Pharmaceutical Marketing Training Report on Cleanser+ Face Wash

Pharmaceutical Marketing Training Report on Cleanser+
2013

1 Balaji Panigrahi, Registration No. 11101057, Report on Cleanser
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Face Wash

ACKNOWLEDGEMENT

I would like to express my deepest appreciation to all those who provided me the
possibility to complete this report. A special gratitude to my Mentor Guide Dr.
Manish Vyas and special thanks to our class teacher Sachin Singh who helped a lot
in making the formulation and special thanks to all teachers who helped me a lot.
Whose contribution in stimulating suggestions and encouragement helped me to
co-ordinate my project especially in writing this report.
Furthermore I would also like to acknowledge with much appreciation the crucial
role of Training co-ordinator, who gave the permission to use all
required equipment and the necessary materials to complete the task Cleanser
+
Neem Face Wash

.A special thanks goes to my team mate,
Ayodhya,Anmol,Sorbh, who help me to assemble the parts and gave suggestion
about the task Cleanser
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Neem Face Wash. Last but not least, many thanks go to
the head of the project, Dileep Baghel whose have invested his full effort in
guiding the team in achieving the goal. I have to appreciate the guidance given by
other supervisor as well as the panels especially in our project presentation that has
improved our presentation skills thanks to their comment and advices.

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Abbreviation Table:-

l. Liter .
ml. Millilitre.
Fam. Family .
PS. Primary Standards.
TS. Transverse Section.
Lf. Leaf.
IN. INDIA.
NY. New York.
x1. Expenditue of manufacturer.

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Action Plan for Cleanser
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.
Sl. Work done Start date End date Requirments
1 Product Designing 25/5/12 26/5/12 Books, Internet, Journals
2 Literature Review 29/5/12 1/6/2012 Books, Internet, Journals
3
Market survey/
Purchase Ingredients 2/6/2012 2/6/2012 Raw Drug
4
Identification of
Ingredients 4/6/2012 5/6/2012
Drugs, furnace,Beakers, Conical flasks,
Alcohol, HCL, Distilled water
Hot plate, weighing balance, Oven
5 Production 6/6/2012 17/6/12 Herabal Drugs,Beakers, Conical flasks,
Heating mental,Propler,Mixer.
6 Packing & Labeling 18/6/12 19/6/12 Labels,Cutter,Scale
7 Marketing 20/6/12 22/6/12 -
8
Final submission of
Report 23/6/12 24/6/12 -

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INTRODUCTION.

Ayurveda is the oldest system among all life sciences.
The Ayurvedic drugs are derived from the various natural sources like
Herbal,Mineral,Marine. Ayurvedic medicines are based on plants, animals extract
and minerals both in single ingredient drugs and compound formulations, however,
Ayurveda does not rule out any substances from being used as a potential source of
medicine. There are several formulations in Tropical use are Lepa, Taila, Ghrit, etc.
Because of the new types of drug delivery system are established in Ayurvedic
medicines/drugs are becoming popular day-by-day and demand for its usage is
increasing not only in the country but also worldwide the inherent quality of
Ayurvedic treatment of having minimal side effects, has made great potential for
its production. A large number of medicinal plants, herbs, shrubs etc. are available
in our country in the hilly/forest regions. In order to boost the production of
Ayurvedic/herbal drugs the new techniques of delivery system are Introduced such
as Face wash, Hand wash & sanitizers, Mouthwashes, Creams, ointments,
liniments, Gels, Emulsions, Jellys etc.

