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Lett study something about 2,6-Dihydroxyacetophenone 2,6-Dihydroxyacetophenone, guidechem, 699-83-2 Molecular Formula:C8H8O3 Molecular Weight:152.15 HS Code:29145000 Solubility:50 mg/mL in dioxane Density:1.291 g/cm3 Boiling Point:262.8 C at 760 mmHg Melting Point:155-158 C Flash Point:127 C Appearance:yellowish-beige powder EINECS:211-833-6 CAS Registry Number:699-83-2 Stability:Stable at room temperature in closed containers under normal storage and handling conditions. Storage Temperature: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. 2,6-Dihydroxyacetophenone(CAS NO: 699-83-2), three-necked round-bottomed flask is fitted with a reflux condenser, a dropping funnel, and a glass tube, extending to the bottom of the flask, connected to a cylinder of nitrogen. In the flask are placed 148 g. (0.68 mole) of 4-methyl-7-hydroxy-8-acetylcoumarin and 500 ml. of distilled water. A rapid stream of nitrogen is bubbled through the water suspension until all the air in the apparatus is displaced, and then a slow stream of the gas is kept passing through the solution. A solution of 129 g. (3.23 moles) of sodium hydroxide in 580 ml. of water is added through the dropping funnel, and the mixture is heated on a steam bath for 5 hours. The solution is then cooled and acidified by the addition of about 1 l. of dilute (1:3) hydrochloric acid. The stream of nitrogen gas is continued throughout the period of heating and while the solution is cooling. It may be stopped after the solution is acid. The crude 2,6-Dihydroxyacetophenone which separates on acidification is collected on a filter, washed three times with 50-ml. portions of cold water, and air-dried. A yield of 90-95 g. (87-92% based on the 4-methyl-7-hydroxy-8-acetylcoumarin) of light-yellow solid is obtained. The purification is accomplished by dissolving the crude product in 1 l. of 95% ethanol, adding 20 g. of Norit, and heating the mixture on a steam cone for 15 minutes with occasional shaking. After this time, 800 ml. of warm water is added, and the solution is heated 5 more minutes and filtered

through a hot funnel. The greenish filtrate is chilled in an ice-salt bath, and the first crop (about 65 g.) of lemon-yellow needles of 2,6-Dihydroxyacetophenone is removed by filtration. The filtrate is then concentrated under reduced pressure to a volume of 800 ml., again chilled, and the second crop of product (about 15 g.) collected on a filter. The total yield of purified 2,6-Dihydroxyacetophenone, melting at 154-155 C, is 75-85 g. (a recovery of 8389%) . Want to learn more information about 2,6-Dihydroxyacetophenone, you can access the guidechem.com. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.