Hematology Atlas

Image Atlas Categorical Index
Bloodline Image Atlas Categorical Index

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About Click on any entry to access a list of applicable images.
Blood
Educational Features
● normal
Image Atlas ● capillary
Case Studies ● EDTA anticoagulated
Private Lectures
Conference Reviews
Area
Journal Articles
Book Reviews
Glossary ● dense area
● thin area
● tail area
● side edge
Resources
Conference Calendar Bone Marrow

Grants & Fellowships
Hematology Links
● normal
Full Text Journals
● biopsy
Classifieds
● imprint
● particle
● hypercellular
hypocellular
Specialties
●
BMT/Stem Cell
Buffy Coat Preparation
Cord Blood
Thrombosis
Hemostasis Diseases
Laboratory
Malignancies ● Acute myeloid leukemia
Pediatrics ● AIDS
Red Cell Disorders ● Aplastic anemia
Infections ● Arthritis
Transfusion Medicine ● Autoimmune hemolytic anemia (AHD; AIHD)
Veterinary ● Cancer
● Chronic myeloid leukemia
● Disseminated intravascular coagulation (DIC)
● Essential thrombocytosis (ET)
● Gaucher's disease
http://image.bloodline.net/category (1 of 5)13/07/2005 03:34:22

News ● Gray platelet syndrome

● Hemolytic anemia
Hematology News ● Hypersplenism
Blood News Update ● Idiopathic thrombocytopenic purpura (ITP)
● Infection
● Infectious mononucleosis
● Iron deficiency
Discussion
● Megakaryocytic (M-7) leukemia
Today's Discussion ● Megakaryocytic leukemia, in remission
Create New Topic ● Monocytic leukemia (M-4)
List by Topic ● Monocytic leukemia (M-5)
● Multiple myeloma
● Myelodysplastic syndrome (MDS)
● Myeloid (granulocytic) leukemia (CML)
● Myeloid leukemia (AML) (M-1, M-2)
● Myeloid metaplasia with myelofibrosis
● Myeloproliferative disease
● Neuroblastoma
● Pernicious anemia
● Platelet clumping in EDTA anticoagulated blood
● Platelet Satelletism
● Sepsis
● Thalassemia minor
● Thrombocytosis
● Thrombotic thrombocytopenic purpura (TTP)
● Viral reaction
Macrophage
Mast Cell
Megakaryocyte
● abnormal
● mature
● late
● promegakaryocyte
● young
● intermediate
● megakaryocyte cytoplasmic fragment
● megakaryoblast
● binucleated
● micromegakaryocyte
● mitotic form
● small
● bare nucleus (nuclei)
● nuclear mass
● emperipolis
● reticulin fibers

Monocyte
● early monocyte
● immature monocyte
● young monocyte
● monoblast
● reactive monocyte
● toxic monocyte
● cytoplasmic fragments
Non-hemopoietic Cells
● endothelial cell
● epithelial (squamous) cells
● fat cell
● microorganisms
● neuroblastoma cells
● osteoblast
● osteoclast
Nucleated Red Blood Cell (NRBC)
● late erythroblast (normoblast, metarubicyte)

● orthochromatic erythroblast (normoblast, metarubicyte)
● intermediate erythroblast (normoblast, rubicyte)
● polychromatic erythroblast (normoblast, rubicyte)
● early erythroblast (normoblast, rubiblast)
● basophilic erythroblast (normoblast, prorubicyte)
● proerythroblast (normoblast, rubiblast)
Plasma Cell
● plasma cell with multiple vacuoles

● plasma cell with vacuoles over nucleus
● binucleated plasma cell
● multinucleated plasma cell
● Mott cell
Platelets
● normal
● abnormal
● agranular
● clump
● colorless
● small
● overlying a red cell
● cytoplasmic fragments
● platelet ribbon

Megathrombocyte
● normal
● abnormal
● agranular
Red Blood Cells
● normochromic
● microcytic
● macrocytic
● oval macrocytes
● polychromatophilic RBC
Stains
● Acid Phosphatase
● Esterase
● Glycoprotein IIb,IIIa
● Hematoxylin and Eosin (H & E) stain
● Iron
● Periodic Acid Schiff (PAS)
● Peroxidase
● Toluidine Blue
● Wrights-Giemsa
White Blood Cell (WBC)
Basophil
● mature
● young
Eosinophil
● mature eosinophil
● band eosinophil
● eosinophilic metamyelocyte
● eosinophlic myelocyte
Neutrophil
● mature neutrophil
● band neutrophil
● metamyelocyte
● myelocyte

● promyelocyte (progranulocyte)
● myeloblast
● reticular cell
● hypersegmented neutrophil
● toxic neutrophil
● disrupted
● smashed
● smudged cell
● Pelgeroid
● abnormal
● colorless cytoplasm
● double nucleus
● neutrophil surrounded by platelets
● segmented
Lymphocyte
● mature
● large
● reactive
● plasmacytoid
● young lymphocyte
● lymphoblast
● smudge cell
● large granular lymphocyte (LGL)
● small
Blast
● normal
● abnormal
Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All

rights reserved. The material available at this site is for educational
purposes only and is NOT intended for any diagnostic, clinically
related, or other purpose. Carden Jennings Publishing Co., Ltd., assumes no
responsibility for any use or misuse of this material and makes no warranty
or representation of any kind with respect to the material available at this
site.

BloodLine Image Atlas
Bloodline BloodLine Image Featured Resources
Home
About
Atlas
The first installment of this fully searchable
directory features more than 800
hematological slides depicting various blood
disorders and malignancies.
Image Atlas
Case Studies The Image Atlas represents some twenty years
Private Lectures of work by Jean Shafer, Assistant Professor of
Conference Reviews Medicine at the Rochester School of Medicine. Bloodline Reviews
Journal Articles Volume 1, Issue 3
Book Reviews Use one of the following methods to access Hematological Testing
Glossary images: for Blood Doping in
Sports
Categorical Index (disease,
cell type, etc.)
Resources
Conference Calendar Keyword Search

Hematology Links
Full Text Journals
Classifieds
Copyright 1995-2005 - Carden Jennings

Specialties Publishing Co., Ltd. All rights reserved.
The material available at this site is for
BMT/Stem Cell educational purposes only and is NOT intended
Cord Blood for any diagnostic, clinically related, or other
Thrombosis purpose. Carden Jennings Publishing Co., Ltd.,
Hemostasis assumes no responsibility for any use or
Laboratory misuse of this material and makes no warranty
Malignancies or representation of any kind with respect to
Pediatrics the material available at this site.
Red Cell Disorders
Infections Bloodline Reviews
Transfusion Medicine Volume 1, Issue 4
Veterinary Recombinant Factor VIIa
for Bleeding in Surgery
and Trauma
http://image.bloodline.net/ (1 of 2)13/07/2005 03:34:37

News
Hematology News
Blood News Update
Discussion
Today's Discussion
BMTR Volume 11 No. 2
Create New Topic
Prophylaxis for
List by Topic
Opportunistic Infections
Autologous Blood and

Marrow Transplantation
X:
Proceedings of the Tenth
International
Symposium
http://image.bloodline.net/ (2 of 2)13/07/2005 03:34:37

Blood
Bloodline Blood
Home
About ● Lymphocyte, platelet fragment, megathrombocyte, M-7 leukemia
● Small platelets, megathrombocyte, M-7 leukemia
● Small platelets, acute megakaryocytic (M-7) leukemia
● Abnormal neutrophils, Pelgeroid, platelets, AML blood
Educational Features ● Hyposegmented neutrophil, blasts, megathrombocyte, AML blood
Pelgeroid neutrophil, lymphocyte, AML blood
Image Atlas
●
Pelgeroid neutrophil, monocyte, blast, platelets, AML blood

Case Studies
●
Myelocytes, abnormal platelets, AML blood

Private Lectures
●
Mature neutrophil, blast, acute megakaryocytic leukemia

Conference Reviews
●
Blasts, megathrombocyte, acute megkaryocytic leukemia

Journal Articles
●
Blasts, megathrombocyte, neutrophil, monocyte, AML blood

Book Reviews
●
Late neutrophil, Pelgeroid, colorless cytoplasm, AML blood

Glossary
●
● Agranular megathrombocytes, AML capillary blood

● Megathrombocytes, agranular platelet, AML capillary blood
● Blast, late neutrophil, megathrombocytes, AML blood
Resources ● Pelgeroid and intermediate neutrophils, blasts, AML relapse
● Blasts, Pelgeroid neutrophils, AML in relapse
Conference Calendar
● Blasts, neutrophilic myelocyte, band neutrophil, AML relapse
● Pelgeroid neutrophils, blasts, AML in relapse
Hematology Links
● Blasts, abnormal megathrombocyte, AML in relapse
Full Text Journals
● Blasts, neutrophilic myelocyte, monocyte, AML in relapse
Classifieds
● Blasts, Acute Megakaryocytic Leukemia (M-7) in relapse
● Blasts, neutrophilic promyelocyte, AML in relapse
● Pelgeroid neutrophil, progranulocyte, AML in relapse
Progranulocytes, acute megakaryocytic leukemia in relapse
Specialties
●
● Pelgeroid eutrophil, Megakaryocyte, Megakaryocytic Leukemia

BMT/Stem Cell ● Young Basophil, neutrophilic myelocyte, M-7 leukemia
Cord Blood ● Abnormal agranular megathrombocytes, megakaryocytic leukemia
Thrombosis ● Abnormal late neutrophils, colorless cytoplasm, M-7 leukemia
Hemostasis ● Abnormal late neutrophils, Pelgeroid, M-7 leukemia
Laboratory ● Pelgeroid neutrophil, blasts, M-7 leukemia
Malignancies ● Blast, progranulocyte, M-7 leukemia
Pediatrics ● Progranulocytes, neutrophilic myelocyte, M-7 leukemia
Red Cell Disorders ● Abnormal megakaryoblasts, myelocytes, M-7 leukemia
Infections ● Abnormal megathrombocyte, M-7 leukemia
Transfusion Medicine ● Peroxidase and Wright's-Giemsa stains, M-7 leukemia
Veterinary ● Peroxidase and Wright's-Giemsa stains, M-7 leukemia blood
● Peroxidase and Wright's-Giemsa stains, M-7 leukemia blood
● Blasts, peroxidase stain, M-7 leukemia blood
● Peroxidase and Wright's-Giemsa stains, M-7 leukemia blood
● Late neutrophil, platelet, PAS stain, M-7 leukemia
http://image.bloodline.net/bd (1 of 7)13/07/2005 03:34:54

Blood
News ● Neutrophils, PAS stain, ds, ds18, ds19, bd

● Peroxidase stain, M-7 leukemia blood
Hematology News ● Blast, transmission electron micrograph, M-7 leukemia
Blood News Update ● Transmission electron micrograph, M-7 leukemia in relapse
● Abnormal megathrombocytes and platelets, TEM, M-7 leukemia
● Von Willebrand antibody plus fluorescein stain, M-7 leukemia
● Von Willebrand antibody plus fluorescein stain, M-7 leukemia
Discussion
● Platelets, Von Willebrand antibody, M-7 leukemia
Today's Discussion ● Von Willebrand antibody plus fluorescein stain, M-7 leukemia
Create New Topic ● Platelets, Von Willebrand antibody, M-7 leukemia
List by Topic ● Late NRBC, Mature Lymphocyte, AML
● Basophil, AML
● Bare Nucleus, Megakaryocyte, Blast, AML
● Bare Nuclei, Megakaryocytes, Blast, AML
● Blast, Late NRBC, Progranulocyte, Basophil, AML
● Late NRBC, Basophil, Megakaryocyte, Blast, AML
● Monocyte, Bare Nucleus, Megakaryocyte, AML
● Blasts, AML
● Blasts, Megakaryocyte nucleus, AML
● Platelets, Glycoprotein IIbIIIa stain, AML
● Blast, Glycoprotein IIbIIIa stain, AML
● Blasts, Platelets, AML
● Blasts, AML
● Megathrombocytes, Blast, AML
● Bare nucleus, AML
● Blasts, AML
● Blast, AML
● Blast, Megathrombocyte, AML
● Normal Platelets, Normal EDTA anticoagulated blood
● Normal Platelets , Normal EDTA anticoagulated blood
● Normal Platelets , Proper Thickness, Field to Examine
● Normal Platelets, Normocytic, normochromic RBC, Normal EDTA
● Platelets, Thrombocytopenia, Normal RBC, EDTA
● Clump of Platelets, Normal Capillary blood
● Clumps of Platelets, Thrombocytosis, Capillary blood
● Clump of Platelets, Thrombocytosis, Capillary blood
● Clumps of Platelets, Thrombocytosis, Capillary blood
● Platelet Ribbon, Normal blood
● Small Platelets, Megathrombocyte, Band Neutrophil
● Small Platelets, Megathrombocyte, Platelets Overlying RBC
● Small Platelets, Megathrombocytes
● Platelets, Normal EDTA anticoagulated blood
● Platelets, Megathrombocyte, EDTA anticoagulated blood
● Platelet, Megathrombocyte, Mature, ITP
● Megathrombocyte, Normal capillary blood smear
● Abnormal megathrombocytes, Capillary blood, MDS
● Platelet overlying a red cell, Megathrombocyte, MDS
● Megathrombocyte, EDTA anticoagulated blood, ET
● Colorless Platelets, Gray Platelet syndrome blood
● Colorless Platelets, Gray Platelet Syndrome blood
● Platelet , Mature Neutrophil, (PAS) stain
● Cytoplasmic Fragments, Leukemic Monocytes, Platelets, M-5

Blood
● Immature Monocytes, cytoplasmic fragmentation, M-5

● Immature Monocytes, Cytoplasmic Fragments, M-5 leukemia
● Immature Monocytes, Megakaryocyte Nucleus, M-5
● Neutrophils surrounded by platelets, Platelet Satellitism
● Neutrophil Surrounded by Platelets, Platelet Satellitism
● Late Neutrophil Surrounded - Platelets, Platelet Satellitism
● Mature Neutrophils surrounded by Platelets, Satellitism
● Mature Neutrophils, Platelet Satellitism
● Monocyte, engulfed platelets, Platelet Satellitism
● Platelet Satellitism
● Neutrophils, platelet satellitism, marrow
● Reactive lymphocytes, Hepatitis blood
● Reactive, plasmacytoid, basophilic, reticular lymphocytes
● Plasmacytoid lymphocytes, viral infection blood
● Monocyte, plasmacytoid lymphocyte, LGL, viral infection
● Reactive lymphocytes, viral infection blood
● Reactive lymphocyte, viral infection blood
● Reactive lymphocyte, viral infection blood
● Cytomegalovirus infection blood
● Reactive lymphocyte, plasmacytoid, cytomegalovirus infection
● Reactive lymphocytes, Cytomegalovirus infection blood
● Reactive, plasmacytoid lymphocytes, LGL, Cytomegalovirus
● Plasmacytoid lymphocyte
● Plasmacytoid lymphocyte, renal infection blood
● Plasmacytoid Lymphocyte
● Plasmacytoid lymphocytes, viral infection
● Plasmacytoid lymphocyte, Idiopathic thrombocytopenic purpura
● Plasmacytoid lymphocytes, viral or bacterial infection
● Plasmacytoid lymphocytes, drug reaction blood
● Reactive, plasmacytoid, viral infection blood
● Plasmacytoid lymphs, infectious mononucleosis blood
● Plasmacytoid lymphoid, infectious mononucleosis blood
● Plasma cell, alcoholic, liver disease
● Plasma Cell, alcoholic, liver disease blood
● Plasmacytoid, mature, plasma cell, alcoholic, liver disease
● Plasmacytoid, plasma cell, alcoholic, liver disease blood
● Plasmacytoid lymphocyte, alcoholic, liver disease blood
● Plasmacytoid lymphocyte, neutrophilic myelocyte, alcoholic
● Blast cell, plasmacytoid lymphocyte, alcoholic/liver disease
● Mott Cell, alcoholic with liver disease
● Plasma cell, Mott Cell, alcoholic, liver disease
● Mott Cell, plasmacytoid lymphocyte, alcoholic, liver disease

Blood
● Plasmacytoid lymphocyte, alcoholic, liver disease blood

● Plasmacytoid lymphocytes, severe arthritis with osteoporosis
● Plasmacytoid lymphocytes, Mott Cell, arthritis, osteoporosis
● Plasmacytoid, plasma cells, severe arthritis, osteoporosis
● Plasmacytoid lymphocyte, severe arthritis with osteoporosis
● Plasmacytoid lymphocyte, severe arthritis with osteoporosis
● Plasma cells, severe arthritis with osteoporosis
● Plasmacytoid, plasma cell, severe arthritis, osteoporosis
● Plasmacytoid, plasma cell, severe arthritis, osteoporosis
● Plasma cell, bacterial infection blood
● Plasma cell, monocytes, platelets, breast cancer blood
● Dying plasma cell, late neutrophils
● Plasma cell, Mott cell, buffy coat preparation
● Mott cell, Russell bodies, red cell transfusion
● Mott cell, plasmacytoid lymphocyte, viral infection
● Plasmacytoid lymphocyte, Thrombotic thrombocytopenic purpura
● Plasmacytoid lymphocyte, serum sickness
● Plasmacytoid lymphocyte, serum sickness
● Rouleaux formation, Multiple myeloma
● Rouleaux formation, plasma cell, Multiple myeloma
● Pathologic rouleaux formation, Multiple myeloma
● Pathologic rouleaux, plasma cell, Multiple myeloma
● Pathologic rouleaux, Multiple myeloma
● Agglutination, Cold agglutinin hemolytic anemia
● Eosinophil, Normal blood
● Band eosinophil, mature neutrophil, Normal blood
● Basophil, eosinophils, Normal blood
● Crushed eosinophil
● Late neutrophils, eosinophil, basophil
● Basophil
● Basophil
● Basophil
● Basophils, mature neutrophils, CML blood
● Young basophils, CML blood
● Crushed basophil
● Crushed basophil
● Epithelial cells
● Epithelial cells, microorganisms
● Epithelial cell, microorganisms
● Mature megakaryocyte, blood smear
● Mature megakaryocyte, Essential Thrombocytosis
● Late megakaryocyte, buffy coat, lung cancer blood

Blood
● Bare megakaryocyte nuclei, thrombocytosis

● Small megakaryocyte, Thrombotic Thrombocytopenic Purpura
● Bare megakaryocyte nuclei, Thalassemia minor blood
● Bare megakaryocyte nuclei, NRBC, cancer blood
● Bare megakaryocyte nuclei, Thalassemia minor blood
● Bare megakaryocyte nuclei, Multiple myeloma blood
● Megakaryocytes, lung cancer, buffy coat
● Megakaryocyte nucleus, lung cancer blood
● Bare megakaryocyte nucleus, Myeloid metaplasia
● Mature megakaryocyte, myeloid metaplasia with myelofibrosis
● Micromegakaryocytes, myeloid metaplasia with myelofibrosis
● Micromegakaryocytes, myeloid metaplasia myelofibrosis blood
● Megakaryocyte nuclei, myeloid metaplasia with myelofibrosis
● Megakaryocyte nuclei, megathrombocytes, myeloid metaplasia
● Bare megakaryocyte nuclei, myeloid metaplasia
● Megakaryocyte nucleus, megakaryocyte cytoplasmic fragment
● Micromegakaryocytes, megathrombocytes, myeloid leukemia
● Micromegakaryocytes, megathrombocyte, myeloid leukemia blood
● Micromegakaryocyte, megathrombocytes, myeloid leukemia blood
● Myeloblast, micromegakaryocyte, myeloid leukemia blood
● Micromegakaryocytes, myeloid leukemia, M-7 leukemia
● Megakaryoblasts, chronic myeloid leukemia, M-7 leukemia
● megakaryocyte nucleus, M-7 and chronic myeloid leukemias
● Megathrombocyte, PAS stain, myeloid metaplasia
● Megakaryocyte nuclei, PAS stain, myeloid metaplasia
● Megakaryocyte nuclei, PAS stain, myeloid metaplasia
● Megakaryocyte nucleus, myeloid metaplasia with myelofibrosis
● Micromegakaryocyte, myeloid metaplasia with myelofibrosis
● Platelets, neutrophil, monocyte, GP IIbIIIa stain
● Micromegakaryocytes, GP IIb,IIIa stain, myeloid metaplasia
● Normal blood
● Normal blood
● Normal blood, dense area
● Normal blood - dense area
● Normal blood - dense area, segmented neutrophil
● Normal blood - dense area, lyphocyte, segmented neutrophil
● Normal blood - thin area
● Blood - thin area, lymphocytes, neutrophils
● Blood - thin area, lymphocyte, smudge cell
● Blood - tail area, segmented neutrophils
● Normal blood - side edge, large cells
● Normal blood, segmented neutrophil, small lymphocyte
● Normal blood, segmented neutrophils, lymphocyte
● Normal blood, segmented neutrophils
● Normal blood, segmented and hypersegmented neutrophils
● Hypersegmented neutrophil, buffy coat of pernicious anemia
● Segmented neutrophils, band neutrophils, normal blood
● Segmented neutrophil, band neutrophil, normal blood
● Segmented neutrophil, monocyte, normal blood
● Segmented neutrophil, lymphocyte, normal blood
● Segmented and band neutrophils, lymphocyte, normal blood
● Lymphocyte, normal blood

Blood

● Lymphocytes, normal blood
● Segmented neutrophil, lymphocyte, thin area blood
● Segmented neutrophil, lymphocytes, normal blood
● Very large, reactive lymphocyte, normal blood
● Very large lymphocyte, normal blood
● Lymphocyte, thin tail area blood
● Large reactive lymphocyte, normal blood
● Reactive lymphocyte, infectious mononucleosis blood
● Lymphocyte with granules, tail area of normal blood
● Large granular lymphocyte, normal blood
● Segmented neutrophil, monocyte, lymphocytes, normal blood
● Lymphocyte, monocyte, neutrophil, normal blood
● Very small lymphocyte, monocyte, normal blood
● Plasmacytoid lymphocyte, viral reaction blood
● Lymphocyte, monocyte, normal blooad
● Lymphocyte, monocyte, normal blood
● Monocyte, dense area, normal blood
● Monocyte, plasmacytoid lymphocyte, normal blood
● Large granular lymphocyte, monocyte, normal blood
● Monocyte, normal blood
● Monocyte with several small vacuoles, normal blood
● Monocyte with folded nucleus, normal blood
● Monocyte with band shaped nucleus, normal blood
● Monocyte, band neutrophil, normal blood
● Monocyte, large lymphocyte, normal blood
● Lymphocytes, monocytes, neutrophil, buffy coat, normal blood
● Monocyte, lymphocyte, segmented neutrophil, normal blood
● Monocyte, segmented neutrophil, lymphocyte, normal blood
● Segmented neutrophil, lymphocyte, monocyte, normal blood
● Small lymphocyte, monocyte, neutrophil, normal blood
● Monocytes, segmented neutrophil, normal blood
● Moncyte, platelets, normal blood
● Monocyte, RBC, disseminated intravascular hemolysis blood
● Monocyte with engulfed platelets, tail area blood
● Young monocyte, normal blood
● Young monocytes, normal blood
● Young monocyte, infection blood
● Normal blood


Blood

site.

