Professional Documents
Culture Documents
Bibliography:
Science regarding
Treatment-Based
Approaches in Autism
by Elizabeth Mumper, MD, Teresa Binstock, Jane Johnson
The authors wish to acknowledge the help of colleagues at the Autism Research Institute for their work in contributing to this bibliography.
Autism is a whole-body condition, and there may be multiple etiologies that culminate in common pathways that result in the
pattern of behaviors we describe as “autism.” “Autism” as a label does not tell us about the underlying issues that affect the
patient, most importantly, immune dysregulation, intestinal inflammation, metabolic abnormalities, neuroinflammation, and
other pathologies that have bearing upon cognitive function. When we understand the medical issues, we can begin to most
efficiently help the affected individual. The science that substantiates medical issues in autism is sound and has been presented
by scientists in the disciplines of gastroenterology, immunology, endocrinology, neuropathology, and toxicology and published
in peer-reviewed literature. As a resource for all who are interested in the science that substantiates the Defeat Autism Now! and
other treatment-based approaches [Editor’s note: as indicated in the previous article in this magazine], we present following a
comprehensive but incomplete bibliography of scientific studies related to autism.
Adams JB, Holloway C. Pilot study of a moderate dose Ashwood P, Anthony A, Pellicer AA, Torrente F, Walker- Belluzzi A, Brignola C, Campieri M, Pera A, Boschi S,
multivitamin/mineral supplement for children with autistic Smith JA, Wakefield AJ. Intestinal lymphocyte populations Miglioli M. Effect of an enteric-coated fish-oil preparation
spectrum disorder. J Altern Complement Med. 2004 in children with regressive autism: evidence for extensive on relapses in Crohn’s disease. N Engl J Med. 1996 Jun
Dec;10(6):1033-9. mucosal immunopathology. J Clin Immunol. 2003 13;334(24):1557-60.
Adams JB, George F, Audhya T. Abnormally high plasma Nov;23(6):504-17. Biller JA, Katz AJ, Flores AF, Buie TM, Gorbach SL.
levels of vitamin B6 in children with autism not taking Ashwood P, Anthony A, Torrente F, Wakefield AJ. Treatment of recurrent Clostridium difficile colitis with
supplements compared to controls not taking supplements. Spontaneous mucosal lymphocyte cytokine profiles in Lactobacillus GG. J Pediatr Gastroenterol Nutr. 1995
J Altern Complement Med. 2006 Jan-Feb;12(1):59-63. children with autism and gastrointestinal symptoms: Aug;21(2):224-6.
Afzal N, Murch S, Thirrupathy K, Berger L, Fagbemi A, mucosal immune activation and reduced counter regulatory Boris M, Goldblatt A, Galanko J, James J. Association
Heuschkel R. Constipation with acquired megarectum in interleukin-10. J Clin Immunol. 2004 Nov;24(6):664-73. of MTHFR gene variants with autism. J Am Phys Surg.
children with autism. Pediatrics. 2003 Oct;112(4):939-42. Ashwood P, Van de Water J. Is autism an autoimmune 2004;9(4)106-8.
Alberti A, Pirrone P, Elia M, Waring R, Romano C. Sulphation disease? Autoimmun Rev. 2004 Nov;3(7-8):557-62. Boris M, Kaiser C, Goldblatt A, Elice MW, Edelson SM,
deficit in “low-functioning” autistic children: a pilot study. Ashwood P, Wakefield AJ. Immune activation of peripheral Feinstein DL. Effect of Pioglitazone treatment on behavioral
Biol Psychiatry 1999; 46 (3), 420-424. blood and mucosal CD3+ lymphocyte cytokine profiles symptoms in autistic children. J Neuroinflammation. 2007
in children with autism and gastrointestinal symptoms. J Jan 5;4:3.
