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ENGN 1490: Biomaterials (Fall 2014)

MWF, 2-2:50 pm
Barus & Holley 153

Professor:
Ian Wong (ian_wong@brown.edu)
Barus & Holley 747
Office Hours: 3 4 pm Fri (or by appointment)

Teaching Assistants:
Daniel Keenan (Daniel_Keenan@brown.edu)
Arnold 310 (91 Waterman St)
Office Hours: Tues, 11 am noon

Zeyang Yu (Zeyang_Yu@brown.edu)
Wilson 304
Office Hours: Tues, 6 pm 7 pm
Mark Scimone (Mark_Scimone@brown.edu)
Arnold 310 (91 Waterman St)
Office Hours: Mon, 4 pm 5 pm

Course Description: Biomaterials science, the study of the application of materials to problems in
biology and medicine, is characterized by medical needs, basic research, and advanced technological
development. Topics covered in this course include chemical structure, physical properties, mechanical
properties, biomaterial degradation, biomaterials processing, micro/nanofabrication, surface properties,
protein interactions, cell-biomaterals interactions, implantation and acute inflammation, wound healing,
drug delivery and tissue engineering.
Course Outcomes:
Students completing ENGN 1490 should:
1. Apply skills learned from core undergraduate coursework to their study of biomaterials, bridging
engineering, biology, and medicine.
2. Be able to read critically the scientific literature on biomaterials.
3. Be able to develop new ideas and solutions to problems with biomaterials presently in use by the
medical profession and to formulate these ideas into a written research paper and oral presentation.

Primary Textbook:
Biomaterials: The Intersection of Biology and Materials Science
J.S. Temenoff and A. G. Mikos (Pearson Prentice Hall Bioengineering, 2008)

Supplementary Textbooks (Additional Resources):
Materials Science and Engineering An Introduction, 8
th
Ed.
William D. Callister, David G. Rethwisch (Wiley, 2010)
Molecular Biology of the Cell, 5
th
Ed
Bruce Alberts et al. (Garland Science, 2007)
Robbins & Cotran Pathologic Basis of Disease, 8
th
Ed
Vinay Kumar et al. (Saunders, 2009)
An Introduction to Tissue-Biomaterial Interactions
Kay C. Dee et al. (Wiley-Liss, 2002)
Biomaterials Science: An Introduction to Materials in Medicine, 3
rd
Ed.
Buddy Ratner et al. (Academic Press, 2012)

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Reading Assignments: The relevant textbook chapters are listed below in the lecture schedule (subject
to change). Additional handouts/references may be provided throughout the semester.
Lecture Schedule:
Week Topics Reading
Sep. 3 Introduction to Biomaterials

TM 1
Sep. 8 Chemical Structure of Biomaterials
Physical Properties of Biomaterials
TM 2.1, 2.2, 2.3, 2.4, 2.5.1
TM 3.1, 3.2, 3.3, 3.4, 3.5, 3.6,

Sep. 15 Mechanical Properties of Biomaterials

TM 4.1, 4.2, 4.3, 4.4, 4.5
Sep. 22 Biomaterials Processing

TM 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7
Sep. 29 Biomaterials Processing

TM 5.1, 5.2, 5.3, 5.4
Oct. 6 Protein Interactions with Biomaterials
Surface Properties of Biomaterials
TM 8.1, 8.2, 8.3, 8.4
TM 7.1, 7.2, 7.3
Oct. 15 Review


EXAM 1 (October 17)
Oct. 20 Cell Interactions with Biomaterials TM 9

Oct. 27 Guest: Prof. E. Darling (Stem Cell Mechanics)
Guest: Prof. B. Bilgen (Cartilage Engineering)
Guest: Prof. A. Shukla (Drug Delivery)


Nov. 3 Biomaterials and Thrombosis, Inflammation
Guest: T. Valentin (Non-Fouling Surfaces)

TM 13
Nov. 10 Wound Healing and Biomaterials
Guest: Prof. J. Ou (Intro to Histology)

TM 10
TM 11
Nov. 17 Specialized Tissues
Guest: Prof. K. Coulombe (Cardiovascular
Tissues)

Nov. 24 Review / Make-up Lectures


Dec. 1 Review / Make-up Lectures


EXAM 2 (December 5)
Final Project Report (December 10)
Final Project Presentation (Final exam period December 17)


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Homework: Homework will be assigned and due at the end of class according to this schedule.
Homework # Assigned Due
0* Monday, September 8 Wednesday, September 17
1 Monday, September 15 Wednesday, September 24
2 Monday, September 22 Wednesday, October 1
3 Monday, September 29 Wednesday, October 8
4 Monday, October 27 Wednesday, November 5
5 Monday, November 3 Wednesday, November 12
6 Monday, November 10 Wednesday, November 19
*note: HW 0 will earn you a maximum of 5% bonus on your final course grade.
Homework should have the following format
-Begin each question on a new sheet of paper.
-Write your name at the top of every page.
-Write the names of collaborating students at the top of the first page for each problem.
-Show all work/calculations (i.e. numerical answers that do not show which formulas and/or
calculations were used will not receive full credit, even if the answer is correct).
-If you use Excel, MATLAB, etc. to answer a question, print out your code/etc.
-Include references if you use sources other than the textbook or lecture notes
-State any assumptions you make in solving a problem; justify the assumption(s) if needed.

Final Project: A final project in the form of a research paper and presentation will be assigned to groups
of approximately 4 students. Details will be provided during the week of October 20. Final project
reports will be due on Wednesday, December 10. Project presentations will be made during the final
exam period on December 17.
Grading:
Homework 30 %
Exam 1 20 %
Exam 2 20 %
Final Report (20 %) and Presentation (10 %) 30 %

Homework Collaboration Policy: Students may work in groups of up to 4. List all students that
worked on the assignment on the front page of the homework. Each student must write up their own
solutions.

Late Homework Policy: Homework handed in after the end of class will be considered late. Please
coordinate with the TAs via email for handing in late homework.

Lateness Total Taken Off Final HW Score
Same Day (After class) 20%
2
nd
Day 40%
3
rd
Day (Last day to hand in late HW) 60%

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Scheduling conflicts: In the case of an unavoidable situation that prevents you from taking the
exam/completing an assignment by the assigned deadline, please inform the professor as soon as you are
aware of this (with documentation).

Other considerations: Please notify the professor if you have a disability or other condition that might
require some modification of any of these course procedures. You may speak with us after class or
during office hours. For more information contact Student and Employee Accessibility Services at 401-
863-9588 or SEAS@brown.edu.


Please review the Brown University Academic Code:
http://www.brown.edu/Administration/Dean_of_the_College/curriculum/documents/academic-code.pdf

Violations of the academic code will lead to strict disciplinary action.