Research Triangle Regions Life Sciences Directory 2012

Research Triangle Region of North Carolina
Life Science Directory

June 2012
3F LLC of Raleigh produces bio-based, high-strength reinforcing fibers for structural applications. 3F also provides consulting and product development services in technology areas related to green fibers and their structural application, particularly from kenaf. www.3fllc.com 3TEX Inc. of Cary develops products for prosthetic joints and limbs, fibrous scaffolds for surgical repair and tissue engineering through advanced three-dimensional woven fabrics and composites. www.3tex.com A1-Laboratories of Raleigh provides DNA testing and drug screening products and services. www.a1-labs.com AAIPharma Inc. of Morrisville and Chapel Hill is a global provider of product development and support services to the pharmaceutical, biotechnology and medical device industries. www.aaipharma.com APP Pharmaceuticals of Raleigh manufactures injectable pharmaceutical products in four therapeutic areas: anti-infective, anesthesia/analgesia, critical care and oncology. www.apppharma.com AbD Serotec of Raleigh, a division of MorphoSys, designs, manufactures and sells immunological and cell biology reagents for research. www.ab-direct.com Adherex Technologies Inc. of Durham conducts discovery and development for novel cancer therapeutics. It has multiple products in the clinical stage of development, including eniluracil, ADH-1 and sodium thiosulfate. www.adherex.com Adroit Pharmaceutical Development of Raleigh identifies new and improved formulations and process technologies. Its primary focus is on inhalation and dermatological product development. www.adroitpharmdev.com Advanced Animal Diagnostics Inc. of Durham commercializes proprietary technology for the diagnosis of valuable farm animal diseases, including those that affect milk and milk products. www.advancedanimaldiagnostics.com Advanced Liquid Logic Inc. of Morrisville develops digital microfluidic lab-on-a chip devices for highly automated, rapid and portable liquid handlers for a diverse range of applications. www.liquid-logic.com Aerial BioPharma of Morrisville develops biologic and small-molecule central nervous system therapeutics, including treatments for narcolepsy and chronic pain. www.aerialbio.com Research Triangle Region of North Carolina 1
Aerie Pharmaceuticals Inc. in The Research Triangle Park is dedicated to the discovery and development of medical innovations in the field of ophthalmology. Based on intellectual property licensed from Duke University Medical Center, Aerie is developing a pipeline of proprietary products for the pharmaceutical treatment of glaucoma. www.aeriepharma.com Affinergy Inc. of Durham develops site-specific biological systems using biofriendly binders that selectively adhere to proteins, drugs, cells and other biomaterial surfaces to kick start biology toward an intended outcome. Affinergy is focused in the orthopedic and biologic drug delivery markets with a growing interest in cardiovascular applications. www.affinergy.com Agarigen Inc. in The Research Triangle Park is engaged in the development of novel biopharmaceutical expression and processing technology. Agarigen is developing ways to make commercially viable proteins using mushrooms. www.agarigen.com Agile Sciences Inc. of Raleigh has identified novel small molecules that inhibit and disperse bacterial biofilms. The company is investigating multiple applications in medicine, agriculture and industry. www.agilesci.com Agilent Technologies Inc. of Raleigh is the worlds premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. www.home.agilent.com AIHF Clinical Research LLC of Raleigh conducts clinical research studies in multiple therapeutic areas of family practice, internal medicine, sports medicine and orthopedics. www.aihf.net Ajinomoto AminoScience LLC of Raleigh is the only pharmaceutical L-amino acid manufacturer in the United States with services that include patented amino acid production technology. www.ajiaminoscience.com Alaeras Inc. of Cary specializes in design and manufacturing of drug delivery products. The company is currently developing a platform technology for dry powder nasal vaccines that do not require refrigeration. www.alaeras.com Alba Bioscience Inc. of Durham distributes blood group monoclonals and research reagents in North and South America that are manufactured in the United Kingdom by Alba Bioscience Ltd. This wellestablished GMP facility has research and development laboratories and extensive collaboration with a variety of centers within the immunohematology world. www.albabioscience.co.uk/usa_home.aspx Research Triangle Region of North Carolina 2
Aldagen Inc. of Durham is a biotechnology company advancing a pipeline of clinical-stage regenerative therapies. Aldagen has three product candidates in clinical development for chronic heart failure, critical limb ischemia and pediatric metabolic disorders and malignancies. www.aldagen.com Alera Labs LLC of the RTP provides contract research, molecular microbiology and analytical chemistry laboratory services to small and mid-size pharmaceutical and medical device companies. www.aleralabs.com Algynomics Inc. of Chapel Hill is developing and marketing genetic markers in the field of pain and developing medical devices that integrate information from genetic pain biomarkers with neurological and psychological assessments. www.algynomics.com Alion Science and Technology Corp. of Durham provides technical expertise and operational support to government and commercial customers. Alion has three labs in The Research Triangle Park: a human exposure and atmospheric sciences laboratory, life sciences and inhalation toxicology laboratory and wind tunnel laboratory. www.alionscience.com Almac Diagnostics of Durham develops and delivers genomics solutions for the advancement of science and the improvement of patient care. www.almacgroup.com Alnis BioSciences Inc. in The Research Triangle Park has expertise in the fabrication of nanoparticles and the use of these particles for life science applications. Alnis is currently developing proprietary MagNaGel nanoparticles that combine diagnostic, drug and device capabilities to better detect, characterize and treat cancer. Alpax Pharmaceutical of Morrisville is a contract manufacturer of cGMP level APIs, formulations and finished dosages. www.alpaxpharma.com Alpha-Gamma Technologies Inc. of Raleigh provides research and consulting services in environment and life sciences. Its services include research and consulting in toxicogenomics, bioinformatics, data mining and warehousing for government, biotechnology and pharma clients. www.alpha-gamma.com AlphaVax Inc. in The Research Triangle Park is developing a new vaccine technology with broad applications for infectious disease, cancer and biodefense threats that have the potential to redefine vaccines and the role they play in medicine. AlphaVax uses a specialized viral vector system to make alphavirus replicon vaccines, called alphavaccines, which have shown excellent protection in multiple models for infectious disease and cancer. www.alphavax.com Research Triangle Region of North Carolina 3
Alte Biosciences Inc. of Cary is a drug delivery-based therapeutics company that commercializes technologies to enhance the safety and performance of proprietary drug products. www.altebio.com American Agricultural Services Inc. of Cary is a full-service agricultural, chemical (pesticide) and biotechnology study management firm. American Ag has developed methods for managing research, development and registration for the ag-chem and ag-biotech industries worldwide. www.amagsrv.com Amorsus Pharma LLC of Raleigh is developing a sustained-release product incorporating both bupivacaine and dexamethasone for use following tooth extraction to provide patients with prolonged anesthesia to reduce intra-operative and post-procedure pain. www.amorsus.com Analytical Solutions Inc. of Durham is a contract analytical laboratory that provides quality, timely and cost-efficient analytical and bioanalytical services to the pharmaceutical, biotechnology and nutraceutical industries. www.asi-rtp.com Appealing Products Inc. of Raleigh is a research and development company located on the Centennial Campus of North Carolina State University. API has developed products in the areas of forensics, toxic gas and liquid detection, detection of trace explosives, detection of poisons in food and personal protection from toxic materials. www.appealingproducts.com Applied Micro Products Inc. of Chapel Hill uses environmentally friendly treatments to extend the functional life of wood structures. www.appliedmicroproducts.com Applied Technologies Inc. of Cary is a product design and engineering firm providing product development, materials selection and process-development services to a wide range of end markets, including medical, transportation and electronics, in both the industrial and commercial sectors. www.ati-engineers.com Arbovax Inc. of Raleigh has a unique technology that modifies arthropod-borne viruses (arboviruses) preventing them from replicating in mammalian cells. Arbovax will leverage this technology to facilitate development of a portfolio of improved vaccines against the worldwide threat of arthropod-borne diseases. www.arbovax.com Arcato Laboratories of Durham develops oral healthcare products to serve specialty oral healthcare practitioners, such as orthodontists and oral surgeons. www.arcatolabs.com Research Triangle Region of North Carolina 4
Argolyn Bioscience Inc. of Durham uses proprietary peptide modification methods to repeatedly derive and develop novel and value-added therapeutic products to address major unmet medical needs. www.argolynbioscience.com Argos Therapeutics Inc. of Durham develops breakthrough immunotherapies that target the unique features of a patients disease. This new generation of personalized cancer and infectious disease therapeutics, created using Arcelis technology, trains the immune system to recognize and attack the disease. Argos scientific leadership in RNA-loaded dendritic cells and advanced manufacturing processes provide a platform to tackle virtually all forms of cancers and infectious diseases. www.argostherapeutics.com Aristos Pharmaceuticals Inc. of Cary provides generic medications throughout various therapeutic classes. The headquarters and executive offices are located in the Cary office. www.aristospharm.com Array BioPharma Inc. of Morrisville is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs in the areas of cancer, inflammatory diseases and pain. www.arraybiopharma.com ArrayXpress Inc. of Raleigh is a laboratory services company that designs, produces and analyzes microarrays. www.arrayxpress.com Arysta LifeScience North America LLC of Cary provides customer-driven products and services to cropprotection customers, primarily in specialty crops and niche markets. www.arysta-na.com Ascletis Inc. of the RTP develops treatments for cancer and infectious disease. www.ascletis.com Asklpios Biopharmaceutical Inc. of Chapel Hill is a biotechnology company engaged in the development and delivery of novel protein and cellular-based therapies through design of proprietary biological nano particles. www.askbio.com Asymchem Laboratories Inc. of Morrisville is a contract manufacturer of advanced chemical intermediates for the pharmaceutical and biotech industries. Asymchems administrative headquarters is in North Carolina and its manufacturing plants are in China. www.asymchem.com ATEX Technologies Inc. of Pinebluff designs, develops and manufactures medical textiles and component solutions for the medical industry. www.atextechnologies.com Research Triangle Region of North Carolina 5