Lymphocyte, platelet fragment, megathrombocyte, M-7 leukemia
Bloodline Lymphocyte, platelet fragment,

Home
About
megathrombocyte, M-7 leukemia
One small lymphocyte, several small Platelet Fragments, 1 large Megathrombocyte showing very few granules. Acute
Megakaryocytic Leukemia (M-7). EDTA anticoagulated blood - 100X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Transfusion Medicine Image ID: 0137-001
Veterinary
News Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All rights reserved. The material
available at this site is for educational purposes only and is NOT intended for any diagnostic, clinically
Hematology News
related, or other purpose. Carden Jennings Publishing Co., Ltd., assumes no responsibility for any use
Blood News Update
or misuse of this material and makes no warranty or representation of any kind with respect to the material
available at this site.
Discussion
Today's Discussion
Create New Topic
List by Topic
http://image.bloodline.net/stories/storyReader$522 (1 of 2)13/07/2005 03:35:08

Lymphocyte, platelet fragment, megathrombocyte, M-7 leukemia

Small platelets, megathrombocyte, M-7 leukemia
Bloodline Small platelets, megathrombocyte, M-7

Home
About
leukemia
Numerous small platelets, some of which lack granules. 1 Megathrombocyte, several large red cells. Acute
Megakaryocytic Leukemia (M-7). EDTA anticoagulated blood - 100X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary
Hematology News
Blood News Update
Discussion
Today's Discussion
Create New Topic
List by Topic

Small platelets, megathrombocyte, M-7 leukemia

Small platelets, acute megakaryocytic (M-7) leukemia
Bloodline Small platelets, acute megakaryocytic (M-7)

Home
About
leukemia
Numerous Small Platelets, a few large red cells, increased red cell poikilocytosis. Acute Megakaryocytic Leukemia (M-
7). EDTA anticoagulated blood - 100X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary
Hematology News
Blood News Update
Discussion
Today's Discussion
Create New Topic
List by Topic

Small platelets, acute megakaryocytic (M-7) leukemia

Abnormal neutrophils, Pelgeroid, platelets, AML blood
Bloodline Abnormal neutrophils, Pelgeroid, platelets, AML

Home
About
blood
Three Abnormal Late Neutrophils showing dense chromatin, hyposegmentation (Pelgeroid) and colorless cytoplasm.
Two clumps of swollen and agranular platelets and one large agranular platelet (left edge) is present. Acute
Megakaryocytic Leukemia (M-7). Blood - 50X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Transfusion Medicine
Veterinary Image ID: 0137-041
News
Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All rights reserved. The material
Hematology News
Blood News Update
Discussion
Today's Discussion
Create New Topic
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Abnormal neutrophils, Pelgeroid, platelets, AML blood

Hyposegmented neutrophil, blasts, megathrombocyte, AML blood
Bloodline Hyposegmented neutrophil, blasts,

Home
About
megathrombocyte, AML blood
One Hyposegmented Neutrophil (Pelgeroid) with colorless cytoplasm. Two Blasts show fine nuclear chromatin,
nucleoli, more cytoplasm than usual for blasts. One has an attached fragment that is similar to the abnormal platelets
in the field. One Abnormal Megathrombocyte with localized central granulation is at left center. Acute Megakaryocytic
Leukemia (M-7). Blood - 50X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary
Image ID: 0137-042
News
Hematology News Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All rights reserved. The material
Blood News Update available at this site is for educational purposes only and is NOT intended for any diagnostic, clinically
Discussion
Today's Discussion
Create New Topic
List by Topic

Hyposegmented neutrophil, blasts, megathrombocyte, AML blood

Bloodline Pelgeroid neutrophil, lymphocyte, AML blood

Home
About One neutrophil with a dense hyposegmented (Pelgeroid) nucleus and colorless cytoplasm at top edge. One large
lymphocyte at right edge. One blast at lower edge has a high nuclear/cytoplasmic ratio, gray-blue cytoplasm and two
prominent nucleoli. Acute Megakaryocytic Leukemia (M-7). Capillary blood - 50X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections Image ID: 0137-043
Veterinary
News available at this site is for educational purposes only and is NOT intended for any diagnostic, clinically
Hematology News
Blood News Update available at this site.
Discussion
Today's Discussion
Create New Topic
List by Topic


Bloodline Pelgeroid neutrophil, monocyte, blast,

Home
About
platelets, AML blood
One late neutrophil with a very dense band shaped nucleus (Pelgeroid) at left edge, 1 monocyte at left center, 1 Blast
above it, 1 megathrombocyte at right center and 1 lymphocyte above it which appears to have some platelets
adhered to it. Several platelets are scattered throughout the field; some of which are agranular. The rouleaux
formation of the red cells is due to the density of the area. Acute Megakaryocytic Leukemia (M-7). Blood - 50X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary
Image ID: 0137-045
News
Discussion
Today's Discussion
Create New Topic
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Bloodline Myelocytes, abnormal platelets, AML blood

Home
About Two myelocytes, one with and the other without primary or coarse azurophilic granules. Both contain vacuoles. Their
nuclear chromatin is showing some heterochromatin deveopment. Several abnormal (agranular) platelets are
present. Acute Megakaryocytic Leukemia (M-7). Blood - 100X
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
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Bloodline Mature neutrophil, blast, acute megakaryocytic

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One mature neutrophil with three nuclear lobes; two of which have projecting nuclear sticks. One Blast with plentiful
cytoplasm and a few scattered azurophilic granules and vacuoles. There are two large nucleoli in the nucleus. Acute
Megakaryocytic Leukemia (M-7). Blood - 100X
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Bloodline Blasts, megathrombocyte, acute megkaryocytic

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Left frame: 1 Blast Middle frame: 1 band neutrophil with a rather dense nuclear chromatin and colorless cytoplasm. 1
Blast with multiple large azurophilic granules; some of which have a colorless center. The nucleus has a rather dense
nuclear chromatin. Right frame: 1 Abnormal neutrophil with at least five nuclear lobes, which show semi-dense
chromatin, and colorless cytoplasm. Acute Megkaryocytic Leukemia (M-7). Blood - 100X
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Bloodline Blasts, megathrombocyte, neutrophil,

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monocyte, AML blood
Left frame: 1 Blast with a generous amount of cytoplasm and two large nucleoli, 1 megathrombocyte with peripheral
agranular "wings". Center frame: 1 late neutrophil with very dense nuclear chromatin, 1 Blast with two prominent
nucleoli. Right frame: 1 monocyte at top, 1 Blast with vacuolated cytoplasm beneath it. Acute Megakaryocytic
Leukemia (M-7). Blood - 100X
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Bloodline Late neutrophil, Pelgeroid, colorless cytoplasm,

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AML blood
Left frame: 1 abnormal late neutrophil with dense nuclear chromatin and sticks projecting from some lobes. Its
cytoplasm is colorless. Two large platelets are agranular. Right frame: 1 Late Neutrophil with very dense nuclear
chromatin and only two nuclear lobes (Pelgeroid). Its Cytoplasm is Colorless. 4 platelets are agranular and two are
large. The red cells show increased poikilocytosis and size variation. Acute Megakaryocytic Leukemia (M-7). Blood -
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Agranular megathrombocytes, AML capillary blood
Bloodline Agranular megathrombocytes, AML capillary

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blood
Left frame: 2 Megathrombocytes. One is Agranular. The other is Partially Agranular yet contains a few very large
granules. Center frame: One Abnormal ellipto-shaped Agranular Megathrombocyte. Right frame: 1 Normal
Megathrombocyte. Acute Megakaryocytic Leukemia (M-7). Capillary blood - 100X
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Agranular megathrombocytes, AML capillary blood

Megathrombocytes, agranular platelet, AML capillary blood
Bloodline Megathrombocytes, agranular platelet, AML

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capillary blood
1 large granular lymphocyte, 2 Megathrombocytes, 1 agranular large platelet and 1 normal platelet. Acute
Megakaryocytic Leukemia (M-7). Capillary blood - 100X
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Megathrombocytes, agranular platelet, AML capillary blood

Blast, late neutrophil, megathrombocytes, AML blood
Bloodline Blast, late neutrophil, megathrombocytes, AML

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blood
Left frame: 1 probable Blast with a semi-dense nuclear chromatin. Right frame: 1 Late Neutrophil with colorless
cytoplasm. 1 megathrombocyte, two agranular megathrombocytes; one of which has an irregular shape. Acute
Megakaryocytic Leukemia (M-7). Capillary blood - 100X
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Blast, late neutrophil, megathrombocytes, AML blood

Pelgeroid and intermediate neutrophils, blasts, AML relapse
Bloodline Pelgeroid and intermediate neutrophils, blasts,

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One late Neutrophil with a very dense band shaped nucleus (Pelgeroid) and vacuolated cytoplasm at left edge, 3
Blasts in center; one containing several large granules with a pale center, 2 intermediate neutrophils at right edge.
Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 50X
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Pelgeroid and intermediate neutrophils, blasts, AML relapse

Blasts, Pelgeroid neutrophils, AML in relapse
Bloodline Blasts, Pelgeroid neutrophils, AML in relapse

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About Four Blasts and 4 Pelgeroid Neutrophils. The blasts show a few coarse azurophilic granules. Acute Megakaryocytic
Leukemia (M-7) in relapse. Blood - 50X
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Blasts, Pelgeroid neutrophils, AML in relapse

Blasts, neutrophilic myelocyte, band neutrophil, AML relapse
Bloodline Blasts, neutrophilic myelocyte, band

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neutrophil, AML relapse
Two Blasts, 1 neutrophilic myelocyte, three neutrophils with band shaped nuclei and one monocyte with lacy
chromatin and a convoluted nucleus. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 50X
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Blasts, neutrophilic myelocyte, band neutrophil, AML relapse

Pelgeroid neutrophils, blasts, AML in relapse
Bloodline Pelgeroid neutrophils, blasts, AML in relapse

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About Three Neutrophils with non-segmented dense nuclei (Pelgeroid) and five Blasts, some of which show coarse
azurophilic granulation. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 50X
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Pelgeroid neutrophils, blasts, AML in relapse

Blasts, abnormal megathrombocyte, AML in relapse
Bloodline Blasts, abnormal megathrombocyte, AML in

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relapse
Two cells with semi-dense chromatin which appear to be neutrophilic myelocytes. The other four cells are probably
Blasts from the appearance of their nuclear chromatin. One Abnormal Megathrombocyte is at top right. Acute
Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Blasts, abnormal megathrombocyte, AML in relapse

Blasts, neutrophilic myelocyte, monocyte, AML in relapse
Bloodline Blasts, neutrophilic myelocyte, monocyte, AML

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One neutrophilic myelocyte at top left, another at center right and top right. A blast at lower left and top center left.
A monocyte at lower right and a very abnormal cell with nuclear chromatin and nucleoli consistent with a blast and
highly granulated cytoplasm at right of center. The center of each granule appears to be colorless. Acute
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Blasts, neutrophilic myelocyte, monocyte, AML in relapse

Blasts, Acute Megakaryocytic Leukemia (M-7) in relapse
Bloodline Blasts, Acute Megakaryocytic Leukemia (M-7)

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in relapse
Five cells, some with fine azurophilic granulation. Their nuclear chromatin suggests they are Blasts, but the
cytoplasmic maturation is later in some. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Blasts, Acute Megakaryocytic Leukemia (M-7) in relapse

Blasts, neutrophilic promyelocyte, AML in relapse
Bloodline Blasts, neutrophilic promyelocyte, AML in

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relapse
Two Blasts; one with prominent large granules which are colorless in their center. A heavily granulated neutrophilic
promyelocyte is at left edge. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Blasts, neutrophilic promyelocyte, AML in relapse

Pelgeroid neutrophil, progranulocyte, AML in relapse
Bloodline Pelgeroid neutrophil, progranulocyte, AML in

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One Neutrophil with a very dense non-segmented nucleus (Pelgeroid), a blast with a few large azurophilic granules at
top right and a Progranulocyte at lower left. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Pelgeroid neutrophil, progranulocyte, AML in relapse

Bloodline Progranulocytes, acute megakaryocytic

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leukemia in relapse
Four immature cells. The high nuclear/cytoplasmic ratio, chromatin distribution, nucleoli, and coarse cytoplasmic
granulation indicate they are progranulocytes. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Pelgeroid eutrophil, Megakaryocyte, Megakaryocytic Leukemia
Bloodline Pelgeroid eutrophil, Megakaryocyte,

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Megakaryocytic Leukemia
One Neutrophil with a dense non-segmented nucleus (Pelgeroid), 1 huge Cytoplasmic Fragment from a
Megakaryocyte, and 1 neutrophilic myelocyte. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Pelgeroid eutrophil, Megakaryocyte, Megakaryocytic Leukemia

Young Basophil, neutrophilic myelocyte, M-7 leukemia
Bloodline Young Basophil, neutrophilic myelocyte, M-7

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leukemia
One Young Basophil at left edge, 1 neutrophilic myelocyte at top right and 1 blast containing a few azurophilic
granules. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood 100X
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Young Basophil, neutrophilic myelocyte, M-7 leukemia

Abnormal agranular megathrombocytes, megakaryocytic leukemia
Bloodline Abnormal agranular megathrombocytes,

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megakaryocytic leukemia
One probable blast at top left, 1 neutrophilic myelocyte at lower edge, and another partial neutrophilic myelocyte at
lower left corner, 2 abnormal agranular Megathrombocytes (one large, one normal size) at left center, 1 normal
megathrombocyte at top right. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Abnormal agranular megathrombocytes, megakaryocytic leukemia

Abnormal late neutrophils, colorless cytoplasm, M-7 leukemia
Bloodline Abnormal late neutrophils, colorless cytoplasm,

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M-7 leukemia
Four Abnormal Late neutrophils. Top left frame: 5 lobed neutrophil with very dense chromatin and nuclear stick
projections. Its cytoplasm is vacuolated. Top right frame: Segmented neutrophil with very dense cytoplasm and
Colorless Cytoplasm. Lower left frame: Segmented neutrophil with a very dense chromatin Lower right frame: Non-
segmented late neutrophil with very dense chromatin and colorless cytoplasm. Acute Megakaryocytic Leukemia (M-7)
Image Atlas in relapse. Blood - 100X
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Abnormal late neutrophils, colorless cytoplasm, M-7 leukemia

Abnormal late neutrophils, Pelgeroid, M-7 leukemia
Bloodline Abnormal late neutrophils, Pelgeroid, M-7

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leukemia
Four Abnormal Late Neutrophils Top left frame: Segmented neutrophil with dense nuclear chromatin Other frames:
Non-segmented late neutrophils with very dense nuclear chromatin (Pelgeroid). Acute Megakaryocytic Leukemia (M-
7) in relapse. Blood - 100X
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Abnormal late neutrophils, Pelgeroid, M-7 leukemia

Pelgeroid neutrophil, blasts, M-7 leukemia
Bloodline Pelgeroid neutrophil, blasts, M-7 leukemia

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About Top left frame: Acquired Pelger Huet (Pelgeroid) type of neutrophil with only two nuclear lobes. Cytoplasm contains
multiple azurophilic granules and vacuoles. Lower left frame: Abnormal Late Neutrophil with a very high nuclear/
cytoplasmic ratio, very dense nuclear chromatin and an irregularly outlined nucleus. Right frame: 2 Blasts, 1
abnormal late neutrophil with a high nuclear/cytoplasmic ratio, and very dense nuclear chromatin in a non-
segmented nucleus. The cytoplasm shows heavy localized granulation. Acute Megakaryocytic Leukemia (M-7) in
Educational Features relapse. Blood - 100X
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Pelgeroid neutrophil, blasts, M-7 leukemia

Blast, progranulocyte, M-7 leukemia
Bloodline Blast, progranulocyte, M-7 leukemia

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About Top left frame: 1 Blast with plentiful cytoplasm and prominent nucleoli Top right frame: Similar cell but shows
multiple azurophilic granules Lower left frame: Blast with several huge azurophilic granules which have a colorless
center Lower right frame: Progranulocyte with multiple azurophilic granules Acute Megakaryocytic Leukemia (M-7) in
relapse. Blood - 100X
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Blast, progranulocyte, M-7 leukemia

Progranulocytes, neutrophilic myelocyte, M-7 leukemia
Bloodline Progranulocytes, neutrophilic myelocyte, M-7

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leukemia
Top frame: 1 early progranulocyte with numerous azurophilic granules on left side, 1 late progranulocyte with
multiple azurophilic granules on right side. Some of the granules are very large and colorless in their center. Both
Progranulocytes show very large prominent nucleoli. Lower left frame: 1 progranulocyte with numerous azurophilic
granules, some of which are very large and colorless in their center. Lower right frame: A neutrophilic myelocyte
Image Atlas showing no azurophilic granules on the left, a neutrophilic myelocyte showing numerous small azurophilic granules in
Case Studies the center, a Neutrophilic Myelocyte with a Double Nucleus and showing no azurophilic granules on the right. Acute
Megakaryocytic Leukemia (M-7) in relapse. Blood 100X
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Progranulocytes, neutrophilic myelocyte, M-7 leukemia

Abnormal megakaryoblasts, myelocytes, M-7 leukemia
Bloodline Abnormal megakaryoblasts, myelocytes, M-7

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leukemia
Left frames: 1 promyelocyte in each frame. The nuclei in each appear to be blastic but the cytoplasm shows
numerous azurophilic granules. Perhaps they are Abnormal Megakaryoblasts. Center frame: 2 abnormal intermediate
neutrophils (myelocytes); the lower cell shows a small lobe fragmented from the large nuclear mass. Right frame: 3
neutrophilic myelocytes. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Abnormal megakaryoblasts, myelocytes, M-7 leukemia

Abnormal megathrombocyte, M-7 leukemia
Bloodline Abnormal megathrombocyte, M-7 leukemia

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About Top left frame: 1 Abnormal Megathrombocyte with centralized hypergranulation. Top right frame: bare
megakaryocyte nucleus. Lower left frame: 1 large Abnormal Megathrombocyte and 1 smaller form. Both are
agranular. Lower right frame: 1 Abnormal Megathrombocyte which is huge; agranular and irregular in shape. Acute
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Abnormal megathrombocyte, M-7 leukemia

Peroxidase and Wright's-Giemsa stains, M-7 leukemia
Bloodline Peroxidase and Wright's-Giemsa stains, M-7

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leukemia
Four negative blasts and/or early cells. Two positive cells (multiple coarse black granules); the lower one appearing
to be an early cell. Peroxidase stain plus Wright‚s-Giemsa counterstain. Acute Megakaryocytic Leukemia (M-7) in
relapse. Blood - 100X
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Peroxidase and Wright's-Giemsa stains, M-7 leukemia

Peroxidase and Wright's-Giemsa stains, M-7 leukemia blood

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leukemia blood
Five negative early-to-intermediate stage cells and two positive (multiple coarse black granules) cells. Both positive
cells appear to be early cells. Peroxidase stain plus Wright's-Giemsa counterstain. Acute Megakaryocytic Leukemia (M-
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leukemia blood
Four negative cells; two of which show large azurophlic granules with colorless center. One positive metamyelocyte
lies at the lower left corner. Peroxidase stain plus Wright's-Giemsa counterstain. Acute Megakaryocytic Leukemia (M-
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Blasts, peroxidase stain, M-7 leukemia blood
Bloodline Blasts, peroxidase stain, M-7 leukemia blood

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About Five negative cells, all of which appear to be Blasts. Two positive cells, one containing a fine sprinkling of black
granules and the other one is very positive similar to progranulocytes and myelocytes. Peroxidase stain with no
counterstain. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Blasts, peroxidase stain, M-7 leukemia blood


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leukemia blood
Left frame: negative cells. Peroxidase stain with no counterstain Right frame: 4 negative and 1 positive cell.
Peroxidase stain plus Wright's-Giemsa counterstain. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Late neutrophil, platelet, PAS stain, M-7 leukemia
Bloodline Late neutrophil, platelet, PAS stain, M-7

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leukemia
One positive late neutrophil and 3 positive (multiple red granules) early cells and one positive platelet. Periodic Acid
Schiff (PAS) stain. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Late neutrophil, platelet, PAS stain, M-7 leukemia

Neutrophils, PAS stain, ds, ds18, ds19, bd
Bloodline Neutrophils, PAS stain, ds, ds18, ds19, bd

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About A clump of early cells, most of which show fine/medium size red granules, and 3 very positive neutrophils are in the
field. Periodic acid Schiff (PAS) stain. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Neutrophils, PAS stain, ds, ds18, ds19, bd