The plant neem is variously known as "Sacred Tree," "Heal all," "Nature's
Drugstore," "Village Pharmacy" and "Panacea for all diseases"
The medicinal properties of the Neem tree have been well known in India
for over 4,000 years. The healing properties of Neem are spoken about in some of
the worlds oldest books.
The Sanskrit word for Neem was Nimba Which Means good health The Vedas
called Neem sarva roga nivarini Which means one that cure all the ailments and
ills
Neem is perceived in India as a beauty aid. Powdered leaves are a major
component of at least one widely used facial cream. Purified neem oil is used in
making of Toiletries & cosmetics Products made from neem trees have been used
in India for over two millennia for their medicinal properties: neem products are
believed to be anthelmintic, antifungal[11], Anti-diabetic,antibacterial,antiviral,
contraceptive. And sedative.It is considered a major component
in Ayurvedic and Unani medicine And is particularly prescribed for skin
disease.For the women, the Neem was the mainstay of the herbal beauty tradition.
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The Neem proved an invaluable source of health, hygiene and beauty that was
freely available.
Having a bath with Neem leaves kept their skin supple and healthy. Neem
leaf powder or crushed leaves incorporated into their face packs provided emollient
and anti-aging action. The antiseptic properties of Neem leaf extracts helped in
controlling pimples and acne.
Ancient face cleansing technique are bit complicated the consumer had to
buy the powder make the paste then apply it. The method of applying formulation
is difficult and incompatibility with requirement of the customers in Modern era
[1]Medicines in the form of a paste under for external application are called
lepas.The drug are made in to a fine powder .Before use on the body, it is mixed
with some liquid or other medium indicated in each preparation and made in to a
soft paste. Water, cow urine , oil and ghee are some of the media used for
mixing.[1] But as the mankind demand increases the specialty and quality depend
upon it ability of the product that how it easily the consumer should have the
interface to do a great and compatible outsource to have that facility and from
which the person will have a faster approach to the product. So, as to fasten the
speed with and greater compatibility the technology had developed. A cleanser is a
product used to cleanse something, such as a detergent or industrial cleaning agent.
A popular type of cleanser is a facial care product that is used to
remove make-up, dead skin cells, oil, dirt, and other types of pollutants from the
skin of the face. This helps to unclog pores and prevent skin conditions such
as acne. Many people use a cleanser once or more times a day as part of their skin
care regimen together with a toner and moisturizer.
Different types of cleansers have been developed for people with different
skin types. Active cleansers are more suitable for oily skins to prevent breakouts.
But they may overdry and irritate dry skin, this may make the skin appear and feel
worse. Very dry skin may require a creamy lotion-type cleanser. These are
normally too gentle to be effective on oily or even normal skin, but dry skin
requires much less cleansing power. It may be a good idea to select a cleanser that
is alcohol-free for use on dry, sensitive, or dehydrated skin. Some cleansers may
incorporate fragrance or essential oils. However, for some people, these cleansers
may irritate the skin and often provoke allergic responses. People with such
sensitivity should find cleansers that are pH-balanced cosmetic balanced contain
fewer irritants, suit many variation skin types, and do not make the skin feel
dehydrated directly after cleansing. Tight, uncomfortable skin is often dehydrated
and may appear shiny after cleansing, even when no sebum is present. This is due
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to the tightening and 'stripping' effect some cleaners can have on the skin. One
should discontinue use of a cleanser that upsets the balance of the skin; cleansers
should work with the skin not against it. Finding the right cleanser can involve
some trial-and-error. [2]Dirt on the skin may consist of Residues of the skin
secretion as well as deposits from the surrounding, the dirt is bound by oily
substances, is very adherent and required special method of removal. Washing with
water is not adequate since the grime is generally oil bound.[2]

Marketed Formulation of Face wash.
- Himalaya Neem Face wash.
- Vedicline Face Wash.
- Lotus Herbals Cleansers Face Wash.
- Khadi Neem Herbal Face Wash.
- Ayur Neem Face Wash

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Section 1 - Review of literature (Ayurvedic & Modern View).

Ayurvedic Review.
The medicine intended for external use only. For that purpose in ayurveda
different form of external application are described for the contingency of
treatment of different diseases. They are Lepa kalpana. As per Ayurveda in
sarangadhar samhita the facial lepa is being described Medicines in the form of a
paste under for external application is called lepas. The drug are made in to a fine
powder .Before use on the body, it is mixed with some liquid or other medium
indicated in each preparation and made in to a soft paste. Water, cowurin, oil and
ghee are some of the media used for mixing. Wet medicine drug are made in to
kalka(Paste) from, it drug are in dry state, they are converted in to paste from
adding little amount of Water and grinding. That kalka is used for the external
application and applied in the face and after some time wash it.
Importance of Lepa kalpana: In Susruta Samhita, in the context of Vrana and
Sopha treatment alepa is given prime importance.
While explaining the efficacy of lepa it is mentioned that by pouring water,
over a burning house, how the fire get stopped immediately, same manner by
application of lepa provoked dosas of Vrana (Vedana, Sotha etc. complication of
Vrana) will get subsided.Lepa is having actions like sodhana utsadana,Ropana etc.
Acharya Sarangadhar concept regarding lepa Kalpana: on the basis of the
drug used for the preparation of lepa kalpana and their action Acharya
Sarangadhara has classified lepa kalpana like wise
Lepa kalpana is of three types, viz:
- Doshaghnalepa(anti-dosic)
- Visaghnalepa(anti-poisonous)
- Varnya Mukta Lepa (Cosmetic application over the face to improve colour
and complexion).
Many individuals of the Royal family became icons of beauty using this natural,
clay cleanser. The natural, herbal clay cleans and tightens the skin, removing dead
skin and smoothing wrinkles.