Attagene Inc. of Morrisville is a biotechnological company that develops new generations of molecular technologies for systematic analysis of cell signaling. Attagenes flagship technology is FACTORIAL that a first-in-class technological platform for assessing activities of practically unlimited numbers of transcription factors within a cell. www.attagene.com Avioq Inc. in The Research Triangle Park is developing and manufacturing immunodiagnostic products. The companys first product, the Avioq HIV-1 Microelisa System, is a U.S. Food and Drug Administrationapproved HIV assay licensed from BioMerieux. www.avioq.com Avjet Biotech of Pinehurst has two divisions: Red Wolf Refining, whose thermal catalytic refining system to converts triglycerides into aviation biofuels; and Pinehurst Biologics, which produces enzymes and other products from algae. www.redwolfrefining.com b3bio Inc. in The Research Triangle Park develops medicines using small RNA molecules to target individual cells and tissues with precision. The companys technology could be used to treat cancer, inflammation and infection. BASF Crop Protection in The Research Triangle Park and Holly Springs is a leading producer of agricultural products, including herbicides, fungicides, insecticides, plant regulators and seed technologies, which offer the highest level of crop-protection solutions to farmers across the United States. www.agproducts.basf.com BASF Plant Science LP in The Research Triangle Park focuses in the areas of more efficient agriculture, renewable raw material and nutritional food and feed crops. www.basf.com/plantscience BASF Professional Turf and Ornamentals in The Research Triangle Park is a business group that develops and markets chemical solutions for improving turf quality through pest management, which includes weed, disease and insect control. www.betterturf.com Bayer CropScience LP in The Research Triangle Park, Clayton, and Morrisville focuses on preventing diseases through diagnosis, vaccines and innovative medicines and offering high-quality nutrition by the process of agriculture. Bayer CropScience is expanding in Morrisville by adding a research and development center and the firms bianalytics and regulatory affairs operations. www.bayercropscienceus.com
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BD Biosciences of Durham sells premium products and instrumentation, including antibodies and reagents for flow cytometry, western blotting, immunofluorescence and ELISA, as well as bioimagers, flow cytometers and cell sorters for research and clinical applications in the fields of immunology, oncology and drug discovery. www.bdbiosciences.com BD BioVenture Center in The Research Triangle Park was established by BD Technologies as the first private life science new business incubator. www.bd.com/technologies/bvc/index.asp BD Diagnostics-TriPath of Durham manufactures, assembles and markets systems for improving cervical cancer screening through advanced preparation techniques and computer-assisted screening technologies. www.bd.com/tripath BD Technologies in The Research Triangle Park develops next-generation and new technologies in the areas of parenteral drug delivery, diabetes care, diagnostics and biosensors and cell and tissue engineering. www.bd.com/technologies Better Medicines LLC of Durham has expertise in pediatric, immunological, cardiovascular and central nervous system diseases. Better Medicines currently focuses on diseases with an established causeeffect relationship and readily accessible clinical models. www.bettermedicines.net Bendiner Technologies of Pinehurst is a specialty chemical company that produces a wide variety of preservation products for the food and beverage, animal feed and agriculture industries. www.bentechonline.com BHV of the RTP develops therapeutics for metabolic disorders, including diabetes and obesity. www.bhvpharma.com BioCryst Pharmaceuticals Inc. of Durham has expertise in drug discovery, clinical development and regulatory affairs. BioCryst advances its compounds, peramivir, forodesine and BCX4208 and generates new compounds from its own discovery engine structure-based drug design. www.biocryst.com BioDelivery Sciences International Inc. of Raleigh is a specialty pharmaceutical company focused on developing innovative products to address growing market opportunities, including pain. BioDelivery utilizes its owned and licensed patented drug delivery technologies to develop, partner and commercialize clinically significant new products using proven therapeutics. www.bdsinternational.com
Biofuels Center of North Carolina of Oxford is a nonprofit organization assisting all aspects of biofuels development. The centers goal is to develop a statewide biofuels industry to reduce the state's dependence on imported liquid fuels. www.biofuelscenter.org BioGaia Biologics Inc. of Raleigh sells products and licenses to companies operating in the area of functional foods and beverages and healthcare. BioGaia conducts research into development and manufacturing of probiotic solutions that build human health. www.biogaia.com Biogen Idec Inc. in The Research Triangle Park is a biopharmaceutical company principally engaged in discovering and developing drugs for human healthcare through genetic engineering. Biogens research and development activities are focused on novel products for multiple sclerosis, inflammatory, respiratory, kidney and cardiovascular diseases and in developmental biology and gene therapy. www.biogenidec.com BioKier Inc. of Chapel Hill is an early-stage pharmaceutical company developing new proprietary drugs for diabetes and related disorders. BioKier has identified a therapeutic opportunity and is developing a novel treatment for type 2 diabetes. This treatment will potentially also have effects in metabolic syndrome and obesity. BioLeap of Chapel Hill provides drug-discovery and -design services using computational fragment-based drug-design technology. www.bioleap.com BioLink Life Sciences Inc. of Cary develops high-value-added research tools and products for the life sciences, clinical and animal health communities. www.biolinkonline.com BioLume Inc. of Morrisville is a privately held biotechnology company that develops and commercializes a portfolio of proprietary bioluminescent (light-producing) proteins with many first-in-class applications in the food, beverage, cosmetic and diagnostic imaging markets. www.biolume.net Biolex Therapeutics Inc. of Pittsboro and Durham is a clinical-stage biopharmaceutical company that uses its patented LEX System to develop hard-to-make therapeutic proteins and optimize monoclonal antibodies. www.biolex.com BioMarck Pharmaceuticals Ltd. of Durham and Raleigh is a privately owned biopharmaceutical company dedicated to the discovery and development of new drugs for the treatment of pulmonary diseases and disorders associated with the over-secretion of mucus and pulmonary inflammation in patients with chronic obstructive pulmonary disease, asthma and cystic fibrosis. www.biomarck.com Research Triangle Region of North Carolina 8
Biomanufacturing Research Institute & Technology Enterprise (BRITE) Center for Excellence of Durham, located on the campus of N.C. Central University, provides biotechnology and pharmaceutical sciences education. It is part of a statewide initiative funded by the Golden LEAF Foundation to make North Carolina a premier provider of skilled workers for the biotechnology industry. http://brite.nccu.edu Biomanufacturing Training and Education Center (BTEC) of Raleigh, located at N.C. State Universitys Centennial Campus, works to fuel the growth of the states emerging biomanufacturing industry by creating the most well-trained, industry-focused workforce in the world. BTEC deploys an unparalleled system of advanced, hands-on training and education in a current Good Manufacturing Practice (cGMP) environment using facilities and equipment that match those in place at the worlds leading biomanufacturing companies. www.engr.ncsu.edu/btec BioMedical Devices Inc. of Apex specializes in designing and manufacturing a wide variety of medical and surgical devices including but not limited to those for use in the fields of laproscopy, cardiology, neurology, gynecology and vascular surgery. www.biomedicaldevicesinc.com BioMedomics Inc. in The Research Triangle Park develops and markets advanced research and clinical reagents, assay instruments and data analyzing/processing tools to serve broad ranges of biomedical applications related to drug discovery and development and clinical diagnostics. www.biomedomics.com bioMrieux Inc. of Durham provides diagnostic solutions (reagents, instruments, software) that determine the source of disease and contamination to improve patient health and ensure consumer safety. bioMrieuxs products are used for diagnosing infectious diseases and providing high-medicalvalue results for cardiovascular emergencies and cancer screening and monitoring as well as detecting microorganisms in agri-food, pharmaceutical and cosmetic products. www.biomerieux-usa.com Bioplastics Inc. of Durham manufactures high-precision accurate dynamic multi-sensor validation services and instruments for polymerase chain reaction (PCR), real-time PCR and incubator laboratory cyclers. Bioplastics manufactures injection-molded vessels for use in the molecular biology laboratory, specializing in PCR and real-time PCR. www.bpcti.com Bioptigen Inc. in Durham developed a new class of in vivo optical imaging systems for biomedical applications. These systems provide real-time imaging of internal tissue microstructure, advancing critical applications in drug development, genetics research, tissue engineering and medical vision. www.bioptigen.com BioResource International Inc. of Morrisville is a global biotechnology company focused on harnessing the natural power of enzymes to address unique agricultural and industrial concerns. www.briworldwide.com Research Triangle Region of North Carolina 9
BioSignia Inc. of Durham is a leading technology company focused on bringing innovative predictive modeling solutions to the preventive health and life insurance markets. BioSignia develops cutting-edge technology that determines the risk of morbidity and/or mortality. www.biosignia.com BioTechnology Transfer LLC of Raleigh provides solutions and services to early-stage companies that want to develop their technologies. BioTechnology Transfer specializes in regulatory solutions and uses a multi-disciplinary team approach for strong system designs. www.biotechtrans.com Biotecnol Pharmaceuticals Inc. of Durham is a fully owned subsidiary of the public company Biotecnol SA that is developing a diverse pipeline of antibody products. The Research Triangle Park site eventually will be a research and development facility. www.biotecnol.com Boron Molecular Inc. in The Research Triangle Park is a specialist fine chemicals manufacturing company providing building-block compounds, focusing on boronic acids, boronic esters, biaryls, cubanes and specialist chemistry services to the global pharmaceutical, biotechnology, fine chemicals and materials markets. www.boronmolecular.com Botanics Integrated LLC in The Research Triangle Park is a startup company engaging in the research and development of safe and effective mechanism-based standardized botanical extracts (as dietary supplements) for human use. Its research has identified specific botanical extracts that may be useful to patients suffering from hyperuricemia, gout or hypertension. www.botanicsintegrated.com Brainerd LLC of North Carolina of Dunn provides the highest-quality industrial, reagent, food and specialty chemicals. Brainerd supplies more than 10,000 unique chemicals for industrial and government use. www.brainerdchemical.com Bruce Technologies Inc. of Chapel Hill produces radionuclides for diagnosis and therapy in nuclear medicine. www.brucetechnologiesinc.com Burleson Research Technologies of Morrisville is a contract research organization that provides laboratory services to clients from the biotechnology, pharmaceutical, chemical manufacturing and health care industries with proof-of-concept, pre-clinical, clinical and toxicology studies that reflect BRT staff scientific expertise. www.brt-labs.com Burt's Bees of Morrisville develops and manufactures natural personal care products, including skin care products, hair care products, soaps, lotions and natural baby products. www.burtsbees.com Research Triangle Region of North Carolina 10
Capture Pharmaceuticals of Chapel Hill develops oral and topical formulations of diethylenetriaminepentaacetic acid prodrugs as radionuclide decorporation agents. Carbon-to-Liquids (C2L) Development Center of Durham, a unit of Southern Research Institute, provides independent technical support to clients who are developing and integrating advanced energy systems and transportation fuel production technology. C2L facilitates the commercial development and acceptance of new technologies that convert America's diverse, non-petroleum carbon sources into high-value products, such as clean diesel fuel, jet fuel, methanol, ethanol, ammonia and electric power. www.carbontoliquids.com Carolina BioPharm Inc of Raleigh is dedicated to addressing serious, unmet needs in oncology. Our main focus is the discovery and development of therapeutics that advance the efficacy and safety of treating cancer patients. www.carolinabiopharm.com Carolina Biodiesel LLC of Durham is a biodiesel distributor that grew out of an environmental organization. Its businesses currently include fuel distribution and green transportation (car, bus and limousine rental). www.carolinabiodiesel.org Catalent Pharma Solutions Inc. of Morrisville provides analytical and other scientific services as well as inhalation product development. The Raleigh facility is designed to manufacture liquid and lyophilized formulations in glass vials ranging from 2cc to 100cc. The facility is also equipped with segregated cell culture and fermentation trains for bulk biochemical manufacturing operations. www.catalent.com Catena Pharmaceuticals Inc. of Durham is a drug discovery company developing proprietary antiangiogenic G-protein coupled receptor (GPCR) antagonist compounds with a focus on cancer and fibrosis. www.catenapharma.com Cato Research Ltd. of Durham is a global, full-service contract research and development organization providing strategic and tactical support for clients in the pharmaceutical, biotechnology, medical device and medical diagnostic industries. Cato Researchs services range from design and management of preclinical and clinical studies to submission of regulatory documents required for marketing approval. www.cato.com CD Neural Technologies of Durham focuses on design and development of advanced tools, equipment and methodology for neuroscience research. www.cdneural.com CellzDirect Inc. of Durham and Pittsboro is a preeminent cell-based bioscience company that provides innovative ADME products and services to expedite rapid, accurate data with valid interpretations to accelerate the development of safe and effective drugs. www.cellzdirect.com Research Triangle Region of North Carolina 11