Peroxidase stain, M-7 leukemia blood
Bloodline Peroxidase stain, M-7 leukemia blood

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About Left frame: 2 PAS positive and 3 PAS negative cells. Right frame: One Peroxidase positive and three peroxidase
negative cells. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Peroxidase stain, M-7 leukemia blood

Blast, transmission electron micrograph, M-7 leukemia
Bloodline Blast, transmission electron micrograph, M-7

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leukemia
One Blast showing a very high nuclear/cytoplasmic ratio, primitive chromatin with little dense or heterochromatin
clumping, a large nucleolus, and a few scattered primary granules. Transmission electron micrograph (TEM). Acute
Megakaryocytic Leukemia (M-7) in relapse. Blood
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Blast, transmission electron micrograph, M-7 leukemia

Transmission electron micrograph, M-7 leukemia in relapse
Bloodline Transmission electron micrograph, M-7

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leukemia in relapse
A later cell than in the last image. It has more heterochromatin development in the nucleus but very little cytoplasmic
granulation. Transmission electron micrograph (TEM). Acute Megakaryocytic Leukemia (M-7) in relapse. Blood
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Transmission electron micrograph, M-7 leukemia in relapse

Abnormal megathrombocytes and platelets, TEM, M-7 leukemia
Bloodline Abnormal megathrombocytes and platelets,

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TEM, M-7 leukemia
Abnormal Megathrombocytes and Platelets. Transmission electron micrograph (TEM). Acute Megakaryocytic Leukemia
(M-7) in relapse. Buffy coat. Blood
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Abnormal megathrombocytes and platelets, TEM, M-7 leukemia

Von Willebrand antibody plus fluorescein stain, M-7 leukemia
Bloodline Von Willebrand antibody plus fluorescein stain,

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M-7 leukemia
Two positive cells and several positive platelets (fine black granulation) and several negative cells. Von Willebrand
antibody plus fluorescein stain. Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Home
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M-7 leukemia
Three positive and several negative cells (fine, black granulation). Von Willebrand antibody plus fluorescein stain.
Acute Megakaryocytic Leukemia (M-7) in relapse. Blood - 100X
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Platelets, Von Willebrand antibody, M-7 leukemia
Bloodline Platelets, Von Willebrand antibody, M-7

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leukemia
Three positive (scattered black granules) and several negative cells. One clump of five positive platelets and another
positive platelet. Von Willebrand antibody plus fluorescein stain. Acute Megakaryocytic Leukemia (M-7) in relapse.
Blood - 100X
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Home
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M-7 leukemia
Three positive cells (scattered and heavy black granulation). Von Willebrand antibody plus fluorescein stain. Acute
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Bloodline Platelets, Von Willebrand antibody, M-7

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leukemia
Five positive cells and a clump of positive platelets. Von Willebrand antibody plus fluorescein stain. Acute
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Late NRBC, Mature Lymphocyte, AML
Bloodline Late NRBC, Mature Lymphocyte, AML

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About One Late NRBC at upper left and one Mature Lymphocyte at lower right. Many platelets are scattered throughout the
field. An Abnormal Megathrombocyte, which is huge, irregular in shape and agranular, is at the left center. Acute
Megakaryocytic Leukemia (M-7) untreated. Blood - 50X
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Late NRBC, Mature Lymphocyte, AML

Basophil, AML
Bloodline Basophil, AML

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About One partially disrupted early Basophil with coarse black granules. An agranular megathrombocyte lies at its left.
Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Basophil, AML

Bare Nucleus, Megakaryocyte, Blast, AML
Bloodline Bare Nucleus, Megakaryocyte, Blast, AML

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About Top frame: One Bare Nucleus of a Megakaryocyte, one mature neutrophil, one megathrombocyte, several platelets.
Lower frame: One lymphocyte at left edge and one Blast at right edge. Acute Megakaryocytic Leukemia (M-7)
untreated. Blood -100X
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Bare Nucleus, Megakaryocyte, Blast, AML

Bare Nuclei, Megakaryocytes, Blast, AML
Bloodline Bare Nuclei, Megakaryocytes, Blast, AML

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About Top left and right frames: Bare Nuclei from Megakaryocytes. Lower left frame: One Blast. Lower right frame: One
blast or bare nucleus from a megakaryocyte. It has more cytoplasm than a "bare nucleus" but the nuclear chromatin
is denser than the blast. Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Bare Nuclei, Megakaryocytes, Blast, AML

Blast, Late NRBC, Progranulocyte, Basophil, AML
Bloodline Blast, Late NRBC, Progranulocyte, Basophil,

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AML
Top left frame: One Blast. Top right frame: One Late NRBC. Lower left frame: One Progranulocyte. Lower right
frame: One Basophil. Acute Megakaryocytic Leukemia (M-7) untreated. Blood ˆ 100X
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Blast, Late NRBC, Progranulocyte, Basophil, AML

Late NRBC, Basophil, Megakaryocyte, Blast, AML
Bloodline Late NRBC, Basophil, Megakaryocyte, Blast, AML

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About Top left frame: One Late NRBC. Top right frame: One mature Basophil with some of its granules washed out. Lower
left frame: One Bare Nucleus from a Megakaryocyte. Lower right frame: One Blast. Acute Megakaryocytic Leukemia
(M-7) untreated. Blood - 100X
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Late NRBC, Basophil, Megakaryocyte, Blast, AML

Monocyte, Bare Nucleus, Megakaryocyte, AML
Bloodline Monocyte, Bare Nucleus, Megakaryocyte, AML

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About Top left frame: One cell (? Monocyte) with an engulfed piece of nuclear material. Top right frame: One Bare Nucleus
from a Megakaryocyte. Lower left frame: One Promyelocyte. Lower right frame: One Blast on the left, 1 Bare
Megakaryocyte nucleus with some attached platelets and a megathrombocyte. Acute Megakaryocytic Leukemia (M-7)
untreated. Blood -100X
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Monocyte, Bare Nucleus, Megakaryocyte, AML

Blasts, AML
Bloodline Blasts, AML

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About Many Blasts and late neutrophils. Tail area on blood smear. Acute Megakaryocytic Leukemia (M-7) untreated. Blood -
100X
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Blasts, AML

Blasts, Megakaryocyte nucleus, AML
Bloodline Blasts, Megakaryocyte nucleus, AML

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About Blasts in all frames except lower right which contains a mature Megakaryocyte nucleus with some residual cytoplasm.
Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Blasts, Megakaryocyte nucleus, AML

Platelets, Glycoprotein IIbIIIa stain, AML
Bloodline Platelets, Glycoprotein IIbIIIa stain, AML

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About One blast with many positive orange-brown granules, and many positive platelets. Glycoprotein IIbIIIa stain. Acute
Megakaryocytic leukemia (M-7) untreated. Blood - 100X
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Platelets, Glycoprotein IIbIIIa stain, AML

Blast, Glycoprotein IIbIIIa stain, AML
Bloodline Blast, Glycoprotein IIbIIIa stain, AML

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About Two negative late neutrophils, one very positive (orange-brown granules) Blast and several positive platelets.
Glycoprotein IIbIIIa stain. Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Blast, Glycoprotein IIbIIIa stain, AML

Blasts, Platelets, AML
Bloodline Blasts, Platelets, AML

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About Positive Blasts and Platelets. Von Willebrand antibody immunofluorescent stain. Acute Megakaryocytic Leukemia (M-
7) untreated. Blood
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Blasts, Platelets, AML

Blasts, AML

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About Two Blasts (center and lower right), two small lymphs, one highly vacuolated cell, one smudge cell and several
platelets; some of which are agranular. Child with Down's syndrome and Acute Megakaryocytic Leukemia (M-7)
untreated. Blood - 50X
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Blasts, AML

Megathrombocytes, Blast, AML
Bloodline Megathrombocytes, Blast, AML

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About Top frame (left to right): Several Megathrombocytes, 1 lymphocyte, 2 late neutrophils, 1 bare megakaryocyte
nucleus and 1 probable blast (right side). Lower frame (left to right): 1 Blast, 1 highly vacuolated cell, 1 blast, 1
lymph, 1 smudge cell. Child with Down's syndrome and Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 50X
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Megathrombocytes, Blast, AML

Bare nucleus, AML
Bloodline Bare nucleus, AML

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About One late neutrophil, 1 bare nucleus (? megakaryocytic), several platelets, some of which are agranular. Child with
Down‚s syndrome and Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Bare nucleus, AML

Blasts, AML

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About Two Blasts, 1 late neutrophil, 1 agranular megathrombocyte, and several agranular platelets. Child with Down's
syndrome and Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Blasts, AML

Blast, AML
Bloodline Blast, AML

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About One Blast in each frame. Child with Down's syndrome and Acute Megakaryocytic Leukemia (M-7) untreated. Blood -
100X
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Blast, AML

Blast, Megathrombocyte, AML
Bloodline Blast, Megathrombocyte, AML

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About Top left frame: 1 Blast and 1 Megathrombocyte. Lower left frame: 1 blast. Right frame: 1 late neutrophil and 1 bare
nucleus. Child with Down's syndrome and Acute Megakaryocytic Leukemia (M-7) untreated. Blood - 100X
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Blast, Megathrombocyte, AML

Normal Platelets, Normal EDTA anticoagulated blood
Bloodline Normal Platelets, Normal EDTA anticoagulated

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blood
Normal Platelets scattered throughout the field. Note one within the halo (biconcave) area of a red cell at top right.
The normal average number of platelets in a proper field ranges from 8 to 15. In EDTA anticoagulated samples they
are more evenly distributed, are usually rounded up and may be slightly swollen and/or slightly degranulated. One
segmented neutrophil. Normocytic, normochromic RBC. Normal EDTA anticoagulated blood - 100X
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Image ID: 0144-064
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Normal Platelets, Normal EDTA anticoagulated blood

Normal Platelets , Normal EDTA anticoagulated blood
Bloodline Normal Platelets , Normal EDTA anticoagulated

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blood
Normal Platelets scattered throughout the field. The normal average number of platelets in a proper field ranges from
8 to 15. In EDTA anticoagulated samples they are more evenly distributed, are usually rounded up and may be
slightly swollen and/or slightly degranulated. One small mature lymphocyte. Normal RBC. Normal EDTA
anticoagulated blood - 100X
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Normal Platelets , Normal EDTA anticoagulated blood

Normal Platelets , Proper Thickness, Field to Examine
Bloodline Normal Platelets , Proper Thickness, Field to

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Examine
Normal Platelets scattered throughout the field. There are slightly fewer than in the previous fields, but within normal
numbers. This is a Proper Thickness of a Field to Examine, where the red cells are just touching each other or barely
overlapping. Count the number of platelets in at least 10 similar fields and figure the average number per field to
derive a platelet estimate. The Red Cells are Normocytic, Normochromic. The white cell is a Normal Mature
Image Atlas Neutrophil. Normal blood - 100X.
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Normal Platelets, Normocytic, normochromic RBC, Normal EDTA
Bloodline Normal Platelets, Normocytic, normochromic

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RBC, Normal EDTA
Normal Platelets in number and morphology. Normocytic, normochromic RBC. Normal EDTA anticoagulated blood -
100X
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Platelets, Thrombocytopenia, Normal RBC, EDTA
Bloodline Platelets, Thrombocytopenia, Normal RBC, EDTA

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About Fewer Platelets than in previous fields. If all fields were similar the platelet estimate would be low and consistent with
Thrombocytopenia. One mature neutrophil. Normal RBC. EDTA anticoagulated blood - 100X
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Clump of Platelets, Normal Capillary blood
Bloodline Clump of Platelets, Normal Capillary blood

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About Small Clump of Platelets on a capillary blood smear. There is one large fully granulated platelet and several normal
size fragments. On a capillary blood smear the platelets have the tendency to clump, retain granules and show an
irregular shape. Normal Capillary blood - 100X
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Clump of Platelets, Normal Capillary blood

Clumps of Platelets, Thrombocytosis, Capillary blood
Bloodline Clumps of Platelets, Thrombocytosis, Capillary

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blood
Many small Clumps of Platelets. They are all small fragment forms. Two mature neutrophils. Red cells have increased
poikilocytosis. Thrombocytosis. Capillary blood smear - 100X
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Clump of Platelets, Thrombocytosis, Capillary blood
Bloodline Clump of Platelets, Thrombocytosis, Capillary

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blood
A large Clump of Platelets. They are all small, normal appearing fragments. Thrombocytosis. Capillary blood - 100X
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Bloodline Clumps of Platelets, Thrombocytosis, Capillary

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blood
One large and two small Clumps of Platelets. They are normal, small fragments. Thrombocytosis. Capillary blood -
100X
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Platelet Ribbon, Normal blood
Bloodline Platelet Ribbon, Normal blood

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About A string of platelets or Platelet Ribbon. This is the appearance of normal platelets when being shed by a
megakaryocyte into the marrow sinus. The ribbon then breaks up into numerous small platelet fragments. Normal
blood - 100X
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Small Platelets, Megathrombocyte, Band Neutrophil
Bloodline Small Platelets, Megathrombocyte, Band

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Neutrophil
Ten small Platelets which are round and slightly swollen, 3 larger platelets and 1 Megathrombocyte. A normal Band
Neutrophil is in the field. Normal EDTA anticoagulated blood - 100X
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Small Platelets, Megathrombocyte, Platelets Overlying RBC
Bloodline Small Platelets, Megathrombocyte, Platelets

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Overlying RBC
Ten small Platelets, 5 larger forms, and a Megathrombocyte. All are normal in morphology. A megathrombocyte is
larger than half the size of a normocytic RBC. Note two Platelets Overlying Red Cells in the center of the field. They
are located in the biconcave area of a red cell. Normal EDTA anticoagulated blood - 100X
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Small Platelets, Megathrombocytes
Bloodline Small Platelets, Megathrombocytes

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About Three small Platelets, several large platelets and 4 Megathrombocytes. All are of normal morphology. One large
Platelet Overlies a Red Cell at top right. Normal EDTA anticoagulated blood - 100X
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Platelets, Normal EDTA anticoagulated blood
Bloodline Platelets, Normal EDTA anticoagulated blood

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About Seven small Platelets, 2 large platelets and 2 megathrombocytes. A large granular lymphocyte (LGL) is at top left.
Normal EDTA anticoagulated blood - 100X
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Platelets, Megathrombocyte, EDTA anticoagulated blood
Bloodline Platelets, Megathrombocyte, EDTA

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anticoagulated blood
Two small Platelets, 1 large platelet and 1 Megathrombocyte. Normal EDTA anticoagulated blood - 100X
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Platelet, Megathrombocyte, Mature, ITP
Bloodline Platelet, Megathrombocyte, Mature, ITP

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About Left frame: 1 small Platelet, 1 Megathrombocyte and 1 Mature Neutrophil Center frame: 1 large Platelet Overlying a
RBC and a megathrombocyte. Right frame: One huge megathrombocyte which is rounded and has most of its
granules centralized. Idiopathic thrombocytopenic purpura in recovery. Blood - 100X
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Platelet, Megathrombocyte, Mature, ITP

Megathrombocyte, Normal capillary blood smear
Bloodline Megathrombocyte, Normal capillary blood

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smear
One giant platelet (Megathrombocyte) of elongated shape on a capillary blood smear. If this were EDTA
anticoagulated blood, this megathrombocyte would be round in shape as would the 3 small platelets. Normal capillary
blood smear - 100X
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Abnormal megathrombocytes, Capillary blood, MDS
Bloodline Abnormal megathrombocytes, Capillary blood,

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MDS
Left frame: Abnormally large elongated megathrombocyte and 1 mature neutrophil. Center frame: 1 Abnormal
shaped megathrombocyte and 1 band neutrophil. Right frame: Clump of small platelets and one huge elongated
megathrombocyte. Capillary blood from patient with Myelodysplastic Syndrome (MDS) - 100X
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Platelet overlying a red cell, Megathrombocyte, MDS
Bloodline Platelet overlying a red cell, Megathrombocyte,

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MDS
Left frame: 1 mature neutrophil, several small platelets; one Platelet overlying a red cell, and one large platelet
attached to three small ones. Center frame: 1 small platelet and 1 elongated megathrombocyte. Right frame: 1 very
large oval shaped Megathrombocyte; 3 normal platelets. Capillary blood from a patient with Myelodysplastic
Syndrome (MDS) - 100X
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Megathrombocyte, EDTA anticoagulated blood, ET
Bloodline Megathrombocyte, EDTA anticoagulated blood,

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ET
Left frame: Numerous small and large platelets and 1 large megathrombocyte. All are round in shape, swollen in size
and partially agranular - common changes in EDTA anticoagulated blood. Right frame: Many small and large platelets
and two megathrombocytes; one of which is elliptical shape. Note the heavy granulation in the platelets and
megathrombocytes in this capillary blood smear. Essential Thrombocytosis EDTA and capillary blood samples on the
Image Atlas same patient -100X
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Colorless Platelets, Gray Platelet syndrome blood
Bloodline Colorless Platelets, Gray Platelet syndrome

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blood
Eight Colorless Platelets and one with a few granules. Gray Platelet syndrome blood - 100X
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Colorless Platelets, Gray Platelet syndrome blood

Colorless Platelets, Gray Platelet Syndrome blood
Bloodline Colorless Platelets, Gray Platelet Syndrome

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blood
Five Colorless Platelets; 2 of which are enlarged. Gray Platelet Syndrome blood - 100X
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Colorless Platelets, Gray Platelet Syndrome blood

Platelet , Mature Neutrophil, (PAS) stain
Bloodline Platelet , Mature Neutrophil, (PAS) stain

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About One positive (red staining) large Platelet (left center) and 1 positive Mature Neutrophil. Periodic acid Schiff (PAS)
stain. Gray Platelet Syndrome blood - 100X
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Platelet , Mature Neutrophil, (PAS) stain

Cytoplasmic Fragments, Leukemic Monocytes, Platelets, M-5
Bloodline Cytoplasmic Fragments, Leukemic Monocytes,

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Platelets, M-5
Cytoplasmic Fragments from Leukemic Monocytes that resemble Platelets. Two fragments (top right and lower left)
are probably valid platelets. Seven immature monocytes. Acute Monocytic Leukemia (M-5). Blood -100X
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Cytoplasmic Fragments, Leukemic Monocytes, Platelets, M-5

Immature Monocytes, cytoplasmic fragmentation, M-5
Bloodline Immature Monocytes, cytoplasmic

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fragmentation, M-5
Two Immature Monocytes, one of which shows cytoplasmic fragmentation. These fragments resemble Platelets and
may be erroneously counted as such. The two fragments to the right of the monocytes may be real platelets. Acute
Monocytic Leukemia ( M-5). Blood - 100X
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Immature Monocytes, cytoplasmic fragmentation, M-5

Immature Monocytes, Cytoplasmic Fragments, M-5 leukemia
Bloodline Immature Monocytes, Cytoplasmic Fragments,

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M-5 leukemia
Four Immature Monocytes. Two of the cells are shedding large Cytoplasmic Fragments which can resemble a
Megathrombocyte and/or Platelets. Acute Monocytic Leukemia (M-5). Blood - 100X
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Immature Monocytes, Cytoplasmic Fragments, M-5 leukemia

Immature Monocytes, Megakaryocyte Nucleus, M-5
Bloodline Immature Monocytes, Megakaryocyte Nucleus,

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M-5
Three Immature Monocytes, 1 bare Megakaryocyte Nucleus with an attached Platelet, 1 large Clump of Platelets,
many small individual platelets, a few Cytoplasmic Fragments and one large rounded mass of cytoplasm which
resembles the monocytic cytoplasm more than the platelet clump. The monocyte on the right seems to be shedding
its cytoplasm as fragments. Acute Monocytic Leukemia (M-5). Blood - 100X
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Immature Monocytes, Megakaryocyte Nucleus, M-5

Neutrophils surrounded by platelets, Platelet Satellitism
Bloodline Neutrophils surrounded by platelets, Platelet

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Satellitism
Two lymphocytes, 1 monocyte, 3 mature neutrophils. The Neutrophils are surrounded by platelets but the other cells
are not affected. There are only a few isolated platelets. This rare phenomenon occurs only in EDTA anticoagulated
blood of some individuals who have no clinically associated disorder. The resemblance to a satellite is the origin of
the term Platelet Satellitism. EDTA blood - 50X
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Neutrophil Surrounded by Platelets, Platelet Satellitism
Bloodline Neutrophil Surrounded by Platelets, Platelet

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Satellitism
One eosinophil which is not affected and one Mature Neutrophil Surrounded by Platelets. There are no isolated
platelets in the field. Platelet counts will be erroneously low in these samples. Platelet Satellitism. EDTA blood - 100X
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Neutrophil Surrounded by Platelets, Platelet Satellitism

Late Neutrophil Surrounded - Platelets, Platelet Satellitism
Bloodline Late Neutrophil Surrounded - Platelets, Platelet

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Satellitism
A single Late Neutrophil Surrounded by Platelets. There are a few isolated platelets in the field. Two larger fragments
at upper right may be artifacts. Platelet Satellitism. EDTA blood - 100X
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Late Neutrophil Surrounded - Platelets, Platelet Satellitism


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Satellitism
One unaffected lymphocyte and three Neutrophils surrounded by platelets. Platelet Satellitism. EDTA blood - 100X
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Mature Neutrophils surrounded by Platelets, Satellitism
Bloodline Mature Neutrophils surrounded by Platelets,

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Satellitism
One unaffected lymphocyte, two Mature Neutrophils surrounded by Platelets. Note the tendency of the affected
neutrophils to adhere to each other. Platelet Satellitism. EDTA blood - 100X
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Mature Neutrophils surrounded by Platelets, Satellitism

Mature Neutrophils, Platelet Satellitism
Bloodline Mature Neutrophils, Platelet Satellitism

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About One huge clump of nine Mature Neutrophils, each of which is surrounded by platelets. It is probably the stickiness of
the platelets for each other that enhances this clumping. The white cell count may be erroneously low in such cases.
Platelet Satellitism. EDTA blood - 100X
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Mature Neutrophils, Platelet Satellitism