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Modern Review.
A healthy skin is generally considered to be a clean and well kept skin. In
general, a good toilet soap and water is the best way of achieving this cleanliness.
A final rinse with clean, cold water is an excellent measure to promote circulation
and toning of the skin and it is the best way of achieving a facial cleanser is a
product used to cleanse something, such as a detergent or industrial cleaning agent.
A popular type of cleanser is a facial care product that is used to
remove make-up, dead skin cells, oil, dirt, and other types of pollutants from the
skin of the face. This helps to unclog pores and prevent skin conditions such
as acne. Many people use a cleanser once or more times a day as part of their skin
care regimen together with a toner and moisturizer.
Cleansers may incorporate fragrance or essential oils. However, for some
people, these cleansers may irritate the skin and often provoke allergic responses.
People with such sensitivity should find cleansers that are pH-balanced cosmetic
balanced, contain fewer irritants, suit many variating skin types, and do not make
the skin feel dehydrated directly after cleansing.
The regular use of the face wash can give a clean and clear pimple free oil
free face.
Drug Review:-
Main Ingredient:-
Neem
Nimba (Leaf) consists of dried leaf of Azadirachta indica A . Juss Syn. Melia azadirachta Linn. (Fam.
Meliaceae); a moderate sized to fairly large evergreen tree, attaining a height of 12-15 m with stout trunk
and spreading branches, occurring throughout the country up to an elevation of 900 m.
DESCRIPTION
a)Macroscopic Leaves - Compound, alternate, rachis 15-25 cm long, 0.1 cm thick; leaflets with oblique
base, opposite, exstipulate, lanceolate, acute, serrate, 7-8.5 cm long and 1.0-1.7 cm wide, slightly
yellowish-green; odour, indistinct; taste, bitter
b) Microscopic Leaf- Midrib -leaflet through midrib shows a biconvex outline; epidermis on either side
covered externally with thick cuticle; below epidermis 4-5 layered collenchyma present; stele composed
of one crescent-shaped vascular bundle towards lower and two to three smaller bundle towards upper
surface; rest of tissues composed of thin-walled, parenchymatous cells having secretory cells and rosette
crystals of calcium oxalate; phloem surrounded by non-lignified fibre strand; crystals also present in
phloem region. Lamina - shows dorsiventral structure; epidermis on either surface, composed of thin
walled, tangentially elongated cells, covered externally with thick cuticle; anomocytic stomata present on
lower surface only; palisade single layered; spongy parenchyma composed of 5-6 layered, thin-walled
cells, traversed by a number of veins; rosette crystals of calcium oxalate present in a few cells; palisade
ratio 3.0-4.5; stomatal Index 13.0-14.5 on lower surface and 8.0-11.5 on upper surface. Powder - Green;
shows vessels, fibres, rosette crystals of calcium oxalate, fragments of spongy and palisade parenchyma.
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Section -2. Production details - Material and Method

Cleanser
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Ref: -
[7]
Guardian Laboratories. NY
[7]

Material required:-
Sl. Ing Qnty Activity
1 Neem Extract 60 %
Alcoholic
200 ml Alcohol Soluble nimbin
compound .
2 Neem Extract Aqueous 500 ml Anti bacterial,Anti
fungal,Antimicrobial.
3 Glycerin 1.5 liter. Thickening Agent &
Moisturizer.
4 SLS 240 gm Surfactant.
5 EDTA 4gm Anti-oxidant &
Stabilizer.
6 Methyl Paraben 10gm Preservative.
7 Boric Acid
(Tankan)
10 gm Anti- Acne.
8 Salicilic acid. 2 gm Anti-Fungal.
9 Sodium Chloride 20 gm Thickener enhancer
10 CMC 24 gm Thickener.
11 Strawberry
Fragrance
60 ml Fragrance.
12 Mint
Fragrance
30 ml Fragrance.
13 Rose
Fragrance
20 ml Fragrance.
14 Colour(Pink & Green) 0.07 gm Colouring Agent.
15 Distilled Water Make up to
100%
Make up Volume.
Total 3000 ml -

Bottle 60 x Quantity 50 ML= Total - 3000 ml

Equipment required:-
10 liter Plastic Container, 1000, 500,100ml 50,ml Beakers 2 Piece each, Measuring
Cylinder 1000,100,
50,10,Propler, Mixi, Weighing balance, Distillation Assembly,
Porcelain, Filteration Assembly, Filter Paper, Heating Mental

