BIOAVAILABILITY PHARMACOKINETICS PRACTICE PROBLEMS 1. If the bioavailability factor (F) for a 100-mg tablet of a drug is 0.

70 compared with the bioavailability factor of 1.0 for an injection of the same drug, how many milliliters of the injection containing 40 mg/mL would be considered bioequivalent to the tablet? 2. If 5 mL of an elixir containing 2 mg/mL of a drug is bioequivalent to a 15 mg tablet having a bioavailability factor of 0.60, what is the bioavailability factor of the elixir? 3. If 500 mg of a drug are administered orally and 300 mg are absorbed into the circulation, calculate the bioavailability factor (F). 4. A drug is 40% bioavailable by the oral route and 58% bioavailable by the transdermal route. If a patient is taking a 2.5 mg oral dose twice a day and is switched to the counterpart 2% ointment, how many grams of the ointment should be administered to provide the equivalent dose of the drug? 5. A drug used to treat asthma is 55% bioavailable as 5mg tablets. If a patient is switched to the inhalant form of the drug, which is 87% bioavailable, how many metered 500-g sprays should the patient administer every 12 hours to receive an equivalent drug dose? 6. If a 6-mg dose of a drug is administered intravenously and produces a blood concentration of 0.4 g/mL, calculate its apparent volume of distribution. 7. If at equilibrium, two thirds of the amount of a drug substance in the blood is bound is bound to protein, what would be the alpha () value of the drug? 8. The alpha () value for a drug in the blood is 0.90, equating to 0.55 ng/mL. What is the concentration of total drug in the blood? 9. A patient received an intravenous dose of 10 mg of a drug. A blood sample was drawn and it contained 40g/100 mL. Calculate the apparent volume of distribution? 10. The volume of distribution for a drug was found to be 10 liters with a blood level concentration of 2 g/mL. Calculate the total amount of drug present in the patient? 11. Calculate the elimination rate constant for a drug having an elimination half-life of 1.7 hours? 12. What percentage of an originally administered intravenous dose of a drug remains in the body following three half-lives?

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13. If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5 g/mL, calculate the apparent volume of distribution? 14. If the dose of 1g of a drug is administered intravenously to a patient and the drug plasma concentration is determined to be 65 g/mL, calculate the apparent volume of distribution? 15. The volume of distribution for chlordiazepoxide has been determined to be 34 liters. Calculate the expected drug plasma concentration of the drug in micrograms per deciliter, immediately after an intravenous dose of 5 mg. 16. In normal subjects, blood makes up about 7% of body weight. A) Calculate the approximate blood volume in liters, for a man weighing 70 kg. B) If the drug ZANTAC reached peak blood levels of about 500ng/mL, 2 to 3 hours after an oral dose, calculate the total amount of the drug, in milligrams, in the blood of the patient described in (A) when peak blood levels are achieved.

PRACTICE PROBLEMS

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