Cempra Pharmaceuticals Inc. of Chapel Hill is a biotechnology company that develops medicines to meet the increasing need for treating drug-resistant bacterial infections in the community and hospital. www.cempra.com Cenduit LLC of Durham is an interactive response technology joint venture between Thermo Fisher Scientific and Quintiles Transnational Corp. that opens the door to a new level of clinical trial support by acting as the central conduit of data between the clinical supplies and the clinical development markets. www.cenduit.com CeNeRx Biopharma Inc. of Cary is a drug development company with a therapeutic focus on diseases of the central nervous system. CeneRx focuses on identifying and developing promising therapeutics to treat diseases related to neurotransmitters and the nervous system. www.cenerx.com Centice Corp. of Morrisville designs and manufactures molecular spectroscopy optical sensors that are used in general purpose and application-specific products. Computational sensors combine multiplexing optical designs with electronics and proprietary mathematical algorithms to achieve both extreme sensitivity and uncompromised resolution. www.centice.com Cerene Biomedics of Durham is developing an implantable medical device that will prevent epileptic seizures by delivering targeted micro-scale thermoelectric cooling to the neocortex of the brain. www.cerenebiomedics.com Cetero Research of Cary is a world leader in early clinical, bioanalytical and niche late-stage research services. www.cetero.com Chaperone Therapeutics Inc. of Chapel Hill is an early-phase biotechnology company researching cellular protein folding mechanisms to treat diseases associated with abnormal protein folding and aggregation, such as Alzheimers, Parkinsons, ALS and Huntingtons disease. www.chaperonetherapeutics.com Charis Diagnostics Corp. of Raleigh is a contract research organization that specializes in producing monoclonal antibodies to small molecules or haptens. Charis has years of assay design and development experience with multiple detection systems, including polymerase chain reaction, time-resolved fluorescence and colorimetrics. www.charisdiagnostics.com Charles River Laboratories Inc. of Raleigh and Cary provides research models, laboratory animal support services and pre-clinical and clinical services to the biomedical market. www.criver.com
Charles River Laboratories Inc. PAI of Durham is one of the largest preclinical services companies with highly technical and a broad range of essential preclinical services around the world bringing quality, responsiveness and innovation to the pharmaceutical, biotechnology and healthcare industries. www.criver.com/preclinical_services Cheminova Inc., headquartered in The Research Triangle Park, is the U.S. subsidiary of Cheminova A/S, a Danish company that develops and produces herbicides and other plant protection products. www.cheminova.com ChemoGenics Biopharma LLC in The Research Triangle Park provides drug discovery research services to pharmaceutical and biotechnology companies. Services range from preclinical to clinical aspects of drug discovery, including phase I-III studies. www.chemogenicsbiopharma.com Chesson Laboratory Associates Inc. of Durham is a healthcare products company that has sole licensing rights to all medical applications of unique, patented polymers. www.chessonlabs.com Chimerix Inc. of Durham discovers, develops and commercializes therapeutics with enhanced pharmaceutical properties that are active against a broad range of viral diseases. www.chimerix-inc.com Cirrus Pharmaceuticals Inc. of Durham is a contract product development company assisting biotechnology and pharmaceutical companies with dosage form development projects. Cirrus works with startup, mid-size and multinational companies to provide a broad array of research and development services, including physical and chemical characterization, formulation development, stability testing, container/closure selection and process development as well as scale-up and technical transfer to manufacturing. www.cirruspharm.com CivaTech Corp. of Raleigh utilizes proprietary processes to develop novel sleeve-like materials for radiation therapy, including coronary stent applications. www.civatech.com CivaTech Oncology Inc. in The Research Triangle Park and Chapel Hill creates a product that will be the standard of care for low-dose-rate brachytherapy. The first focus of CivaTech Oncology will be on prostate cancer, seeking to provide physicians and patients with a superior brachytherapy treatment option for battling cancer. www.civatechoncology.com Clearside Biomedical of Raleigh develops and commercializes ophthalmic therapeutic products that use an ocular microinjection platform to target individual compartments of the eye. www.clearsidebio.com
Clinical Sensors Inc. of Chapel Hill has developed a catheter sensor to detect the onset of sepsis and monitor the effectiveness of treatment. Code Refinery LLC of Apex is dedicated to help design, develop and ensure the accuracy and compliance of software that performs in vital applications. With an emphasis on U.S. Food and Drug Administrationregulated systems, Code Refinery works extensively with medical devices, lab automation and specimen handling. www.code-refinery.com Cogenics, a subsidiary of Beckman Coulter Genetics, of Morrisville provides a full range of genomics services for both research and regulated projects, including services to support pharmacogenomics discovery and validation and biomarker research and development. Cogenics offers integrated services for DNA and RNA extraction, genotyping, full-sequencing services, including next-generation genomic sequencing, and gene expression. www.beckmangenomics.com Cognosci Inc. in The Research Triangle Park develops anti-inflammatory compounds for treatment of neuroinflammatory diseases, such as multiple sclerosis, Alzheimers disease, and traumatic brain injuries. www.cognosci.com CoLucid Pharmaceuticals Inc. of Durham is a biotechnology company focusing on therapies for central nervous system (CNS) disorders. CoLucid is developing migraine therapy with the clinical development of a neurally acting anti-migraine agent. www.colucid.com Constant Systems Inc. of Sanford, designs, develops and manufactures high-pressure cell disruption equipment. www.constantsystems.com COResearch of Durham, a business unit of Duke Medical Strategies Inc., is an electrocardiography and imaging core laboratory that provides cardiac safety services for pre-human, first-in-man, phase I-IV clinical trials. www.coresearch.biz Cornerstone Therapeutics Inc. of Cary is an emerging specialty pharmaceutical company focused on the development and commercialization of niche prescription medication within the respiratory arena. www.crtx.com Cotton Inc. of Cary improves cotton cultivation through genetic and biotechnology tools, enhancing yield, quality and resistance of cotton varieties. www.cottoninc.com
Covidien Inc of Raleigh manufactures acetaminophen, the active ingredient in Tylenol. It is the world's largest acetaminophen plant, supplying customers in more than 100 countries around the world. www covidien.com Cromoz Inc. in The Research Triangle Park is developing innovative techniques that will provide researchers at biotechnology and pharmaceutical companies a vehicle for target drug delivery. The primary objective of the drug delivery tool is to reduce the amount of drug used during chemotherapy and reduce potential drug side effects. www.cromoz.com Cropsolution Inc. of Morrisville is a product-based company focusing on the discovery of new proprietary antibiotics through proprietary technologies that permit the rapid synthesis and selection of biologically active molecules. www.cropsolution.com CryoFacets Inc. of Durham is developing advanced technology for the blood industry. www.cryofacets.com Cytex Therapeutics Inc. of Durham is developing bio-artificial devices to treat orthopedic diseases and improve quality of life for patients. www.cytextherapeutics.com Cytonet LLC of Durham is a cell therapy company focused on liver repair. The company has two clinical trial programs for liver metabolism disorders, including urea cycle defects and Criglar-Najjar syndrome. www.cytonet.de DARA BioSciences Inc. of Raleigh is a development-stage pharmaceutical company that acquires promising therapeutic molecules and medical technologies directly or through investment in established companies. DARA focuses its therapeutic development efforts on small molecules from late preclinical development through phase II clinical trials. www.darabiosciences.com DaVINCI Biomedical Research Products Inc. of Garner provides innovative pre-instrumented animals, surgical services and patented devices to lab animal researchers in leading research organizations worldwide. www.davincibiomed.com Digital Healthcare Inc. of Wake Forest is the worlds leading provider of technology for the early detection of sight threatening eye disease. www.retasure.com Doe & Ingalls of North Carolina LLC of Durham is a fully integrated chemical distributor recognized as a premier supplier of high-purity raw materials to microelectronic and biopharmaceutical manufacturers and reagents to the laboratory testing market. www.doeingalls.com Research Triangle Region of North Carolina 15
The Drug Discovery Center of Innovation of The Research Triangle Park is a non-profit, comprehensive drug discovery and development center that facilitates the translation of discoveries into effective new medicines. www.ddcoi.org Drug Safety Alliance of Durham is a privately held company specializing in safety, surveillance and pharmacovigilance services for the biopharmaceutical and medical device industries. www.drugsafetyalliance.com Duke Clinical Research Institute of Durham is a large academic clinical research organization that is capable of conducting any clinical research project from pilot study to global trials, device trials to outcomes analyses. www.dcri.duke.edu Duke Mass Spectrometry Facility in The Research Triangle Park uses mass spectrometry technology to discover and diagnose biochemically based genetic disorders in newborns and young children. It operates as a shared facility for analysis of peptides and proteins using electrospray-tandem mass spectrometry. http://medgenetics.pediatrics.duke.edu Effipharma Inc. in Chapel Hill is engaged in the discovery and development of novel therapeutics to treat disorders of the central nervous system. www.effipharma.com Eisai Inc. in The Research Triangle Park discovers, develops and markets pharmaceuticals in three main therapeutic areas neurology, gastrointestinal disorders and oncology/critical care. Eisais RTP facility is a pharmaceutical production and formulation research and development facility. www.eisai.com ENCO Analytic Inc. of Cary is a full-service, independent contract analytical laboratory. ENCO specializes in providing high-quality, timely results in conformance with cGMP. http://analytix.encolabs.com Endacea Inc. of The Research Triangle Park is developing a series of proprietary A1 adenosine receptor (AR) antagonists as drugs for inflammatory diseases, including asthma and sepsis, and an endotoxin assay as a biomarker for patients at risk of sepsis. Endacea is also interested in developing one or more of its water soluble, orally bioavailable A1 AR antagonists as oral drugs for patients with congestive heart failure and impaired renal function. www.endacea.com ENDLS Optics of Durham is developing optical systems for the clinical detection of cancer.