Aldred S, Moore KM, Fitzgerald M, Waring RH. Plasma
amino acid levels in children with autism and their families. Neuroimmunol. 2006 Apr;173(1-2):126-34. Bradstreet JJ, smith S, Granpeesheh D, El_Dahr, JM,
J Autism Dev Disord. 2003 Feb;33(1):93-7. Ashwood P, Willis S, Van de Water J. The immune response in Rossignol D. Spironolactone might be a desirable
autism: a new frontier for autism research. J Leuk Biol. 2006 immunologic and hormonal intervention in autism spectrum
Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin
Jul:80;1-15. disorders. Med Hypothesis. 2006 Dec 4.
therapy stimulates variant enzymes with decreased
coenzyme binding affinity (increased K (m)): relevance to Balzola F, Barbon V, Repici A, Rizzetto M. Panenteric IBD- Bradstreet JJ, El Dahr JM, Anthony A, Kartzinel JJ,
genetic disease and polymorphisms. Am J Clin Nutr. 2002 like disease in a patient with regressive autism shown for the Wakefield, AJ. Detection of measles virus genomic RNA in
Apr;75(4):616-58. first time by the wireless capsule enteroscopy: another piece cerebrospinal fluid of children with regressive autism: a report
in the jigsaw of this gut-brain syndrome? Am J Gastro. 2005; of three cases. J Am Phys Surg. 2004:9 (2): 38-45.
Amminger GP, Berger GE, Schafer MR, Klier C, Friedrich
MH, Feucht M. Omega-3 Fatty Acids Supplementation in 979-981. Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto
Children with Autism: A Double-blind Randomized, Placebo- Balzola F, Daniela C, Repici A, Barbon V, Sapino A, Barbera I, Hansen R, Croen LA, Pessah IN, Van de Water J. Autism:
controlled Pilot Study. Biol Psychiatry. 2006 Aug 22; [Epub C, Calvo PL, Gandione M, Rigardetto R, Rizzetto M. Autistic Maternally derived antibodies specific for fetal brain proteins.
ahead of print]. enterocolitis: confirmation of a new inflammatory bowel Neurotoxicology. 2007 Nov 6.
Andersen IM, Kaczmarska J, McGrew SG, Malow BA. disease in an Italian cohort of patients. Gastroenterology. Buts JP, De Keyser N, De Raedemaeker L. Saccharomyces
Melatonin for Insomnia in Children With Autism Spectrum 2005;128:Suppl.2;A-303. boulardii enhances rat intestinal enzyme expression by
Disorders. J Child Neurol. 2008 Jan 8. Balzola F, et al. Autistic Enterocolitis in childhood: the early endoluminal release of polyamines. Pediatr Res. 1994
evidence of the later Crohn’s disease in autistic adulthood? Oct;36(4):522-7.
Arnold GL et al. Plasma amino acids profiles in children with
autism: potential risk of nutritional deficiencies. J Autism Gastroenterology April 2007 Vol 132, N. 4, suppl 2 W 1100 Buts JP, De Keyser N. Effects of Saccharomyces boulardii on
Dev Disord 2003 33(4):449-54. PMID: 12959424. A 660 intestinal mucosa. Dig Dis Sci. 2006 Aug;51(8):1485-92.
Ashwood P et al. Intestinal lymphocyte populations in Balzola F, et al. Beneficial behavioural effects of IBD Buts JP, De Keyser N, Marandi S, Hermans D, Sokal
children with regressive autism: evidence for extensive therapy and gluten/casein-free diet in an Italian cohort of EM, Chae YH, Lambotte L, Chanteux H, Tulkens PM.
mucosal immunopathology. J Clin Immunol. 2003 patients with autistic enterocolitis followed over one year. Saccharomyces boulardii upgrades cellular adaptation after
Nov;23(6):504-17. PMID: 15031638. Gastroenterology, April 2006 Vol 130 Number 4 suppl. 2 proximal enterectomy in rats. Gut. 1999 Jul;45(1):89-96.
S1364 A-21.
ISSUE 30 2009
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