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Satellitism
Thirteen mature Neutrophils in a clump along the side edge of the blood smear. Each is surrounded by platelets.
Larger cells and clumps of cells are more likely to aggregate in peripheral areas (side and tail edges) than in the body
of the smear. Platelet Satellitism. EDTA blood - 100X
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Monocyte, engulfed platelets, Platelet Satellitism
Bloodline Monocyte, engulfed platelets, Platelet

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Satellitism
One monocyte with several engulfed platelets. Platelet Satellitism. EDTA blood - 100X
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Monocyte, engulfed platelets, Platelet Satellitism

Platelet Satellitism
Bloodline Platelet Satellitism

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About Mature, band and myelocyte stage neutrophils, several late NRBC and lymphocytes. The neutrophils are not
surrounded by platelets. Child with Platelet Satellitism. Non-EDTA anticoagulated marrow smear - 50X
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Neutrophils, platelet satellitism, marrow
Bloodline Neutrophils, platelet satellitism, marrow

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About Many Late Neutrophils surrounded by Platelets. The earlier neutrophils, NRBC and lymphocytes are unaffected. Same
marrow sample as the previous image which has been anticoagulated with EDTA. Child with Platelet Satellitism.
Marrow aspirate - 50X
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Bloodline Neutrophils, platelet satellitism, marrow

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About Many Late Neutrophils surrounded by Platelets. The earlier neutrophils, NRBC and lymphocytes are unaffected. This
marrow sample has been anticoagulated with EDTA. Child with Platelet Satellitism. Marrow aspirate - 50X
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Bloodline Platelet Satellitism

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About Left frame: Several mature neutrophils surrounded by platelets. Band and earlier neutrophils are not affected. This is
a marrow aspirate sample to which EDTA has been added.
Right frame: 4 mature neutrophils, several immature neutrophils and NRBC which show no platelet adherence. This is
a marrow smear made at the bedside with no anticoagulant added. Child with Platelet Satellitism. Marrow - 50X
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Hematology News
or other purpose. Carden Jennings Publishing Co., Ltd., assumes no responsibility for any use or
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Platelet clumping in EDTA anticoagulated blood
Bloodline Platelet clumping in EDTA anticoagulated blood

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About Five small Clumps of Platelets. There are few isolated platelets. This phenomenon of platelet clumping in an EDTA
anticoagulated blood sample is a rare occurrence but will be consistent in some patients. The platelet count will be
erroneously low. Platelet Clumping in EDTA anticoagulated blood - 50X
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Bloodline Platelet clumping in EDTA anticoagulated blood

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About Three large Clumps of Platelets in EDTA anticoagulated blood. This is a different patient than the previous image and
every sample showed this phenomenon. Platelet Clumping in EDTA anticoagulated blood - 100X
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Reactive lymphocytes, Hepatitis blood
Bloodline Reactive lymphocytes, Hepatitis blood

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About One mature neutrophil, 1 small lymphocyte with a distorted shape, 5 Reactive Lymphocytes. The reactive
lymphocytes are medium-to-large in size, show plentiful gray-blue (basophilic) color at the cell's periphery, an
irregular shaped nucleus with a semi-dense chromatin. These features indicate they are lymphoid cells and their
heterogeneity is consistent with reactivity. Hepatitis blood - 50X
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Reactive lymphocytes, Hepatitis blood

Reactive, plasmacytoid, basophilic, reticular lymphocytes
Bloodline Reactive, plasmacytoid, basophilic, reticular

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lymphocytes
Top left frame: A Reactive Lymphocyte showing medium-large size, generous blue cytoplasm, irregular shaped cell
outline and nucleus, semi-dense nuclear chromatin.
Lower left frame: A Plasmacytoid Lymphocyte of large size, abundant basophilic cytoplasm which contains several
vacuoles, and coarse nuclear chromatin. They are called Plasmacytoid lymphocytes because of their similarity to
Image Atlas plasma cells in cytoplasmic color and nuclear density. They have also been termed Basophilic Lymphocytes due to
Case Studies their cytoplasmic color or Reticular Lymphocyte due to their coarse reticular nuclear pattern. The term Turk Cell has
also been used. They are lymphocytes that have been stimulated and are in transition to plasma cells.
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Right frame: 1 small Plasmacytoid Lymphocyte with very basophilic blue cytoplasm and a dense nuclear chromatin. It
Conference Reviews resembles a plasma cell in these two features. One late neutrophil with only two lobes. Chicken pox blood - 100X
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Reactive, plasmacytoid, basophilic, reticular lymphocytes

Plasmacytoid lymphocytes, viral infection blood
Bloodline Plasmacytoid lymphocytes, viral infection blood

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About Top left frame: A Plasmacytoid Lymphocyte with basophilic blue cytoplasm and a contorted shaped nucleus with
coarse chromatin.
Top right frame: A Plasmacytoid Lymphocyte showing some plasma cell features. The abundant cytoplasm is
basophilic blue with a light area (Golgi body) adjacent to the nucleus which contains a coarse chromatin.
Lower frame: 2 Plasmacytoid Lymphocytes; one of which has a very distorted shape. Viral infection blood - 100X
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Plasmacytoid lymphocytes, viral infection blood

Monocyte, plasmacytoid lymphocyte, LGL, viral infection
Bloodline Monocyte, plasmacytoid lymphocyte, LGL, viral

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infection
Top left frame: Monocyte with an irregular outline, gray cytoplasm containing a few azurophilic granules and
vacuoles, and a nucleus with an open or lacy chromatin distribution.
Lower left frame: 1 Plasmacytoid Lymphocyte. Compare its basophilic cytoplasm with the pale gray cytoplasm of the
monocyte in the top left frame and its coarse chromatin with that in the monocyte.
Image Atlas Right frame: A partially distorted lymphocyte which contains several large azurophilic granules. It is a Large Granular
Case Studies Lymphocyte (LGL). Below it is a large cell that could be a monocyte or reactive lymphocyte. The cytoplasm is
colorless except at the periphery; a common feature of reactive lymphocytes. The evenly distributed nuclear
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chromatin is slightly more dense than usual in monocytes but less dense than in reactive lymphocytes. Viral infection
Conference Reviews blood - 100X
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Monocyte, plasmacytoid lymphocyte, LGL, viral infection

Reactive lymphocytes, viral infection blood
Bloodline Reactive lymphocytes, viral infection blood

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About Reactive Lymphocytes in each frame. All are large in size, has a generous amount of basophilic blue cytoplasm, a
semi-dense nuclear chromatin in an irregular shaped nucleus. There is a mature neutrophil in the lower left frame.
Viral infection blood - 100X
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Reactive lymphocytes, viral infection blood

Reactive lymphocyte, viral infection blood
Bloodline Reactive lymphocyte, viral infection blood

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About A Reactive Lymphocyte in each frame. Reactive lymphocytes are medium-to-large in size and show much more
cytoplasm than usual lymphocytes. The cell outline may or may not be irregular. Cytoplasmic color is gray or gray-
blue, frequently showing increased basophilic color at the periphery. Vacuoles and/or azurophilic granules may be
present. The nucleus is frequently irregular (oval, elliptical, triangular, indented, overlapping) in shape. Chromatin
often is less dense and/or more evenly distributed than in the usual lymphocyte. A nucleolus may be seen. Viral
Educational Features infection blood - 100X
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Bloodline Reactive lymphocyte, viral infection blood

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About One Reactive Lymphocyte at top right. The cell at lower left may be a monocyte as suggested by its contorted nuclear
shape and gray cytoplasm containing small azurophilic granules. Viral infection blood - 100X
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Cytomegalovirus infection blood
Bloodline Cytomegalovirus infection blood

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About One small mature lymphocyte and 4 Reactive Lymphocytes. The reactive lymphocytes show size variation, increased
cytoplasm in most, peripheral basophilia in some and nuclear shape distortion. Cytomegalovirus infection blood - 50X
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Cytomegalovirus infection blood

Reactive lymphocyte, plasmacytoid, cytomegalovirus infection
Bloodline Reactive lymphocyte, plasmacytoid,

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cytomegalovirus infection
Two Reactive Lymphocytes and 1 Plasmacytoid lymphocyte. Cytomegalovirus infection blood - 50X
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Reactive lymphocyte, plasmacytoid, cytomegalovirus infection

Reactive lymphocytes, Cytomegalovirus infection blood
Bloodline Reactive lymphocytes, Cytomegalovirus

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infection blood
Two Reactive Lymphocytes seen at lower magnification in previous image. They are larger than the red cells, have
increased blueness in their cytoplasm, especially at the periphery, and one has an exaggerated indented nucleus.
Cytomegalovirus infection blood - 60X
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Reactive lymphocytes, Cytomegalovirus infection blood

Reactive, plasmacytoid lymphocytes, LGL, Cytomegalovirus
Bloodline Reactive, plasmacytoid lymphocytes, LGL,

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Cytomegalovirus
Three Reactive Lymphocytes in the top and lower left frames. One large granular lymphocyte in the lower left frame.
One Plasmacytoid Lymphocyte in lower right frame. Cytomegalovirus infection blood - 100X
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Reactive, plasmacytoid lymphocytes, LGL, Cytomegalovirus

Plasmacytoid lymphocyte
Bloodline Plasmacytoid lymphocyte

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About One Plasmacytoid Lymphocyte and 2 small mature lymphocytes. Normal blood - 100X
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Plasmacytoid lymphocyte

Plasmacytoid lymphocyte, renal infection blood
Bloodline Plasmacytoid lymphocyte, renal infection blood

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About One Plasmacytoid Lymphocyte. Renal infection blood - 100X
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Plasmacytoid lymphocyte, renal infection blood

Plasmacytoid Lymphocyte
Bloodline Plasmacytoid Lymphocyte

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About One Plasmacytoid Lymphocyte. Normal blood - 100X
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Plasmacytoid Lymphocyte

Plasmacytoid lymphocytes, viral infection
Bloodline Plasmacytoid lymphocytes, viral infection

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About Two Plasmacytoid Lymphocytes. Child with viral infection blood - 100X
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Plasmacytoid lymphocytes, viral infection

Plasmacytoid lymphocyte, Idiopathic thrombocytopenic purpura
Bloodline Plasmacytoid lymphocyte, Idiopathic

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thrombocytopenic purpura
One Plasmacytoid Lymphocyte. Idiopathic thrombocytopenic purpura (ITP) blood - 100X
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Plasmacytoid lymphocyte, Idiopathic thrombocytopenic purpura

Plasmacytoid lymphocytes, viral or bacterial infection
Bloodline Plasmacytoid lymphocytes, viral or bacterial

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infection
Plasmacytoid Lymphocytes in each frame. Variety of bloods - normal and viral or bacterial infection - 100X
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Plasmacytoid lymphocytes, drug reaction blood
Bloodline Plasmacytoid lymphocytes, drug reaction blood

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About Plasmacytoid Lymphocytes in each frame. Drug reaction blood - 100X
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Plasmacytoid lymphocytes, drug reaction blood

Bloodline Plasmacytoid lymphocytes, viral or bacterial

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infection
Plasmacytoid Lymphocytes in each frame. Variety of bloods - normal and viral and/or bacterial infection - 100X
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Reactive, plasmacytoid, viral infection blood
Bloodline Reactive, plasmacytoid, viral infection blood

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About Two Reactive, 1 Plasmacytoid and 1 small mature lymphocyte. Viral infection blood - 100X
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Reactive, plasmacytoid, viral infection blood

Plasmacytoid lymphs, infectious mononucleosis blood
Bloodline Plasmacytoid lymphs, infectious mononucleosis

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blood
One band neutrophil, 2 Plasmacytoid Lymphs which have a distorted shape. Infectious mononucleosis blood - 100X
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Plasmacytoid lymphs, infectious mononucleosis blood

Plasmacytoid lymphoid, infectious mononucleosis blood
Bloodline Plasmacytoid lymphoid, infectious

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mononucleosis blood
One small mature lymphocyte, 1 Plasmacytoid Lymphoid with a contorted nucleus. Infectious mononucleosis blood -
100X
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Plasmacytoid lymphoid, infectious mononucleosis blood

Plasma cell, alcoholic, liver disease
Bloodline Plasma cell, alcoholic, liver disease

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About One monocyte at left edge and one Plasma Cell at right edge. The plasma cell is medium in size, has an eccentrically
located nucleus which shows a dense chromatin with a few randomly located open areas. The abundant cytoplasm is
very basophilic blue, contains a few vacuoles and shows an almost colorless area (Golgi) adjacent to the nucleus.
Alcoholic with liver disease blood - 100X
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Plasma cell, alcoholic, liver disease

Plasma Cell, alcoholic, liver disease blood
Bloodline Plasma Cell, alcoholic, liver disease blood

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About One Plasma Cell with an eccentrically located nucleus and 2 lymphocytes with similar basophilic blue cytoplasm and
coarse nuclear chromatin. They may be small plasmacytoid lymphocytes. A mature neutrophil is also present.
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Home
About One Plasma Cell containing several vacuoles which represent stored immunoglobulin which does not stain with
Wright's-Giemsa. The red cells lack of central pallor is a preparation artifact seen in thin areas of a smear. The
platelets are slightly swollen due to this being an EDTA anticoagulated sample. Alcoholic with liver disease blood -
100X
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Home
About One Plasma Cell of medium size with an eccentrically located nucleus, basophilic cytoplasm, a colorless area (Golgi)
adjacent to the nucleus which has a dense chromatin with a few randomly located open areas. The red cells show no
central pallor because they have been spread out on the glass in this thin area of the smear. The platelet is swollen
from being in an EDTA anticoagulated sample. Alcoholic with liver disease blood - 100X
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Plasmacytoid, mature, plasma cell, alcoholic, liver disease
Bloodline Plasmacytoid, mature, plasma cell, alcoholic,

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liver disease
Left frame: 1 Mature Lymphocyte and 1 Plasmacytoid Lymphocyte.
Center frame: 1 Plasma cell
Right frame: 1 Plasmacytoid Lymph with a few vacuoles and 1 Mature Lymphocyte. Alcoholic with liver disease blood
- 100X
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Plasmacytoid, mature, plasma cell, alcoholic, liver disease

Plasmacytoid, plasma cell, alcoholic, liver disease blood
Bloodline Plasmacytoid, plasma cell, alcoholic, liver

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disease blood
Top left frame: 1 Plasmacytoid Lymphocyte with a convoluted nuclear shape.
Top right frame: 1 Plasma Cell with cytoplasmic color less blue than usual but does show a low nuclear/cytoplasmic
ratio, a Golgi area and an eccentrically located nucleus.
Lower left: 1 Plasma Cell and 1 band neutrophil. Lower right: 1 Plasma Cell
Image Atlas Alcoholic with liver disease blood - 100X
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Plasmacytoid, plasma cell, alcoholic, liver disease blood

Plasmacytoid lymphocyte, alcoholic, liver disease blood
Bloodline Plasmacytoid lymphocyte, alcoholic, liver

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disease blood
Left frame: 1 Plasmacytoid Lymphocyte
Center frame: 1 larger Plasmacytoid Lymphocyte with an eccentrically located nucleus.
Right frame: 1 Plasmacytoid Lymphocyte and 1 small mature lymphocyte.
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Plasmacytoid lymphocyte, neutrophilic myelocyte, alcoholic
Bloodline Plasmacytoid lymphocyte, neutrophilic

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myelocyte, alcoholic
Left frame: 1 monocyte with numerous vacuoles and 1 Plasmacytoid Lymphocyte
Center frame: 1 monocyte with a convoluted nucleus, 1 band neutrophil and 1 large Mitotic Form of a probable
plasmacytoid lymphocyte.
Right frame: 1 Neutrophilic Myelocyte and 1 small mature lymphocyte.
Image Atlas Alcoholic with liver disease blood - 100X
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Plasmacytoid lymphocyte, neutrophilic myelocyte, alcoholic

Blast cell, plasmacytoid lymphocyte, alcoholic/liver disease
Bloodline Blast cell, plasmacytoid lymphocyte, alcoholic/

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liver disease
Top left frame: 1 Blast Cell with a very high nuclear/cytoplasmic ratio, scant blue cytoplasm and uniformly distributed
nuclear chromatin. Compare this cell with those in the other frames for nuclear/cytoplasmic ratio and nuclear
chromatin pattern.
Top right frame: 1 Plasmacytoid Lymphocyte with abundant cytoplasm and 1 mature lymphocyte
Image Atlas Lower left frame: 1 Plasmacytoid Lymphocyte. Lower right frame: 1 Plasma Cell.
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Blast cell, plasmacytoid lymphocyte, alcoholic/liver disease

Mott Cell, alcoholic with liver disease
Bloodline Mott Cell, alcoholic with liver disease

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About One plasma cell containing several large packets of immunoglobulin which appear as vacuoles. They have been
termed Russell bodies and a cell containing them called a Mott Cell. Their bluish tinge is a result of buffer in the
staining solution being on the basic side and/or their location in the blue cytoplasm. Alcoholic with liver disease blood
- 50X
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Mott Cell, alcoholic with liver disease

Plasma cell, Mott Cell, alcoholic, liver disease
Bloodline Plasma cell, Mott Cell, alcoholic, liver disease

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About Top left frame: 1 large Plasma Cell
Top right frame: 1 smaller Plasma Cell which contains numerous vacuoles which represent stored immunoglobulin
Lower left frame: 1 Plasma Cell
Lower right frame: 1 Plasma cell with three large vacuoles which represent stored immunoglobulin. These vacuoles
have been termed Russell bodies and the cell may be referred to as a Mott Cell. The vacuoles are usually clear or
Educational Features colorless but may be pink or bluish dependent upon the pH of the stain and/or whether overlying the cytoplasm or
Image Atlas nucleus. They may be blue when overlying the cytoplasm or pink when overlying the nucleus. Their size reflects the
size of the packet of the stored immunoglobulin. Alcoholic with liver disease blood - 100X
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Plasma cell, Mott Cell, alcoholic, liver disease

Mott Cell, plasmacytoid lymphocyte, alcoholic, liver disease
Bloodline Mott Cell, plasmacytoid lymphocyte, alcoholic,

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liver disease
Top left frame: 1 plasma cell with several vacuoles (Mott Cell with stored immunoglobulin).
Top right frame: 1 small Plasmacytoid Lymphocyte with a few small vacuoles.
Lower left frame: 1 Plasmacytoid Lymphocyte with multiple small vacuoles giving the cytoplasm a bubbly
appearance.
Image Atlas Lower right frame: 1 Plasmacytoid Lymphocyte with a few cytoplasmic vacuoles.
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Bloodline Mott Cell, plasmacytoid lymphocyte, alcoholic,

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liver disease
One plasma cell with vacuoles (Mott Cell), 1 mature neutrophil, 1 smudged band neutrophil, 1 Plasmacytoid
Lymphocyte, 1 monocyte with a band shaped nucleus and several vacuoles in its gray cytoplasm, 1 neutrophilic
myelocyte, 1 small mature lymphocyte. There is an accumulation of cells, especially larger cells, at the tail or
feathered area of this blood smear. Alcoholic with liver disease blood - 100X
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Bloodline Plasmacytoid lymphocyte, alcoholic, liver

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disease blood
One Plasmacytoid Lymphocyte with numerous vacuoles and 1 basophil in center of field. One Plasmacytoid
Lymphocyte at lower left center, 2 monocytes below it and 1 monocyte at top right. 2 mature neutrophils at top left.
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Plasmacytoid lymphocytes, severe arthritis with osteoporosis
Bloodline Plasmacytoid lymphocytes, severe arthritis

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with osteoporosis
Two Plasmacytoid Lymphocytes, 1 monocyte, 3 late and 1 band neutrophil accumulated in tail area on blood smear.
Severe arthritis with osteoporosis blood - 100X
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Bloodline Plasmacytoid lymphocytes, severe arthritis

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with osteoporosis
Two Plasmacytoid Lymphocytes, 1 band and 1 mature neutrophil. Side edge of smear can be another site where
large, and/or immature, and/or abnormal nucleated cells accumulate. Severe arthritis with osteoporosis blood - 100X
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Plasmacytoid lymphocytes, Mott Cell, arthritis, osteoporosis
Bloodline Plasmacytoid lymphocytes, Mott Cell, arthritis,

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Two Plasmacytoid Lymphocytes; one of which contains numerous vacuoles (Mott Cell). Severe arthritis with
osteoporosis blood - 100X
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Plasmacytoid lymphocytes, Mott Cell, arthritis, osteoporosis

Plasmacytoid, plasma cells, severe arthritis, osteoporosis
Bloodline Plasmacytoid, plasma cells, severe arthritis,

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osteoporosis
Two Plasmacytoid Lymphocytes vs Plasma Cells. The nuclear/ cytoplasmic ratio and eccentrically located nuclei
suggest they are already plasma cells. Nuclear chromatin and cytoplasmic color are compatible with both cell types.
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Plasmacytoid, plasma cells, severe arthritis, osteoporosis

Plasmacytoid lymphocyte, severe arthritis with osteoporosis
Bloodline Plasmacytoid lymphocyte, severe arthritis with

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osteoporosis
One Plasmacytoid Lymphocyte. It is a classic excample: large size, deep basophilic blue cytoplasm, nucleus centrally
located with a dense chromatin with a few randomly distributed open or colorless areas. Severe arthritis with
osteoporosis blood - 100X
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Bloodline Plasmacytoid lymphocyte, severe arthritis with

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osteoporosis
Left frame: 1 Plasmacytoid Lymphocyte with a double nucleus, 1 mature neutrophil.
Center frame: 1 mature lymphocyte and 1 small Plasmacytoid Lymphocyte.
Right frame: 1 Plasmacytoid Lymphocyte with a contorted nucleus and 1 late smudged form.
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Plasma cells, severe arthritis with osteoporosis
Bloodline Plasma cells, severe arthritis with osteoporosis

