NEWS LETTER OF
ARMARC
FEBRAVERY -2010
Editorial
So called quote in rural India as ‘obesity is a
symbol of wealth and fertility’, is referred with a dumb
expression arising from error of thinking and knowledge.
Obesity is stigmatized in the modern intellectual world.
According to WHO (World Health Organization),
obesity is abnormal or excessive fat accumulation that
presents a risk to health. Body mass index (BMI), a
measurement which compares weight and height, defines
people as overweight (pre-obese) when their BMI is
between 25 kg/m2 and 30 kg/m2, and obese when it is
greater than 30 kg/m2. Obesity increases the likelihood
of various diseases, particularly heart disease, type 2
diabetes, breathing difficulties during sleep, certain types
of cancer, and osteoarthritis. Obesity is most commonly
caused by a combination of excessive dietary calories,
lack of physical activity, and genetic susceptibility,
although a few cases are caused primarily by genes,
endocrine disorders, medications or psychiatric illness.
Evidence to support the view that some obese people
eat little yet gain weight due to a slow metabolism is
limited. On average obese people have a greater energy
expenditure than their thin counterparts due to the
energy required to maintain an increased body mass.
The obesity may be of following types as:
· Severe obesity : BMI e” 35 or 40
· Morbid obesity : BMI of e” 35 or 40–44.9 or
49.9
· Super obesity : BMI of e” 45 or 50
The normal and healthy life is symbolic exposure
of Ayurveda insisting on ‘Ahar-vihar’. The Swastha-
vritta guidelines may be helpful to hinder the obesity as:
1. Intelligent selection of food should be followed.
Even allopathic medical science emphasize on
Vol 1.92
fibrous food. Similarly Ayurveda too suggests the
more of green vegetables.
2. The sweet, salty and oily food must be avoided
during night.
3. The Moonga and Masoor are used to treat
obesity.
4. Warm water is suggested at many places after
meal.
5. Curd must be avoided.
6. Triphala, Guduchi etc. are good bet for this as
they are rasayana and beneficial for body by
other means too.
7. Amalaki intake is also proposed.
8. Brihatpanchmoola powder is prescribed.
9. Hypolipidemic formulations like Guggulu-based
medicine may be taken after hint from physician.
Other than these many other precautions can
help anyone to reduce obesity as:
1. Avoiding the sleeping during day.
2. More calories burning with physical activities etc.
We must be careful about this deadly sweet
poison as obesity is not arbitrary sign of wealth but alarm
to be careful regarding our help. So break your duck
and be ready to make a healthy nation and society.
In This Issue
1) ANTIOXIDANT ACTIVITY OF A
POLYHERBAL ANTI-DIADIABETIC
FORMULATION
2) CONCEPT OF SANDHIGATAVATA,
AMAVATA, VATARAKTA & THEIR
TRADITIONAL MANAGEMENT
3) Formulation Profile (Series-A/13)
Guduchyadi Kwatha
4) Herbal Drug Profile (Series-A/14)
Brihad Gokshura
 Newsletter of ARMARC 2 FEB -2010
ANTIOXIDANT ACTIVITY OF A POLYHERBAL ANTI-DIADIABETIC FORMULATION
Manas Ranjan Mishra , Ashutosh Mishra, Dusmanta Kumar Pradhan , S. Jha
* The Pharmaceutical College, Samaleswari Vihar, Tingipali, Barpali, Bargarh-768029, Odisha.
* Dept. of Pharmaceutical Sciences, Birla Institute of Technology, Mesra-835215, Ranchi, Jharkhand.
ABSTRACT: physiological setting is to prevent ROS concentrations
Madhuhari Churna (MC) is one of the anti- from reaching a high-enough level within a cell that dam-
diabetic formulations developed by Shiv Herbal age may occur. Cellular antioxidants may be enzymatic
Research Laboratory Limited Nagpur. It consist (catalase, glutathione peroxidase, superoxide dismutase)
of nine plants sources Gymnema sylvestre leaf, or nonenzymatic (glutathione, thiols, some vitamins and
Momordica charantia seed, Syzygium cumini seed, metals, or phytochemicals such as isoflavones, polyphe-
Acacia arabica bark, Curcuma amada rhizome, nols, and flavanoids). To avoid or to delay the
Aegle marmelos leaf, Tinospora cordifolia stem, preoxidation process, addition of antioxidants to food is
Picrorhiza kurroa root, Azadirachta indica leaf and
the most extensive method. Synthetic antioxidants, e.g.
