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  • Tuesday, August 18, 2009

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    zorbax
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    Transporte activo. Canales de Na, Ca, Glucosa, ATPasas tipo V, P, F, ABC

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    Bombas ATPasas

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    Transporte activo. Canales de Na, Ca, Glucosa, ATPasas tipo V, P, F, ABC

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    222 views47 pages

    Tuesday, August 18, 2009

    Uploaded by

    zorbax
    Transporte activo. Canales de Na, Ca, Glucosa, ATPasas tipo V, P, F, ABC

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 47

    Tuesday, August 18, 2009

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    ESTRUCTURA DE LA Na+,K+-ATPasa

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    OUABAINA

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    Sitio para Na+
    (encendido) 1
    Sitio para K+
    (apagado)
    2

    ATP
    3
    ADP

    Na+ 4

    OUABAINA K+ 5

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    Na+,K+-ATPase β-SUBUNIT
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    OUABAIN

    Na+,K+-ATPase Na+
    Cell-cell
    adhesion
    Na+
    K+ P Ca++
    molecules

    Na+/Ca2+ exchanger
    P MAPK
    K+

    Cell-substrate
    Ca++
    Ca++
    adhesion molecules

    CONTROL EFFECT OF OUABAIN DETACHMENT


    Na+,K+-ATPase and Na+/Ca2+
    exchanger stop.
    Cytosolic free-Ca2+ increases.
    Cell increases its volume.
    Tyrosine phosphorylation increases.
    MAPK and small G proteins activate.
    Cell-adhesion molecules are retrieved
    and their amount in the cell decreased.

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