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About Plasma Cells in each frame. They vary in size but all have an eccentrically located nucleus, blue cytoplasm, a light
area (Golgi) adjacent to the nucleus which has a dense chromatin pattern. The plasma cell in the right frame contains
multiple small vacuoles. A mature neutrophil is above it. Severe arthritis with osteoporosis blood - 100X
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Plasmacytoid, plasma cell, severe arthritis, osteoporosis
Bloodline Plasmacytoid, plasma cell, severe arthritis,

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osteoporosis
Left frame: 1 Plasmacytoid Lymphocyte with several vacuoles and a contorted nucleus, 1 monocyte with a band
shaped nucleus.
Center frame: 1 small lymphocyte partially smudged, 1 small Plasmacytoid Lymphocyte with multiple vacuoles.
Compare the nuclear chromatin of the two cells.
Image Atlas Right frame: 1 mature neutrophil, 2 Plasma Cells. The cell on the left could also be called a plasmacytoid lymphocyte
Case Studies since the nucleus is centrally located.
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Bloodline Plasmacytoid, plasma cell, severe arthritis,

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osteoporosis
Top left frame: 1 Plasmacytoid Lymphocyte with extremely basophilic blue cytoplasm and dense nuclear chromatin.
Such cells have been called Turk Cells.
Top right frame: 1 band neutrophil, one plasma cell/plasmacytoid lymphocyte.
Lower left frame: 1 Plasmacytoid Lymphocyte with a contorted nucleus. Lower right frame: 1 Plasma Cell.
Image Atlas Severe arthritis with osteoporosis blood - 100X
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Image ID: 0147-081
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Plasma cell, bacterial infection blood
Bloodline Plasma cell, bacterial infection blood

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About One Plasma Cell, oval in shape, with a low nuclear/cytoplasmic ratio, eccentrically located nucleus, deep basophilic
blue cytoplasm containing a few vacuoles, dense nuclear chromatin with a few randomly distributed less dense areas.
A monocyte is at lower left corner. Bacterial infection blood - 100X
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Plasma cell, monocytes, platelets, breast cancer blood
Bloodline Plasma cell, monocytes, platelets, breast

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cancer blood
One Plasma Cell, 2 Monocytes and 1 small mature lymphocyte. Platelets are markedly increased in number. Breast
cancer blood - 100X
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Plasma cell, monocytes, platelets, breast cancer blood

Dying plasma cell, late neutrophils
Bloodline Dying plasma cell, late neutrophils

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About One Plasma Cell that is Dying, thus the very dense, pyknotic nuclear chromatin. Two late neutrophils are also in the
field. Blood - 100X
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Dying plasma cell, late neutrophils

Plasma cell, Mott cell, buffy coat preparation
Bloodline Plasma cell, Mott cell, buffy coat preparation

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About One Plasma Cell or plasmacytoid lymphocyte with many vacuoles (Mott cell), many mature neutrophils and 1
monocyte. Side edge of buffy coat preparation of blood. Immature and abnormal cells are more likely to be found in
peripheral areas (side edges and tail end) than in the body of a smear. A concentrate of the nucleated cells or buffy
coat preparation, greatly enhances finding these cells when present in small numbers. Fever of unknown etiology.
Buffy coat preparation blood - 50X
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Mott cell, Russell bodies, red cell transfusion
Bloodline Mott cell, Russell bodies, red cell transfusion

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About Top left frame: 2 plasma cells, one with many vacuoles - a Mott Cell.
Top right frame: 1 Mott cell which is either a plasma cell or a plasmacytoid lymphocyte with much stored
immunoglobulin
Lower left frame: 1 large plasma cell with several vacuoles.
Lower right frame: 1 plasma cell with two nuclei and numerous vacuoles which represent stored immunoglobulin and
Educational Features have been termed Russell bodies.
Image Atlas Following several red cell transfusions. Blood - 100X
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Image ID: 0148-026
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Mott cell, Russell bodies, red cell transfusion

Mott cell, plasmacytoid lymphocyte, viral infection
Bloodline Mott cell, plasmacytoid lymphocyte, viral

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infection
One Mott Cell - plasmacytoid lymphocyte with multiple vacuoles. The round shape and high nuclear/cytoplasmic ratio
indicate it is a plasmacytoid lymphocyte rather than a plasma cell. One band neutrophil is also in the field. Viral
infection blood - 100X
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Mott cell, plasmacytoid lymphocyte, viral infection

Plasmacytoid lymphocyte, Thrombotic thrombocytopenic purpura
Bloodline Plasmacytoid lymphocyte, Thrombotic

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thrombocytopenic purpura
One Plasmacytoid Lymphocyte with multiple vacuoles. It is round, has a high nuclear/cytoplasmic ratio, deep blue
cytoplasm with many vacuoles and a coarse nuclear chromatin. Two nuclear smudges and 1 mature neutrophil are
also in the field. Thrombotic thrombocytopenic purpura following RBC transfusions. Blood - 100X
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Plasmacytoid lymphocyte, Thrombotic thrombocytopenic purpura

Plasmacytoid lymphocyte, serum sickness
Bloodline Plasmacytoid lymphocyte, serum sickness

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About One Plasmacytoid Lymphocyte with multiple clear staining crystals which represent stored crystalized
immunoglobulin. Serum sickness. Blood - 100X
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Bloodline Plasmacytoid lymphocyte, serum sickness

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About One Plasmacytoid Lymphocyte with multiple colorless crystals, which represent stored crystalized immunoglobulin.
Serum sickness. Blood - 100X
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Rouleaux formation, Multiple myeloma
Bloodline Rouleaux formation, Multiple myeloma

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About Rouleaux formation of the red cells, which appear in chains or stacks in a proper field for examination. In addition to
long chains there are many doublets and triplets. There is a slight bluish color in the background due to plasma
proteins which have precipitated on the glass slide and been stained. Multiple myeloma. Blood - 60X
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About Rouleaux formation of the red cells which settle in long chains or stacks when the blood is spread on a glass slide.
There are a few doublets and triplets in this field of proper thickness for evaluation. The background shows a faint
blue color due to precipitated plasma proteins which have been stained. One small mature lymphocyte and one
monocyte are in the field. Multiple myeloma. Blood - 50X
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Rouleaux formation, plasma cell, Multiple myeloma
Bloodline Rouleaux formation, plasma cell, Multiple

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myeloma
Rouleaux formation of the red cells, one mature Plasma Cell and a blue tinge to the background. This is an area of
good thickness for proper evaluation of a blood smear. Multiple myeloma. Blood - 50X
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About Much rouleaux formation of the red cells in this thick area of red cell distribution. This is pathologic rouleaux in
contrast to normal stacking of red cells in a thick area of a normal smear. A monocyte is in the field. The background
has a bluish tinge. Multiple myeloma. Blood - 50X
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Pathologic rouleaux formation, Multiple myeloma
Bloodline Pathologic rouleaux formation, Multiple

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myeloma
Much rouleaux formation of the red cells in this thick area of red cell distribution. This is pathologic rouleaux in
contrast to normal stacking of red cells in a thick area of a normal blood smear. The background has a bluish tinge.
Two small lymphocytes and one mature neutrophil are in the field. Multiple myeloma. Blood - 50X
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Pathologic rouleaux, plasma cell, Multiple myeloma
Bloodline Pathologic rouleaux, plasma cell, Multiple

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myeloma
An area thinner than ideal for proper evaluation. On a normal smear most of the red cells would be separate. In this
field there are many doublets, triplets and even longer chains of the red cells. This is pathologic rouleaux and
suggests increased and/or abnormal plasma proteins. There is a bluish tinge to the background. One mature
neutrophil and one Plasma Cell are present. Multiple myeloma. Blood - 50X
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Pathologic rouleaux, plasma cell, Multiple myeloma

Pathologic rouleaux, Multiple myeloma
Bloodline Pathologic rouleaux, Multiple myeloma

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About An area even thinner than in last image. Normally the red cells should be separate, but there are some doublets and
triplets present; an indication of pathologic rouleaux. A band and mature neutrophil are present. The background has
a bluish tinge. Multiple myeloma. Blood - 50X
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Pathologic rouleaux, Multiple myeloma

Agglutination, Cold agglutinin hemolytic anemia
Bloodline Agglutination, Cold agglutinin hemolytic anemia

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About Red cell Agglutination. Most of the red cells are in amorphous clumps. Clumping of the red cells indicates a cold
antibody disorder whereas rouleaux formation indicates a protein disorder. Cold agglutinin hemolytic anemia. Blood -
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Agglutination, Cold agglutinin hemolytic anemia

Eosinophil, Normal blood
Bloodline Eosinophil, Normal blood

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Bloodline Eosinophil, Normal blood

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About One 3-lobed eosinophil, 1 2-lobed eosinophil, 2 mature neutrophils; composite. Normal blood - 100X
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Band eosinophil, mature neutrophil, Normal blood
Bloodline Band eosinophil, mature neutrophil, Normal

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One band eosinophil, 1 mature neutrophil. Normal blood - 100X
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Band eosinophil, mature neutrophil, Normal blood

Basophil, eosinophils, Normal blood
Bloodline Basophil, eosinophils, Normal blood

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About One basophil, 3 eosinophils; composite. Normal blood - 100X
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Basophil, eosinophils, Normal blood

Crushed eosinophil
Bloodline Crushed eosinophil

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About One crushed late eosinophil. Normal blood - 100X
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Crushed eosinophil

Crushed eosinophil
Bloodline Crushed eosinophil

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Crushed eosinophil

Late neutrophils, eosinophil, basophil
Bloodline Late neutrophils, eosinophil, basophil

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About Four late neutrophils, 1 eosinophil (top left), 1 basophil (lower left); composite. Normal blood - 100X
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Late neutrophils, eosinophil, basophil

Basophil
Bloodline Basophil
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Basophil

Basophil
Bloodline Basophil
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Basophil

Basophil
Bloodline Basophil
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About One mature basophil with reduced granules - ? washed out. Normal blood - 100X
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Basophil

Basophils, mature neutrophils, CML blood
Bloodline Basophils, mature neutrophils, CML blood

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About Three mature basophils, 2 mature neutrophils. Chronic myeloid leukemia blood - 100X
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Basophils, mature neutrophils, CML blood

Young basophils, CML blood
Bloodline Young basophils, CML blood

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About Five young basophils; composite. Chronic myeloid leukemia blood - 100X
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Young basophils, CML blood

Crushed basophil
Bloodline Crushed basophil

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About One crushed late basophil. Normal blood - 100X
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Crushed basophil

Crushed basophil
Bloodline Crushed basophil

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Crushed basophil

Epithelial cells
Bloodline Epithelial cells

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About One clump of epithelial cells in center of field. Normal capillary blood smear -20X
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Epithelial cells

Epithelial cells

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About One clump of epithelial cells. Normal capillary blood smear. 100X
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Epithelial cells

Epithelial cells

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About Epithelial cells. Capillary blood smear from normal patients -20X
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Epithelial cells

Epithelial cells, microorganisms
Bloodline Epithelial cells, microorganisms

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About Higher magnificatiion of one of the clumps of epithelial cells in previous image. Numerous microorganisms are
present. Capillary blood smear from a normal patient -50X
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Bloodline Epithelial cells, microorganisms

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About Higher magnification of another clump of epithelial cells on the same capillary blood smear. Numerous
microorganisms are present. They are a contaminant from the skin -100X
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Epithelial cell, microorganisms
Bloodline Epithelial cell, microorganisms

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About One epithelial cell and a clump of microorganisms on the same capillary blood smear as previous three images.
Microorganisms are a contaminant from the skin -100X
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Epithelial cells

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About Several squamous epithelial cells on capillary blood smear from a normal child -50X
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Epithelial cells

Bloodline Epithelial cell, microorganisms

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About One squamous epithelial cell on capillary blood smear from a normal child. The numerous microorganisms are
contaminant. A large clump of platelets is at left center -100X
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Mature megakaryocyte, blood smear
Bloodline Mature megakaryocyte, blood smear

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About Late mature megakaryocyte at tail of blood smear. It is at center field surrounded by mature and band neutrophils
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Mature megakaryocyte, blood smear

Mature megakaryocyte, Essential Thrombocytosis
Bloodline Mature megakaryocyte, Essential

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Thrombocytosis
Higher magnification of late mature megakaryocyte in image 2661-017 . A scant amount of granular cytoplasm
surrounds the nucleus. Essential Thrombocytosis EDTA anticoagulated blood -100X
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Mature megakaryocyte, Essential Thrombocytosis

Late megakaryocyte, buffy coat, lung cancer blood
Bloodline Late megakaryocyte, buffy coat, lung cancer

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Late megakaryocyte at tail area of buffy coat preparation of blood of a patient with lung cancer. Buffy coat - 100X
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Bare megakaryocyte nuclei, thrombocytosis
Bloodline Bare megakaryocyte nuclei, thrombocytosis

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About Bare megakaryocyte lobulated nuclei. Reactive thrombocytosis blood - 100X
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Bare megakaryocyte nuclei, thrombocytosis

Small megakaryocyte, Thrombotic Thrombocytopenic Purpura
Bloodline Small megakaryocyte, Thrombotic

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Thrombocytopenic Purpura
Late small megakaryocyte with lobulated nuclei. Tail area. Thrombotic Thrombocytopenic Purpura (TTP) blood - 100X
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Bare megakaryocyte nuclei, Thalassemia minor blood
Bloodline Bare megakaryocyte nuclei, Thalassemia minor

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Bare lobulated megakaryocyte nuclei. Thalassemia minor blood - 100X
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Bare megakaryocyte nuclei, NRBC, cancer blood
Bloodline Bare megakaryocyte nuclei, NRBC, cancer blood

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About Bare lobulated megakaryocyte nuclei, 1 late NRBC and 2 band neutrophils. Dense area. Metastatic cancer blood -
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Bloodline Bare megakaryocyte nuclei, Thalassemia minor

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Bare lobulated megakaryocyte nuclei. Thalassemia minor blood - 100X
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Bare megakaryocyte nuclei, Multiple myeloma blood
Bloodline Bare megakaryocyte nuclei, Multiple myeloma

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blood
Left frame: Bare lobulated megakaryocyte nuclei at top. Small lymphocyte at bottom - 20X. Right frame: Higher
magnification of the bare lobulated megakaryocyte nuclei. Multiple myeloma blood - 50X
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Bare megakaryocyte nuclei, Multiple myeloma blood

Megakaryocytes, lung cancer, buffy coat
Bloodline Megakaryocytes, lung cancer, buffy coat

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About Left frame: Late small mature megakaryocyte - 100X. Right frame: Bare lobulated megakaryocyte nuclei. Metastatic
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Megakaryocytes, lung cancer, buffy coat

Megakaryocyte nucleus, lung cancer blood
Bloodline Megakaryocyte nucleus, lung cancer blood

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About Single megakaryocyte nucleus with scant fragmenting cytoplasm. Metastatic lung cancer blood - 100X
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Megakaryocyte nucleus, lung cancer blood

Bare megakaryocyte nucleus, Myeloid metaplasia
Bloodline Bare megakaryocyte nucleus, Myeloid

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Single bare megakaryocyte nucleus, a clump of large and small platelet fragments. Myeloid metaplasia with
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Bare megakaryocyte nucleus, Myeloid metaplasia

Mature megakaryocyte, myeloid metaplasia with myelofibrosis
Bloodline Mature megakaryocyte, myeloid metaplasia

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with myelofibrosis
Huge mature megakaryocyte with some scattered nuclei. Myeloid metaplasia with myelofibrosis following
splenectomy. Capillary blood - 50X
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Mature megakaryocyte, myeloid metaplasia with myelofibrosis

Micromegakaryocytes, myeloid metaplasia with myelofibrosis
Bloodline Micromegakaryocytes, myeloid metaplasia with

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myelofibrosis
Three megakaryocyte nuclei (? micromegakaryocytes) with scanty attached cytoplasm (platelets), 1 bare
megakaryocyte nucleus, 1 neutrophilic myelocyte, numerous megathrombocytes. Myeloid metaplasia with
myelofibrosis following splenectomy capillary blood - 50X
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Micromegakaryocytes, myeloid metaplasia with myelofibrosis

Micromegakaryocytes, myeloid metaplasia myelofibrosis blood
Bloodline Micromegakaryocytes, myeloid metaplasia

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myelofibrosis blood
Three megakaryocyte nuclei (? micromegakaryocytes) with attached cytoplasm (platelets), several
megathrombocytes and many platelets; some in clumps. Myeloid metaplasia with myelofibrosis following splenectomy
capillary blood - 100X
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Micromegakaryocytes, myeloid metaplasia myelofibrosis blood

Megakaryocyte nuclei, myeloid metaplasia with myelofibrosis
Bloodline Megakaryocyte nuclei, myeloid metaplasia with

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myelofibrosis
Three megakaryocyte nuclei, many megathrombocytes and many platelets. Myeloid metaplasia with myelofibrosis
following splenectomy capillary blood - 100X
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Megakaryocyte nuclei, myeloid metaplasia with myelofibrosis

Megakaryocyte nuclei, megathrombocytes, myeloid metaplasia
Bloodline Megakaryocyte nuclei, megathrombocytes,

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myeloid metaplasia
Two megakaryocyte nuclei one of which - left side - may be a micromegakaryocyte, 1 neutrophilic metamyelocyte,
numerous megathrombocytes and platelets, many of which lack granulation. Myeloid metaplasia with myelofibrosis
following splenectomy capillary blood - 100X
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Bare megakaryocyte nuclei, myeloid metaplasia
Bloodline Bare megakaryocyte nuclei, myeloid metaplasia

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About Top left frame: 2 bare megakaryocyte nuclei with attached platelets. Top right frame: 1 late NRBC after ejecting its
nucleus, 1 megathrombocyte nucleus with attached platelets (? micromegakaryocyte), 1 early megakaryocyte
nucleus. Lower frame: 1 megakaryocyte nucleus with attached platelets, 1 mature lymphocyte, several
megathrombocytes and many platelets. Myeloid metaplasia with myelofibrosis following splenectomy capillary blood -
100X
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Bare megakaryocyte nuclei, myeloid metaplasia

Megakaryocyte nucleus, megakaryocyte cytoplasmic fragment
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cytoplasmic fragment
One megakaryocyte nucleus in each frame. The one in the lower right frame may qualify as a micromegakaryocyte.
Lower left frame also contains a huge megakaryocyte cytoplasmic fragment and a megathrombocyte. Myeloid
metaplasia with myelofibrosis following splenectomy capillary blood - 100X
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Megakaryocyte nucleus, megakaryocyte cytoplasmic fragment

Micromegakaryocytes, megathrombocytes, myeloid leukemia
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myeloid leukemia
Three mature micromegakaryocytes showing a single nucleus surrounded by granulated and vacuolated cytoplasm,
which is also fragmenting. Numerous megathrombocytes are present. They are swollen and lighter in stain quality
because this is an EDTA anticoagulated sample, wherein platelets usually show these changes. Chronic myeloid
leukemia following splenectomy EDTA anticoagulated blood - 100X
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Micromegakaryocytes, megathrombocytes, myeloid leukemia

Micromegakaryocytes, megathrombocyte, myeloid leukemia blood
Bloodline Micromegakaryocytes, megathrombocyte,

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myeloid leukemia blood
Two mature micromegakaryocytes, several megathrombocytes. Chronic myeloid leukemia following splenectomy
EDTA anticoagulated blood - 100X
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Micromegakaryocytes, megathrombocyte, myeloid leukemia blood

Micromegakaryocyte, megathrombocytes, myeloid leukemia blood
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myeloid leukemia blood
One mature micromegakaryocyte in a cluster of megathrombocytes. Chronic myeloid leukemia following splenectomy
EDTA anticoagulated blood - 100X
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Micromegakaryocyte, megathrombocytes, myeloid leukemia blood

Myeloblast, micromegakaryocyte, myeloid leukemia blood
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leukemia blood
One myeloblast at left of center, 1 lymphocyte above it, 1 micromegakaryocyte at center, 2 bare mature
megakaryocyte nuclei to its right, many megathrombocytes. Chronic myeloid leukemia following EDTA anticoagulated
blood - 100X
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Myeloblast, micromegakaryocyte, myeloid leukemia blood

Micromegakaryocytes, myeloid leukemia, M-7 leukemia
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leukemia
Clump of 4 micromegakaryocytes, 1 almost bare megakaryocyte nucleus, 1 neutrophilic myelocyte, 2 mature
neutrophils, 1 band neutrophil, 4 ungranulated megathrombocytes. Chronic myeloid leukemia transforming into acute
megakaryocytic (M-7) leukemia blood - 100X
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Micromegakaryocytes, myeloid leukemia, M-7 leukemia

Megakaryoblasts, chronic myeloid leukemia, M-7 leukemia
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7 leukemia
Two megakaryoblasts at top left, 1 micromegakaryocyte at top right and 1 micromegakaryocyte at lower left, 1
myeloblast at center right and 1 megakaryocyte cytoplasmic fragment beneath it. Chronic myeloid leukemia
transforming into acute megakaryocytic (M-7) leukemia blood - 100X
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Megakaryoblasts, chronic myeloid leukemia, M-7 leukemia

megakaryocyte nucleus, M-7 and chronic myeloid leukemias
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myeloid leukemias
A megakaryocyte nucleus with slightly attached cytoplasm at left, 1 small lymphocyte and 1 myeloblast at center, 1
megakaryoblast at lower center, 1 neutrophilic myelocyte at right. Chronic myeloid leukemia transforming into acute
megakaryocytic (M-7) leukemia blood - 100X
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megakaryocyte nucleus, M-7 and chronic myeloid leukemias

Megathrombocyte, PAS stain, myeloid metaplasia
Bloodline Megathrombocyte, PAS stain, myeloid