Eno Research and Development Inc. in The Research Triangle Park is a full-service contract research organization that offers a wide range of pre-clinical development services to meet the needs of pharmaceutical, biotechnology, medical device, animal health and nutraceutical companies. ERDIs services range from lead discovery, custom synthesis and formulations through new drug applications and bringing a product to market. www.enoresearch.com Entegrion Inc. in The Research Triangle Park specializes in technologies for the control of hemorrhage, wound management and associated tissue repair. Entegrion indentifies, invents and develops device and biological technologies to meet clearly defined medical needs. www.entegrion.com Enthalpy Analytical Inc. of Durham provides analytical support for the environmental and pharmaceutical industries. Enthalpy provides accurate, high-quality analytical services in a timely manner and for a reasonable cost. www.enthalpy.com Entogenex Biotechnology LLC in Chapel Hill is developing trypsin modulating oostatic factor (TMOF) technology for commercial applications. TMOF is a small protein that interferes with digestion in mosquito larvae, leading to their starvation. www.entogenex.com Envigen Pharmaceuticals Inc. in The Research Triangle Park is a drug discovery company focused on the development of small molecules as protease inhibitors that can be used as effective treatments for HIV/AIDS, Alzheimers and Parkinsons disease. www.envigenpharma.com EPL Inc. of Durham offers experimental and toxicological pathology services on a contract basis. www.epl-inc.com Erimos Pharmaceuticals LLC of Raleigh is a growing biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapeutics to treat cancer. www.erimos.com Esoterix Inc. in The Research Triangle Park is a specialized laboratory service provider focused on high science, superior customer service and innovative new products. www.esoterix.com ETHICON Inc. of Raleigh is a global medical device company that is the leader in surgical sutures (stitches). ETHICON has expanded its expertise into wound management, womens health and cardiovascular surgery. www.ethicon.com
Eton Bioscience Inc. in The Research Triangle Park specializes in DNA sequencing and offers other services, such as gene synthesis, mutagenesis and peptide synthesis. www.etonbio.com eTrials Worldwide Inc. of Morrisville is an eClinical software and service company dedicated to making pharmaceutical, biotechnology, device and contract research organizations more efficient in the important work they do in drug and device research. www.etrials.com Experimental Pathology Laboratories Inc. of Durham is the largest independent organization offering experimental and toxicologic pathology services on a contract basis. www.epl-inc.com Expression Analysis Inc. of Durham is recognized as the market leader in microarray outsourcing for gene expression, genotyping and re-sequencing analysis. Expression Analysis provides experimental design consultation, biologic sample preparation, sample processing and data/statistical analysis services to clients worldwide. www.expressionanalysis.com Family Health International of Durham is among the largest and most established nonprofit organizations active in international public health with a mission to improve lives worldwide through research, education and service in family health. FHI offers a range of technical services, including clinical and other research in HIV/AIDS, sexually transmitted infections and other infectious diseases, contraceptive technology and womens health. www.fhi.org Filtara Inc. of Cary is developing a lightweight medical oxygen device. The enabling technology is a patented nano-filter membrane. First Flight Venture Center in The Research Triangle Park is an incubator facility for seed and early-stage diagnostics and pharmaceutical companies. www.ffvcnc.org Flexcell International Corp. of Hillsborough specializes in designing and manufacturing products to service the cytomechanics marketplace. Cytomechanics is a field of study involving cell responses to mechanical load. www.flexcellint.com For Patients Inc. of Durham and Chapel Hill develops, test, manufactures, markets and distributes innovative medical devices and products. For Patients is the exclusive manufacturer and nationwide distributor of the CathSling, a patented, non-adhesive catheter securement device that supports the infusion lines of central venous catheters, portacaths and peripherally inserted central catheters. Also available is the animal CathSling. www.forpatientsinc.com Research Triangle Region of North Carolina 18
Fujifilm Diosynth Biotechnologies of Morrisville, Cary and The Research Triangle Park supplies contract manufacturing services for the global biotechnology industry. Fujifilm Diosynth is a global leader in technology-driven process development and cGMP manufacturing of recombinant proteins, monoclonal antibodies and peptides. www.fujifilmdiosynth.com Fulcrum Pharma PLC of Morrisville is a global strategic drug development and regulatory service company providing services to the pharmaceutical and biotechnology industries. www.fulcrumpharma.com Galaxy Diagnostics Inc of Raleigh is a clinical testing company providing diagnostic testing for the detection of Bartonella infection in animals and humans. www.galaxydiagnostics.com GE Healthcare of Durham is a market-leading global provider of in vivo medical diagnostic products for the early and accurate detection of disease. GE Healthcares products are injected into the body to improve pictures obtained during medical scans and are focused on three areas of growing clinical need cardiology, neurology and cancer. www.gehealthcare.com GeneCare Medical Genetics Center of Chapel Hill is a private, academic medical genetics center with the mission to provide the highest-quality medical genetics services available. www.genecare.com Gentris Clinical Genetics Inc. of Morrisville is an established market leader and expert in providing superior quality applied pharmacogenomic (PGx) services in a highly regulated and complex clinical environment. Gentris has developed comprehensive and scalable laboratory processes and has provided PGx support domestically and globally for more than 200 phase I-III clinical trials. www.gentris.com Gilero Biomedical of Durham and Raleigh is a full-service biomedical product development company specializing in high-volume disposables, such as drug and fluid delivery systems, and other medical devices constructed primarily of plastic and silicone materials. www.gilero.com GlaxoSmithKline PLC, headquartered in The Research Triangle Park, is a research-based company with a wide portfolio of pharmaceutical products covering anti-infectives, central nervous system, respiratory, gastro-intestinal/metabolic, oncology and vaccines products. GSK manufactures inhaled respiratory products, such as Advair Diskus, a powder inhaler delivery system for asthma medication, at its Zebulon facility. www.gsk.com
Global Vaccines Inc. in The Research Triangle Park licenses early-stage vaccine technologies from universities and works in conjunction with the originating scientists to further develop the technology into usable products. www.globalvaccines.org Gorbec Pharmaceutical Services Inc. of Durham provides bioanalytical, formulation, development and pilot-scale production for the pharmaceutical industry. www.gorbec.com GrassRoots Biotechnology Inc. of Chapel Hill is an agricultural biotechnology company utilizing a systems biology approach to develop new valuable crop lines for the biofuel, food and industrial markets. www.grassrootsbio.com Grifols Inc. of The Research Triangle Park develops and produces medical treatments using blood or blood components for people with life-threatening disorders in a variety of therapeutic areas including immunology, pulmonology and hemostasis. Its manufacturing facility in Clayton produces proteins to treat rare diseases including immune deficiencies and genetic emphysema. Grifols also has a research facility on N.C. State Universitys Centennial Campus that serves as their R&D bioanalytics facility and a R&D facility for nucleic acid technologies in Raleigh. www.grifols.com Hatteras Instruments Inc. of Cary designs, develops and manufactures physiological research instruments. www.hatterasinstruments.com Health Decisions Inc. of Chapel Hill is a full-service clinical research company that accelerates clinical trial development and delivers performance through its innovation and integration of technologies and processes. www.healthdec.com Heat Biologics Inc. of Chapel Hill develops therapeutic vaccines to combat a range of cancers and infectious diseases. www.heatbio.com Hemodynamic Therapeutics of Durham is researching combination therapy for obesity-related hypertension. www.hemodynamictx.com Hemoscience Corp. of Raleigh develops next-generation wound therapy products through the integration of biopolymers and devices. Its services include design, development, regulatory consulting, manufacturing and packaging engineering. www.hemoscience.com
Hibernaid Inc. of Chapel Hill develops drug-induced hypothermia mechanisms to treat stroke, cardiorespiratory arrest and other ischemia reperfusion injuries. HOMS LLC of Pittsboro develops, manufactures and markets natural pesticide products, such as the Bite Blocker line of insect repellents. www.homs.com Hongene Biotechnology USA Inc. of Morrisville develops and manufactures bio-reagents such as nucleosides, nucleotides, and phosphoramidite products. www.hongeneusa.com Hospira Inc. of Clayton is a global healthcare company that develops, markets and manufactures medication delivery systems, specialty injectable pharmaceuticals and critical care devices. Hospira offers essential hospital products, broad and unique manufacturing capabilities, and new technology solutions for hospitals to improve medication and safety management. www.hospira.com Howard Associates LLC in The Research Triangle Park provides contract research services to the pharmaceutical industry. It uses rodent models to predict the efficacy of experimental compounds, especially for central nervous system diseases, and predict central nervous system side effects for any therapeutic class. www.howardassociates.net HTG Inland Technologies of Creedmoor designs, manufactures and supplies precision injection-molded plastic components and assembly services to the medical industry www.hi-tech-group.com Humacyte Inc. in The Research Triangle Park engineers human-based tissue scaffolds that can be shaped into tubes, sheets or particulate conformations and can be applied to many specific applications. The process results in the creation of an off-the-shelf product that can be utilized in any patient. Humacyte is developing its products for vascular replacement, injectable applications and indications that require a sheet. www.humacyte.com Hybrizyme Corp. of Raleigh develops and sells biological-based tests (PCB food-test kits, TCDD test kits and PCB soil-test kits) that allow for rapid and inexpensive testing of environmental and food samples. www.hybrizyme.com HyperBranch Medical Technology Inc. of Durham is a biosurgical device company focused on the design, development and manufacture of novel surgical sealants for general and specialty surgery use, including general surgery, ocular surgery and plastic cosmetic and reconstructive surgery. www.hyperbranch.com
i3 Global of Cary is a contract research organization that focuses on central nervous system, oncology, respiratory and infectious diseases, endocrinology and metabolic diseases, and cardiology. www.i3global.com i3 Research Inc. of Cary is a full-service, global clinical research organization therapeutically focused on central nervous system, oncology, respiratory and infectious diseases, endocrinology and metabolic diseases, and cardiology. www.i3research.com ibiliti of Durham is a member-funded nonprofit organization with a mission to make North Carolinas medical device and diagnostic industry a research, development and production world leader. NCMD connects a broad sector of the industry, including research, development and manufacturing firms, suppliers, service companies, hospitals, clinics and educational institutions. NCMD is primarily focused on the medical device industry, including combination products, diagnostics and medical information systems. www.ncmedicaldevice.org ICON Clinical Research of Durham is a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. It specializes in the strategic development, management and analysis of programs that support clinical development from compound selection to phase I-IV clinical studies www.iconclinical.com ImmunoBiosciences Inc. of Raleigh has proprietary rights to a novel immune complex vaccine technology that is broadly applicable to both human vaccines and animal vaccines. Also referred to as antibody-antigen complex vaccine technology, the technology allows for improved safety and efficacy of viral and bacterial vaccines, thus offering better vaccination strategies. www.immunobiosciences.com ImmunoReagents Inc. of Raleigh produces antibodies used in the in vitro diagnostic and life science markets within cGMP guidelines and QSRs. ImmunoReagents provides an extensive line of secondary antibodies developed in chickens, goats, rabbits and donkeys that are cross absorbed to remove unwanted activity to other species antibodies. It also provides affinity purified polyclonal antibodies to serum proteins, cancer and cardiac markers plus immunoglobulins and bulk serum. www.immunoreagents.com Inanovate Inc. of Durham is developing nano-structured biochip substrates for high-throughput protein screening and analysis. The company also provides a variety of microarray services such as protein printing/arraying and assay development. www.inanovate.com
INC Research Inc., headquartered in Raleigh, is a therapeutically focused contract research organization with a reputation for conducting global clinical development programs of the highest integrity. Pharmaceutical and biotechnology companies look to INC Research for a complete range of customized phase I-IV programs in therapeutic areas of specialty and in innovative pediatric trials. www.incresearch.com Incumed Inc. of Raleigh is a fully integrated medical device incubator dedicated to the creation and development of novel medical products. Incumed is staffed with proven talent and equipped to manage product development programs from concept to clinical evaluation. www.incu-med.com InnerPulse Inc. in The Research Triangle Park is an early-stage company that has created a disruptive technology platform for cardiac rhythm management devices using interventional technology. www.inner-pulse.com (website under construction) InnovaSyn LLC of Chapel Hill sells SynthArray-6 and SynthArray-24 parallel synthesis reactors. www.innovasyn.com InnovaTech Inc. in The Research Triangle Park is a filtration company developing a method to economically harvest algae for bio-fuel production. They also develop mechanical filtration methods for air and water purification. www.novafilter.com Innovative Neurophysiology Inc. of Durham designs and develops advanced tools, equipment and methodology for neuroscience research. www.inphysiology.com InoLife Technologies Inc. of Raleigh develops personalized medicine services and genetic testing for biomarkers including DNA testing for paternity and ancestral origin, response to Plavis medication, and predisposition to certain diseases. www.inolifetech.com Integrated BioChem LLC of Raleigh specializes in converting the biomass from industrial and agricultural waste streams into specialty chemicals, animal feed, and other value-added products. www.integratedbiochem.com Integrated Clinical Trial Services LLC of Cary provides the best solution for patient recruitment, enrollment, retention and compliance challenges. www.icts.us Integrated Development LLC of Willow Springs specializes in delivering products and services to help pharmaceutical and biotechnology companies meet and exceed cGMP standards. www.integradev.com
Integrated Laboratory Systems Inc. in The Research Triangle Park and Durham provides research, testing and support services in the health and environmental sciences. The company serves federal, state and local governments, as well as a broad range of commercial clients. www.ils-inc.com Invisar Inc. of Durham is an engineering product design services and test systems company focused on providing solutions to the medical device, medical equipment, pharmaceutical and biotechnology industries. www.invisar.com Invitrox Inc. in The Research Triangle Park provides diagnostic and therapeutic assays and drug development services to the pharmaceutical and contract research industries that offer a high degree of specificity and sensitivity. www.invitrox.com IPL Therapeutics LLC of Raleigh is a specialty pharmaceutical company focused on acquiring, marketing and developing therapies for children and adults. http://ipltherapeutics.com JABB of the Carolinas Inc. of Pine Level develops fungal pesticides and provides biopesticide products that are safe, effective and economical alternatives to conventional pesticides. www.jabb.bz Jenken Biosciences Inc. in The Research Triangle Park is a specialty pharmaceutical company that develops drugs that modulate cytokine release involved in chronic inflammation-associated organ damage, a $10 billion worldwide market. Jenkens current focus within this broad opportunity is chronic inflammatory liver disease, which includes chronic hepatitis, cirrhosis and non-alcoholic steatohepatitis. www.jenkenbio.com Jubilant Clinsys Inc. of Raleigh provides clinical research services in support of Phase I-IV drug development. www.clinsys.com Kainos Medicine USA Inc. of Morrisville is dedicated to the discovery and development of novel drug candidates for the treatment of a variety of diseases. www.kainosmedicine.com KaryLogic Inc. in The Research Triangle Park provides chromosome analysis services, such as karyotyping of human, rat, and mouse cell lines, to research laboratories. www.karyologic.com Katharos Inc. of Raleigh develops a medical device technology for phosphate-selective absorption to treat high blood phosphate levels in end-stage renal disease hemodialysis patients.