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Method of preparation :- ( Step wise)
1. Neem Aqueous & 60 % Alcoholic extract is made put in a side and rap it
with foil to avoid contamination.
2. Put the glycerin in the 10 liter container and mix it with the help of Propler.
3. Side by side 24gm of CMC is mixed in extra water and mix it with the help
of mixi.
4. Then after mixing of that CMC put it in the Container and maintained the
consistency and left some for after mixing.
5. After wards add the ingredient 1&2 then extract of neem is added to the
formulation.
6. Then 4 to 6 all ingredients and dissolve in appropriate water and heated it
and after proper dissolvesation and filter it.
7. Add SLS and mix it for 30 min by the help of propler. Dont rotate the
propler speed to the extreme make it medium
8. Add all the Organoleptic Ingredient no 11-14.
9. Mix the whole formulation for 30 min and mix the makeup volume
10. Then the reaming CMC is added according to how much viscosity you want.
11. Mix properly to make a stable formulation.
12. Fill it in the bottle Label it properly and dispense it.

Precautions:-
1. Proper attention should be taken in Extraction. Check the water flow time to
time. 2. Mixing should be at slow speed.
3. Organoleptics ingredient are been added should be added during mixing.
4. Mixing should be done for 30 min.
5. Container in which we make the formulation should be plastics or glass
container. No metal container is used.
6. Always use Distilled water.
7. pH should be maintained 5.5.
8. Viscosity should not be high. If happen it will stick to the bottle.
9. Sodium Chloride should be added slowly.
10. Colour should be mixed in liquid media.
11. Container should be cleaned properly.
12. Special care on filing of the bottle because of the slippery nature of the
formulation.
13. Label should be properly fixed in the bottle.
14. CMC should not be heated.
15. Filtration should be done properly.

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Product details:-
Cleanser
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Neem Face Wash

Description: Cleanser
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specially formulated to give you clear, problem free skin,
daily use face wash liquid gel that cleanses your skin by removing excess oil and
impurities without over-drying. Neem, well-known for its purifying and
antibacterial properties, kills problem-causing bacteria. It helps control acne and
pimples leaving your skin soft, clear, refreshed and problem-free.

Indications:
Clears skin, prevents pimples

Use Directions:
Moisten face, apply a small quantity of Cleanser
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and gently work up lather with a
circular motion. Wash off and pat dry.

Typical Properties:
Form : Viscous liquid gel
Colour: Green & Reddish Pink
Clarity: Clear
PH (at 20 to 25
o
C) : 6
% Methyl Paraben: 0.12

Tested: It is not irritating to the skin, and is not a sensitizer. A summary of safety
tests performed using Cleanser
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(See Annexure 2 - Safety data sheet)

Derivation: We do not use animal derived ingredients in the manufacture of
Cleanser
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All raw materials used in Cleanser
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are of Herbal vegetable origin drugs,
Mineral origin and synthetic.

Storage and Handling: Cleanser
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is very slippery and appropriate care should be
taken during handling. Avoid contact with strong acids, alkalis or oxidizing
agents. Avoid exposure to x-rays. Avoid excess expose to more sunlight.

Labeling: Cleanser
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is clearly explained that the product is used for external use
only and how to use it and some other information like store in cool and dry place.

Packing: Cleanser
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is Packed in 50 ml Plastic container.

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Label of Neem Face Wash Label of Neem Face wash in Strawberry Fragrance.

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Section -3 -Promotional details Marketing:

According to market survey the global market for cosmetics and toiletries reached
nearly $150 billion in 2004, increase by more then 4 percent 2003, which highlight
major growth in key developing market.
The herbal market has been boosted by increasing demand for natural alternative
medicines; world demand for herbal product has been growing at the rate of 10% -
15% per annum. The medicinal plant related trade in india alone is approximately
Rs.5.5 billion. World health organization (WHO) has forcasted that the global
market for herbal product would be worth $5 trillion by the year 2050.Global sales
of herbal product are expected to reach $26.2 billion dollars in 2007. Europe and
the united states are the two major herbal product markets in the world, with a
market share of 41 percant and 20 percent respectively.
According to world bank the global market of medicinal plant and their products
includes the potential sectors of Pharmaceuticals, Neutraceutical, Cosmeceuticals
to be estimated of worth US$62 billion, offers a plethora of opportunities for the
Indian pharma and cosmetics companies.
Today a new hot topic in the cosmetic industry is cosmeceuticals, which is the
fastest growing segment of the natural personal care industry. Cosmeceuticals are
topical cosmetic pharmaceutical hybrids intended to enhance the beauty through
ingredients that provide additional health-related function or benefit. They are
applied topically as cosmetics, but contain ingredients that influence the skins
biological function.
These Cosmeceuticals, serving as a bridge between personal care products and
pharmaceuticals, have been developed specifically for their medicinal and
cosmetic benefits. Tracing the origin of cosmetics, the first recorded use of
cosmetics is attributed to Egyptians, circa 4000 BC. The ancient Sumerians,
Babylonians, and Hebrews also applied cosmetics.

