Seewaboon Sireeratawong

(Academic Position) (Associate Professor) (Education) D.V.M. (Veterinary Medicine) Khon Kaen University, Thailand Ph.D. (Pharmacology) (Contacts) 5 (Level 5, Kunakorn Building) +66 (0)-2926-9710 seewaboon@gmail.com Chiang Mai University, Thailand

(Research Interests) My general research interests are the areas of pharmacology and toxicology of herbal medicine and natural products. My current research focuses on various pharmacological activities of the extracts for herbs or herbal recipes of Thai folk medicine such as anti-cancer, anti-oxidant, anti-inflammatory, antipyretic, analgesic, anti-ulcerogenic and hormone-like effects etc. We are currently using various experimental models including cell culture and animals. Moreover, my other area of research interest is toxicology field, which is in the aspects of toxicity evaluation of herbs or herbal recipes extracts. With the expanding collaboration with many prominence institutes, I am not only a coordinator but a director of many projects in which we evaluate acute, sub-acute, sub-chronic and chronic toxicities in animals. Funded by research grants from several Thai government funding agencies since 2004, there have been more than 70 projects conducted and approximately 25 original articles published with in 5 years. Our major goal is to provide health professionals scientific supports for substantiating the claimed pharmacological effects of traditional medicine in order to facilitate an effective and safe use of complementary and alternative medicine among Thai.

 (Published Original Articles) 1. Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninan K, Panthong A. Acute and subacute toxicity study of the ethanol extract from Alternanthera philoxeroides Griseb. Songklanakarin Journal of Science and Technology. 2005; 32 (12):4-14. 2. Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninan K, Panthong A. Acute and subacute toxicity study of the ethanol extract from the rhizomes of Cyperus rotundus Linn. Mahidol University J Pharm Sci. 2005; 32 (1-2):15-22. 3. Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninan K, Panthong A. Acute and subacute toxicity study of the ethanol extract from the fruits of Terminalia belerica. Mahidol University J Pharm Sci. 2006; 33 (1-4):23-30. 4. Thanabhorn S, Jaijoy K, Thamaree S, Ingkaninan K, Panthong A. Acute and subacute toxicity study of the ethanol extract from Lonicera japonica Thunb. Journal of Ethnopharmacology. 2006; 370-373. 5. Chunlaratthanaphorn S, Lertprasertsuke N, Srisawat U, Thuppia A, Ngamjariyawat A, Suwanlikhid N, Jaijoy K. Acute and subchronic toxicities of the water extract from Piper nigrum L. Songklanakarin Journal of Science and Technology. 2007; 29(Suppl.1):109-124. 6. Chunlaratthanaphorn S, Lertprasertsuke N, Srisawat U, Thuppia A, Ngamjariyawat A, Suwanlikhid N, Jaijoy K. Acute and subchronic toxicities of the water extract from Citrus aurantifolia (Christm. et Panz.) Swingle. Songklanakarin Journal of Science and Technology. 2007; 29(Suppl.1):125-139. 7. Chunlaratthanaphorn S, Lertprasertsuke N, Srisawat U, Thuppia A, Ngamjariyawat A, Suwanlikhid N, Jaijoy K. Acute and subchronic toxicities of the water extract from Imperata cylindrica (Linn.) Raeusch. Songklanakarin Journal of Science and Technology. 2007; 29(Suppl.1):141-155. 8. Pinmai K, Chunlaratthanabhorn S, Ngamkitidechakul C, Soonthornchareon N, Hahnvajanawong C. Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells. World Journal Gastoenterology. 2008; 14(10):1477-1640. 9. Sireeratawong S, Lertprasertsuke N, Srisawat U, Thuppia A, Ngamjariyawat A, Suwanlikhid N, Jaijoy K. Acute and subchronic toxicities of the water extract from Tiliacora triandra (Colebr.) Songklanakarin Journal of Science and Technology. 2008; 30(5):611-619. 10. Sireeratawong S, Lertprasertsuke N, Srisawat U, Thuppia A, Ngamjariyawat A, Suwanlikhid N, Jaijoy K. Acute and subchronic toxicities of the water from root of Sida rhombifolia Linn. Songklanakarin Journal of Science and Technology. 2008; 30(6):729-737. 11. Hansakul P, Ngamkitidechakul C, Ingkaninan K, Sireeratawong S, Panunto W. Apoptotic induction activity of Dactyloctenium aegyptium (L.) P.B. and Eleusine indica (L.) Gaerth. Songklanakarin Journal of Science and Technology. 2009; 31(3):273-279. 12. Kandee N, Sireeratawong S, Burawat B, Utama-Ang N, Lerdvuthisopon N. The effect of rice barn extract on insulin resistance in high fat diet-induced obese rats. Thammasat Medical Journal. 2009; 9(2):140-147.

