Zinc Sulfate Syrup (Zinc Sulfate capsule) Information GENERIC NAME: Zinc Sulfate Brand Name: Neosporin Ointment

What is Zinc Sulfate and for what Zinc Sulfate is used? Zinc Sulfate medication belong to Mineral class. Zinc Sulfate acts as integral part of several enzymes important to protein and carbohydrate metabolism, wound healing, maintenance of normal growth and skin hydration, and senses of taste and smell. How to Take Zinc Sulfate Take Zinc Sulfate exactly as prescribed by health care provider. Zinc Sulfate is generally available in market in the form Blisters of powder for oral inhalation 5 mg. After dilution, the solution is physically and chemically stable for 24 hr at room temperature and 48 hr if refrigerated. As an additional precaution, administer the diluted solution within 8 hr if stored at room temperature or 24 hr if refrigerated to minimize the potential administration of a microbially contaminated solution. Store undiluted vials at room temperature and protect from light. Do not administer with probenecid, acetaminophen, aspirin, or indomethacin (may inhibit metabolism or decrease clearance of Zinc Sulfate; serum concentrations may increase to potentially toxic levels). Dosage Instructions for Zinc Sulfate Drug Dietary supplementation; supplement to IV solutions given for TPN; treatment or prevention of zinc deficiencies. Ophthalmic solution used as mild astringent for relief of eye irritation. Unlabeled Useof Zinc Sulfate Drug : Treatment of acrodermatitis enteropathica and delayed wound healing associated with zinc deficiency; treatment of acne, rheumatoid arthritis, Wilson's disease. Interactions of Zinc Sulfate with other drugs Fluoroquinolones; tetracyclines: Absorption of these agents may be decreased.

What are the Side Effects of Zinc Sulfate Like other medicines, Zinc Sulfate can cause side effects. Some of the more common side effects of Zinc Sulfate include
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Pain; dizziness; insomnia; somnolence; malaise; nervousness; hypertonia. Abdominal pain Nausea; vomiting (especially in large oral doses).

Warnings and precautions before taking Zinc Sulfate :

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Identify food sources of zinc (eg, seafood, organ meats, wheat germ). Inform patient before taking Zinc Sulfate that sense of taste and smell, skin hydration, and wound healing should improve. Instruct patient to follow RDA guidelines and limitations in terms of vitamin and mineral supplementation. Tell patient before taking Zinc Sulfate to take with food if GI upset occurs but to avoid foods high in calcium, phosphorus, and phytate. Inform patient that bran, caffeine, and dairy products may decrease absorption. Tell patient before taking Zinc Sulfate to notify health care provider if change in vision occurs or if eye irritation or pain persists or increases while using ophthalmic form. Teach patient proper administration technique for eye drops. Caution patient before taking Zinc Sulfate to inform the health care provider if pregnant, planning to become pregnant, or breastfeeding.

What if Overdose of Zinc Sulfate ? If you think you or anyone else taken overdose of Zinc Sulfate , immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention. Nausea, vomiting, dehydration, restlessness, sideroblastic anemia, profuse sweating, hyperamylasemia are may be the overdose symptoms of Zinc Sulfate . What if Missed Dose of Zinc Sulfate ? If you miss a dose of Zinc Sulfate medicine and you remember within an hour or so, take the dose immediately. If you do not remember until later,

