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Ngnh (divisio): Magnoliophyta Lp (class): B (familia): Chi (genus) Loi (species): Magnoliopsida Pedaliaceae Sesamum S. indicum
Ht m
Lignan Compounds
Nhng hp cht Lignan
Ant-oxidant
Ant-oxidant
Sc k ca Sesamol v sesamolin
Sesamin, mt trong nhng lignans c tm thy nhiu nht trong ht v du m, kim sot huyt p cao. Nhng nh nghin cu i loan thng bo trong trong tp ch Journal of Hypertension thng 12 nm 2004.
sesamin c th kim sot ci thin huyt p bi n kch thch t bo sn xut oxide nitric, t y c kh nng c ch s sn xut ET-1 (ET-1 production) lm gim huyt p i vi bnh cao huyt p. Sesamin cn lm gim thp mc lipid mu, cn c tc dng nh l cht chng oxy ha, v c chc nng iu ha khng th.
Kh nng chng oxy ha c ch qu trnh hnh thnh gc t do peroxit cht bo ca mt s dn xut sesamin Vitamin E
% Lipid b oxy ha (
Phn ng hydroxid sesamolin bin thnh sesaminol c kh nng ch chng oxy h ha a cao
Ht H t m tr tr ng ng, , m nu v m en
Ht m
Lignan trong h ht t m cng cng c trong m mt s s loi loi du n kh khc c, c c coi l ch ch t ch chng oxy h ha a
Lignan trong ht m c hot ng chng oxy ha mnh v ko di hn lignan trong nhng du n khc, kt qu nghin cu t n . Lignan du m c n nh chng oxy ha hn nhng loi du n thc vt khc. V vy du m c tim nng chng oxy ha cao, s l loi du n c s dng trong cng ngh thc phm ngy cng nhiu trn th gii trong tng lai. edible oil; S phi trn du m vi nhng du n khc c a thch s lm tng kh nng chng oxy ha ca du ln nhiu ln. l ngun du n c tim nng ln trong tng lai. Antioxidant. Du thc vt phi hp vi du m s thay th cho du thc vt c bo qun bng cht chng oxy ha nhn to.
wrote the authors in the journal Food Chemistry.
NAD(P)H + H+
NAD(P)-
DHLA, GSH
Se
(glutathionine peroxidase)
Vitamin E Radical
Adapted from Packer, L. In, Vitamin C in Health and Disease. Eds. L.Packer & J. Fuchs. 1997. Pp 95-107. MF9665:114967
Nhng cng tr Nh trnh nh nghin c cu kh khc c v v tc tc d dng ng ca c a lignan trong h ht t m n n trao i ch cht b bo o Lignans ca ht m ci thin qu trnh tao i cht bo trong gan. PubMed PubMed Sesamin c th kim sot bnh cao huyt p, v phng cc mu ng gy t qu. PubMed PubMed Lignan nh l cht pinoresinol c th ng vai t quan trng trong khu phn n ci thin sc khe ca ngi dn a trng hi ( y ngi ta dng du live, nhng cn ngun tt hn l du m). ClinChem.org PubMed
O OH
O O
Matairesinol
O HO
O HO O
O OH
O O HO HO
OH
Hydroxymatairesinol
OH
Enterolactone (ENL)
ENL l mt loi lignan ca ng vt c v c h tun hon s khai. N c s dng nh l biomarker nguyn thy cho s hp thu lignan thc vt. Trn ngi c s khc nhau ng k trong kh nng trao i cht nhng lignan thc vt nh: Khc nhau v thi gian i qua ng tiu ha Khc nhau v thnh phn vi sinh vt ng rut Khc nhau do s dng cc loi khng sinh
Enterolactone C ch ch hot hot ng ti tim nng ENL trong ph phng ng ch chng b bnh ung th
Hot ng nh l hormon
Gim thp t l 2OHE (2-hydroxyestrone)/16OHE (16-hydroxyestrone) C kh nng gn kt vi SHBG (Sex hormone-binding globulin) c ch hormon, x l ung th v, bung trng: Aromatase inhibition
Hot ng nh l cht chng oxy ha (Antioxidant) Hot ng nh l cht chng vim (Anti-inflammatory) Chng s tng nhanh chng t bo (Anti-Proliferative)/ Khi u cho apotosis (Pro-Apoptoic)
Link Apotosis
Nhm, N
Ca ung th v Pre-mp =68 Post-mp =126 i chng = 208 Ca ung th v Pre-mp = 220 i chng = 237 Nhng u nang (Papapaple cysts), n= 258
Kt qu
Tng quan nghch c ngha gia ENL huyt thanh vi nguy c ung th v trong c hai trng hp: tin mn kinh v sau mn kinh (Pre-, -post-mp)
Case-control
Piller, et al., Eur J Nguy c ung th v giai on tin mn kinh gim vi s tng ln ENL Cancer Prevent 2006;15:225-32. huyt tng, nhng khng phi genistein. C tng quan ENL gia huyt thanh v dch trong u nang. C tng quan nghch gia ENL trong dch u nang v EGF (Epidermal growth factor)- yu t tng trng. Ung th biu hin m tnh vi ER, s c bo v tt mc trn 20 nmol/L ENL Boccardo et al., Breast Cancer Res Treat 2003;79:17-23.
Cohort study
Cohort study
Sn xut du m en
My M y t tch ch h ht t m