a mineral pitch (Shilajeet). For the antioxidant
butylated hydroxytoluene (BHT), butylated hydroxyani-
activity of MC, the total extractable phenol (TEP)
sole (BHA), and tert-butylhydroquinone (TBHQ), have
was determined by 1-Diphenyl-2, picrylhydrazyl
been used as antioxidants in food for years. Restriction
(DPPH) free radicals scavenging, reducing power
on the use of synthetic antioxidants is due to their carci-
determination and electrochemical analysis. The
nogenic nature which has lead to a growing interest in
finding showed that the antioxidant activity of MC-
TEP was equivalent to gallic acid in all three recent years in natural antioxidants of plant origin for ap-
performed antioxidant activity. plication in food industry to combat food deterioration [2].
INTRODUCTION: As for tocopherol and ascorbic acid, both are extensively
The health promotion, disease preventive and used as natural antioxidants; however, the antioxidant
rejuvenation approach available in the Indian systems of activities of tocopherol and ascorbic acid are lower than
medicine like ‘Ayurveda’ is gaining greater attention and those of synthetic antioxidants [3]. Flavonoid glycosides
popularity throughout globe. At present, majority of constitute an important class of bio-molecules having an-
diseases are reported to be due to the shift in the balance timicrobial, anticancer or antioxidant properties.
of the pro-oxidant and the antioxidant homeostatic The component drugs of the formulation are proved
phenomenon in the body. Pro-oxidant conditions antioxidants as Gymnema sylvestre has been recently
dominate either due to the increased generation of the reported with isolation and structural characterization of
free radicals caused by excessive oxidative stress of the a new flavonol triglycoside, which is an important bio-
present day life, or due to the poor scavenging/quenching molecule as a potential antioxidant compared to a-
in the body caused by depletion of the dietary antioxidants tocopherol [4, 5, 6].
[1]
. The antioxidant property of Azadirachta. indica
Antioxidants are of interest to biologists and cli-
has been reported. Neem leaf extracts showed its
nicians, because they may help to protect the human body
chemoprotective effects on potent gastric carcinogen N-
against damage by reactive oxygen species (ROS). Dur-
methyl-N-nitro-N-nitrosoguanidine (MNNG)-induced
ing hydrogen peroxide (H2O2), superoxide ion (O2-), and
oxidative stress by decreasing lipid peroxidation (LPO)
hydroxide radical (OH-). These compounds, when
and enhancing the antioxidant enzymes like superoxide
present in a high enough concentration, can damage cel-
lular proteins and lipids or form DNA adducts that may dismutase (SOD), catalase (CAT), glutathione (GSH-px)
promote carcinogenic activity. The purpose of antioxi- and glutathione-Stransferanse (GST) in male rats.
dants in a Ethanolic neem leaf extract exerts protective effects
 Newsletter of ARMARC
against MNNG-induced genotoxicity and oxidative stress
by augmenting host antioxidant defense mechanisms [7].
The effective hypoglycemic action of Momordica
charantia fruits has been deeply studied. The anti-
mutagenic activity may reside in the peculiar lipid structure
of acylglucosil sterols. The fruit extract has anti-diabetic
activity whether in animals or in clinical trials, therefore it
is utilized to treat diabetes all over the world [8-10].
Syzygium cumini seed promotes optimal
antioxidant status in the pancreas and liver, two important
blood glucose regulating organs that are susceptible to
oxidative stress. S. cumini seed also encourages healthy
cholesterol and glucose levels within a normal range in
the blood [11]. S. cumini aqueous and ethanolic extracts
from the seeds reduced the glycaemia of diabetic animals,
an effect that may be associated with some inorganic
constituents. However, the decoction of leaves has neither
presented anti-diabetic activity in rats nor altered the
glucose tolerance test in non-diabetic humans [12, 13].
Picrorhiza kurroa is a well known herb in Ayurvedic
system of medicine and has traditionally been used to
treat disorders of the liver and upper respiratory tract,
reduce fever and treat dyspepsia, chronic disorders and
scorpion sting [14].
Acacia arabica an ingredient of various
traditional preparations, used in the treatment of asthma,
bronchitis, diabetes, dysentery, diarrhoea and skin
diseases has been selected. The polyphenol rich active
fraction of A. arabica is a potent free radical scavenger
and hepatoprotective and protects Tertiary butyl
hydroperoxide (TBH) induced lipid peroxidation and
carbon tetrachloride induced hepatic damage [15].
