4-Methoxy-N-ethylcathinone

TheDrugEnforcementAdministration'sSpecialTestingandResearchLaboratory
generated this monograph using structurally confirmed reference material.

O
NH

CH3

CH3

O
CH3
1. GENERAL INFORMATION
IUPAC Name:

2-(ethylamino)-1-(4-methoxyphenyl)propan-1-one

CAS#:

Not Available

Synonyms:

N/A

Source:

DEA Reference Material Collection

Appearance:

White powder (HCl)

UVmax (nm):

Not Determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA
Form

Chemical Formula

Molecular Weight

Melting Point ( oC)

Base

C12H17NO2

207

Not Determined

HCl

C12H17NO2 . HCl

243

214.4

Latest Revision: 06/13/2014

SWGDRUG.org/monographs.htm

Page 1 of 5

4-Methoxy-N-ethylcathinone
TheDrugEnforcementAdministration'sSpecialTestingandResearchLaboratory
generated this monograph using structurally confirmed reference material.
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~15 mg/mL in D 2O containing TSP for 0 ppm reference and maleic
acid as quantitative internal standard.
400 MHz NMR spectrometer
Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds

Instrument:
Parameters:

H NMR: 4-Methoxy-N-ethylcathinone HCl Lot # TAD0411; D 2O; 400MHz

Maleic Acid

HDO

1.00

0.75

TSP

0.50

0.25

0
2
8

2
8.04

8.02

1
7

2
7.125

Latest Revision: 06/13/2014

5.100

3.935

3
3

2
3.25

3.20

SWGDRUG.org/monographs.htm

3.15

3
3.10

1.6

3
1.5

1.4

Page 2 of 5

4-Methoxy-N-ethylcathinone
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~1 mg/mL base extracted into chloroform.
Agilent gas chromatograph operated in split mode with MS detector
DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 m
Helium at 1 mL/min
Injector: 280oC
MSD transfer line: 280oC
MS Source: 230 oC
MS Quad: 150oC
Oven program:
1) 100oC initial temperature for 1.0 min
2) Ramp to 300 oC at 12 oC/min
3) Hold final temperature for 9.0 min
Injection Parameters:
Split Ratio = 20:1, 1 L injected
MS Parameters:
Mass scan range: 30-550 amu
Threshold: 100
Tune file: stune.u
Acquisition mode: scan
Retention Time:
9.217min
EI Mass Spectrum: 4-Methoxy-N-ethylcathinone HCl Lot # TAD0411

5
Intensity [x 10 ]

72

Instrument:
Column:
Carrier Gas:
Temperatures:

5
4

44

40

60

Latest Revision: 06/13/2014

80

100

120

140

SWGDRUG.org/monographs.htm

160

180

207

192

174

164

145

135

121

107

92

77

64

EI+

56

38
42

200

m/z

Page 3 of 5

4-Methoxy-N-ethylcathinone
The Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.3 INFRARED SPECTROSCOPY (FTIR)
FTIR with diamond ATR attachment (3 bounce)
Number of scans: 32
Number of background scans: 32
Resolution: 4 cm-1
Sample gain: 8
Aperture: 150

Insrument:
Scan Parameters:

436 426
515
538

762
607
847

30

1184

1603
1686

40

688

50

978
1026
1038
1115

60

860

70

1240
1315 1255
1346
1419
1460 1435
1576

3016

2382
2453
2482
2696
2733
2748
2806
2895
2916
2937

%Transmittance

FTIR ATR (Diamond, 3 Bounce): 4-Methoxy-N-ethylcathinone HCl Lot # TAD0411

20
3000

2000

1500

Wavenumber (cm-1)

436

741
515
538

634
607

847

978

1026

1240
1255

1115

762

1038

798

688

426

827
860
916
931

1011

1057

1132

1201

1315

1603

1184

1686

30

1281

1419

50
40

1435

1576

60

2500

1346
1389
1396

1514

70

1460

%Transmittance

3500

20
1700

1600

1500

Latest Revision: 06/13/2014

1400

1300

1200

1100

1000

SWGDRUG.org/monographs.htm

900

800

700 Wavenumber (cm-1)

Page 4 of 5

4-Methoxy-N-ethylcathinone
TheDrugEnforcementAdministration'sSpecialTestingandResearchLaboratory
generated this monograph using structurally confirmed reference material.
4. ADDITIONAL RESOURCES
No resources identified as of 5/21/14.

Latest Revision: 06/13/2014

SWGDRUG.org/monographs.htm

Page 5 of 5