Promotion - Push & Pull Strategies.
"Push or Pull"?
Marketing theory distinguishes between two main kinds of promotional strategy -
"push" and "pull".
Push.
A push promotional strategy makes use of a company's sales force and trade
promotion activities to create consumer demand for a product.
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The producer promotes the product to wholesalers, the wholesalers promote it to
retailers, and the retailers promote it to consumers.
A "push" strategy tries to sell directly to the consumer, bypassing other distribution
channels. With this type of strategy, consumer promotions and advertising are the
most likely promotional tools.
Pull ( Our stagey )
A pull selling strategy is one that requires high spending on advertising and
consumer promotion to build up consumer demand for a product.
If the strategy is successful, consumers will ask their retailers for the product, the
retailers will ask the wholesalers, and the wholesalers will ask the producers.
We apply Pull strategy. By 20 % OFF Promotional strategy.
Sales promotion relates to short term incentives or activities that encourage the
purchase or sale of a product or service. Sales promotions initiatives are often
referred to as below the line activities.

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BROUCHER:-

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SECTION 4 Report & Result:-

Ingredient Report:-
Neem Sample

Test Topic Value
Foreign matter 1%
Total Ash 9%
Acid-insoluble ash 0.5%
Alcohol-soluble extractive 24%
Water-soluble extractive 22.4%

Report on Finished formulation.
Appearance: Clear, Green & reddish pink, viscous liquid gel
Odor: 1.Mint 2.Strawberry

pH: 5.0-5.5

Melting Point: < 0C
Boiling Point: > 100C
Evaporation Rate: Less than water
Flammability: Not flammable

Solubility: Water soluble: Complete

Stability studies (As per Physical Pharmacy by S.P.Agarwal)

Sl.n
o
Storage Temperature
in (
O
C)
pH Viscosity Formulation
1 30
o
5.5 Standard viscous Stable.
2 40
o
3 50
o

Result:- Cleanser
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Neem face wash was standardization of the herbal drugs the
formulation is made which is ready for cosmoceutical use it is of good quality
Product and it found and tested in healthy human and apply but no irritation is
found. As it is a stable formulation upon study many research study says that neem
pharmacological activity.
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Summary:-

Cosmoceutical sectors as the herbal cosmetic products are growing day by day so
with Conceptual model represent the formulation. But the main focus is to
consume the market trend in the cosmetics thats from Cleanser
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Neem face wash
is a haptic Formulation to extrapolate the model and range of it more over
products are available in market but the trend says Compatibility. As INDIA is a
country of fashion and Tradional culture. So we combine both the things fashion
with tradional knowledge for healthy wellbeing and make the formulation and
grow able to come in completion with the beauty products as neem is known as the
good for skin disorder in Ayurveda. We formulate and standardize as per the
possible criteria and condition and marketed as the push marketing strategy. And
the sale of the Cleanser
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Neem face Wash .And made a new advance drug delivery
system which is compatible to the modern era.

Conclusion:-
The conclusion summarizes the major inferences that can be drawn from the
information presented in the report. It concludes our effort that had been darned in
the formulation to engage with the project and after the formulation of the
Cleanser
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. And we know the formulation well how to formulation how to stable it
and various consequences that effect also but we tackle it and made a stable
formulation. And after the formulation in the sales we manage it well manner and
Complete sales of the product and got a good response. And the sales success it the
Proper Marketing and advertising tricks the attract the customers by using the
pamphlets we attract the customer and after the sales the main response in the
Female category and sales in the young age people. And after the effort we get its
color in Positive signs of sales. So, If anyone interested in this project it is really
profitable and knowledge gaining project.

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Annexure 1.(Analysis of Raw drugs and finished products ,Costing,Sales etc )

Analysis of Raw drugs.

Neem

Nimba (Leaf) consists of dried leaf of Azadirachta indica A . Juss Syn. Melia
azadirachta Linn. (Fam. Meliaceae); a moderate sized to fairly large evergreen
tree, attaining a height of 12-15 m with stout trunk and spreading branches,
occurring throughout the country up to an elevation of 900 m.