skip the dose you missed and go back to your regular schedule. Do not double doses. Storage Conditions for Zinc Sulfate :
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Zinc Sulfate Available only in PO form. Store Zinc Sulfate tablets at room temperature (20 to 25C; 68 to 77F). Keep Zinc Sulfate in tightly sealed container, protected from light. Zinc Sulfate May be taken with meals and at bed time Zinc Sulfate Syrup (Zinc Sulfate capsule) Information Alien Sheng May 18, 2007 What is Zinc Sulfate and for what Zinc Sulfate is used? Zinc Sulfate medication belong to Mineral class. Zinc Sulfate acts as integral part of several enzymes important to protein and carbohydrate metabolism, wound healing, maintenance of normal growth and skin hydration, and senses of taste and smell. Dosage Instructions for Zinc Sulfate Drug Dietary supplementation; supplement to IV solutions given for TPN; treatment or prevention of zinc deficiencies. Ophthalmic solution used as mild astringent for relief of eye irritation. Unlabeled Useof Zinc Sulfate Drug : Treatment of acrodermatitis enteropathica and delayed wound healing associated with zinc deficiency; treatment of acne, rheumatoid arthritis, Wilson's disease. Interactions of Zinc Sulfate with other drugs Fluoroquinolones; tetracyclines: Absorption of these agents may be decreased. What are the Side Effects of Zinc Sulfate Like other medicines, Zinc Sulfate can cause side effects. Some of

the more common side effects of Zinc Sulfate include Pain; dizziness; insomnia; somnolence; malaise; nervousness; hypertonia. Abdominal pain Nausea; vomiting (especially in large oral doses). Warnings and precautions before taking Zinc Sulfate : Identify food sources of zinc (eg, seafood, organ meats, wheat germ). Inform patient before taking Zinc Sulfate that sense of taste and smell, skin hydration, and wound healing should improve.

Instruct patient to follow RDA guidelines and limitations in terms of vitamin and mineral supplementation. Tell patient before taking Zinc Sulfate to take with food if GI upset occurs but to avoid foods high in calcium, phosphorus, and phytate. Inform patient that bran, caffeine, and dairy products may decrease absorption. Tell patient before taking Zinc Sulfate to notify health care provider if change in vision occurs or if eye irritation or pain persists or increases while using ophthalmic form. Teach patient proper administration technique for eye drops. Caution patient before taking Zinc Sulfate to inform the health care provider if pregnant, planning to become pregnant, or breastfeeding. What if Overdose of Zinc Sulfate ? If you think you or anyone else taken overdose of Zinc Sulfate , immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You

may need urgent medical attention. Nausea, vomiting, dehydration, restlessness, sideroblastic anemia, profuse sweating, hyperamylasemia are may be the overdose symptoms of Zinc Sulfate . What if Missed Dose of Zinc Sulfate ? If you miss a dose of Zinc Sulfate medicine and you remember within an hour or so, take the dose immediately. If you do not remember until later, skip the dose you missed and go back to your regular schedule. Do not double doses. Storage Conditions for Zinc Sulfate : Zinc Sulfate Available only in PO form. Store Zinc Sulfate tablets at room temperature (20 to 25C; 68 to 77F). Keep Zinc Sulfate in tightly sealed container, protected from light. Zinc Sulfate May be taken with meals and at bed time
Loperamide Hcl 2 Mg Norfloxacin 400 Mg + Metronidazole 500 Mg Norfloxacin 400 Mg + Tinidazole 600 Mg Ofloxacin 200 Mg + Ornidazole 600 Mg Racecadotril 10/30/100 Mg Zinc Sulfate 10mg/20mg (Dispersible Tablet Usp)

syrups
Zinc sulfate heptahydrate
y ZINC SULPHATE Zinc dispersible tablet and syrup

