FEA RoR fe BT DAL > Se ESE ESS + atk + KB ABBAS BS SBE (sporadic) » Rete (familial) Be SEE (hereditary) HALRB Be LENA FE BRT a PRIS > PEDRO HE Be De BRI Be Sth FARA EOSEL Ss SEISEAISE © EPRI BIA SEANA— AMM ABA BSE Sr Bl + ARIES > Ce EA EES 15, OOO TY ABS EL aE A OUR BEA + A EE th Bea BOEIN 6, 000(f8 ERA Is Fi ait Bil > WRU Ib > KiB EL Bait te SEER BS AM BES RY I PEI 3 AF HLS AER TS SEV MR BAK + ith K BABEAK SPB TEEL + 10 378 SER BED BRDU RAEI LE UAE + SCR LF RANA AS a ive « ORE: X + Bl 1 0 FB EY 38 HE ie AIR ZS RE RISE > IRAE FAB EE AT ACRE + A — BF PEASE GE PRSHE > MLO» LAG > TDK ERO > RE A LR ¢ RBA > A KM BSA Cl — ) LA Be BB eS ‘We ar CCE) — ) ELAS ea SUD MS WHO ‘NE RR TMB SM ISTNM stage: T3N2aM0 (IIIB) > *H DR EHASL DFM CCEA) LA Be AB A LA EAC HIT Be 2S FS CE TE BS ELA «A BIAGERE 2 Ale Ke aE CB LSE ER AASB + BOP EH it FTE BI + PREHEAT LL TIRE EWU DE» — (i SB We FS at TAUB RGB RFA‘Hie BB EA BES By signet ring cell carcinoma » [iiRRA/IVRy A x 5.3 om’ 5 FRLTABEES TEGO HL > FEC 1 By STEN, WAS 16%4}Fypoor differentiated ; lymph-vascular invasionLAK perineural ah) 35 Fy Ma te BCE + HSL 1B (T3N2bMO) + 5 AY RG eR HEY A BA Beh Bo FyBRAF wild type (mutation was not found in codon 600); KRAS wild type (mutation was not found in codons 61 and 146, 12 and 13)L\KNRAS wild type (mutation was not found in codons 12, 13,59, 61,117 and 146) ° ZEAPC geneJyifi + FeMw ae Bifeexon 15/1 Zes4H ° ‘ite — MB BAER {ei EIT —2RHIMFOLFOX 6 (85 mg/ n’ dose of oxiplatin + 2000 mg/ m’ dose of 5-FU) WOBNTE(LHE > 53 SMALE CEA NS Hawes — FRE RE TE IE A Ania AREA BHR HES COIR GRE TERESI A EASE AEF fii Be BCE A he RE FELIS OPED HEE RAT EAB BBE ° Stefi: HRAKB ABH 379 DABS T HDA RS: AaB © ANI ERAIF > Mlulcerative rectocolitis, adenomatous polyposis (FAP) Lh B& hereditary nonpolyposis colorectal cancer (HNPCC) + 4£ LO BRL HiT HK Be EB A EP EMA HSS © — Fs SME HEN MH (da Costa Vieira RA et al. 2015) 95H > 185546.2 RISE SCSCRRIBIA + 10 pe DUBIN RHA 1S EL > ERA AAA B16 fF ADIT ° LOR ZMKMBEAB ABO LAA RS TAABA BHEHIO. 4 to 0.9 % Heyer PARE. 2: 1° SERINE AZE CRURNRAS SM > te Dukes LAS EDukes CFAUD > HARA ASI ABT SRI HB hs > CMM Ls AMR AME MARIA 01 loi dsRsignet A AWHE TRIS (median and mean Kaplan-Meier survival) KAS 262140. 5 fA Fl + Ba — sien AI EB Bas A FALE > HAIRS FAIRE > familial adenocarcinoma pv aemucinous + ring cell. De tH IES Ftc BR IF Ld Be TR aE BAR AE > WERE A APSA PERI FRR SE BEF AP DA BHNPCCSEHS FD© TION 2015. vol REGGIE JOURNAL OF KAOHSIUNG MEDICAL ASSt 23, No.4 WEE Fike > RE AMEE LA AER TT AUD SCE ALAS MISES» HERE > (IRAE By LASS > TD BONA BA ASABE FE BREF LY Be Hk ARS AG BEE ID 7 EAE > WISE LE — 2 NUR RA SU TRTRIE SEM: I.da Costa Vicira RA, Tramonte MS, Lopes LF. Colorectal carcinoma in the first decade of life: a systematic review. Int J Colorectal Dis. 2015 Aug;30(8):1001-6. 2.Ferrari A, Rognone A, Casanova M, Zaffignani E, Piva L, Collini P, Bertario L, Sala P, Leo E, Belli F, Gallino G.Colorectal carcinoma in children and adolescents: the experience of the Hl. ABEBARA: BRECMSSHRe 380 Istituto Nazionale Tumori of Milan, Italy. Pediatr Blood Cancer. 2008 Mar;50(3):588-93. 3.Siegel R, Desantis C, Jemal A Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014 Mar-Apr;64(2):104- 17. 4.Brown RA, Rode H, Millar AJ, Sinclair- Smith C 'ywes S.Colorectal carcinoma in children. J Pediatr Surg. 1992 Jul;27(7):919-21 5.Rahman MA, Chowdhury TK, Bhuiyan MA, Al Farooq MA, Sajid MM, Banu T.Color ctal carcinoma in first decade of life: our experience. Pediatr Surg Int. 2014 Aug;30(8):847-51 6.Karnak I, Ciftei AO, Senocak ME, Biyakpamukgu N. Colorectal carcinoma in children. J Pediatr Surg. 1999. oct;34(10):1499-504 S: ROBES CERES HRES TR