DESCRIPTION
a) Macroscopic Leaves - Compound, alternate, rachis 15-25 cm long, 0.1 cm
thick; leaflets with oblique base, opposite, exstipulate, lanceolate, acute,
serrate, 7-8.5 cm long and 1.0-1.7 cm wide, slightly yellowish-green; odour,
indistinct; taste, bitter

Constants Features
Shape - Oblique, lanceolate.
Size - 3.9-5.1 cm in length and 1-1.4 cm in wide
Colour - Fresh leaves are green and in the dry state green to light brown
Base - Symmetric.
Margin - Serrate.
Apex - Acuminate.
Venation - Pinnate type.
Orientation - Dorsiventral.
Texture - Thin papery.
Taste - Bitter.
Odour - Unpleasent.

b) Microscopic Leaf- Midrib -leaflet through midrib shows a biconvex outline;
epidermis on either side covered externally with thick cuticle; below epidermis 4-5
layered collenchyma present; stele composed of one crescent-shaped vascular
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bundle towards lower and two to three smaller bundle towards upper surface; rest
of tissues composed of thin-walled, parenchymatous cells having secretory cells
and rosette crystals of calcium oxalate; phloem surrounded by non-lignified fibre
strand; crystals also present in phloem region.
Lamina - shows dorsiventral structure; epidermis on either surface, composed of
thin walled, tangentially elongated cells, covered externally with thick cuticle;
anomocytic stomata present on lower surface only; palisade single layered; spongy
parenchyma composed of 5-6 layered, thin-walled cells, traversed by a number of
veins; rosette crystals of calcium oxalate present in a few cells; palisade ratio 3.0-
4.5; stomatal index 13.0-14.5 on lower surface and 8.0-11.5 on upper surface.
Powder - Green; shows vessels, fibres, rosette crystals of calcium oxalate,
fragments of spongy and palisade parenchyma.

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Quality Testing of Raw or Crude drugs.:-
- Raw Material Quality Testing
- Finished Product Quality Testing
Raw Material Quality Testing:-
1. Foreign matter determination
2. Total Ash
3. Acid insoluble ash
4. Alcohol soluble extractive
5. Water-soluble extractive
1. Foreign matter determination:-
Foreign matter is material consisting of any of the following
(1) Matter coming from the source plant but not defined as original sample
(2) Matter not coming from the source plant.
(3) Matter of mineral origin such as sand, stone, soil, dust, etc.
Method and Procedure
(1) Weigh 100500 g of sample and spread in a thin layer. Sort the foreign matter
into groups either
by visual inspection, using a magnifying lens (510 x), or with the help of a
suitable sieve.
(2) Weigh each group of foreign matter separately, and calculate the percentage of
foreign matter in the
weight of sample.
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2. Total Ash determination procedure:-
Incinerate about 2 to 3 g accurately weighed, of the ground drug in a tared
platinum or silica dish at a temperature not exceeding 4500 until free from carbon,
cool and weigh. If a carbon free ash cannot be obtained in this way, exhaust the
charred mass with hot water, collect the residue on an ashless filter paper,
incinerate the residue and filter paper, add the filtrate, evaporate to dryness, and
ignite at a temperature not exceeding 4500. Calculate the percentage of ash with
reference to the air-dried drug.
3. Acid-insoluble ash determination procedure:-
To the crucible containing total ash, add 25 ml of dilute hydrochloric acid. Collect
the insoluble matter on an ashless filter paper (Whatman 41) and wash with hot
water until the filtrate is neutral. Transfer the filter paper containing the insoluble
matter to the original crucible, dry on a hot-plate and ignite to constant weight.
Allow the residue to cool in a suitable desiccator for 30 minutes and weigh without
delay. Calculate the content of acid-insoluble ash with reference to the air-dried
drug.
4. Determination of Alcohol Soluble Extractive:-
Macerate 5 g of the air dried drug, coarsely powdered, with 100 ml of alcohol the
specified strength in a closed flask for twenty-four hours, shaking frequently
during six hours and allowing standing for eighteen hours. Filter rapidly, taking
precautions against loss of solvent, evaporate 25 ml of the filtrate to dryness in a
tarred flat bottomed shallow dish, and dry at 105C, to constant weight and weigh.
Calculate the percentage of alcohol-soluble extractive with reference to the air-
dried drug. For determination of methanol soluble extractive use methanol on place
of alcohol.
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5. Determination of Water Soluble Extractive:
Macerate 5 g of the air dried drug, coarsely powdered, with 100 ml of Water the
specified strength in a closed flask for twenty-four hours, shaking frequently
during six hours and allowing to stand for eighteen hours. Filter rapidly, taking
precautions against loss of solvent, evaporate 25 ml of the filtrate to dryness in a
tared flat bottomed shallow dish, and dry at 1050, to constant weight and weigh.
Calculate the percentage of Water-soluble extractive with reference to the air-dried
drug.
IDENTITY, PURITY AND STRENGTH

