Preliminary Outline Organizational Chart

Supporting Detail 1
1 Main/General
Idea
st

Cannabidiol has less

side effects than
amisulpride.

Cannabidiol exert
antipsychotic effects in
schizophrenics.
(Cannabidiol enhances
anandamide)
Both amisulpride and
cannabidiol had
significant improvement
for the schizophrenic
patients in the blind
experiment
(Cannabidiol enhances
anandamide)
No difference in
proportion of
responders: CBD=
15/20, AMI= 14/19.
(Cannabidiol enhances
anandamide)
No relevant difference in
the treatment itself and
its reducing effect of
psychotic symptoms
(Cannabidiol enhances
anandamide)

Supporting Detail 2

Side effects
measured through
Extrapyramidal
Symptom Scale
(EPS) included:
measurement of
serum prolactin,
body weight,
routine blood
parameters,
electrocardiograms,
etc. (Cannabidiol
enhances
anandamide)
Unwanted side
effects: CBD= 3
patients; AMI= 5
patients
(Cannabidiol
enhances
anandamide)
Patients undergoing
either cannabidiol
or amisulpride
treatment showed
significant clinical
improvement
(Cannabidiol
enhances
anandamide)

Supporting Detail 3

No relevant
differences
between both
amisulpride and
cannabidiol.
(Cannabidiol
enhances
anandamide)
Less side effects
than amisulpride
(Safety and Side
Effects of
Cannabidiol).
cannabidiol was
associated with
significantly fewer
extrapyramidal
symptoms less
weight gain and
lower prolactin
increase
(Cannabidiol
enhances
anandamide)
found no
difference in the
proportion of
responders ( 20%
improvement in
PANSS total score)
to each treatment
(CBD 15/20, AMI
14/19, P=1.000).

Stats/Vocab
Cannabidiol- nonpsychotropic
component of
marijuana that binds
to CB1 receptors with
only comparably very
low affinity and is
devoid of overt
cannabimimetic or
pro-psychotic
properties.
Amisulpride- an
antipsychotic drug for
schizophrenia.
Deemed most
effective.
Endocannabinoid(ECS) a group of
endogenous
cannabinoid receptors
in the mammalian
brain and throughout
the central and
peripheral nervous
systems, consisting of
neuromodulatory
lipids and their
receptors.
Prolactin- predictor of
galactorrhoea and
sexual dysfunction

2 Main/General
Idea
nd

Effects of Amisulpride

Extrapyramidal side effects:

parkinsonian syndrome
(Extrapyramidal side
effects with low doses of
amisulpride)
slowed gait
(Extrapyramidal side
effects with low doses of
amisulpride)
mild rigidity
(Extrapyramidal side
effects with low doses of
amisulpride)
tremor of tongue and
hands. (Extrapyramidal
side effects with low
doses of amisulpride)
Akathisia
(Extrapyramidal side
effects with low doses of
amisulpride)
acute dystonic reaction
with oculogyric crisis,
spasm of neck, and hand
muscles

Other side effects:

Sexual dysfunction
(Cannabidiol
enhances
anandamide)
Weight gain
(Cannabidiol
enhances
anandamide)
Affect hepatic or
cardiac functions
(Cannabidiol
enhances
anandamide)
Dry mouth
(Cannabidiol
enhances
anandamide)

(Cannabidiol
enhances
anandamide)
lorazepam comedication did not
significantly
influence the
results
(Cannabidiol
enhances
anandamide)
Benefits:
Manages positive
symptoms
(Clinical
Advantages of
Amisulpride)
Affects
neurotransmitter,
dopamine.
(Clinical
Advantages of
Amisulpride)
Blocks CB1
receptors
(Clinical
Advantages of
Amisulpride)

Lorazepam- medicine
that treats seizures
FAAH- Fatty Acid
Amide Hydrolase

Parkinsonian
syndrome: clinical
syndrome
characterized by
tremor, bradykinesia,
rigidity, and postural
instability
Akathisia: a state of
agitation, distress, and
restlessness that is an
occasional side-effect
of antipsychotic and
antidepressant drugs.