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metaplasia
One micromegakaryocyte nucleus showing many PAS positive cytoplasmic granules, 1 megathrombocyte with PAS
positive granules. Periodic Acid Schiff (PAS) stain. Myeloid metaplasia with myelofibrosis following splenectomy
capillary blood - 100X
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Megathrombocyte, PAS stain, myeloid metaplasia

Megakaryocyte nuclei, PAS stain, myeloid metaplasia
Bloodline Megakaryocyte nuclei, PAS stain, myeloid

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metaplasia
Two megakaryocyte nuclei showing PAS positive cytoplasmic granules, many PAS positive platelets. PAS stain.
Myeloid metaplasia with myelofibrosis following splenectomy capillary blood - 100X
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Bloodline Megakaryocyte nuclei, PAS stain, myeloid

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Two megakaryocyte nuclei showing PAS positive cytoplasmic granules, many PAS positive platelets. PAS stain.
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Megakaryocyte nucleus, myeloid metaplasia with myelofibrosis
Bloodline Megakaryocyte nucleus, myeloid metaplasia

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with myelofibrosis
Left frame: 1 megakaryocyte nucleus and many PAS positive granules. Top right frame: 1 megakaryocyte nucleus
with attached granules showing PAS positivity. Lower right frame: normal lymphocyte showing PAS positivity, Note
the PAS positive granules are intracellular in the lymphocytes rather than extracellular as with micromegakaryocytes.
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Megakaryocyte nucleus, myeloid metaplasia with myelofibrosis

Micromegakaryocyte, myeloid metaplasia with myelofibrosis
Bloodline Micromegakaryocyte, myeloid metaplasia with

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myelofibrosis
Top left frame: 1 micromegakaryocyte with PAS positive attached granules. 1 mature lymphocyte with some
intracellular PAS positive granules. Top right frame: 1 megakaryocyte nucleus (? micromegakaryocyte) with PAS
positive attached granules. Lower left frame: 1 megakaryocyte nucleus (? micromegakaryocyte) with PAS positive
attached granules. Lower right frame: 1 mature lymphocyte with a few PAS positive intracellular cytoplasmic
Image Atlas granules. Myeloid metaplasia with myelofibrosis following splenectomy capillary blood -100X
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Micromegakaryocyte, myeloid metaplasia with myelofibrosis

Platelets, neutrophil, monocyte, GP IIbIIIa stain
Bloodline Platelets, neutrophil, monocyte, GP IIbIIIa

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stain
Numerous platelets, all of which are positive with the glycoprotein IIb, IIIa stain. The neutrophil and monocyte in the
field are negative. GP IIbIIIa stain. Normal blood - 100X
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Platelets, neutrophil, monocyte, GP IIbIIIa stain

Micromegakaryocytes, GP IIb,IIIa stain, myeloid metaplasia
Bloodline Micromegakaryocytes, GP IIb,IIIa stain,

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myeloid metaplasia
Two micromegakaryocytes which are positive with the glycoprotein IIb,IIIa stain. GP IIb,IIIa stain. Myeloid
metaplasia with myelofibrosis following splenectomy blood - 100X
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Micromegakaryocytes, GP IIb,IIIa stain, myeloid metaplasia

Normal blood
Bloodline Normal blood

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Normal blood

Normal blood

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Normal blood

Normal blood, dense area
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Normal blood - dense area
Bloodline Normal blood - dense area

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Normal blood - dense area, segmented neutrophil
Bloodline Normal blood - dense area, segmented

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neutrophil
Normal blood - dense area - ? segmented neutrophil - 100X
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Normal blood - dense area, lyphocyte, segmented neutrophil
Bloodline Normal blood - dense area, lyphocyte,

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segmented neutrophil
Normal blood - dense area - ? lymphocyte and segmented neutrophil - 100X
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Normal blood - thin area
Bloodline Normal blood - thin area

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Normal blood - thin area

Blood - thin area, lymphocytes, neutrophils
Bloodline Blood - thin area, lymphocytes, neutrophils

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About Thin area - 2 lymphocytes, 1 band neutrophil, 2 disrupted neutrophils - 100X
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Blood - thin area, lymphocytes, neutrophils

Blood - thin area, lymphocyte, smudge cell
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Blood - tail area, segmented neutrophils
Bloodline Blood - tail area, segmented neutrophils

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Normal blood - side edge, large cells
Bloodline Normal blood - side edge, large cells

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Normal blood - side edge, large cells

Normal blood, segmented neutrophil, small lymphocyte
Bloodline Normal blood, segmented neutrophil, small

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lymphocyte
Normal blood - 1 segmented neutrophil and 1 small lymphocyte - 100X
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Normal blood, segmented neutrophil, small lymphocyte

Normal blood, segmented neutrophils, lymphocyte
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lymphocyte
Normal blood - 2 segmented neutrophils, 1 lymphocyte - 100X
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Normal blood, segmented neutrophils, lymphocyte

Normal blood, segmented neutrophils
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Normal blood, segmented neutrophils

Normal blood, segmented and hypersegmented neutrophils
Bloodline Normal blood, segmented and hypersegmented

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neutrophils
Normal blood - 2 segmented neutrophils, 1 ? hypersegmented neutrophil - 100X
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Normal blood, segmented and hypersegmented neutrophils

Hypersegmented neutrophil, buffy coat of pernicious anemia
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pernicious anemia
One hypersegmented neutrophil, 1 possible hypersegmented neutrophil, 1 small lymphocyte, macrocytic red cells.
Buffy coat of pernicious anemia blood - 100X
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Hypersegmented neutrophil, buffy coat of pernicious anemia

Segmented neutrophils, band neutrophils, normal blood
Bloodline Segmented neutrophils, band neutrophils,

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normal blood
Segmented neutrophils and band neutrophils composite; 2 band neutrophils (top frames) and 2 segmented
neutrophils (lower frame). Normal blood - 100X
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Segmented neutrophils, band neutrophils, normal blood

Segmented neutrophil, band neutrophil, normal blood
Bloodline Segmented neutrophil, band neutrophil, normal

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blood
One segmented neutrophil and 1 band neutrophil. Normal blood - 100X
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Segmented neutrophil, band neutrophil, normal blood

Segmented neutrophil, monocyte, normal blood
Bloodline Segmented neutrophil, monocyte, normal blood

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About One segmented neutrophil and 1 monocyte (band shaped nucleus). Note differences in chromatin and cytoplasm
color. Normal blood ˆ 100X
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Segmented neutrophil, lymphocyte, normal blood
Bloodline Segmented neutrophil, lymphocyte, normal

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blood
One segmented neutrophil, 1 lymphocyte. Normal blood - 100X
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Segmented neutrophil, lymphocyte, normal blood

Segmented and band neutrophils, lymphocyte, normal blood
Bloodline Segmented and band neutrophils, lymphocyte,

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normal blood
One segmented neutrophil, 1 band neutrophil, 1 lymphocyte. Normal blood - 100X
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Segmented and band neutrophils, lymphocyte, normal blood

Lymphocyte, normal blood
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Lymphocytes, normal blood
Bloodline Lymphocytes, normal blood

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Lymphocytes, normal blood

Segmented neutrophil, lymphocyte, thin area blood
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Segmented neutrophil, lymphocytes, normal blood
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Segmented neutrophil, lymphocytes, normal blood

Very large, reactive lymphocyte, normal blood
Bloodline Very large, reactive lymphocyte, normal blood

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Very large, reactive lymphocyte, normal blood

Very large lymphocyte, normal blood
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Very large lymphocyte, normal blood

Lymphocyte, thin tail area blood
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Large reactive lymphocyte, normal blood
Bloodline Large reactive lymphocyte, normal blood

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Large reactive lymphocyte, normal blood

Reactive lymphocyte, infectious mononucleosis blood
Bloodline Reactive lymphocyte, infectious mononucleosis

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Reactive lymphocyte, infectious mononucleosis blood

Lymphocyte with granules, tail area of normal blood
Bloodline Lymphocyte with granules, tail area of normal

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Two lymphocytes; 1 with prominent granules, 1 with fine granules. Tail area of normal blood smear - 100X
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Large granular lymphocyte, normal blood
Bloodline Large granular lymphocyte, normal blood

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3 medium lymphocytes in lower left and right frames. Normal blood - 100X
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Large granular lymphocyte, normal blood

Segmented neutrophil, monocyte, lymphocytes, normal blood
Bloodline Segmented neutrophil, monocyte, lymphocytes,

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One segmented neutrophil, 1 monocyte, 2 lymphocytes; Normal blood - 50X
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Segmented neutrophil, monocyte, lymphocytes, normal blood

Lymphocyte, monocyte, neutrophil, normal blood
Bloodline Lymphocyte, monocyte, neutrophil, normal

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One lymphocyte, 1 monocyte, 1 segmented neutrophil; Normal blood - 50X
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Lymphocyte, monocyte, neutrophil, normal blood

Bloodline Segmented neutrophil, monocyte, normal blood

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About One segmented neutrophil, 1 monocyte with a band shaped nucleus. Compare nuclear chromatin and cytoplasmic
color. Normal blood - 100X
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Very small lymphocyte, monocyte, normal blood
Bloodline Very small lymphocyte, monocyte, normal blood

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Very small lymphocyte, monocyte, normal blood

Plasmacytoid lymphocyte, viral reaction blood
Bloodline Plasmacytoid lymphocyte, viral reaction blood

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About Plasmacytoid lymphocyte showing large size, deep basophilic blue cytoplasm, coarse reticular chromatin and 2
prominent nucleoli. Viral reaction blood - 100X
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Plasmacytoid lymphocyte, viral reaction blood

Lymphocyte, monocyte, normal blooad
Bloodline Lymphocyte, monocyte, normal blooad

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Lymphocyte, monocyte, normal blooad

Lymphocyte, monocyte, normal blood
Bloodline Lymphocyte, monocyte, normal blood

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About One lymphocyte, 1 monocyte (band shaped nucleus). Normal blood - 100X
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Lymphocyte, monocyte, normal blood

Monocyte, dense area, normal blood
Bloodline Monocyte, dense area, normal blood

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Monocyte, plasmacytoid lymphocyte, normal blood
Bloodline Monocyte, plasmacytoid lymphocyte, normal

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One monocyte, 1 large lymphocyte (plasmacytoid). Normal blood - 100X
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Monocyte, plasmacytoid lymphocyte, normal blood

Large granular lymphocyte, monocyte, normal blood
Bloodline Large granular lymphocyte, monocyte, normal

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Three lymphocytes (1 large granular lymphocyte in top right frame and 2 small lymphocytes in lower frame), 1
monocyte in top left frame. Normal blood - 100X
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Large granular lymphocyte, monocyte, normal blood

Monocyte, normal blood
Bloodline Monocyte, normal blood

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About One monocyte with vacuole in center of nucleus. Normal blood - 100X
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Monocyte with several small vacuoles, normal blood
Bloodline Monocyte with several small vacuoles, normal

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One monocyte with several small vacuoles. Normal blood - 100X
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Monocyte with several small vacuoles, normal blood


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About One monocyte (sl. oval - elliptical shape). Normal blood - 100X
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Monocyte with folded nucleus, normal blood
Bloodline Monocyte with folded nucleus, normal blood

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Monocyte with folded nucleus, normal blood


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Monocyte with band shaped nucleus, normal blood
Bloodline Monocyte with band shaped nucleus, normal

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Monocyte, band neutrophil, normal blood
Bloodline Monocyte, band neutrophil, normal blood

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About One monocyte with a band shaped nucleus in left frame, 1 band neutrophil in right frame. Compare nuclear
chromatin and cytoplasmic color. Normal blood - 100X
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Monocyte, band neutrophil, normal blood

Monocyte, large lymphocyte, normal blood
Bloodline Monocyte, large lymphocyte, normal blood

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About One monocyte (left), 1 large lymphocyte. Normal blood - 100X
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Monocyte, large lymphocyte, normal blood

Lymphocytes, monocytes, neutrophil, buffy coat, normal blood
Bloodline Lymphocytes, monocytes, neutrophil, buffy

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coat, normal blood
One small lymphocyte (top left corner), 2 monocytes (left center), 1 plasmacytoid reactive lymphocyte, 1 band
neutrophil. Buffy coat preparation of normal blood - 100X
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Lymphocytes, monocytes, neutrophil, buffy coat, normal blood

Monocyte, lymphocyte, segmented neutrophil, normal blood
Bloodline Monocyte, lymphocyte, segmented neutrophil,

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One monocyte, 1 lymphocyte, 1 segmented neutrophil. Normal blood - 100X
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Monocyte, lymphocyte, segmented neutrophil, normal blood

Monocyte, segmented neutrophil, lymphocyte, normal blood
Bloodline Monocyte, segmented neutrophil, lymphocyte,

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One monocyte, 1 segmented neutrophil, 1 large (reactive) lymphocyte at lower right; Normal blood - 100X
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Monocyte, segmented neutrophil, lymphocyte, normal blood

Segmented neutrophil, lymphocyte, monocyte, normal blood
Bloodline Segmented neutrophil, lymphocyte, monocyte,

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normal blood
One segmented neutrophil, 1 small lymphocyte with spiculated cytoplasm, 1 monocyte with extended cytoplasm;
Normal blood - 100X
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Segmented neutrophil, lymphocyte, monocyte, normal blood

Small lymphocyte, monocyte, neutrophil, normal blood
Bloodline Small lymphocyte, monocyte, neutrophil,

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One small lymphocyte,1 monocyte, 1 segmented neutrophil. Normal blood - 100X
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Small lymphocyte, monocyte, neutrophil, normal blood

Monocytes, segmented neutrophil, normal blood
Bloodline Monocytes, segmented neutrophil, normal blood

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About One monocyte with vacuoles, 1 band monocyte, 1 ? segmented monocyte (lower left), 1 segmented neutrophil.
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Monocytes, segmented neutrophil, normal blood

Moncyte, platelets, normal blood
Bloodline Moncyte, platelets, normal blood

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About One monocyte with vacuoles, several degranulated and swollen platelets. Normal blood - 100X
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Moncyte, platelets, normal blood

Bloodline Monocyte with band shaped nucleus, normal

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Monocyte with band shaped nucleus and vacuoles. Normal blood - 100X
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Monocyte, RBC, disseminated intravascular hemolysis blood
Bloodline Monocyte, RBC, disseminated intravascular

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hemolysis blood
Monocyte containing an RBC (erythrophagocytosis); Disseminated intravascular hemolysis blood - 100X
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Monocyte, RBC, disseminated intravascular hemolysis blood

Monocyte with engulfed platelets, tail area blood
Bloodline Monocyte with engulfed platelets, tail area

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Monocyte with engulfed platelets; tail area - 100X
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About ? Monocyte; Normal blood - 100X
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Young monocyte, normal blood
Bloodline Young monocyte, normal blood

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Young monocyte, normal blood

Young monocytes, normal blood
Bloodline Young monocytes, normal blood

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Young monocytes, normal blood

Young monocyte, infection blood
Bloodline Young monocyte, infection blood

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Young monocyte, infection blood

Normal blood

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Normal blood

Blood: normal
Bloodline Blood: normal

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About ● Normal Platelets, Normal EDTA anticoagulated blood
● Normal Platelets , Normal EDTA anticoagulated blood
● Normal Platelets, Normocytic, normochromic RBC, Normal EDTA
● Clump of Platelets, Normal Capillary blood
Educational Features ● Clumps of Platelets, Thrombocytosis, Capillary blood
Image Atlas
●

Case Studies
●

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●

Conference Reviews
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Journal Articles
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Glossary
●
● Plasmacytoid lymphocyte
● Plasmacytoid Lymphocyte
Resources ● Plasmacytoid lymphocytes, viral or bacterial infection
Conference Calendar
● Band eosinophil, mature neutrophil, Normal blood
Hematology Links
● Basophil, eosinophils, Normal blood
Full Text Journals
Classifieds
● Late neutrophils, eosinophil, basophil
● Basophil
Basophil
Specialties
●
● Basophil
BMT/Stem Cell ● Crushed basophil
Cord Blood ● Crushed basophil
Thrombosis ● Platelets, neutrophil, monocyte, GP IIbIIIa stain
Hemostasis ● Normal blood
Laboratory ● Normal blood
Malignancies ● Normal blood, dense area
Pediatrics ● Normal blood - dense area
Red Cell Disorders ● Normal blood - dense area, segmented neutrophil
Infections ● Normal blood - dense area, lyphocyte, segmented neutrophil
Transfusion Medicine ● Normal blood - thin area
Veterinary ● Normal blood - side edge, large cells
● Normal blood, segmented neutrophil, small lymphocyte
● Normal blood, segmented neutrophils, lymphocyte
● Normal blood, segmented neutrophils
● Normal blood, segmented and hypersegmented neutrophils
http://image.bloodline.net/bd1 (1 of 3)13/07/2005 04:27:46

Blood: normal
News ● Segmented neutrophils, band neutrophils, normal blood

Hematology News ● Segmented neutrophil, lymphocyte, normal blood
Blood News Update ● Segmented and band neutrophils, lymphocyte, normal blood
Discussion
● Lymphocytes, normal blood
Today's Discussion ● Segmented neutrophil, lymphocytes, normal blood
Create New Topic ● Very large, reactive lymphocyte, normal blood
List by Topic ● Very large lymphocyte, normal blood
● Lymphocyte, thin tail area blood
● Large reactive lymphocyte, normal blood
● Lymphocyte with granules, tail area of normal blood
● Large granular lymphocyte, normal blood
● Segmented neutrophil, monocyte, lymphocytes, normal blood
● Lymphocyte, monocyte, neutrophil, normal blood
● Very small lymphocyte, monocyte, normal blood
● Lymphocyte, monocyte, normal blooad
● Lymphocyte, monocyte, normal blood
● Monocyte, dense area, normal blood
● Monocyte, plasmacytoid lymphocyte, normal blood
● Large granular lymphocyte, monocyte, normal blood
● Monocyte with several small vacuoles, normal blood
● Monocyte with folded nucleus, normal blood
● Monocyte, band neutrophil, normal blood
● Monocyte, large lymphocyte, normal blood
● Lymphocytes, monocytes, neutrophil, buffy coat, normal blood
● Monocyte, lymphocyte, segmented neutrophil, normal blood
● Monocyte, segmented neutrophil, lymphocyte, normal blood
● Segmented neutrophil, lymphocyte, monocyte, normal blood
● Small lymphocyte, monocyte, neutrophil, normal blood
● Monocytes, segmented neutrophil, normal blood
● Moncyte, platelets, normal blood
● Young monocyte, normal blood
● Young monocytes, normal blood
● Normal blood


Blood: normal
site.

Blood: capillary
Bloodline Blood: capillary

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About ● Pelgeroid neutrophil, lymphocyte, AML blood
● Agranular megathrombocytes, AML capillary blood
● Megathrombocytes, agranular platelet, AML capillary blood
● Blast, late neutrophil, megathrombocytes, AML blood
Educational Features ● Clump of Platelets, Normal Capillary blood
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●

Case Studies
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Conference Reviews
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Journal Articles
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Glossary
●
Resources ● Epithelial cells, microorganisms
Conference Calendar
Hematology Links
Full Text Journals
● Mature megakaryocyte, myeloid metaplasia with myelofibrosis
Classifieds
● Micromegakaryocytes, myeloid metaplasia with myelofibrosis
● Micromegakaryocytes, myeloid metaplasia myelofibrosis blood
● Megakaryocyte nuclei, myeloid metaplasia with myelofibrosis
Specialties
●
● Bare megakaryocyte nuclei, myeloid metaplasia

BMT/Stem Cell ● Megakaryocyte nucleus, megakaryocyte cytoplasmic fragment
Cord Blood ● Megathrombocyte, PAS stain, myeloid metaplasia
Thrombosis ● Megakaryocyte nuclei, PAS stain, myeloid metaplasia
Hemostasis ● Megakaryocyte nuclei, PAS stain, myeloid metaplasia
Laboratory ● Megakaryocyte nucleus, myeloid metaplasia with myelofibrosis
Malignancies ● Micromegakaryocyte, myeloid metaplasia with myelofibrosis
Pediatrics ● Segmented neutrophil, band neutrophil, normal blood
Red Cell Disorders
Infections
Veterinary

Blood: capillary
News or representation of any kind with respect to the material available at this
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Blood: EDTA anticoagulated
Bloodline Blood: EDTA anticoagulated

Home
About ● Lymphocyte, platelet fragment, megathrombocyte, M-7 leukemia
● Small platelets, megathrombocyte, M-7 leukemia
● Small platelets, acute megakaryocytic (M-7) leukemia
● Normal Platelets, Normal EDTA anticoagulated blood
Educational Features ● Normal Platelets , Normal EDTA anticoagulated blood
Image Atlas
●

Case Studies
●

Private Lectures
●

Conference Reviews
●

Journal Articles
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Book Reviews
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Glossary
●
● Platelets, Megathrombocyte, EDTA anticoagulated blood

● Megathrombocyte, EDTA anticoagulated blood, ET
Resources ● Late Neutrophil Surrounded - Platelets, Platelet Satellitism
Conference Calendar
● Mature Neutrophils surrounded by Platelets, Satellitism
● Mature Neutrophils, Platelet Satellitism
Hematology Links
Full Text Journals
● Monocyte, engulfed platelets, Platelet Satellitism
Classifieds
Specialties
●

BMT/Stem Cell ● Plasma Cell, alcoholic, liver disease blood
Cord Blood ● Plasma Cell, alcoholic, liver disease blood
Thrombosis ● Mature megakaryocyte, Essential Thrombocytosis
Hemostasis ● Micromegakaryocytes, megathrombocytes, myeloid leukemia
Laboratory ● Micromegakaryocytes, megathrombocyte, myeloid leukemia blood
Malignancies ● Micromegakaryocyte, megathrombocytes, myeloid leukemia blood
Pediatrics ● Myeloblast, micromegakaryocyte, myeloid leukemia blood
Red Cell Disorders
Infections
Veterinary

Blood: EDTA anticoagulated
News or representation of any kind with respect to the material available at this
site.
Hematology News
Blood News Update
Discussion
Today's Discussion
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Blood Area
Bloodline Blood Area

