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Something about the usages of 2-Deoxy-D-glucose 2-Deoxy-D-glucose, guidechem,154-17-6 2-Deoxy-D-glucose is a kind of white powders with Molecular Formula: C6H12O5 and Molecular Weight:164.16. It is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. It is stable under normal temperatures and pressures, soluable in water to clear, colorless to faintly yellow liquds. The CAS Registry Number is 154-17-6. 2-Deoxy-D-glucose is a glucose antimetabolite, inhibiting glycolysis, it is a widely used research tool to study glucose-dependent or -mediated reactions. In most cells, glucose hexokinase phosphorylates 2-Deoxy-D-glucose, trapping the product 2-Deoxy-D-glucose-6-phosphate intracellularly; thus, labeled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxy-D-glucose(CAS NO:154-17-6) labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy. The glucose analogue 2-deoxy-D-glucose restrains growth of normal and malignant cells, prolongs the lifespan of C. elegans, and is widely used as a glycolytic inhibitor to study metabolic activity with regard to cancer, neurodegeneration, calorie restriction, and aging. Here, we report that separating glycolysis and the pentose phosphate pathway highly increases cellular tolerance to it. This finding indicates that 2-deoxy-D-glucose does not block cell growth solely by preventing glucose catabolism. In addition, it provoked similar concentration changes of sugar-phosphate intermediates in wild-type and 2-deoxy-D-glucose-resistant yeast strains and in human primary fibroblasts. Finally, a genome-wide analysis revealed 19 2-deoxy-D-glucose-resistant yeast knockouts of genes implicated in carbohydrate metabolism and mitochondrial homeostasis, as well as ribosome biogenesis, mRNA decay, transcriptional regulation, and cell cycle. Thus, processes beyond the metabolic block are essential for the biological properties of this chemical. Clinicians have noted that 2-Deoxy-D-glucose is metabolised in the pentose phosphate pathway in red blood cells at least, although the significance of this for other cell types and for cancer treatment in general is unclear. 2-Deoxy-D-glucose has been used as a targeted optical imaging agent for fluorescent in vivo imaging. In clinical medical imaging,fluorodeoxyglucose is used, where one of the 2-hydrogens of 2-Deoxy-D-glucose is replaced with the positron-emitting isotope fluorine-18, which emits paired

gamma rays, allowing distribution of the tracer to be imaged by external gamma camera(s). This is increasingly done in tandem with a CT function which is part of the same PET/CT machine, to allow better localization of small-volume tissue glucose-uptake differences. Want to learn more information about 2-Deoxy-D-glucose, you can access the guidechem.com. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.