Foreign matter Not more than 2
Neem sample
The total amount of drug sample - 100gm
Total amount of foreign matter - 1gm
% of foreign matter - Given amount X 100
Total amount
- 1/100 X 100 = 1
% of foreign matter - 1%
(In API mention foreign matter not more than 2% in Neem.)
Total Ash Not more than 10
Empty Crucible weight (W) - 24.44gm
Sample weight - 2gm
Weight of Crucible with sample (W1) - 26.44gm
Then make ash with the help of furnace at 450* temperature.
Weight of Crucible with sample after making ash (W2) - 24.62gm
Weight of ash of drug - 0.18gm
% of total ash = Wt of Ash/wt of sample X 100
0.18/2 X 100 = 9%
% of total ash = 9%
(In API mention total ash not more than 10% in Neem.)

Acid-insoluble ash Not more than 1

Weight of Ash - 0.02gm
Weight of ash of filter paper - 0.01gm
% of Acid insoluble ash = Weight of ash - Weight of ash of filter paper/2 X 100
% of Acid insoluble ash = 0.5%
2013

+
Face Wash

(In API mention Acid-insoluble extractive value not less then 1% of Neem)

Alcohol-soluble extractive Not less than 13
Weight of sample (W) - 5 gm
Weight of empty crucible (W1) - 57.25gm
Weight of residue (W4) - 0.30gm
% of Acid soluble extractive = 0.30x100x100/5x25
= 24%
% of Acid soluble extractive = 24%
(In API mention Alcohol-soluble extractive value not less then 13% of Neem)

Water-soluble extractive Not less than 19
Weight of sample (W) - 5 gm
Weight of empty crucible (W1) - 55.56gm
Weight of residue (W4) - 0.28gm
% of Water soluble extractive = 100 (W4 / W X Volume make up/Taken)
=0.28x100x100/5x25= 22.4%
% of Water soluble extractive = 22.4 %
(In API mention total ash not less then 19% of Neem)

2013

+
Face Wash

Analysis and Evaluation of Finished formulation.
Properly evaluating of face wash products ranges from personal testing to
understanding terms found on product containers and labels. In addition to making
your own informed decisions, dermatologists can recommend various products
specific to your skin care condition.


Odor: 1.Mint 2.Strawberry

pH: 5.5-6

Melting Point: < 0C
Boiling Point: > 100C


Irritancy test:
Mark an area (1sq.cm) on the left hand dorsal surface. The Cleanser
+
was applied
to the specified area and time was noted. Irritancy, erythematic, edema, was
checked if any for regular intervals up to 6 hrs and reported.
Result:- Non Irritant tested in 2 healthy person

Stability studies:
The prepared formulation was filled.
Stability Study for 7 days at 20
o
30
o
40
o
(After extrapolated stability study stable
up to 6 months.)

Sl.no Storage Temperature
in (
O
C)
pH Viscosity Formulation
1 30
o
2 40
o
3 50
o

2013

+
Face Wash

Costing:-
Total Manufacturing Cost
Sl.no Title Price .(Rs/-)
1 Herbal Ingredient 240
2 Chemical Ing. 650
3 Organoleptic Ing. 80
3 Cointainer 330
4 Label 140
5 Traveling expn 100
6 Electricity 40
7 Advertising
Pamphlets-Print
media
100
- Total 1680

Whole expenditure of manufacturer.
28 x 60 =1680

(x
1
) Per bottle expenditure of manufacturer 1680/60 = 28

Formula of Making Market price per bottle = Expenditure of manufacturer x 2.5
%+=

Calculation of market price per bottle:-
28 (x1) x 2.5 %=+ - Rs 40 ( Actually 39.2 but round up )
Therefore, Marketed price for per bottle is Rs.40

40 x 60 = 2400 Total return to manufacturer

Total Sales of bottle 55 bottle.
Total Sales (Rs)40 x 55(Bottle) = 2200
Profit of Rs.520
2013

+
Face Wash

Sales:-
Sales report of the Cleanser
+
.

Sales According to Sex.
The most of the consumer are of female category.

Sales According to Age Group.

