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Double Membrane
Inner Membrane is
supported by the
Nuclear Lamina
All macromolecules
that pass into / out of
the nucleus must pass
through a nuclear pore
complex.
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-- P-P-K-K-K-R-L-V---
In the nucleus
In the cytoplasm
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Ran-GTP-NIR complex
Ran-GTP decreases
affinity of NIR for cargo
Ran-GTP increases
affinity of NER for cargo
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dorsal in cytoplasm
Future Fly
dorsal in nucleus
Future Ventral Side
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SEM Image
Figure 12-19 Molecular Biology of the Cell ( Garland Science 2008)
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Sorting Signal
Bound to MIR
Figure 12-22 Molecular Biology of the Cell ( Garland Science 2008)
Mitochondrial Protein
Translocation Complexes
Must cross
2 membranes
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Endoplasmic Reticulum
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Figure 12-47 (part 1 of 2) Molecular Biology of the Cell ( Garland Science 2008)
Figure 12-47 (part 2 of 2) Molecular Biology of the Cell ( Garland Science 2008)
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