KBI Biopharma Inc. of Durham is a leading contract development organization for the biopharmaceutical industry. KBI accelerates and optimizes drug development and manufacturing programs for client partners, including global pharmaceutical and biotechnology companies and organizations in bio-defense. KBI is positioned to expand its capabilities in other areas of biopharmaceutical product development, such as process development, clinical manufacture, including fill/finish and GMP release, and stability testing. www.kbibiopharma.com KHH BioSci Inc. of Raleigh develops and manufactures a bioprotectant, called Milsana, which induces disease resistance in plants. This product is derived from a plant extract. Kowa Research Institute Inc. of Morrisville is developing over-the-counter pharmaceuticals with a focus on the therapeutic areas of cardiovascular and metabolic diseases, immunology, dermatology and ophthalmology. www.kowa.us Krenitsky Pharmaceuticals Inc. of Durham has a therapeutic focus on disorders of the nervous system. Two drug candidates discovered by KPI have been licensed to other companies for clinical development, manufacturing and marketing. KPI continues to conduct mechanism-of-action studies on one drug candidate. www.kpi-pharma.com Kryosphere Inc. of Durham is a biostorage company that provides biorepository, logistical and management services and will houses up to 5 million biological research samples at ultra-low temperatures. www.kryosphere.com KSE Scientific of Durham sells scientific, safety and production supplies to the pharmaceutical, biotech and environmental research and production markets. www.ksescientific.com Kurve Technology Inc. of Cary offers pharmaceutical companies versatile, cost-effective and compact nasal drug delivery devices for local, systemic and nose-to-brain medical therapies. www.kurvetech.com L&M BioTech Inc. of Raleigh provides laboratory automation and life sciences products to clinical, research and industrial laboratories. www.lmbiotech.com LaamScience Inc. of Morrisville has developed a nanocoating technology that kills bacteria and viruses when exposed to light. Potential uses for the coating include its application to surgical masks to help combat airborne threats, such as SARS. The patent technology uses biocompatible materials than can be attached to woven, nonwoven, natural and synthetic fabrics and surfaces and, when subjected to light, kills or inactivates most viruses and bacteria. www.laamscience.com Research Triangle Region of North Carolina 25
Laboratory Corp. of America Holdings has two centers of excellence located in The Research Triangle Park. The Center for Molecular Biology and Pathology leads the industry in the development and application of polymerase chain reaction, a technology widely used in genomic testing. The centers expertise is focused in diagnostic, genetics, oncology and infectious disease. The Center for Occupational Testing Services is the leading provider of urine, hair, oral fluid and point-of-collection drugs of abuse testing services. www.labcorp.com LEAP Technologies Inc. of Carrboro offers automation applications specializing in customizations based on CTC Analytics PAL Autosampler Platform. LEAP serves automation needs in analytical laboratories. www.leaptec.com LeukoMed Inc. of Raleigh is a drug-development company that has lead compounds that work through an entirely new mechanism of action that inhibits the production of the potent inflammatory cytokine TNF-alpha and certain of its related cytokine family members. This unique mechanism of action provides these compounds with safe, highly selective, yet very potent anti-inflammatory activity useful in targeting the wide variety of diseases in which TNF-alpha and its related family members play a role. www.leukomed.com Life Technologies Inc. of Durham develops human and animal hepatic cell products and provides contract laboratory (in vitro) services, focused primarily on drug metabolism and toxicology. www.invitrogen.com LipoScience Inc. of Raleigh is a medical technology company dedicated to developing and marketing clinical diagnostic applications of nuclear magnetic resonance (NMR) spectroscopy. The NMR LipoProfile test is the companys flagship product, the only commercially available diagnostic test that can quantify the number of lipoproteins in a persons blood. www.liposcience.com Liquidia Technologies Inc. of Durham utilizes a proprietary platform technology to design, develop and manufacture precisely engineered nanoparticles and patterned films for high-value applications in Engineered Drug Therapies and optical films. www.liquidia.com Lumena Pharmaceuticals Inc. in The Research Triangle Park develops treatments for metabolic diseases such as obesity and type 2 diabetes through non-systemically absorbed compounds having targets in the lumen of the gut. www.lumenapharma.com Makhteshim Agan of North America Inc. (MANA) of Raleigh, the North American subsidiary of a global agrochemical company, offers more than 50 branded insecticides, fungicides, herbicides, PGRs and harvest aids from a portfolio of more than 40 strategic active ingredients. www.manainc.com Research Triangle Region of North Carolina 26
Mardil Inc. of Morrisville is a medical device company focused on innovations in minimally invasive treatments for mitral valve regurgitation. Its mission is to design, develop and market new and innovative patented technologies in the cardiac medical device field. www.mardil.com MastCell Pharmaceuticals Inc. of Raleigh focuses on the development of therapeutic agents for treatment of allergic disorders. Maverick Biofuels Inc. of Chapel Hill converts biomass, municipal waste, coal, and natural gas into petroleum-free fuels and plastics. www.maverickbiofuels.com MDS Inc. of Raleigh is a global life sciences company that provides market-leading products and services used to develop drugs and diagnose and treat disease. www.mdsinc.com MDx Health Inc. of Durham develops gene methylation diagnostic tests for early cancer detection and personalized treatment decisions. www.mdxhealth.com Med-El Corp. of Durham is pioneering cochlear implant technology and research worldwide. The Durham location manufactures cochlear implants and is also the North American headquarters. www.medel.com/US/index.php MedFaxx Inc. of Wake Forest is a specialist in alternative medical technologies with proven effectiveness. It provides alternative solutions and relief for sufferers of back pain, fibromyalgia pain, sciatica pain and other health conditions. www.medfaxxinc.com Medis Medical Imaging Systems Inc. of Raleigh is the leading provider of software for the quantification of cardiovascular images. www.medis.nl MedKoo Biosciences Inc. of Chapel Hill manufactures small molecular anticancer reference agents for oncology research and provides drug discovery contract research services. www.medkoo.com Medicago USA Inc. of Durham develops vaccines based on proprietary manufacturing technologies and Virus-Like-Particles. The vaccines are manufactured using transient protein expression system in tobacco plants. www.medicago.com MedTec Inc. of Hillsborough specializes in the development of state-of-the-art laboratory test and validation equipment for the biomedical and genomics field. www.medtecbiolab.com Research Triangle Region of North Carolina 27
Merck & Co. Inc. of Durham is building a vaccine production plant that will produce two vaccines one for chicken pox and the other for measles, mumps and rubella. The plant is expected to eventually produce more than two thirds of Mercks annual live virus vaccine stock, which could amount to more than 25 million doses per year. The plant will also manufacture Zostavx, the companys new shingles vaccine, approved by the U.S. Food and Drug Administration in 2006. www.merck.com Metabolon Inc. of Durham is an emerging technology company developing proprietary analytical methods and software for biomarker discovery using metabolomics. It conducts a fee-for-service business using metabolomics in pharmaceutical, biotech, agriculture, cosmetic and consumer product research. In addition, it uses its metabolomics platform to develop diagnostics for cancer, amyotropic lateral sclerosis (ALS, or Lou Gehrigs disease) and metabolic diseases. www.metabolon.com Micell Technologies Inc. of Durham is an early-stage biomedical company developing combination product therapies in the cardiovascular, orthopedic and drug-delivery areas. www.micell.com Mimotopes US EAST of Raleigh is an industry leader in the peptide and discovery chemistry sector. Mimotopes develops, markets and distributes sophisticated biochemical products and services for the biotech and pharmaceutical industries. www.mimotopes.com Minu LLC of Pittsboro is an ophthalmology products research and development company. www.minullc.com Molecular Epidemiology, Genomics, Environment and Health Research Center, formed by RTI International, will accelerate research to understand the complex relationships between genetics, genomics, molecular epidemiology and their interactions with environmental factors. www.rti.org/page.cfm/Molecular_Epidemiology_Genomics_Environment_and_Health Molecular Orthopaedics Inc. of Chapel Hill is developing gene therapies for osteoarthritis. Monsanto Company in The Research Triangle Park is a leading global provider of technology-based solutions and agricultural products that improve farm productivity and food quality. Monsanto analyzes genes used in the companys corn and soybean research and development testing pipeline. www.monsanto.com Morphormics Inc. of Chapel Hill develops and delivers medical imaging software systems to dramatically increase efficiency and success rate in image-guided medical treatment planning, intervention and diagnosis. It uses a patented, proprietary, image analysis method that recognizes and extracts anatomical structures in live time from 3D and 2D medical images. www.morphormics.com Research Triangle Region of North Carolina 28
MRPath Inc. of Durham provides magnetic resonance-based information for pathology-related applications that perform complete toxicology, phenotype and teratology studies along with a la carte imaging, software and consulting. www.mrpath.com Mycosynthetix Inc. of Hillsborough owns one of the largest collections of fungi in the world and uses them as a source of new pharmaceuticals for a broad range of indications, including new antibiotics for infectious diseases, such as tuberculosis and other drug-resistant bacteria, and cancer, as well as agricultural pesticides. www.mycosynthetix.com NanoCor Therapeutics Inc. of Chapel Hill is a biotechnology company founded to create the first viable intracellular genetic protein therapy for the treatment of chronic heart failure. www.nanocorthx.com NanoVector Inc. of Raleigh is a formulation-stage therapeutic drug company commercializing a patent pending nanoparticle drug delivery system. www.nanovectorinc.com National Institute of Environmental Health Sciences (NIEHS) in The Research Triangle Park is one of 27 research institutes and centers that comprise the National Institutes of Health, part of the U.S. Department of Health and Human Services. NIEHSs mission is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease. www.niehs.nih.gov National Toxicology Program in The Research Triangle Park addresses scientific, regulatory and Congressional concerns about the human health effects of chemical agents in the environment. http://ntp.niehs.nih.gov Natland International Corp. in The Research Triangle Park provides custom synthesis and contract research and development synthesis and distributes rare organic chemicals. www.natland.com Natural Products & Glycotechnology Research Institute Inc. of Pittsboro is developing new methods for the synthesis of oligosaccharides so that the molecules can be used to develop vaccines and diagnostic tools. nContact Surgical Inc. of Morrisville is a privately held medical device company that develops innovative products for the coagulation of cardiac tissue. nContact received U.S. Food and Drug Administration marketing clearance for its system (VisiTrax) that coagulates cardiac tissue using radiofrequency energy. www.ncontactsurgical.com
ND Analytics LLC of Chapel Hill design and produce specimen collection devices for medical diagnostic test kits. The devices are coupled with report analytics for patients, physicians and disease management firms. Neeman Medical International Inc. of Cary is an India-based contract research organization that provides a full range of clinical research services to global pharmaceutical, biotech and devices companies. www.neeman-medical.com NephroGenex Inc. of Cary a new biotechnology company developing treatments for kidney disease utilizing the latest scientific advancements in molecular profiling. www.nephrogenex.com Neuronex Inc. of Morrisville develops drugs that treat central nervous system diseases and disorders. www.neuronexinc.com NeuroScience Pharmaceuticals Inc. of Durham is a clinical stage pharmaceutical company developing treatments for brain disorders. Neusentis of Durham, a Pfizer company, is a biopharmaceutical company focused on ion channel drug discovery and the scope of work expands to include pain and sensory disorders. Neusentis works collaboratively with its Cambridge, UK office to identify new therapies for human disease. www.icagen.com New Direction Biofuels LLC of Raleigh is a startup biodiesel production company seeking to build a commercial biodiesel plant in central North Carolina. www.newdirectionbiofuels.com NextRay Inc. of Chapel Hill is developing and commercializing next generation x-ray machines that provide a detailed diagnostic image with low radiation exposure. NextRay will initially offer a 2D infant imaging machine and a 3D pediatric CT machine. North Carolina Association for Biomedical Research of Raleigh promotes public understanding and support for bioscience research. www.ncabr.org North Carolina Biosciences Organization in The Research Triangle Park is North Carolinas state-level affiliate of the national Biotechnology Industry Organization. Together, the two groups advocate federal, state and local public policies designed to help the bioscience industry fulfill its extraordinary promise as a source of economic opportunity and improved life quality. www.ncbioscience.org