Home
About ● Blasts, AML
Educational Features ● Plasmacytoid lymphocytes, severe arthritis with osteoporosis
Image Atlas
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Case Studies
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Private Lectures
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Conference Reviews
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Journal Articles
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Book Reviews
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Glossary
●

● Mature megakaryocyte, blood smear
● Late megakaryocyte, buffy coat, lung cancer blood
Resources ● Small megakaryocyte, Thrombotic Thrombocytopenic Purpura
● Bare megakaryocyte nuclei, NRBC, cancer blood
Conference Calendar
● Normal blood, dense area
● Normal blood - dense area
Hematology Links
● Normal blood - dense area, segmented neutrophil
Full Text Journals
● Normal blood - dense area, lyphocyte, segmented neutrophil
Classifieds
● Blood - thin area, lymphocytes, neutrophils
● Blood - thin area, lymphocyte, smudge cell
Specialties
●

BMT/Stem Cell ● Segmented neutrophil, lymphocyte, thin area blood
Cord Blood ● Lymphocyte, thin tail area blood
Thrombosis ● Lymphocyte with granules, tail area of normal blood
Hemostasis ● Monocyte, dense area, normal blood
Laboratory ● Monocyte with engulfed platelets, tail area blood
Malignancies
Pediatrics
Red Cell Disorders
Infections
Transfusion Medicine Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All
Veterinary rights reserved. The material available at this site is for educational
site.
http://image.bloodline.net/ba (1 of 2)13/07/2005 04:28:18

Blood Area
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http://image.bloodline.net/ba (2 of 2)13/07/2005 04:28:18

Blood Area: dense area
Bloodline Blood Area: dense area

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About ● Plasma cells, severe arthritis with osteoporosis
● Plasma cell, bacterial infection blood
● Rouleaux formation, plasma cell, Multiple myeloma
Educational Features ● Pathologic rouleaux formation, Multiple myeloma
Image Atlas
●

Case Studies
●

Private Lectures
●

Conference Reviews
●

Journal Articles
●

Book Reviews
●
Glossary
Resources Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All

Conference Calendar purposes only and is NOT intended for any diagnostic, clinically
Grants & Fellowships related, or other purpose. Carden Jennings Publishing Co., Ltd., assumes no
Hematology Links responsibility for any use or misuse of this material and makes no warranty
Full Text Journals or representation of any kind with respect to the material available at this
Classifieds site.
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary
http://image.bloodline.net/ba1 (1 of 2)13/07/2005 04:28:26

Blood Area: dense area
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Hematology News
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Blood Area: thin area
Bloodline Blood Area: thin area

Home
About ● Plasma Cell, alcoholic, liver disease blood
Educational Features ● Blood - thin area, lymphocytes, neutrophils
Image Atlas
●

Case Studies
●

Private Lectures
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Conference Reviews
Journal Articles
Book Reviews
Glossary
Resources
Conference Calendar or representation of any kind with respect to the material available at this
Grants & Fellowships site.
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
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Veterinary

Blood Area: thin area
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Hematology News
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Blood Area: Tail Area
Bloodline Blood Area: Tail Area

Home
About ● Blasts, AML
Educational Features ● Mature megakaryocyte, blood smear
Image Atlas
●

Case Studies
●

Private Lectures
●

Conference Reviews
●

Journal Articles
●

Book Reviews
●
Glossary
Resources Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All

Conference Calendar purposes only and is NOT intended for any diagnostic, clinically
Grants & Fellowships related, or other purpose. Carden Jennings Publishing Co., Ltd., assumes no
Hematology Links responsibility for any use or misuse of this material and makes no warranty
Full Text Journals or representation of any kind with respect to the material available at this
Classifieds site.
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary

Blood Area: Tail Area
News
Hematology News
Blood News Update
Discussion
Today's Discussion
Create New Topic
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Blood Area: Side Edge
Bloodline Blood Area: Side Edge

Home
About ● Plasmacytoid lymphocytes, severe arthritis with osteoporosis
Image Atlas
Case Studies
Private Lectures
Conference Reviews
Journal Articles related, or other purpose. Carden Jennings Publishing Co., Ltd., assumes no
Book Reviews responsibility for any use or misuse of this material and makes no warranty
Glossary or representation of any kind with respect to the material available at this
site.
Resources
Conference Calendar
Hematology Links
Full Text Journals
Classifieds
Specialties
BMT/Stem Cell
Cord Blood
Thrombosis
Hemostasis
Laboratory
Malignancies
Pediatrics
Red Cell Disorders
Infections
Veterinary

Blood Area: Side Edge
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Hematology News
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Today's Discussion
Create New Topic
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Bone Marrow
Bloodline Bone Marrow

Home
About ● Mature megakaryocytes (abnormal), M-7 leukemia
● Abnormal megakaryocytes, proerythroblast, M-7 leukemia
● Abnormal intermediate stage megakaryocyte, M-7 leukemia
● Mature megakaryocyte, acute megakaryocytic leukemia
Educational Features ● Mature and abnormal megakaryocytes, M-7 leukemia
Abnormal mature megakaryocytes, M-7 leukemia
Image Atlas
●
Abnormal mature megakaryocyte, acute megakaryocytic leukemia

Case Studies
●

Private Lectures
●
Mature and young megakaryocytes, mitosis, M-7 leukemia

Conference Reviews
●
Abnormal small mature megakaryocytes, M-7 leukemia

Journal Articles
●
Abnormal mature megakaryocyte, mitosis, M-7 leukemia

Book Reviews
●
Abnormal mature megakaryocytes, late NRBCs, M-7 leukemia

Glossary
●
● Abnormal mature megakaryocytes, M-7 leukemia

● Abnormal megakaryocyte, acute megakaryocytic leukemia
● Abnormal mature megakaryocyte, acute megakaryocytic leukemia
Resources ● Blasts, polychromatic nrbcs, acute megakaryocytic leukemia
● Giant abnormal NRBC, acute megakaryocytic leukemia
Conference Calendar
● Peroxidase stain, acute megakaryocytic leukemia
● Megakaryocyte, blasts, peroxidase stain, M-7 leukemia
Hematology Links
● Megakaryocytes, PAS stain, acute megakaryocytic leukemia
Full Text Journals
● Megakaryocytes, PAS stain, acute megakaryocytic leukemia
Classifieds
● Megakaryocytes, Glycoprotein IIbIIIa stain, M-7 leukemia
● Megakaryocytes, Glycoprotein IIbIIIa stain, M-7 leukemia
● Megakaryocytes, platelets, Glycoprotein IIbIIIa stain, AML
Megakaryocytes, H & E stain, acute megakaryocytic leukemia
Specialties
●
● Abnormal megakaryocytes, H & E stain, AML marrow biopsy

BMT/Stem Cell ● Abnormal megakaryocytes, late NRBCs, AML marrow biopsy
Cord Blood ● Abnormal megakaryocytes, late NRBCs, H & E stain, AML marrow
Thrombosis ● Megakaryoblasts, megakaryocytes, AML marrow
Hemostasis ● Abnormal megakaryoblasts, lymphocytes, AML marrow
Laboratory ● Megakaryoblasts with cytoplasmic granulation, AML marrow
Malignancies ● Megakaryoblasts with coarse azurophilic granules, AML marrow
Pediatrics ● Osteoblasts, acute megakaryocytic leukemia marrow
Red Cell Disorders ● Megakaryoblast, Glycoprotein IIbIIIa stain, AML marrow
Infections ● Megakaryocyte and platelets, Glycoprotein IIbIIIa stain, AML
Transfusion Medicine ● Megakaryocyte and platelets, Glycoprotein IIbIIIa stain, AML
Veterinary ● Megakaryoblast, Glycoprotein IIbIIIa stain, AML marrow
● Disrupted Megakaryocytes, Wright's-Giemsa stain, AML marrow
● Disrupted Megakaryocytes, Wright's-Giemsa stain, AML marrow
● Abnormal Megakaryocyte, Wright's-Giemsa stain, AML marrow
● Abnormal megakaryocyte, Wright's-Giemsa stain, AML marrow
http://image.bloodline.net/bm (1 of 8)13/07/2005 04:29:01

Bone Marrow
News ● Abnormal and/or immature megakaryocytes, AML marrow biopsy

● Megakaryocytes, NRBC clump, H & E stain, AML marrow
Hematology News ● AML, Marrow biopsy
Blood News Update ● Abnormal Mature Megakaryocyte, Mitosis, AML
● Abnormal Megakaryocytes, Platelets, AML
Discussion
● AML, Marrow biopsy
Today's Discussion ● Abnormal Megakaryocytes, AML, Marrow biopsy
Create New Topic ● Abnormal Megakaryocytes, Blasts, AML, marrow biopsy
List by Topic ● Abnormal Megakaryocytes, AML, Marrow biopsy
● Marked fibrosis, Reticulin stain, AML, Marrow biopsy
● Abnormal Megakaryocytes, AML, Marrow biopsy
● Reticulin stain, Abnormal Megakaryocytes, AML, marrow biopsy
● Reticulin fibers, Megakaryocytes, Blast, AML, Marrow biopsy
● Blasts, AML
● Blasts, M-7 leukemia, neutrophils, NRBC, Down's syndrome
● Blasts, Megakaryocyte, AML
● Blasts, AML
● Mitotic Neutrophilic cell, AML
● Abnormal Megakaryocytes, AML
● Megakaryocyte, AML
● Reticulin Fibers, Reticulin stain, AML, Marrow biopsy
● Abnormal Megakaryocytes, Giemsa stain, AML, Marrow biopsy
● AML (M-7) in Remission
● Acute Megakaryocytic Leukemia (M-7) in Remission
● Acute Megakaryocytic Leukemia (M-7) in Remission
● Plasma cell, polychromatic NRBC
● Plasma cell, lymphocyte
● Plasma cell
● Plasma Cell, polychromatic stage NRBC
● Plasma Cell
● Plasma Cell
● Plasma Cells
● Plasma Cells
● Plasma cell, mature lymphocyte
● Plasma Cells, Acute myelomonocytic (M-4) leukemia
● Plasma cell, NRBCs, hypersplenism
● Plasma cells, late NRBC, progranulocyte
● Plasma cell, NRBC in mitosis

Bone Marrow
● Plasma cell, Myelodysplastic syndrome

● Plasmablast, plasmacytoid lymphocyte
● Plasma cells, proerythroblast, NRBC
● Plasma cells, late NRBC, neutrophilic myelocyte
● Plasma cell, early and late NRBCs
● Plasma cell, proerythroblast
● Mature lymphocyte, proerythroblast, basophilic erythroblast
● Plasma cell, late NRBC, band neutrophil
● Plasma Cells, proerythroblast, normal marrow
● Plasma cell, binucleated plasma cell, normal marrow
● Plasma Cells, binucleated plasma cell, ITP
● Binucleated Plasma Cell, normal marrow
● Binucleated Plasma Cell, orthochromatic NRBC
● Binucleated Plasma cell, orthochromatic NRBC, normal marrow
● Binucleated plasma cell with a fragmenting cytoplasm
● Plasma cell with four nuclei, Acute myeloid leukemia
● Tri-nucleated plasma cell, blasts, Acute myeloid leukemia
● Plasma cell, Iron stain preparation, proerythroblast
● Macrophage, plasma cells, multiple myeloma
● Macrophage, Plasma Cell, normal marrow
● Mott Cell, binucleated early megakaryocyte
● Plasma cell, Morula cell, Mott cell, Russell bodies, ITP
● Plasma cell with multiple vacuoles, normal marrow
● Plasma cell, multiple vacuoles, anemia of chronic infection
● Plasma cell with multiple vacuoles, multiple nuclei
● Grape Cell, marrow
● Plasma cells, multiple vacuoles, Myelodysplastic syndrome
● Plasma Cell with vacuole overlying its nucleus
● Plasma cell with vacuole overlying nucleus
● Plasma Cell, vacuoles overlying nucleus
● Plasma Cell, three large vacuoles overlying its nucleus
● Plasma cell, vacuoles overlying nucleus, monocyte
● Plasma Cell, osteoblast, normal marrow
● Osteoblast, plasma cells, normal marrow
● Eosinophilic myelocyte, neutrophilic myelocytes
● Eosinophilic myelocyte, eosinophilic metamyelocyte, mitosis
● Eosinophilic myelocytes, neutrophilic myelocytes, Marrow
● Eosinophilic myelocyte, neutrophilic myelocyte
● Crushed eosinophilic myelocyte
● Crushed myelocyte, polychromatic, orthochromatic NRBC
● Basophil, Toluidine Blue stain
● Basophils, Toluidine Blue stain, CML
● Mast
● Mast cell
● Mast cells
● Mast cell
● Mast cell, Normal marrow
● Mast cell, Normal marrow
● Mast cell
● Mast cell
● Mast cell, macrophages, Normal marrow
● Mast cell

Bone Marrow
● Mast cell
● Mast cell, Toluidine Blue, Systemic mastocytosis marrow
● Mast, Periodic Acid Schiff, Toluidine Blue stains
● Systemic mastocytosis, mast cells
● Mast cells, Systemic mastocytosis marrow
● Mast cells, Systemic mastocytosis, Marrow
● Mast,Toluidine Blue stain, Systemic mastocytosis marrow
● Osteoblasts
● Osteoblasts, Normal marrow
● Osteoblasts
● Osteoblasts
● Osteoblast
● Plasma cell, osteoblasts
● Osteoblasts
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast
● Osteoclast, megakaryocyte
● Osteoclast, neuroblastoma cells, neuroblastoma
● Osteoclasts
● Osteoclast
● Fat cells. Aplastic anemia marrow
● Fat cells, Aplastic anemia marrow
● Fat cells, Aplastic anemia marrow
● Fat cell, macrophages
● Fat cell, Normal marrow
● Endothelial cells.
● Endothelial cells
● Megakaryocytes
● Mature megakaryocytes
● Megakaryocytes
● Megakaryocytes
● Megakaryocytes, fat cells
● Mature megakaryocytes, emperipolis
● Mature megakaryocytes, dying
● Mature megakaryocyte, plasma cells
● Mature megakaryocytes, macrophage, ITP
● Mature megakaryocyte
● Mature megakaryocyte, hypercellular marrow

Bone Marrow
● Small megakaryocytes
● Mature megakaryocytes, Chronic myeloid leukemia
● Mature megakaryocytes, Idiopathic thrombocytopenic purpura
● Megakaryoblast, intermediate neutrophilic cells, ITP marrow
● Megakaryoblast, normal marrow
● Megakaryoblast, prominent golgi area, normal marrow
● Megakaryoblast, pale golgi area, ITP marrow
● Megakaryoblast, ITP marrow
● Megakaryoblast, irregular nuclear outline, ITP marrow
● Megakaryoblast, ITP marrow
● Large megakaryoblast, normal marrow
● Megakaryoblast, visible cytoplasm, normal marrow
● Megakaryoblast, binucleated megakaryocyte, myeloid leukemia
● Megakaryoblast , fold in nucleus, normal marrow
● Early binucleated megakaryocyte, chronic myelocytic leukemia
● Megakaryoblast, binucleated megakaryocyte, ET marrow
● Normal binucleated megakaryocyte, normal marrow
● Young megakaryocyte, AIDS patient marrow
● Young megakaryocyte, Essential thrombocytosis marrow
● Megakaryocyte with 2 nuclei, normal marrow
● Megakaryocyte with 2 nuclei, prominent golgi area, marrow
● Binucleated megakaryocyte, normal marrow
● Binucleated megakaryocyte, late NRBC, ITP marrow
● Binucleated megakaryocyte, myelocytes, late NRBC
● An almost binucleated megakaryocyte
● Megakaryocyte with nuclear lobulation, normal marrow
● Intermediate megakaryocyte with lobulated nuclei
● Binucleated megakaryocyte, mature megakaryocyte, ITP marrow
● Promegakaryocyte with nuclear separation, normal marrow
● Promegakaryocyte, early nuclear lobulation, normal marrow
● Promegakaryocyte with nuclear separation, lobulation
● Promegakaryocyte, intermediate neutrophilic cell, ITP marrow
● Promegakaryocyte with several nuclei, normal marrow
● Promegakaryocyte with multiple nuclei, ITP marrow
● Promegakaryocyte with multiple nuclei, ITP marrow
● Young megakaryocyte, normal marrow
● Young megakaryocyte, neutrophilic myelocytes, normal marrow
● Intermediate megakaryocyte, normal marrow
● Intermediate megakaryocyte, basophil, smudge cells
● Intermediate stage megakaryocyte, normal marrow
● Intermediate stage megakaryocyte and part of another

Bone Marrow
● Intermediate megakaryocyte, cytoplasmic granulation

● Intermediate to mature stage megakayocyte, normal marrow
● Mature megakaryocyte with multiple nuclei, ITP marrow
● Mature megakaryocyte, ITP marrow
● Mature megakaryocyte with multiple nuclei, normal marrow
● Mature megakaryocyte with multiple nuclei, ITP marrow
● Mature megakaryocyte, plasma cell, ITP marrow
● Mature megakaryocyte, ITP marrow
● Mature megakaryocytes, ITP marrow
● Mature megakaryocyte, osteoclast, NRBC in mitosis
● Mature megakaryocyte, normal marrow
● Mature megakaryocyte, overlapping nuclei, ITP marrow
● Mature megakaryocyte with multiple overlapping nuclei
● Mature megakaryocytes, overlapping nuclei, normal marrow
● Mature megakaryocyte, clumps of platelets
● Mature megakaryocyte, binucleated megakaryocyte
● Mature megakaryocyte with two nuclei, ITP marrow
● Macrophage, mature megakaryocyte, normal marrow
● Mature megakaryocyte, intermediate megakaryocyte, ITP marrow
● Three megakaryocytes: 2 mature, 1 intermediate
● Three megakaryocytes: 1 intermediate, 2 mature
● Megakaryocytes, megakaryocyte cytoplasmic fragment
● Mature megakaryocyte, intermediate megakaryocyte, ITP marrow
● Mature megakaryocyte, megakaryoblast, ITP marrow
● Mature megakaryocytes, binucleated megakaryocyte
● Mature megakaryocyte, megakaryoblast, binucleated
● Eosinophilic myelocyte, Normal marrow
● Osteoblast, Plasma cells, Normal marrow
● Bare megakaryocyte nuclei, Normal marrow
● Late megakaryocyte, Normal marrow
● ITP marrow
● Mitotic form megakaryocyte, ITP marrow
● Mitotic form megakaryocyte, ITP marrow
● Megakaryoblast, Emperipolis, Essential Thrombocytosis
● Megakaryoblast, emperipolis, hemolytic anemia
● Megakaryoblast, NRBC, Emperipolis, Hemolytic anemia
● Intermediate megakaryocyte, ITP marrow
● Intermediate megakaryocyte, Emperipolis, Normal marrow
● Intermediate megakaryocyte, megakaryoblast, normal marrow
● Intermediate megakaryocyte, late NRBC, mature neutrophil
● Intermediate megakaryocytes, emperipolis, macrophage
● Mature megakaryocytes, emperipolis, normal marrow
● Mature megakaryocyte, emperipolis, normal marrow
● Mature megakaryocyte, NRBC, emperipolis, ITP marrow
● Mature megakaryocytes, normal marrow biopsy, H & E stain
● Megakaryocytes, marrow biopsy, H & E stain

Bone Marrow
● Mature megakaryocytes, marrow biopsy, H & E stain

● Megakaryocytes, marrow biopsy, H & E stain
● Mature megakaryocyte, marrow biopsy, H & E stain
● Megakaryocytes, myeloid metaplasia with myelofibrosis marrow
● Abnormal megakaryocytes, myeloid metaplasia/myelofibrosis
● Small megakaryocyte, granulated cytoplasm, ITP marrow
● Small megakaryocyte, ITP marrow
● Small megakaryocyte, ITP marrow
● Micromegakaryocytes, plasma cell, myelodyspastic marrow
● Micromegakaryocyte, ITP marrow
● Abnormal megakaryocytes, essential thrombocytosis marrow
● Small mature megakaryocyte, normal marrow
● Mature micromegakaryocyte, myelodysplastic (MDS) marrow
● Mature micromegakaryocyte, ITP marrow
● Mature binucleated micromegakaryocyte, normal marrow
● Mature megakaryocyte, macrophage, ITP marrow
● Abnormal megakaryocyte, megakaryocytic (M-7) leukemia
● Micromegakaryocyte, megakaryocytic (M-7) leukemia marrow
● Abnormal megakaryocyte, megakaryocytic (M-7) leukemia marrow
● Abnormal megakaryocyte, megakaryocyte (M-7) leukemia marrow
● Mature megakaryocyte, PAS stain, Gaucher's disease marrow
● Mature megakaryocytes, Gauchers' disease marrow, PAS stain
● Late megakaryocyte, PAS stain, normal marrow
● Late megakaryocyte, PAS stain, ITP marrow
● Mature megakaryocyte, acid phosphatase stain, normal marrow
● Megakaryocytes, neutrophilic cell, double esterase stain
● Platelets, GP IIb,IIIa stain
● Mature megakaryocyte, platelets, NRBC, GP IIb,IIIa stain
● Mature megakaryocytes, GP IIb,IIIa stain, normal marrow
● Megakaryoblast, GP IIb,IIIa stain, normal marrow
● Megakaryocytes, GP IIb,IIIa stain, ITP marrow
● Blasts, Wrights-Giemsa stain, chronic myeloid leukemia
● Blasts, GP IIb,IIIa stain, acute megakaryocytic leukemia
● Early monocytes, normal marrow
● Young monocyte, normal marrow
● Monocyte, neutrophilic myelocyte, normal marrow
● Metamyelocyte, normal marrow
● Metamyelocyte, smudge cell, normal marrow
● Metamyelocyte, neutrophilic myelocyte, normal marrow
● Late neutrophilic myelocyte, normal marrow
● Neutrophilic myelocyte, segmented neutrophil, normal marrow
● Neutrophilic myelocyte, normal marrow
● Neutrophilic myelocyte, late NRBC
● Band neutrophil, metamyelocyte, neutrophilic myelocyte, NRBC
● Neutrophilic metamyelocyte, neutrophilic myelocyte

Bone Marrow
● Intermediate neutrophilic myelocyte, normal marrow

● Neutrophilic myelocyte, smudge cell, normal marrow
● Neutrophilic myelocyte, late NRBC, normal marrow
● Intermediate neutrophilic myelocytes, normal marrow
● Neutrophilic myelocyte, almost no granules, normal marrow
● Segmented neutrophils, band neutrophils, myelocytes
● Myelocyte, smashed myelocyte, bare nucleus, smudge cells
● Myelocyte, segmented neutrophil, normal marrow
● Myelocyte, band neutrophil, normal marrow
● Myelocyte with many azure granules, normal marrow
● Myelocytes, band neutrophils, metamyelocyte
● Myelocyte, disrupted band neutrophil
● Myelocytes, promyelocyte, late NRBC, metamyelocyte
● Progranulocyte, band neutrophils
● Progranulocyte, band neutrophils, normal marrow
● Progranulocyte, segmented neutrophil, polychromatic NRBC
● Progranulocyte, band neutrophil, normal marrow
● Progranulocyte, myelocyte, metamyelocyte, monocyte
● Progranulocyte, myelocyte, normal marrow
● Progranulocyte, band neutrophil, lymphocyte, monocyte
● Progranulocyte, dying lymphocyte, normal marrow
● One very early progranulocyte, normal marrow
● Early progranulocyte, normal marrow
● Myeloblast, neutrophilic metamyelocyte, normal marrow
● Myeloblast, late neutrophil, normal marrow
● Myeloblast, normal marrow
● Myeloblast, basophil, normal marrow
● Myeloblasts, lymphocyte, late NRBC, normal marrow
● Myeloblast, band neutrophil, normal marrow
● Myeloblast, polychromatic NRBCs, normal marrow
● Myeloblast, lymphocyte, normal marrow
● Myeloblast, late NRBC, normal marrow
● Reticular cells, polychromatic NRBCs, normal marrow
● Reticular cell, normal marrow
● Reticular cell, monocyte, normal marrow
● Reticular cell, neutrophilic myelocyte, normal marrow

site.