13. Rabintossaporn P, Thuppia A, Saenthaweesuk S, Ingkaninan K, Sireeratawong S. Anti-hyperglycemic and histological effects on the pancreas of the aqueous leaves extract of Annona squamosa L.in normal and diabetic rats. Songklanakarin Journal of Science and Technology. 2009; 31(1):73-78. 14. Rabintossaporn P, Saenthaweesuk S, Thuppia A, Ingkaninan K, Sireeratawong S. The histological examination of livers in normal and streptozotocin-induced diabetic rats received Annona squamosa L. aqueous leaves extract. Thammasat Medical Journal. 2009; 9(1): 39-44. 15. Saenthaweesuk S, Thuppia A, Rabintossaporn P, Ingkaninan K, Sireeratawong S. The study of hypoglycemic effects of the Morus alba L. leave extract and histology of the pancreatic islet cells in diabetic and normal rats. Thammasat Medical Journal. 2009; 9(2):148-155. 16. Thuppia A, Rabintossaporn P, Saenthaweesuk S, Ingkaninan K, Sireeratawong S. Hypoglycemic effect of the water extract from leaves of Lagerstroemia speciosa L. in streptozotocin-induced diabetic rats. Songklanakarin Journal of Science and Technology. 2009; 31(2):133-137. 17. Sireeratawong S, Lertprasertsuke N, Srisawat U, Thuppia A, Ngamjariyawat A, Suwanlikhid N, Jaijoy K. Acute and subchronic toxicities of the water extract from Harrisonia perforata Merr. Songklanakarin Journal of Science and Technology. 2009; 31(1):63-71. 18. Jaijoy K, Soonthornchareonnon N, Panthong A, Sireeratawong S. Anti-inflammatory and analgesic activities of the water extract from the fruit of Phyllanthus emblica Linn. International Journal of Applied Research in Natural Products. 2010; 3(2):28-35. 19. Ngamkitidechakul C, Jaijoy K, Hansakul P, Soonthornchareonnon N, Sireeratawong S. Antitumor effects of Phyllanthus emblica Linn.: Induction of cancer cell apoptosis and inhibition of in vivo tumor promotion and in vitro invasion of human cancer cells. Phytotherapy Research. 2010; 24:1405-1413. 20. Jaijoy K, Soonthornchareonnon N, Lertprasertsuke N, Panthong A, Sireeratawong S. Acute and chronic oral toxicity of standardized water extract from the fruit of Phyllanthus emblica Linn. International Journal of Applied Research in Natural Products. 2010; 3(1):48-58. 21. Panunto W, Jaijoy K, Soonthornchareonnon N, Lertprasertsuke N, Sireeratawong S. Acute and chronic toxicity studies of the water extract from dried fruits of Terminalia chebula Rezt. in rats. International Journal of Applied Research in Natural Products. 2010; 3(4):36-43. 22. Jaijoy K, Vannasiri S, Piyabhan P, Sritiwong S, Khonsung P, Lertprasertsuke N, Sireeratawong S. Acute and subchronic toxicity study of the water extract from the fruits of Piper chaba Hunter in rats. International Journal of Applied Research in Natural Products. 2010; 3(4):29-35. 23. Pinmai K, Hiriote W, Soonthornchareonnon N, Jongsakul K, Sireeratawong S, Tor-Udom S. In Vitro and In Vivo Antiplasmodial Activity and Cytotoxicity of Water Extracts of Phyllanthus emblica, Terminalia chebula, and Terminalia bellerica. Journal of the Medical Association of Thailand. 2010; 93(Suppl.7):S120-S126.