A. marmelos is claimed to be useful in treating pain, fever,
inflammation, respiratory disorders, cardiac disorders,
dysentery and diarrhoea. The aqueous decoction of the
leaves has been reported to have a significant
hypoglycaemic effect. A. marmelos leaves extract also
helps in the regeneration of damaged pancreas (b-cells)
in diabetic rats and is found to be as effective as insulin in
restoration of blood glucose and body weight to normal
levels. The hydro-alcoholic extract of the leaves has been
reported to have the chemo-preventive potential,
3 FEB -2010
especially against chemical carcinogenesis. Fresh aqueous
and alcoholic extracts of the leaves of A. marmelos have
been reported to have a cardiotonic effect like digitalis
and to decrease the requirement of circulatory stimulants
[16, 17]
.
T. cordifolia is a glabrous, climbing shrub has been known
beneficial in treating a wide variety of diseases. The
antioxidant properties of T. cordifolia were earlier
investigated and were found to possess free radical
scavenging property. These ingredients were also found
to produce significant induction in the levels of various
endogenous antioxidant enzymes. T. cordifolia has been
known to promote longevity and increase the body’s
resistance against various diseases. It has also been shown
to enhance immunomodulatory response, and Kupffer
cell functioning in human beings, and to exhibit insulin-
like action under experimental conditions [18, 19].
C. amada commonly know as mango ginger
rhizome, used as an appetizer, alexteric, antipyretic,
aphrodisiac and laxative. It is also used against biliousness,
itching, skin diseases, bronchitis, asthma, hiccups and
inflammation due to injuries. According to Unani systems
of medicine, it is used against inflammation in the mouth,
ear, gleets, ulcers on the male sex organs, scabies,
lumbago and stomatitis [20].
The radicophilicity (antiradical-antioxidant effects)
of processed Shilajeet (Asphaltum) Mineral pitch (SJP)
to oxygen derived free radicals and nitric oxide (NO),
and the attendant H2O2 cleaving effect were evaluated.
SJP provide complete protection to methyl methacrylate
(MMA) against hydroxyl radical-induced polymerization
and act as a reversible NO-captodative agent. shilajeet
is used as an Ayurvedic rasayan (rejuvenator) against
oxidative stress and geriatric complaints [21].
It has been postulated that the etiology of the
complications of diabetes involves oxidative stress
perhaps as a result of hypoglycemia. Glucose itself and
hyperglycemia-related increased protein glycosylation are
important sources of free radicals. Elevated glucose
causes slow but significant non-enzymatic glycosylation
of proteins in diabetes. Glucose auto-oxidise in the
presence of transition metal ions generating oxygen free
 Newsletter of ARMARC
radicals, which make the membrane vulnerable to
oxidative damage. As the diabetogenic action can be
prevented by the SOD, CAT, and other hydroxyl radical
scavengers such as ethanol, dimethyl urea, there are
evidences to suggest that the incidence of diabetes
involves superoxide anion and hydroxyl radicals. In
addition to these enzymes, glutathione reductase (GSH-
R) and GST provide GSH and help to neutralize toxic
electrophiles, respectively. There are clear cut evidences
to show the role of free radicals in diabetes and studies
indicate that tissue injury in diabetes may be due to free
radicals. The significance of oxidative stress in the disease
pathology is uncertain but is frequently proposed to be
related to the hyperglycemia. Other possible sources
include elevated plasma lipids leading to increased lipid
oxidation and decreased levels of antioxidant defense
systems [22, 23].
MATERIALS AND METHODS
Materials
Madhuhari churna was procured from Shiv Research
Laboratory, Nagpur, India, DPPH purchased from sigma
Aldrich India pvt Ltd. Laboratory grades reagents were
used in all experiments. The instruments, UV
spectrophotometer (UV 1700 Simazdu) and
electrochemical analyzer (680B CH Instruments, USA)
were used in experiments.
Methods
Extraction of Total Extractable Polyphenol
The Powdered sample (500 mg) was extracted
sequentially with 40 mL Methanol: Water (50:50 v/v)
and 40 mL Acetone: Water (70:30 v/v) at room
temperature for 60 min each treatment. Supernatants
from these extract were combined. Concentrated to a
small volume under reduced pressure at 50°C, and made
up to 10 mL with the same solvents (v/v). TEP were
assayed spectrophotometrically by the Folin-Ciocalteau
method using gallic acid as a standard and expressed as
gallic acid equivalents [24]. The principle of reaction is
that the phenols react with phosphomolybdic acid in
Folin-Ciocalteau reagent in alkaline medium and produce
blue coloured complex (molybdenum blue).