North Carolina Biotechnology Center in The Research Triangle Park is the worlds first governmentsponsored organization dedicated to developing the biotechnology industry. The center is a private, nonprofit corporation supported by the N.C. General Assembly that provides long-term economic and societal benefits to North Carolina by supporting biotechnology research, business and education statewide. www.ncbiotech.org North Carolina Clinical Research is an independent, multi-therapeutic outpatient clinical research site with locations in Raleigh and Chapel Hill. NCCR has conducted phase I-IV clinical trials. www.nccr.com North Carolina State University Technology Incubator of Raleigh, located on the universitys Centennial Campus, offers a truly collaborative blend of services and resources for the innovative entrepreneur. Entrepreneurs with products as diverse as specialized mold cultures, telecommunications applications and biotechnology breakthroughs call the Incubator their temporary home as they work toward commercializing their products and processes. http://techincubator.ncsu.edu Novametics Inc. of Raleigh develops blood coagulation diagnostic products. www.novametics.com NovaTarg Inc. of Durham discovers, develops and commercializes pharmaceutical treatments for cancer and metabolic diseases. www.noatarg.org Novartis Vaccines and Diagnostics of Holly Springs is the worlds fifth-largest manufacturer and secondlargest supplier of influenza vaccines in the United States. Novartis is building a state-of-the-art facility to manufacture new cell cultured-derived influenza vaccines. It will utilize Novartis proprietary cell culture technology, which promises many advantages over traditional egg-based production, including greater reliability and a reduction in production lead-time. www.novartisvaccines.com Novo Nordisk Pharmaceutical Industries Inc. of Clayton manufactures injectable insulin products for individuals with diabetes. The insulin production process includes product formulation with the mixing of human insulin crystals chemical stabilizers and ultra-pure water, aseptic filling of glass vials or cartridges, inspection and packaging. In addition to its production facilities, the site houses administration and laboratories for quality assurance of raw materials, in-process testing and finished products. www.novonordisk-clayton.com Novolipid Inc. in The Research Triangle Park develops technologies to make current cancer drugs safer and more effective by covalently attaching cytotoxic chemotherapeutic drgs to small lipids. www.novolipid.com
Novovita Inc. of Raleigh is a bio-based agricultural technology company. The Novovita product line is a system of fibrous, mat-like materials that are bio-based and biodegradable. www.novovita.com Novozymes North America Inc. of Franklinton develops, manufactures and sells enzyme preparation and biocultures. The facility is the largest multi-purpose enzyme manufacturing plant in the United States, with departments that represent all business functions. www.novozymes.com Nufarm Americas Inc. in The Research Triangle Park has core capabilities in chemical synthesis, sales and marketing of crop protection, professional turf and industrial vegetation management products. www.nufarm.com Nutrasearch LLC in The Research Triangle Park provides contract research on the effects of foods and food ingredients on disease and pre-disease conditions, such as obesity, diabetes and high blood pressure. Nutrasearch also distributes human primary cells and cell-based products. www.nutrasearch.net Ocean Therapeutics Inc. of Cary in-licenses, out-licenses, and develops new medicines and drug candidates from marine organisms in a variety of therapeutic areas. www.oceantherapeutics.com Ockham Development Group Inc. of Cary is a globally operating contract research organization that provides integration of business, planning and development services to drug companies. www.ockham.com Oncoscope Inc. of Chapel Hill is based on a novel method of optical biopsy that uses light signals to analyze cell structure. In laboratory tests, the Oncoscope prototype instantly, painlessly and accurately assessed the presence of pre-cancerous cells before they had a chance to spread. www.oncoscope.com Oncotide Pharmaceuticals Inc. in The Research Triangle Park discovers and develops drugs that modulate protein phosphatases to disrupt cancer cells ability to proliferate and survive. www.oncotide.com Optotrack Inc. of Cary is a high-tech company leading in the research and development of novel optical, imaging, chemical and biological sensors and microsystems. The company is commercializing its proprietary intellectual properties based on microfabrication and nanotechnology to seize rapidly growing market opportunities in the industries of healthcare, communication and homeland security. www.optotrack.com Oryx Bio Inc. of Raleigh develops biosensors and bioseparation products for use in bioanalysis research and biopharmaceutical production. www.oryxbio.com Research Triangle Region of North Carolina 32
Oxygen Biotherapeutics Inc. of Durham researches, develops and markets oxygen-related therapies. The Durham location is the U.S. headquarters. www.oxybiomed.com Palmer Labs LLC of Durham is a developer of advanced algae cultivation methods. The company also designs processes and systems to burn the algae biomass for renewable electricity. www.palmerlabs.com Pamlico Pharmaceutical Inc. in The Research Triangle Park is an early-stage research company engaged in the discovery of medicines with a primary therapeutic focus on the areas of oncology, inflammation and metabolic disorders. www.pamlicopharma.com Parexel International Corp. of Durham is a leading global bio/pharmaceutical services organization that helps clients expedite time to market through its development and launch services. These include a broad range of clinical development capabilities, integrated advanced technologies, regulatory affairs consulting and commercialization services. www.parexel.com Parion Sciences Inc. of Durham is a development-stage pharmaceutical company focused on the discovery and development of new treatments for serious diseases in multiple therapeutic areas. The primary focus is in pulmonary indications including cystic fibrosis, chronic obstructive pulmonary disease and bronchiectasis. Parions technology corrects defects in the innate defense of mucosal surfaces by developing inhibitors of the epithelial sodium channel. www.parion.com Patheon Inc., headquartered in The Research Triangle Park, is a leading global provider of contract dosage form development and manufacturing services to the pharmaceutical and biotechnology. The Morrisville site is the global headquarters and research laboratory. www.patheon.com Pathfinder Pharmaceuticals Inc. of Raleigh is developing drugs for viral diseases and related cancers. Pathfinder Pharmaceuticals focuses on the earliest stages of drug discovery and development. www.pathfinderpharma.com Pearl Therapeutics Inc. of Raleigh develops combination therapies and formulations of inhaled drugs for chronic respiratory diseases such as asthma and COPD. www.pearltherapeutics.com Peptagen Inc. of Raleigh develops nasally-administered cytotoxic T-lymphocyte nanoparticle vaccines for the prevention and treatment of pathogenic diseases and cancer. www.peptagen.com
Permafuels Inc. of Chapel Hill is developing a system of biodiesel production using supercritical alcohols that will make the supercritical process cost competitive with base catalysis, even for high-quality fuel stocks. www.permafuels.com Pfizer Inc. of Sanford provides leading products in the areas of womens health care, infectious disease, gastrointestinal health, central nervous system, inflammation, transplantation, hemophilia, oncology, vaccines and nutritional products. www.pfizer.com Pfizer Animal Health Global Poultry in The Research Triangle Park was built upon the combined strength and experience of Embrex and Pfizer. Pfizer Poultry Health Division is committed to developing and commercializing novel therapeutic mechanical and data management products, which continue to provide increasing value to the global poultry health industry. www.pfizerglobalpoultry.com Pharmaceutical Calibrations and Instrumentation LLC of Raleigh is a nationwide leader in providing calibration and calibration-related services for pharmaceutical, biotechnology and medical device manufacturers. www.pci-llc.com Pharmaceutical Product Development Inc. (PPD) of Durham and Morrisville is a leading global contract research organization providing discovery, development and post-approval services as well as compound partnering programs. Its clients and partners include pharmaceutical, biotechnology, medical device, academic and government organizations. With offices in 31 countries and more than 10,400 professionals worldwide, PPD applies innovative technologies, therapeutic expertise and a commitment to quality to help its clients and partners maximize returns on their research and development investments and accelerate the delivery of safe and effective therapeutics to patients. www.ppdi.com PharmAthene Inc. of Durham develops and manufactures biological and chemical defense products, including an anthrax vaccine. www.pharmathene.com PharmaDirections Inc. of Cary provides a range of clinical and preclinical development services, including strategic planning, product development, preclinical, regulatory affairs and quality assurance. www.pharmadirections.com PharmaLinkFHI Inc. of Durham is the first full-service clinical research organization to integrate clinical and technological expertise in managing phase I-IV clinical trials online in real time. www.pharmalinkfhi.com
PharmaLogika Inc. of Willow Springs, Medical Care Division is developing prescription medication and medical devices primarily for the treatment of Alpha 1-antitrypsin deficiency, Alzheimer's disease and other related neurological diseases. www.pharmalogika.com PharmaNet/i3 of Cary is a global drug development services company that provides a comprehensive range of services to the pharmaceutical, biotechnology, generic drug and medical device industries. PharmaNet offers clinical-development solutions including consulting services. www.pharmanet-i3.com PharmaSys Inc. of Cary is a contract compliance and validation firm specializing in industries that must comply with the U.S. Food and Drug Administration Code of Federal Regulations Title 21 (pharmaceuticals, bioscience, medical devices and clinical trials). www.pharma-sys.com PharmEng Technology Inc. of Raleigh is a full-service consulting and contract manufacturing company that serves the pharmaceutical, biotechnology and medical device industries. www.pharmeng.com Physcient Inc. of Durham is developing a next-generation surgical retractor that decreases tissue trauma and inflammation during retraction and thereby decreases post-surgical pain, healing and morbidity. www.physcient.com Piedmont Biofuels of Pittsboro is a biofuels cooperative that uses and encourages the use of clean and renewable biofuels in North Carolina. www.biofuels.coop Piedmont Research Center of Morrisville, a division of Pharmaceutical Product Development Inc., is dedicated to preclinical research and evaluation of anticancer agents and therapies. www.ppdi.com/services/preclinical/preclinical_eval/home.htm Pique Therapeutics of Durham is a biotechnology company seeking to become the leading therapeutic vaccine company, focused initially on the treatment of cancer. www.piquetherapeutics.com Plexigen Inc. of Cary is a biotechnology company focused on instrumentation and service for genetic and proteomic testing. Its 3-D biological microarray, the geneCube, overcomes the traditional 2-D array limitations of inflexibility and low throughput. www.plexigen.com Polyzen Inc. of Apex is a leading developer and manufacturer of disposable medical products and devices, such as medical balloons, medical tissue bags, medical barrier sleeves and other medical disposables, for medical industry original equipment manufacturers. www.polyzen.com Research Triangle Region of North Carolina 35
Pozen Inc. of Chapel Hill is a pharmaceutical company committed to developing therapeutic advancements for diseases with unmet medical needs where it can improve efficacy, safety and/or patient convenience. Pozens lead product candidate is Trexima, which is being developed in collaboration with GlaxoSmithKline for the treatment of acute migraine. www.pozen.com PRA International, headquartered in Raleigh, is one of the worlds leading global clinical development organizations delivering reliable service, program-level therapeutic expertise, easy global access to knowledge and an involved senior management. www.praintl.com Precision Biosciences Inc. of Durham develops novel tools for genome manipulation. Its technology, called the Directed Nuclease Editor (DNE), can be applied to nearly every facet of biotechnology, including crop and cell line engineering, antivirals, antibacterials, genetic diagnostics and gene therapy. www.precisionbiosciences.com Premitec Inc. of Raleigh assists companies in new product development by providing complete microfabrication design, development, prototyping, testing and initial manufacturing of advanced medical sensor systems and devices based on micro and nano-technologies. www.premitec.com Prima Biomed USA Inc. of Cary is developing Cvac an autologous, dendritic-cell immune stimulant to treat ovarian cancer. www.primabiomed.com.au ProTrials Research Inc. of Chapel Hill provides clinical operations professionals and services to pharmaceutical, biotechnology and medical device companies. Founded in 1996, ProTrials enables its clients to cost-effectively conduct clinical trials in a wide range of therapeutic areas, from cardiovascular and central nervous system, infectious diseases and oncology to transplants and vaccines. www.protrials.com Proventys of Durham is a personalized medicine knowledge service provider focused on delivering cutting-edge risk prediction technology to power personalized clinical decisions at the point of care. www.proventys.com Purity Systems Inc./Purity Systems Caribe Inc. of Raleigh is the recognized leader in providing independent, third-party assurance and analytical testing services. www.puritysystems.com Qualiber Inc. of Chapel Hill develops nanotechnologies to solve drug delivery challenges for siRNA, small molecules and gene-based therapeutics, with a focus on cancer, hepatitis and liver diseases. www.qualiberinc.com