24. Sireeratawong S, Piyabhan P, Singhalak T, Wongkrajang Y, Temsiririrkkul R, Punsrirat J, Ruangwises N, Saraya S, Jaijoy K. Toxicity evaluation of Sappan wood extract in rats. Journal of the Medical Association of Thailand. 2010; 93(Suppl.7):S50-S59. 25. Sireeratawong S, Vannasiri S, Sritiwong S, Itharat A, Jaijoy K. Anti-inflammatory, Anti-nociceptive and Antipyretic Effects of the Ethanol Extract from Root of Piper sarmentosum Roxb. Journal of the Medical Association of Thailand. 2010; 93(Suppl.7):S1-S6. 26. Charoenteeraboon J, Jaijoy K, Wongnoppavich A, Soonthornchareonnon N, Sireeratawong S. Antioxidant activities of the standardized water extract from fruit of Phyllanthus emblica Linn. Songklanakarin Journal of Science and Technology. 2011; 32(6):599-604. 27. Sireeratawong S, Vannasiri S, Nanna U, Singhalak T, Jaijoy K. Evaluation of acute and chronic toxicities of the water extract from Ziziphus attopensis Pierre. ISRN Pharmacology. 2012;Volume 2012, Article ID 789651, 7 pages doi:10.5402/2012/789651. 28. Sireeratawong S, Lerdvuthisopon N, Piyabhan P, Khonsung P, Boonraeng S, Itharat A, Jaijoy K. Antiinflammatory, Analgesic and Antipyretic Activities of the Ethanol Extract of Piper interruptum Opiz and Piper chaba Linn. ISRN Pharmacology. 2012; Volume 2012, Article ID 480265, 6 pages doi:10.5402/2012/480265. 29. Sireeratawong S, Khonsung P, Nanna U, Vannasiri S, Lertprasertsuke N, Singhalak T, Soonthornchareonnon N, Jaijoy K. Anti-diarrheal Activity and Toxicity of Learng Pid Samud Recipe. African Journal of Traditional, Complementary and Alternative medicines. 2012; 9(4):495-502. 30. Sireeratawong S, Khonsung P, Piyabhan P, Nanna U, Soonthornchareonnon N, Jaijoy K. Anti-inflammatory and Anti-ulcerogenic Activities of Chantaleela Recipe. African Journal of Traditional, Complementary and Alternative medicine. 2012; 9(4):485-495. 31. Sireeratawong S, Thamaree S, Ingkaninan K, Piyabhan P, Vannasiri S, Khonsung P, Singhalak T, Jaijoy K. Evaluation of acute and subacute oral toxicity of the ethanol extract from Antidesma acidum Retz. African Journal of Traditional, Complementary and Alternative medicines. 2012; 9(4):465-469. 32. Sireeratawong S, Chiruntanat N, Nanna U, Lertprasertsuke N, Srithiwong S, Soonthornchareonnon N, Jaijoy K. Acute and Subchronic Toxicity of Chantaleela Recipe in Rats. African Journal of Traditional, Complementary and Alternative medicines. 2013; 10(1):128-133. 33. Sireeratawong S, Nanna U, Vannasiri S, Chiruntanat N, Srithiwong S, Subcharoen P, Termwiset P, Tungsukruthai P, Chuthaputti A, Jaijoy K. Acute and subchronic toxicity study of Tud-Rak-Ka-Sai-Puu Recipe in rats. African Journal of Traditional, Complementary and Alternative medicines. 2013; 10(1):142-148. 34. Sireeratawong S, Jaijoy K, Soonthornchareonnon N. Evaluation of anti-inflammatory and antinociceotive activity of Triphala recipe. African Journal of Traditional, Complementary and Alternative Medicines 2013 (in press).

