Revised formula 1 is: GFR = 0.413 Ht Cr serum height is measured in cm. Serum creatinine is measured in mg / dL. Values >75 should be reported as such rather than as a specific number. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL / min.
Revised formula 1 is: GFR = 0.413 Ht Cr serum height is measured in cm. Serum creatinine is measured in mg / dL. Values >75 should be reported as such rather than as a specific number. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL / min.
Revised formula 1 is: GFR = 0.413 Ht Cr serum height is measured in cm. Serum creatinine is measured in mg / dL. Values >75 should be reported as such rather than as a specific number. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL / min.
Estimate glomerular filtration rate (creatinine clearance) from serum creatinine and the patient's height using the "interim IDMS-traceable" Schwartz estimate published in 2009. Input Serum Creatinine
mg/dL
Input Height
cm in Clear
GFR = mL/min per 1.73 m 2
The revised Schwartz formula 1 is: GFR = 0.413 * Ht Cr serum
Height is measured in cm. Serum creatinine is measured in mg/dL. Measured creatinine should be in steady state. This formula may be most accurate in the range of 15 to 75 mL/min per 1.73 m 2 . Values >75 should be reported as such rather than as a specific number. This formula applies to enzymatic serum creatinine measurements calibrated to reference measurements by isotope dilution mass spectroscopy (IDMS), but not to alkaline picrate ("Jaffe") methods, even those traceable to IDMS. (For more information see National Kidney Disease Education Program.) Serum samples that are hemolyzed or have elevated bilirubin may lower creatinine measurements. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL/min. 1. Schwartz GJ, Muoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. J Am Soc Nephrol. 2009 Mar;20(3):629-37 Special thanks to Dr. Megan Rashid, University of Rochester. Created: September 28, 2010 Revised: October 14, 2010
Creatinine Clearance: Original Schwartz Estimate Estimate glomerular filtration rate (creatinine clearance) from serum creatinine, the patient's height, and a proportionality constant using the original Schwartz method.
k Infant (LBW < 1 year) 0.33 Infant (Term < 1 year) 0.45 Child or Adolescent Girl 0.55 Adolescent Boy 0.70
Input Serum Creatinine
mg/dL
Input Height
cm in Clear
CrCl = mL/min per 1.73 m 2
The original Schwartz formula 1,2 is: CrCl = (k * Ht) Cr serum
Height is measured in cm. Serum creatinine is measured in mg/dL. Measured creatinine should be in steady state. This formula tends to overestimate the actual creatinine clearance and should be used with caution. Estimates of glomerular filtration > 75 mL/min per 1.73 m 2
should not be reported as an exact number (National Kidney Disease Education Program recommendation). This formula should not be used with serum creatinine measurements calibrated to reference measurements by isotope dilution mass spectroscopy (IDMS). See the Revised Schwartz Estimate. Many medications should be adjusted for renal impairment when the CrCl falls below 50 mL/min. 1. Schwartz GJ, Gauthier B. J Pediatr 1985 Mar;106(3):522-6 2. Schwartz GJ, Feld LG, Langford DJ. J Pediatr 1984 Jun;104(6):849-54 Created: January 7, 2000 Revised: October 14, 2010
GIR This calculation is a simple conversion of units (into mg/kg/min): GIR = IV Rate (mL/hr) * Dextrose Conc (g/dL) * 1000 (mg/g) Weight (kg) * 60 (min/hr) * 100 (mL/dL) where the dextrose concentration is expressed as a whole number, e.g. 5 or 10. A GIR of 5-8 mg/kg/min is typical. Infants who are not feeding should not be allowed a rate less than 5 mg/kg/min for any significant period of time. The GIR needed to optimize nutrition in neonates is 14 mg/kg/min. Created: July 13, 2010 Revised: July 13, 2010 Oxygen Content The equation is: C a O 2 = 1.36 * Hgb * S a O 2
+ 0.0031 * P a O 2
100 The constant, 1.36, is the amount of oxygen (ml at 1 atmosphere) bound per gram of hemoglobin. The exact value of this constant varies from 1.34 to 1.39, depending on the reference and the way it is derived. The constant 0.0031 represents the amount of oxygen dissolved in plasma. The dissolved oxygen term is generally small relative to the hemoglobin-bound oxygen, but becomes significant at very high P a O 2 (as in a hyperbaric chamber) or in severe anemia. Created: January 7, 2000 Revised: October 19, 2000