Presentation ZINC SULPHATE 10/20 dispersible Tablet : Each dispersible tablet contains Zinc Sulfate USP (as Monohydrate) 54.88mg equivalent to elemental Zinc 20mg. ZINC SULPHATE 20 Syrup : Each 5 ml of syrup contains Zinc Sulfate USP (as Monohydrate) 54.88mg equivalent to Elemental Zinc 20mg. Description Zinc is an essential trace mineral, which means that it must be obtained from the diet since the body cannot make enough. Next to iron, zinc is the most abundant trace mineral in the body. Stored primarily in muscle, zinc is also found in high concentrations in red and white blood cells, the retina of the eye, bones, skin, kidneys, liver, and pancreas. Some of the symptoms of zinc deficiency include loss of appetite, poor growth, weight loss, impaired taste or smell, poor wound healing, skin abnormalities (such as acne, atopic dermatitis and psoriasis), hair loss, night blindness, hypogonadism and delayed sexual maturation, white spots on the fingernails and feelings of depression. Indications and Uses Indicated for the treatment of diarrhea, zinc deficiency, immune deficiency, age related blindness, prevention and treatment of colds, maintenance of taste and smell, male potency and sex drive, infertility, prostate problem, hair loss and diabetes & rheumatoid arthritis. Contraindications ZINC SULPHATE is contraindicated in patients who are hypersensitive to Zinc or any component of the product. Dosage And Administration Zinc supplements are most effective if they are taken at least 1 hour before or 2 hours after meal. Children Children under 10kg : 1 teaspoonful ZINC SULPHATE 20 syrup daily after food Children within 10-30kg : 1 teaspoonful ZINC SULPHATE 20 syrup daily after food 1-3 times daily; Children over 30kg : 2 teaspoonful ZINC SULPHATE 20 syrup daily after food 1-3 times daily; Adults: 1 ZINC SULPHATE 20 dispersible tablet three times daily or as directed by the physician.

Precautions Food may decrease the absorption of Zinc. Hence the patients are advised to take the preparation at least 1 hour before or 2 hours after meal. Side Effects Most of the supplements including Zinc are considered to be safe. However, few mild side effects such as nausea, vomiting, headache, drowsiness, gastric ulcer, metallic taste may be occurred. Use in pregnancy & lactation The patients should consult to the physician before use the preparation. Commercial Pack ZINC SULPHATE 20 dispersible Tablet: Each box contains 10 blister strips of 10 dispersible tablets. ZINC SULPHATE 20 Syrup: Each bottle contains 100 ml of syrup

Indication & Dosage

Oral Zinc deficiency Adult: 50 mg of elemental zinc tid. Intravenous Zinc deficiency Adult: 6.5 mg elemental zinc (100 micromoles) daily. Ophthalmic Minor eye irritation Adult: In combination with a vasoconstrictor, 1-2 drops are instilled into the eye 2-4 times daily. Incompatibility: Mixing sodium borate, glycerin and methylcellulose with zinc sulfate may cause preciptation.

Special Precautions Adverse Drug Reactions Drug Interactions

Oral/IV: Monitor CBC and serum cholesterol to detect early signs of copper deficiency, especially if prolonged high dose use of zinc. Topical: Consult medical advice if relief not seen within 3 days. Abdominal pain, dyspepsia, nausea, vomiting, diarrhoea, gastric irritation, gastritis. Prolonged use may cause copper deficiency (e.g. sideroblastic anaemia, neutropenia) Reduced absorption of both zinc and oral iron supplements, penicillamine and tetracyclines when admin concomitantly. Phosphorus-containing preparations reduce zinc absorption. Zn sulfate reduces absorption of copper and flouroquinolones e.g. ciprofloxacin, levofloxacin, moxifloxacin,norfloxacin and ofloxacin. Reduced zinc absorption with calcium co-admin. Reduced bisphosphonates absorption with concurrent zinc admin. Absorption of Zn sulfate is reduced by milk, phytates (present in cereals, rice, corn, legumes) and some minerals (e.g. iron, calcium). Ophthalmic: Store below 40C. As an ophthalmic preparation, zinc sulfate precipitates protein and this is responsible for the astringent and weak antiseptic activity of Zn sulfate. It also produces mild vasodilation. Zinc sulfate can also be used orally or systemically as a zinc supplement. 220 mg of zinc sulfate (heptahydrate) contains 50 mg of elemental zinc. Absorption: Following oral administration, 20-30% of dietary Zn is absorbed. Distribution: Widely distributed but concentrated within the muscle, bone, skin and prostatic fluids. Excretion: Primarily via faeces at approx 90%; small amounts via urine at approx 2% and via perspiration.

Food Interaction Storage Mechanism of Action

MIMS Class ATC Classification

Electrolytes / Other Eye Preparations A12CB01 - Zinc sulfate ; Belongs to the class of zinc-containing preparations. Used as dietary supplements.

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