Qualyst Inc. of Raleigh develops and delivers novel and proprietary ADMET products to the life sciences industry that increase the efficiency and effectiveness of drug discovery and development. www.qualyst.com Quintiles Transnational Corp., headquartered in Durham is powering the next generation of healthcare by providing a broad range of professional services in drug development, financial partnering and commercialization for the biotechnology and healthcare industries. Quintiles focuses on providing customer-centric solutions that are the gold standard of the industry. www.quintiles.com REALTROMINS Inc. of Chapel Hill is developing an intensive-care monitoring device that continuously evaluates the condition of critically ill children, enabling early warning to changes in their conditions and thus faster, more-effective treatments. www.realtromins.com Regado Biosciences Inc. of Durham is pioneering the discovery and development of antidote-controlled therapeutics that act on a specific molecular target. Regado's drug-antidote pairs are designed to give physicians the ability to fine tune the therapeutic effect desired for each patient and in each setting. www.regadobiosciences.com RemedEase Inc. of Durham develops disposable products to remedy nosebleeds. Research Triangle Park Laboratories Inc. of Raleigh is a premier provider of analytical laboratory services for the pharmaceutical, biotechnology, environmental, dietary supplements and manufacturing industries. www.rtp-labs.com RF Wastewater of Raleigh focuses on biological wastewater treatment, using lignocellulosic materials as biofilm media for activated sludge system retrofits and upgrades. www.rfwastewater.com Rho Inc. of Chapel Hill is a specialty contract research organization with full-service capabilities that enhance the quality and speed of clinical trials, helping pharmaceutical and biotechnology companies swiftly develop new products. www.rhoworld.com Ribonomics Inc. of Durham is a systems biology company focused on the development of innovative products for the diagnosis and treatment of human diseases. www.ribonomics.com
Ridge Diagnostics Inc. in The Research Triangle Park is a neurodiagnostic company offering its proprietary first-in-class blood test for major depressive disorder (MDD) through its clinical laboratory improvement amendments-certified laboratory in North Carolina. Based upon its proprietary human biomarker library and Biomarker Hyper-Map technology platform, Ridge Diagnostics has developed multi-variant biological marker assays and diagnostic algorithms to diagnose, select and monitor treatment for MDD and other neuropsychiatric disorders. www.ridgedx.com Rockwell Automation Life Sciences of Cary covers the entire life cycle of a pharmaceutical or biotechnology product. The complete architecture includes manufacturing execution solutions spanning the phases of the life cycle from research and development and clinical trial management through production, utilizing integrated architecture solutions. www.rockwellautomation.com/industries/lifesciences RTI Health Solutions in The Research Triangle Park provides leading consulting and research expertise to design risk-management programs, evaluate disease burden, assess safety and measure value for pharmaceutical, biotechnology and medical device products. www.rtihealthsolutions.org RTI International, headquartered in The Research Triangle Park, is a nonprofit research institute that offers innovative research and technical solutions to governments and businesses worldwide in the areas of health and pharmaceuticals, education and training, advanced technology, surveys and statistics, international development and the environment. www.rti.org Saha Pharmaceuticals Inc. of Durham develops technology to reduce the toxicity of anticancer drugs. Salix Pharmaceuticals Inc. of Morrisville is committed to being the leading U.S. specialty pharmaceutical company licensing, developing and marketing innovative products to health care professionals to prevent or treat gastrointestinal disorders in patients. Salix markets COLAZAL, XIFAXAN, OSMOPREP, MOVIPREP, VISICOL, AZASAN, PEPCID, ANUSOLHC and PROCTOCORT. www.salix.com Sandoz Inc. of Durham is a leading respiratory drug delivery and development company serving the pharmaceutical, biotechnology and diagnostic industries in the development and commercialization of innovative pre-metered unit and multi-dose dry powder delivery systems for medicines for asthma and chronic obstructive pulmonary disease. Sandoz has a product development center in Durham. www.us.sandoz.com Sapheon Inc. of Morrisville develops medical devices and technology to treat vascular diseases. www.sapheoninc.com
Scientific Calibration Inc. of Apex offers one of the most complete and flexible service, calibration and validation programs in the marketplace. It offers complete pipette and labsystem multi-drop cassette calibration and service programs in the United States for all brands of pipettes. www.scical.com SciKon Innovation Inc of Chapel Hill develops medical and pharmaceutical biotools using tissueengineering principles to include cell ecosystems, living thermodynamics, nutrient transport and delivery, and cell systems approaches. www.scikoninnovation.com Scintellix LLC of Raleigh aggregates the talents of a large network of professionals in service of biomedical technology development, medical opinion and market data, as well as tactical support of operations. www.scintellix.com Scion NeuroStim LLC of Raleigh has developed an inexpensive non-invasive neurostimulator that is being used in a pilot study to treat migraine patients. The underlying science involves stimulation of innate protective pathways in the body to treat pain. www.scionneurostim.com SciQuest Inc. of Cary is the global leader in helping academic, healthcare and research-centric organizations realize the potential of strategic procurement. SciQuests specialized knowledge, ondemand software and service-first approach empower more than 100 of the best-known academic, pharmaceutical, biotechnology, research hospitals and ambulatory surgical organizations to manage spend, drive ROI and advance their critical missions. www.sciquest.com SCYNEXIS Inc. of Durham is a premier drug discovery and development company delivering effective and innovative drug pipeline solutions to pharmaceutical and global health partners. The company also focuses on developing a proprietary internal pipeline based on cyclophilins, a class of drugs that hold significant potential for the treatment of a broad range of diseases. www.scynexis.com Seachaid Pharmaceuticals Inc. of Durham discovers and develops therapeutic agents to treat human diseases. The approach incorporates rational design with emphases on synthetic, medicinal and analytical chemistry to generate candidates for drug development. www.seachaid.com Sicel Technologies Inc. of Morrisville develops telemetric systems that use miniature implantable wireless sensor technologies to continuously provide real-time feedback about biological and physiological changes in cell and organ systems. www.siceltech.com
Sigma Xi, The Scientific Research Society, in The Research Triangle Park is the international honor society of research scientists and engineers. www.sigmaxi.org Sipcam Agro USA Inc. of Durham provides technology to protect the investment of growers in turf, ornamental and food crops in the United States and Mexico. www.sipcamadvan.com SIRGA Advanced Biopharma Inc. of Raleigh is an early-stage drug discovery and development company, focusing on small molecule drugs to treat HIV and other diseases where drug resistance is a significant problem. www.sirgaab.com SmartFlow Technologies Inc. of Apex provides filtration, separation and purification for biotechnology, biofuels, biopharmaceutical processing, animal healthcare, dairy processing, animal healthcare, dairy processing, enzyme manufacturing and wastewater. www.smartflow-tech.com SmartGene Inc. of Raleigh provides Web-based data management services for the management, analysis and interpretation of genetic sequences to identify bacteria, fungi and viruses. www.smartgene.com Source Food Technology Inc. of Durham is a food ingredient company specializing in nutritionally advanced cooking oils. Southcot Corp. in The Research Triangle Park is a small company specializes in chemical and biochemical reagents for cancer diagnosis. www.hypoxyprobe.com Southeast TechInventures Inc. of Morrisville is a technology accelerator focused on developing and transitioning technologies from university labs to the commercial marketplace. www.southeasttechinventures.com Spectrofuge Corp. of North Carolina Inc. of Durham is one of the pioneer independent service organizations in the maintenance of bio-analytic research equipment and separations instrumentation. www.spectrofuge.com Sprout Pharmaceuticals Inc. of Raleigh is developing a Phase III compound to treat hypoactive sexual desire disorder. www.sproutpharma.com SRA Global Clinical Development LLC in The Research Triangle Park, SRAs global clinical development unit is a full-service contract research organization focused on small- to medium-sized companies. www.sra.com Research Triangle Region of North Carolina 40
Stat-Tech Services LLC of Chapel Hill is a contract research organization that provides biostatistical consulting and analysis, clinical data management, programming solutions, report productions and regulatory support services to pharmaceutical and medical device companies. www.stattechservices.com StatWorks Inc. in The Research Triangle Park is a high-quality specialty provider of biostatistical analysis and consulting, clinical data management and report writing services focused exclusively on clinical trials and drug development. www.statworks.net Stiefel Laboratories Inc. in The Research Triangle Park, a GlaxoSmithKline company, specializes in the research, development and manufacture of prescription and over-the-counter skin care products to treat acne, psoriasis, hyperpigmentation and other skin conditions. www.stiefel.com Stocks Institute for Age Management of Raleigh provides preventative medicine, hormone replacement, and age management therapies. www.stockinstitute.com Straightfoward Solutions LLC of Raleigh provides guidance and assistance on industrialization of drug delivery devices, from concept through commercialization. Sun Dance Genetics of Durham is marrying the insect resistance of wild grasses with commercial corn. SunTech Medical Inc. of Morrisville is a medical device manufacturer of non-invasive blood pressure monitoring products and technology. www.suntechmed.com Synereca Pharmaceuticals of Chapel Hill develops orally active drugs that restore or increase the effectiveness of existing antibiotics. www.synereca.com Synecor LLC of Durham is a privately held business accelerator focused on creating highly proprietary, disruptive technologies in the largest medical device and combination drug/device markets. www.synecor.com Syngenta Biotechnology Inc. in The Research Triangle Park is a world-leading agribusiness committed to sustainable agriculture through innovative research and technology. SBI researchers use a combination of science and cutting-edge technology to develop innovative solutions that help farmers and food companies. www.syngentabiotech.com Synpac (North Carolina) Inc. in The Research Triangle Park is developing a drug for the treatment of glycogen storage disease type II (Pompes disease). Research Triangle Region of North Carolina 41
Synteract Inc. of Morrisville is a privately held, full-service contract research organization that provides clinical trial services for life sciences companies. Synteract focuses on clinical monitoring and site management, safety surveillance and project management. www.synteract.com Synthonix Corp. of Wake Forest manufactures highly functionalized small molecule heterocycles and synthons designed with biological and pharmacological bias. www.synthonix.com Synthon Pharmaceuticals Inc. in The Research Triangle Park discovers, develops and markets both active pharmaceutical ingredients and finished pharmaceutical dosage forms. www.synthon-usa.com TAB Clinical Trials of Cary is a full-service contract research organization that provides clinical trial support from a pre-IND stage of development to post-market approval. TAB Clinical concentrates on helping small, mid-size and specialty biopharmaceutical and pharmaceutical companies expedite the pace of drug development through efficient and cost-effective processes combined with attentive and responsive project management. www.tabclinical.com Tackle Design Inc. of Durham is an industrial design and research and development firm. Tackle Design has a particular specialty in inventing and developing prosthetics. www.tackledesign.com Talecris Plasma Resources, headquartered in The Research Triangle Park and operations also in Raleigh, focuses on ensuring a reliable and safe supply of plasma for the manufacture of medicines that improve and save peoples lives in the United States and around the world. Talecris Plasma Resources, Inc. is a wholly owned subsidiary of Grifols Therapeutics, Inc. www.talecrisplasma.com TearScience Inc. of Morrisville develops diagnostic and treatment procedures for ophthalmology. www.tearscience.com Teleflex Medical of Durham is a global supplier of medical devices, surgical instruments and disposable medical products. Teleflex is committed to solving the challenges of our changing healthcare environment in the areas of critical care and surgical applications by providing solutions that are less invasive, help reduce infections and improve patient safety. www.teleflexmedical.com TeleTracking Technologies Inc. is focused on wireless tracking of medical equipment and patients. TeleTracking has a manufacturing, implementation and customer support service center located in Morrisville. www.teletracking.com