Mature megakaryocytes (abnormal), M-7 leukemia
Bloodline Mature megakaryocytes (abnormal), M-7

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leukemia
Many mature megakaryocytes; some of which appear abnormal with an uneven number of nuclei, unequal size nuclei
and reduced number of nuclei. Acute megakaryocytic leukemia (M-7) marrow - 20X
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Mature megakaryocytes (abnormal), M-7 leukemia

Abnormal megakaryocytes, proerythroblast, M-7 leukemia
Bloodline Abnormal megakaryocytes, proerythroblast, M-

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7 leukemia
Two Abnormal Mature Megakaryocytes. One at left center is small and contains only two nuclei. The mature
megakaryocyte at right center, also small, contains four nuclei and a granulated cytoplasm surrounded by vacuoles.
The smudged remains of another small mature megakaryocyte lies above it. Also in the field are one Proerythroblast
(above the megakaryocyte at left center), a blast of questionable megakaryocytic origin to its right, and several late
Image Atlas NRBC, most of which have little cytoplasm. Acute Megakaryocytic Leukemia (M-7). Marrow - 50X
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Image ID: 0137-005
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Abnormal megakaryocytes, proerythroblast, M-7 leukemia

Abnormal intermediate stage megakaryocyte, M-7 leukemia
Bloodline Abnormal intermediate stage megakaryocyte,

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M-7 leukemia
One Abnormal Intermediate Stage Megakaryocyte at the left which shows only 3 nuclei, one of which is twice the size
of the others. Agranular cytoplasmic fragments are numerous. The small mature form at the right shows a small
amount of nuclear material and normal granulation. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Abnormal intermediate stage megakaryocyte, M-7 leukemia

Mature megakaryocyte, acute megakaryocytic leukemia
Bloodline Mature megakaryocyte, acute megakaryocytic

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leukemia
One very large Mature Megakaryocyte with nuclei of unequal size and poor cytoplasmic granulation. The mature red
cell may be lying on top of the megakaryocyte. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Mature megakaryocyte, acute megakaryocytic leukemia

Mature and abnormal megakaryocytes, M-7 leukemia
Bloodline Mature and abnormal megakaryocytes, M-7

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leukemia
Two Mature and Abnormal Megakaryocytes. Both show unequal size nuclei. One has a long filament connecting two
nuclei. Both have poorly developed cytoplasmic granulation. There are several blasts in the field with dark basophilic
cytoplasm which may be of erythroid or megakaryocytic origin. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Mature and abnormal megakaryocytes, M-7 leukemia

Bloodline Abnormal mature megakaryocytes, M-7

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leukemia
Three Abnormal Mature Megakaryocytes. The large form at the left shows an uneven number of nuclei (7) with some
inequality in size. The cytoplasm is poorly granulated. Beneath it is a small mature megakaryocyte with reduced
nuclear mass and poor cytoplasmic granulation. At right edge is a small mature megakaryocyte with 7 nuclei of
unequal size. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Bloodline Abnormal mature megakaryocyte, acute

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One Abnormal Mature Megakaryocyte with a very high nuclear/ cytoplasmic ratio and multiple nuclei of unequal size
and peripheral cytoplasmic vacuolization. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Home
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One Abnormal Mature stage Megakaryocyte at left shows unequal size nuclei. At its right is a very early binucleated
stage megakaryocyte. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Bloodline Mature and young megakaryocytes, mitosis, M-

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7 leukemia
The Abnormal Mature Megakaryocyte at left center shows an uneven (7) number of nuclei which are unequal in size.
The cytoplasm is surrounded by vacuoles. Above it is a small cell with a very high nuclear/cytoplasmic ratio, a very
dense nucleus and a prominent Golgi area. It could be an early megakaryocyte, however, the dense nucleus suggests
disparity in maturation. At the upper right corner is a small mature megakaryocyte with poor cytoplasmic
Image Atlas development. At lower center is an Abnormal Mature Megakaryocyte with few and unequal size nuclei and poorly
Case Studies developed cytoplasmic granulation. Above it is a Young Megakaryocyte in the process of Mitosis. Acute
Megakaryocytic Leukemia (M-7). Marrow - 50X
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Image ID: 0137-012

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Bloodline Abnormal small mature megakaryocytes, M-7

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Two Abnormal Small Mature Megakaryocytes with scanty cytoplasm. Acute Megakaryocytic Leukemia (M-7). Marrow -
100X
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Bloodline Abnormal mature megakaryocyte, mitosis, M-7

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leukemia
One Abnormal Mature Megakaryocyte in the center with a single nucleus and poorly developed cytoplasmic
granulation. The cytoplasmic pseudopods may fragment off and appear as agranular megathrombocytes in the blood.
The large cell above it is showing nuclear mitosis. The blast to right center may be a proerythroblast or a
megakaryoblast. Several other blasts in the field appear more myeloid. Acute Megakaryocytic Leukemia (M-7).
Image Atlas Marrow - 100X
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Image ID: 0137-014
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Bloodline Abnormal mature megakaryocytes, late NRBCs,

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M-7 leukemia
These Abnormal Mature Megakaryocytes are small, contain reduced numbers of nuclei and reduced amounts of
cytoplasm. At right of center is a young megakaryocyte with a single nucleus and prominent Golgi apparatus and
little granulation. At its right is an early binucleated megakaryocyte. Several late NRBCs with poor cytoplasmic
development are in the field. Acute Megakaryocytic Leukemia (M-7). Marrow - 50X
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Image ID: 0137-015
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Bloodline Abnormal mature megakaryocytes, M-7

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leukemia
Clump of Abnormal Mature Megakaryocytes which are small and show nuclear hypolobulation. Acute Megakaryocytic
Leukemia (M-7). Marrow - 50X
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Abnormal megakaryocyte, acute megakaryocytic leukemia
Bloodline Abnormal megakaryocyte, acute

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One Abnormal small young Megakaryocyte at lower edge, with a prominent Golgi area. At its upper right is a small
abnormal mature megakaryocyte with a single nucleus and cytoplasmic vacuolization replacing granulation. Acute
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Abnormal megakaryocyte, acute megakaryocytic leukemia


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Abnormal Mature Megakaryocyte which is hypergranulated. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Blasts, polychromatic nrbcs, acute megakaryocytic leukemia
Bloodline Blasts, polychromatic nrbcs, acute

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Two Blasts of medium size with fine nuclear chromatin, prominent nucleoli and light blue cytoplasm. Two
Polychromatic stage NRBCs. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Blasts, polychromatic nrbcs, acute megakaryocytic leukemia

Giant abnormal NRBC, acute megakaryocytic leukemia
Bloodline Giant abnormal NRBC, acute megakaryocytic

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leukemia
One Giant Abnormal NRBC with several nuclei displaying a coarse open chromatin pattern. Three blasts of myeloid
appearance lie below. Two large megakaryocyte cytoplasmic fragments (megathrombocytes) are present and four
polychromatic and orthrochromatic NRBCs. Acute Megakaryocytic Leukemia (M-7). Marrow - 100X
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Giant abnormal NRBC, acute megakaryocytic leukemia

Peroxidase stain, acute megakaryocytic leukemia
Bloodline Peroxidase stain, acute megakaryocytic

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leukemia
One negative megakaryocyte and many negative blasts. The dark staining cells are red cells. Peroxidase Stain with
no counterstain. Acute Megakaryocytic Leukemia (M-7). Marrow - 50X
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Peroxidase stain, acute megakaryocytic leukemia

Megakaryocyte, blasts, peroxidase stain, M-7 leukemia
Bloodline Megakaryocyte, blasts, peroxidase stain, M-7

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leukemia
One negative megakaryocyte at lower right and many negative blasts. Two positive neutrophilic cells; one at top
center and the other at the right of the megakaryocyte. The red cells show dark granulation (staining artefact).
Peroxidase Stain with no counterstain. Acute Megakaryocytic Leukemia (M-7). Marrow - 50X
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Megakaryocyte, blasts, peroxidase stain, M-7 leukemia

Megakaryocytes, PAS stain, acute megakaryocytic leukemia
Bloodline Megakaryocytes, PAS stain, acute

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Four positive Megakaryocytes showing red globules and granulation. Periodic acid Schiff (PAS) stain. Acute
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Bloodline Megakaryocytes, PAS stain, acute

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Three positive Megakaryocytes showing red globules and granulation. The small one at left center may be very
young. The cell above it is probably intermediate in stage. Periodic acid Schiff (PAS) stain. Acute Megakaryocytic
Leukemia (M-7). Marrow - 100X
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Megakaryocytes, Glycoprotein IIbIIIa stain, M-7 leukemia
Bloodline Megakaryocytes, Glycoprotein IIbIIIa stain, M-

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7 leukemia
Four positive Megakaryocytes and many positive platelets. Glycoprotein IIbIIIa stain. Acute Megakaryocytic Leukemia
(M-7). Marrow - 50X
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Bloodline Megakaryocytes, Glycoprotein IIbIIIa stain, M-

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7 leukemia
Six positive Megakaryocytes and several positive blasts. Glycoprotein IIbIIIa stain. Acute Megakaryocytic Leukemia
(M-7). Marrow - 10X
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Megakaryocytes, platelets, Glycoprotein IIbIIIa stain, AML
Bloodline Megakaryocytes, platelets, Glycoprotein

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IIbIIIa stain, AML
Two positive Megakaryocytes (one is very small), several positive blasts showing a few scattered cytoplasmic
granules, and many positive platelets. Glycoprotein IIbIIIa stain. Acute Megakaryocytic Leukemia (M-7). Marrow -
100X
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Megakaryocytes, platelets, Glycoprotein IIbIIIa stain, AML

Bloodline Megakaryocytes, H & E stain, acute

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Marked increased number of Megakaryocytes, most of which are small, mature and abnormal. H & E stain. Acute
Megakaryocytic Leukemia (M-7). Marrow biopsy section - 20X
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Abnormal megakaryocytes, H & E stain, AML marrow biopsy
Bloodline Abnormal megakaryocytes, H & E stain, AML

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marrow biopsy
Abnormal Mature Megakaryocytes, many of which are small with a single nucleus. H & E stain. Acute Megakaryocytic
Leukemia (M-7). Marrow biopsy section - 50X
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Abnormal megakaryocytes, H & E stain, AML marrow biopsy

Abnormal megakaryocytes, late NRBCs, AML marrow biopsy
Bloodline Abnormal megakaryocytes, late NRBCs, AML

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marrow biopsy
Abnormal Megakaryocytes of variable size, nuclear lobe numbers and nuclear/cytoplasmic ratio. Many late NRBCs are
scattered throughout the field. H & E stain. Acute Megakaryocytic Leukemia (M-7). Marrow biopsy section - 50X
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Abnormal megakaryocytes, late NRBCs, AML marrow biopsy

Abnormal megakaryocytes, late NRBCs, H & E stain, AML marrow
Bloodline Abnormal megakaryocytes, late NRBCs, H & E

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stain, AML marrow
Abnormal Megakaryocytes and a clump of late NRBCs at lower right. H & E stain. Acute Megakaryocytic Leukemia (M-
7). Marrow biopsy section - 50X
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Abnormal megakaryocytes, late NRBCs, H & E stain, AML marrow

Megakaryoblasts, megakaryocytes, AML marrow
Bloodline Megakaryoblasts, megakaryocytes, AML marrow

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About Two Megakaryoblasts at lower center, one questionable late abnormal megakaryocyte at top right corner, one
abnormal intermediate stage megakaryocyte at its left. Acute Megakaryocytic Leukemia (M-7). Marrow - 50X
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Megakaryoblasts, megakaryocytes, AML marrow

Abnormal megakaryoblasts, lymphocytes, AML marrow
Bloodline Abnormal megakaryoblasts, lymphocytes, AML

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marrow
Two Abnormal Megakaryoblasts showing large size, vacuolization and/or irregular nuclear outline. One abnormal later
form is at lower right corner. Two lymphocytes provide size comparison. Acute Megakaryocytic Leukemia (M-7).
Marrow 100X
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Abnormal megakaryoblasts, lymphocytes, AML marrow

Megakaryoblasts with cytoplasmic granulation, AML marrow
Bloodline Megakaryoblasts with cytoplasmic granulation,

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AML marrow
Four Megakaryoblasts. All show cytoplasmic vacuolization. Two (lower frame) show early cytoplasmic granulation.
Acute Megakaryocytic Leukemia (M-7). Marrow - 200X
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Bone Marrow: Normal

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Bone Marrow: Normal

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Plasma cell, polychromatic NRBC
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NRBC and a bare lymphocyte nucleus are at lower right corner. Normal marrow - 100X
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Blood News Update with respect to the material available at Bloodline Reviews, Vol. 4,
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Patients at Risk for CMV
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A Case of Hereditary Elliptocytosis
Bloodline A Case of Hereditary Elliptocytosis Featured Resources
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Call for Papers Eiad Kahwash, MD, Peter Bauer, MD
Free Membership Martha Yearsley, MD
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Department of Pathology, University of Louisville, Louisville, KY.
Department of Pathology, Ohio State University, Columbus, OH.
Corresponding Author/Reprint: Eiad Kahwash, MD. ekahwash@yahoo.com

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University of Louisville Frontiers in
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Louisville, KY 40292 HematOncology
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Conference Calendar Here are three images from peripheral blood smear from a patient with Hereditary
Grants & Fellowships Elliptocytosis.The patient presented for a general check up when his CBC showed only
Hematology Links mild anemia with slightly increased reticulocytes. The diagnosis was made incidentally
BMT Reviews when blood smear was examined.
Classifieds
Hereditary Elliptocytosis: Online CME
Understanding DNA
Methylation and
Hereditary Elliptocytosis (HE) is a congenital hemolytic disorder in which the red blood
Specialties cells are either elongated (cigar or oval shape) or exhibit irregular degrees of Epigenetic Gene Silencing
poikilocytosis. This abnormality is a result of a defect in one of the skeletal proteins in in Cancer
BMT/Stem Cell
the red blood cells membrane. It is transmitted as an autosomal dominant trait with at
Cord Blood
least 4 genetic loci implicated in the pathogenesis.
Thrombosis
Hemostasis
The elliptical erythrocyte form is acquired in the circulation and that is why the
Laboratory
reticulocytes and bone marrow red blood precursors are normal in shape (1).
Malignancies
Pediatrics
Red Cell Disorders The true incidence is unknown because of it is asymptomatic in the majority of the
cases, but generally it is estimated to be present in 1 per 2000-5000 individuals.(1)
Infections
Morbidity ranges from asymptomatic cases most of the time to severe transfusion
Transfusion Medicine dependent disease, rare fatalities have been documented. While Hereditary
Veterinary Elliptocytosis has no sex predilection, it is more common in African and Mediterranean
Online CME
descents.
Myelodysplastic
Syndromes: Diagnosis
Clinical Findings: and Emerging Therapies
News
Hematology News Most patients with heterozygous (HE) are asymptomatic (common HE), however
Blood News Update homozygous patients with Hereditary pyropoikilocytosis (HPP) may suffer from severe
hemolytic anemia and may become transfusion dependent (2)(3). Stomatocytic
Elliptocytosis is a benign disorder in which red blood cells have a broad and oval shape
with a presence of stomatocytes occasionally (more common in Southeast Asia). The
Discussion most common complications that patients with HE face are gallstones and hemolytic
crisis and to a lesser extent, leg ulcers and/ or dermatitis. (3)
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The diagnosis is made based on the findings on the peripheral blood smears
(elliptocytes)(1). Elliptocytes can be seen in other diseases like in megaloblastic and
iron deficiency anemias, however the elliptocytes in these conditions are less than 25%
of the erythrocytes, in contrast to more than 25% in Hereditary Elliptocytosis Figs (1-2- Online CME
3) and sometimes up to 60%. (1)
http://www.bloodline.net/stories/storyReader$3592 (1 of 3)13/07/2005 18:47:11

Bloodline Reviews, Vol. 4,

Members
Controlled thermal stress test (not required to confirm the diagnosis) is also helpful. Issue 1
Join Now CBC findings of anemia (not common) with increased reticulocyte count (up to 4% may Prophylaxis and Pre-
Login get higher in severe cases)(1) assist in making the diagnosis as well. In addition to Emptive Therapy in
osmotic fragility tests (normal) and DNA testings that are not required but can play Patients at Risk for CMV
important rules in confirming the diagnosis.
Disease After Stem Cell
Transplant
Treatment:
Treatment is not indicated except in severe cases where occasional transfusion might
be required. (2) Daily Folate is recommended for patients with severe hemolysis.
Splenectomy may be considered in patients with severe anemia and significant
symptoms.
Key Words & Abbreviations: HE: Hereditary Elliptocytosis, HPP: Hereditary

pyropoikilocytosis, hemolytic anemia
Images:
Blood and Marrow

Extended
Bloodline Reviews
Volume 3, Issue 2
Immuno-fine-tuning:
Immune Globulin
Selection
Fig (1): Peripheral Blood Smear with Elliptocytosis (Giemsa 500X)
Blood and Marrow

Stem
Fig (2): Peripheral Blood Smear with Elliptocytosis (Giemsa 500X)

Fig (3): Peripheral Blood with Elliptocytosis (Giemsa 1000X)
References:
1 Shirlyn B McKenzie, Hematology, Second Edithion. Hemolytic Anemia Caused by

Intrinsic erythrocyte Defects.1996: 227-229.
2 Mandy Meck, eMedicine, Hereditary Elliptocytosis and Related Disorders. http://www.

emedicine.com/ped/topic987.htm
3 Ronald Hoffman, et al., 3rd Edition. Hematology, Basic Principles and Practice. Red
Blood Cells Disorders, Chapter 33.2000: 587-595
Copyright 1995-2005 - Carden Jennings Publishing Co., Ltd. All rights

reserved. The material available at this site is for educational purposes
only and is NOT intended for any diagnostic, clinically related, or other
purpose. Carden Jennings Publishing Co., Ltd., assumes no responsibility for any
use or misuse of this material and makes no warranty or representation of any
kind with respect to the material available at this site.

Lymphoid Blast Crisis in m-BCR-Positive CML
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CASE REPORT
Lymphoid Blast Crisis Is a Natural Course

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Positive Chronic Myelogenous Leukemia
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Mina Hur, Dong Soon Lee, Han Ik Cho,
Case Studies Seoksan Jung, Sunyang Park Frontiers in
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HematOncology
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Laboratory Hematology 7:65-68 Volume 4, Issue 1
Journal Articles ©2001 Carden Jennings Publishing Co., Ltd.
Book Reviews
Glossary
Patients with Philadelphia (Ph) chromosome-
positive chronic myelogenous leukemia (CML)
and a breakpoint located in the minor
breakpoint cluster region (m-BCR) have rarely
Resources been reported. We report a case of a 69-year-
old woman presenting with CML in lymphoid
Conference Calendar
blast crisis who had an m-BCR breakpoint and
Grants & Fellowships a bone marrow showing myeloproliferative
Hematology Links features such as increased granulopoiesis and
BMT Reviews megakaryopoiesis with focal fibrosis and an
Classifieds increased number of blasts. The leukemia was
in complete remission after induction Online CME
chemotherapy, but m-BCR e1a2 fusion Understanding DNA
transcripts were persistently detected during Methylation and
the remission period. Six months later, the Epigenetic Gene Silencing
patient developed a second lymphoid blast
in Cancer
crisis and an additional Ph chromosome was
observed. Along with the 2 previously
reported cases of m-BCR CML with an onset of
lymphoid blast crisis, this case strongly
suggests that an m-BCR fusion transcript
induces lymphoid differentiation during the
crisis.
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