35. Sireeratawong S, Jaijoy K, Panunto W, Nanna U, Lertprasertsuke N, Soonthornchareonnon N. Acute and chronic toxicity studies of the water extract from dried fruits of Terminalia bellerica (Gaertn.) Roxb. in Spargue-Dawley rats. African Journal of Traditional, Complementary and Alternative Medicines. 2013 (in press). 36. Sireeratawong S, Itharat A, Khonsung P, Lertprasertsuke N, Jaijoy K. Toxicity studies of the water extract from the calyces of Hibiscus sabdariffa L. in rats. African Journal of Traditional, Complementary and Alternative Medicines. 2013 (in press). (Reviewed Article) 1. Sireeratawong S, Wongnophavich A, Jaijoy K. Triphala: The Thai Traditional Herbal Formulation for Cancer Treatment. Songklanakarin Journal of Science and Technology. 2009; 31(2):139-149.

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(Current Research Manuscripts in Preparation) (As Corresponding Author) 1. Anti-inflammatory and analgesic activities of the water extract of Terminalia bellerica 2. Anti-inflammatory and analgesic activities of the water extract of Murdannia loriformis (Hassk.) Rolla Rao et Kammathy 3. Anti-inflammatory and analgesic activities of the water extract of Morinda citrifolia Linn. 4. Acute and subchronic toxicity study of the water extract of Piper sarmentosum Roxb. in rats 5. Acute and subchronic toxicity study of the water extract of Breynia glauca Craib. in rats 6. Acute and subchronic toxicity study of the water extract of Capparis micracantha DC. in rats

7. Antipyretic activity of 10 kinds of Thai medicinal plants in Thai traditional recipe for antimalarial (Sida rhombifolia, Harrisonia perforata, Capparis micracantha, Piper rostratum, Piper chaba, Piper nigrum, Citrus aurantifolia, Tiliacora triandra, Breynia glauca, Imperata cylindrica) 8. Anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract of Plumbago indica L., and Benjakil recipe 9. Antioxidant activity of the standardized water extract from fruit of Terminalia chebula and Terminalia bellerica 10. Pharmacological activities and toxicity of Triphala recipe 11. Anti-inflammatory and analgesic activities of Eurycoma longifolia Jack. and Dracaena loureiri Gagnep. 12. Anti-ulcerogenic activity of Eurycoma longifolia Jack. and Dracaena loureiri Gagnep. 13. Acute and chronic toxicity of piperine extract in rats 14. Pharmacological activities and toxicity of Thai traditional recipe for women (Tamrub Fi-Pra-Lai-Gun) 15. Acute and subchronic toxicity study of Tumrub Ya Sam Rak in rats 16. Acute and subacute toxicity study of Tumrub Ya Wat Mai Seab in rats 17. Antitumor effects of the ethanol extract of Zingiber officinale Roscoe., Piper interruptum Opiz., Piper sarmentosum Roxb., Piper chaba Hunter, Plumbago indica L., and Benjakil recipe Morinda citrifolia Linn.: Inhibition of in vivo tumor promotion (As Co-Corresponding Author) 18. Antitumor effects of Terminalia chebula and Terminalia bellerica: Induction of cancer cell apoptosis and inhibition of in vivo tumor promotion and in vitro invasion of human cancer cells (As Co-Corresponding Author) 19. Antitumor effects of Murdannia loriformis (Hassk.) Rolla Rao et Kammathy.: Induction of cancer cell apoptosis and inhibition of in vivo tumor promotion and in vitro invasion of human cancer cells (As Co-Corresponding Author) 20. Antitumor effects of Morinda citrifolia Linn.: Induction of cancer cell apoptosis and inhibition of in vivo tumor promotion and in vitro invasion of human cancer cells (As Co-Corresponding Author) 21. Antitumor effects of Triphala recipe: Induction of cancer cell apoptosis and inhibition of in vivo tumor promotion and in vitro invasion of human cancer cells (As Co-Corresponding Author)

(As Co-Investigator) 1. Apoptotic induction activity of Panicm repens Linn.