3rd Main/General
Idea
Effects of cannabidiol

(Extrapyramidal side
effects with low doses of
amisulpride)
Benefits of cannabidiol:
CBD metabolite, or a
component of what
people would normally
have in THC. (Interview
with Dr. Elmer)
Doesnt necessarily react
in the same receptors
that the THC reacts to.
THC will react to CB1
or CB2 receptors.
(Interview with Dr.
Elmer)
Cannabidiol acts as an
antagonist and block the
receptors of CB1 or
CB2. (Interview with Dr.
Elmer)
Host other effects on
transmitters that we
think is involved in the
illness. (Interview with
Dr. Elmer)
It may be effective but
not because it's acting as
cannabis but its acting in
the receptors in a way
that will block or
stabilize the receptors in
other pharmacology.
(Interview with Dr. Elmer)
cannabidiol is as
effective at improving

Short term effects

are:
altered senses (for
example, seeing
brighter colors)
("Safety and side
effects of
cannabidiol, a
Cannabis sativa
constituent.")
altered sense of
time ("Safety and
side effects of
cannabidiol, a
Cannabis sativa
constituent.")
changes in mood
("Safety and side
effects of
cannabidiol, a
Cannabis sativa
constituent.")
impaired body
movement ("Safety
and side effects of
cannabidiol, a
Cannabis sativa
constituent.")
Difficulty with
thinking and
problem-solving
("Safety and side
effects of

Mental Side Effects:

Temporary
paranoia and
hallucinations.
("Safety and side
effects of
cannabidiol, a
Cannabis sativa
constituent.")
Increased heart
rate ("Safety and
side effects of
cannabidiol, a
Cannabis sativa
constituent.")
Shortage of
breathing ("Safety
and side effects of
cannabidiol, a
Cannabis sativa
constituent.")
Short-term
memory and other
cognitive deficits
("Safety and side
effects of
cannabidiol, a
Cannabis sativa
constituent.")
Delayed response
("Safety and side
effects of

psychotic symptoms as
the standard
antipsychotic
amisulpride.
(Cannabidiol enhances
anandamide)
may protect anandamide
from deactivation by
interfering with FAAH
activity 15
(Cannabidiol enhances
anandamide)
Doesnt induce catalepsy
Doesnt induce blood
pressure and body
temperature
("Safety and side effects
of cannabidiol, a
Cannabis sativa
constituent.")

cannabidiol, a
Cannabis sativa
constituent.")
impaired memory
("Safety and side
effects of
cannabidiol, a
Cannabis sativa
constituent.")

cannabidiol, a
Cannabis sativa
constituent.")
Hzwaves getting
aroused ("Safety
and side effects of
cannabidiol, a
Cannabis sativa
constituent.")
Generates CO
("Safety and side
effects of
cannabidiol, a
Cannabis sativa
constituent.")

Cited:
Bergamaschi, M. M., R. H. Queiroz, A. W. Zuardi, and J. A. Crippa. "Safety and side effects of cannabidiol, a Cannabis sativa constituent."
National
Center for Biotechnology Information. U.S. National Library of Medicine, 11 Sept. 2011. Web. 01 Mar. 2016.
Burns, T., and R. Bale. "Clinical Advantages of Amisulpride in the Treatment of Acute Schizophrenia." National Center for Biotechnology
Information. U.S. National Library of Medicine, n.d. Web. 13 June 2016.
Leweke, F. M., and D. Piomelli. "Cannabidiol Enhances Anandamide Signaling and Alleviates Psychotic Symptoms of
Schizophrenia."Nature.com.

Nature Publishing Group, 20 Mar. 2012. Web. 13 June 2016.

Mandal, Nikhiles, Om P. Singh, and Subrata Sen. "Extrapyramidal Side Effects with Low Doses of Amisulpride." Indian Journal of Psychiatry.
Medknow Publications & Media Pvt Ltd, Apr. 2014. Web. 13 June 2016.