Tempest Environmental Systems Inc. of Chapel Hill is a world leader in research, development and production of advanced technologies that address specific worldwide environmental challenges. www.aquapura.com Teotten Diagnostics Inc. in The Research Triangle Park is developing diagnostics for infectious diseases associated with hospital procedures and the use of medical devices, such as central venous catheters. www.teotten.com The Hamner Institute for Health Sciences in The Research Triangle Park is an independent, nonprofit organization that unites academia, the private sector and government to conduct translational research for improved human health assessments and the development of new and safe medicines. www.thehamner.org The Institute of Forest Biotechnology of Cary supports the responsible use of biotechnology in forest trees. The institute advances the societal, environmental and economic benefits that biotechnology can bring to forests around the world. It is the only nonprofit organization to address the sustainability of forest biotechnology on a global scale. www.forestbiotech.org Theralogics Inc. of Chapel Hill is developing effective inhibitors of NF-kB and wants to bring these drugs into the clinical arena by establishing a network of investigators in academia and biopharm, each focused on one of the major NF-kB relevant target diseases. www.theralogics.com Thrombotargets Corp. of Durham is developing medicines based on advances in recombinant DNA and small-molecule drug technologies. Thrombotargets has expertise in haemostasis and is focused on inherited and acquired hemorrhagic and thrombotic disorders. www.thrombotargets.com TIRF Technologies Inc. of Morrisville develops and manufactures total internal reflection fluorescence (TIRF) and TIRF-electrochemical biosensor systems for detection and control of biomolecular interaction such as protein-protein, receptor-ligand, protein-DNA, DNA-DNA, protein-membrane and other biomolecular interactions. www.tirftechnologies.com Touch Scientific Inc. of Raleigh develops high-speed diagnostic tests and equipment for the ophthalmic market. www.touchscientific.com Toxicology Services Inc. of Chapel Hill provides drug-development services to pharmaceutical companies and contract research organizations. Toxicology Services specializes in general and genetic toxicology, reproductive toxicology and pharmacokinetics. www.toxicologyservices.net
Trana Discovery Inc. of Cary is a drug-discovery technology company that helps its partners find novel classes of drugs for the treatment of serious viral, fungal and bacterial infectious diseases. The technology identifies compounds that work through a unique mechanism of action: inhibition of the target pathogens ability to use transfer RNA (tRNA) essential for protein synthesis or replication. www.tranadiscovery.com TransEnterix Inc. of Durham is pioneering technology in the area of incision-less surgery, developing a medical device that decreases the number of incisions required for abdominal surgery. Its disruptive technology platform will access and treat the patients gastrointestinal system entirely through a natural orifice. www.transenterix.com TransViragen Inc. in The Research Triangle Park provides in vivo discovery research services, including a full suite of genetically modified mouse and rat model services, from custom-model generatioin to phenotyping. www.transviragen.com Tranzyme Pharma Inc. of Durham is a clinical-stage drug development company that discovers and develops novel small molecule drugs for diseases with a high unmet medical need, such as gastrointestinal and metabolic diseases. www.tranzyme.com Triangle Biology LLC in The Research Triangle Park provides preclinical drug discovery contract research services, including biology assays/assay development, compound profiling, high throughput screening, DMPK and in vivo pharmacology. www.triangle-biology.com Triangle Biomedical Sciences Inc. of Durham designs, develops, manufactures and markets a comprehensive line of innovative instrumentation, apparatus, reagents and consumables for the medical discipline of histology. TBSs technology is marketed globally through a network of regional and national laboratory distributors. www.trianglebiomedical.com Triangle BioSystems Inc. of Durham offers a family of multiplexing channel analog multiplexing headstage subassemblies that are used to provide a reduced wired connection between implanted electrodes and neural recording and analysis equipment. www.trianglebiosystems.com Triangle Biotechnology Center of Durham is a 20,000-square-foot research and development facility for life sciences companies built for access to high-quality, dedicated and robust R&D and critical wet-lab facilities for this highly specialized industry. www.trianglebiotechnologycenter.com
Triangle Research Labs LLC in The Research Triangle Park provides research services focused on drug metabolism, drug-drug interactions, in vivo pharmacokinetics and toxicology, drug characterization, drug transporters, diabetes research, virology, hepatotoxicity, and neural toxicology. TriboFilm Research Inc. of Raleigh is a one-of-a-kind entrepreneurial research incubator with material scientists, chemists and engineers from diverse industries, including medical devices, semiconductor materials processing and polymer and textile chemistry. www.tribofilmresearch.com TriE Medical Inc. of Morrisville provides innovative turnkey medical device design and U.S. Food and Drug Administration documentation services for highly regulated therapeutic and diagnostic devices. www.triemedical.com Trio Clinical Research LLC of Durham is an innovative clinical research services company supporting the pharmaceutical, biotechnology and medical device industry in their quest to bring novel products to the market. www.trioclinicalresearch.com TRx Pharma of Chapel Hill is a specialty pharmaceutical company focused on acquiring, marketing and developing therapies for metabolic and chronic inflammation diseases. www.trxpharma.com Tryton Medical Inc., headquartered in The Research Triangle Park, is the leading developer of stents that are designed to definitively treat bifurcation lesions. The Tryton Side-Branch Stent is a unique balloon-expandable, 5-French-compatible system that is delivered with a single wire. www.trytonmedical.com TVRheinland of North America Inc. of Youngsville is a global leader in independent testing and assessment services. www.us.tuv.com UCB Biosciences Inc. of Raleigh is a leading global biopharmaceutical company dedicated to researching and developing therapeutics to treat central nervous system disorders and immunology diseases. www.ucb.com Unit Dose Solutions Inc. of Morrisville provides outsourced drug repackaging and sterile preparation services in accordance with current good manufacturing practices. www.unitdoseinc.com United States Environmental Protection Agency in The Research Triangle Park develops analytical tools and models used to assess pollutant exposure, investigate human and ecological effects of environmental pollutants and utilize engineering approaches to mitigate or limit industrial and indoor air pollution. RTPs campus is the largest facility ever designed and built by the EPA. www.epa.gov/rtp Research Triangle Region of North Carolina 45
United Therapeutics Corp. in The Research Triangle Park is a biotechnology company focused on the development and commercialization of unique products to address the unmet medical needs of patients with chronic and life-threatening cardiovascular and infectious diseases and cancer. www.unither.com Urogenix Inc. of Durham provides preclinical research focused on urological disorders. Valeant Pharmaceuticals North America of Durham develops and manufactures pharmaceuticals for neurology and dermatology markets. www.valeant.com Valencell Inc. of Raleigh designs, manufactures and markets portable, non-invasive, biomedical diagnostic solutions that use microelectronic sensor technology. www.valencell.com Varian Inc. of Cary has a scientific instrument division located in Cary that is a leading worldwide supplier of scientific instruments and vacuum technologies for life science and industrial applications. Varian provides complete solutions, including instruments, vacuum products, laboratory consumable supplies, software, training and support through its global distribution and support systems. Vascular Biosciences Inc. of Durham Vascular BioSciences is dedicated to enhancing and prolonging human life. Innovative technologies are being developed to detect and treat vascular-based disease, the leading cause of serious illness and death in the industrialized world. www.vascularbiosciences.com Venganza Inc. of Raleigh is a plant biotechnology company that continues to advance its proprietary RNA interference technology to control plant pests (fungi, insects, nematodes, etc.) and reduce the application of fungicides and other pesticides. www.venganzainc.com Viamet Pharmaceuticals Inc. of Durham discovers and develops small molecule compounds that target metalloenzymes in the fields of infectious disease, inflammation and oncology. www.viamet.com Vijaya Pharmaceuticals LLC of Raleigh develops antimicrobial agents active against multi-drug resistant pathogens. Vindica Therapeutics Inc. of Raleigh develops an anti-infective urinary catheter that acts through controlled release of nitric oxide. Its Raleigh location is the global headquarters. Virus Detection Systems Corp. of Cary uses a proprietary separation technology combined with commercial scientific equipment to produce an innovative virus detection system that quickly, conveniently and affordably detects, determines the size for an initial identification and quantifies viruses. www.vdsc.us Research Triangle Region of North Carolina 46
Vision Share of Apex is a not-for-profit consortium of cooperating independent eye banks that provides human donor tissue for medical research. www.visionshare.org vivoPharm Ltd., in The Research Triangle Park is a contract research organization that offers integrated preclinical services in different disease areas (with a focus on cancer) to the biotechnology and pharmaceutical industries. www.vivopharm.com.au Wemco Inc. of Raleigh specializes in automated laboratory equipment, including media grinders, pickand-place robots and glove boxes. Weststar Inc. of Holly Springs is a rapidly growing contract manufacturer of precision devices, components and assemblies for commercial and industrial applications. www.westmedco.com Xenobiotic Detection Systems of Durham offers a full range of diagnostic services. The XDS-CALUX Assay is ideal for use as a low-cost research tool to determine biological activity of a specific substance. It can also be used as a screening assay to measure contamination levels at industrial sites. www.dioxins.com X-in8 Biologicals Corp. of Chapel Hill develops technology to prolong organ transplant potential. XinRay Systems Inc. in The Research Triangle Park develops and manufactures multibeam x-ray sources for a broad range of applications including diagnostic medical imaging, homeland security, and industrial inspection. www.xinraysystems.com Xintek Inc in The Research Triangle Park develops and manufactures nanomaterial-based field emission technologies and products for a broad range of applications including diagnostic medical imaging, homeland security, and information display. www.xintek.com Zen-Bio Inc. in The Research Triangle Park is a supplier of life science discovery tools and in vitro contract research services for metabolic disease researchers. Zen-Bio sells human adipocytes, preadipocytes adipocyte cell extracts, contract assay services and research kits. www.zen-bio.com Zenalux Biomedical Inc. of Durham uses biophotonics to develop diagnostic tools, including an optical system for the clinical detection of cancer. www.zenalux.com
Zylera Pharmaceuticals of Chapel Hill is a specialty pharmaceutical company focused on developing medications that will treat multiple diseases arising within the inflammation and immunosuppressive pathways. Its near-term pipeline includes products for diabetes, elevated cholesterol, osteoporosis and osteoarthritis, utilizing proprietary and patented chemical entities designed to restore key metabolic processes. www.zylera.com
Source: North Carolina Biotechnology Center Company Directory, June 2012, Company Web Sites, Research Triangle Regional Partnership
Research Triangle Regional Partnership P.O. Box 80756 RDU International Airport North Carolina 27623 919-840-7372 Web: www.researchtriangle.org Twitter: @TriangleRegion

Research Triangle Regions Life Sciences Directory 2012

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