0
5
10
15
20
25
30
20-06-2013 21-06-2013 22-06-2013
0
5
10
15
20
25
30
35
40
45
50
Male Female
0
5
10
15
20
25
30
Below 25 25-30 31-onwards
2013

+
Face Wash

Annexure - 2
Safety Data Sheet

SECTION 1 IDENTIFICATION

Product Identifier: Cleanser
+
Face Wash
Recommended Use: Cosmetic / Personal Care
Manufacturer Details: Balaji Panigrahi, Lovely school of Ayurvedic Pharmaceutical Sciences, L.F.A.M.S,
LPU, Punjab
Emergency Phone Number: 08437174022

SECTION 2 HAZARD IDENTIFICATION

NONE No Hazard Class

SECTION 3 FIRST AID MEASURES

First Aid Measures (Skin): Wash affected area with copious amount of water. Seek medical attention if
symptoms persist.
First Aid Measures (Eyes): Flush with water for 15-20 minutes. Seek medical attention.
First Aid Measures (Ingestion): No expected adverse affects. Seek medical attention
First Aid Measures (Inhalation): Move victim to fresh air. Seek medical attention if symptoms persist.

SECTION 4 FIRE-FIGHTING MEASURES

Suitable Extinguishing Media
Class "A" (water) fire extinguisher
Class "B" (carbon dioxide) fire extinguisher
Class "C" (dry chemical) fire extinguisher
Combustion Products
CO
CO2

Fire Fighter PPE: Wear self contained breathing apparatus for firefighting as necessary.

SECTION 5 HANDLING AND STORAGE

Handling Precautions: Slippery
Conditions For Safe Storage: Store in cool and dry place

2013

+
Face Wash

SECTION 6 PHYSICAL AND CHEMICAL PROPERTIES

Odor: Mint & Strawberry
pH: 5.5 to 6
Melting Point: < 0C Boiling Point: > 100C
Flammability: Not flammable

SECTION 7 STABILITY AND REACTIVITY

Reactivity: Non-reactive
Chemical Stability: Stability Study for 15 days at 20
o
30
o
40
o
(After extrapolated stability study stable
upto 6 months.)
Hazardous Reactions: Hazardous polymerization will not occur
Conditions To Avoid: Extreme temperatures
Incompatibility: Strong oxidizers, salts, strong acids or bases
Hazardous Decomposition Products: CO, CO2

SECTION 8 TOXICOLOGICAL INFORMATION

Likely Routes of Exposure: Skin.
Symptoms Of Exposure: None known.
Toxicological Effects: Non-toxic and Non-irritating.

SECTION 9 DISPOSAL INFORMATION

Disposal procedure:- Blue dustbin.

SECTION 10 OTHER INFORMATION

Revision Date: 18 June 2013 Prepared By: Balaji Panigrahi

2013

+
Face Wash

Reference.

1. Page no.649 Ocean of Ayurvedic Pharmaceutics by: Dr.K.Rama Chandra Reddy
First edition 2007 Publisher: Chaukhamba Sanskrit Bhawan,Varanasi .
2. Page no.257 Cosmetics Technology by Sanju Nanda, Arun Nanda, and Roop
K.Khar First edition 2006-2007 Publisher: Birla publication Pvt. Ltd.
3. Page.240 Sarangadhara Samhita (A Theasise on Ayurveda) by
Prof.K.R.Srikanta Murthy Reprint Edition:2010 Publisher: Chaukhamba
Orientalia,Varanasi.
4. Page no.131 Volume 2 API Ayurvedic Pharmacopiea of India.Govt. of India.
5. PROTOCOL FOR TESTING AYURVEDIC, SIDDHA & UNANI
MEDICINES D.R. LOHAR, M.Sc., Ph.D DIRECTOR.
6. Page no 67. Hand Book on Cosmetic Science and Technology by Marc paye Second edition.
7. Guardian laboratories. http://www.u-
g.com/formularies/HTML%20Formulary%20Documents/MoisturizingFaceWash%
2092037V.htm
8. Chapter 6 - Extration technology for medicinal plants and Aromatics Plants by-
Sukhdev Swami Handa (International Centre For science and high technology.)
9. http://scholarsresearchlibrary.com/dpl-vol5-iss1/DPL-2013-5-1-83-88.pdf
10. Page no 2524 and 2525 IP (Indian Pharmacopeia ) Volume 3 .IN
11. https://www.specialchem4cosmetics.com/formulations/selector/formulation.
aspx?id=1442
12. Phytoparasitica, Apr-Jun;21(2):98-101.

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