(Continued next edition..........)
4 FEB -2010
CONCEPT OF SANDHIGATAVATA, AMAVATA,
VATARAKTA & THEIR TRADITIONAL
MANAGEMENT
st
Dr. Sudev. C 1 yr M.D,
Guide :Dr. Suresh. R.D MD(Ayu),MS (C&P),CYS
Dept of Kayachikitsa A.L.N.R.M.A.M.C.Koppa.
Sandhigata Vata, Amavata and Vatarakta are the
diseases which are prevalent nowadays. Regarding the
diagnosis of both the diseases there still exists the
controversy when many of them are interpreting with the
modern terms like Osteoarthritis, Rheumatoid arthritis and
Gouty arthritis respectively. Before going with the
explanations of both Amavata and Vatarakta, it is very
necessary to know regarding the concept of Sandhigata
vata. Charaka has explained the concept of Gatavata and
Avarana in Vatavyadhi chikitsa separately. If we review
them, we can understand that they can exist separately as
well as that might be underlying pathology behind the other
diseases also (Eg. Avarana in case of Vatarakta).
While explaining Sandhigtavata Charaka mentions that
there will be,
1. Vatapoorna drithi sparsha – As if touching in air
filled leather bag.
2. Sotha – Swelling
3. Prasaarana Akunchanayo pravrittishcha
savedana – Pain during flexion and extension.
He has not mentioned the unilateral or bilateral
involvement of the Sandhis. But for blind comparisons
some are interpreting these terms which misleads that
Sandhigata vata is Osteoarthritis itself. But the term only
partially fulfills the concept of Sandhigatavata. So while
we go through the explanations and clinical observations,
we can find these symptoms in Amavata and Vatarakta
also. So it is clear that Sandhigata vata can manifest as a
separate entity and as a stage or a condition where it can
be included under the heading of Amavata and Vatarakta.
How Amavata and Vatarakta are formed?
Due to vataprakopaka Ahara and Vihara vata gets vitiated
and lodges into the Sandhis causes Sandhigata vata. Just
take the predisposing conditions like Mandagnyadi
Amavata nidanas. Then there will be
 Newsletter of ARMARC
Vatarakta = Gouty arthritis ?
It is not necessary that all patients of Gambhera
Vatarakta are of having increased Uric acid level. But to
some extent the signs and symptoms of Gouty arthritis
suits with Gambheera Vatarakta, much specifically with
the Vata pradhana and Rakta pradhana Vatarakta.
Can Amavata turn to Vatarakta?
Now you may be thinking that can it be?,
Definitely. If patient diagnosed as Amavata is under
treatment, usually the physician goes for Amahara chikitsa.
Imagine a condition of Pitta pradhana Amavata. And after
the Amahara chikitsa the patient gets relief but after that
due to the continous Ushna, Rooksha and Theekshna
dravyaprayoga or may due to the Apathya the Pitta may
aggravate once again and further vitiates the Rakta and
mimic like Vatarakta. And those patient are well
responded to the Vatarakta Chikitsa practically. So careful
observation is needed for the treatment. So it is very
essential that to identify the Avastha of the disease and
extent of affection.
If we are clinically observing the Vatarakta
patients, there also existing the Nirama and Amavastha.
The main difference between Amavata and Amapradhana
Vatarakta is that in Amapradhana Vatarakta the Ama
produces further aggravation and complication of the
disease after the manifestation of the Vatarakta. (In Kerala
some Physicians are treating according to this view).
Amavata chikitsa: Usually in clinical practice, first go
for the reduction of the signs and symptom. Or if the
patient can adopt the Sodhana, then go for it.
1. Langhana – Deepana – Pachana (Light diets with
Trikatu or any Deepana pachana dravyas are given
according to the condition)
2. Internally – Amruthotharam Kashayam 20 ml BD with
Yogaraja/Rasnadi/Simhanada guggulu. Because it can act
as Deepana, Pachana, Anulomana and Jwaraghna
1. After clearing of the Amalakshanas the patient can be
given any of the Kashaya mentioned below according to
the condition of the patient, season and availability of the
medicine. Rasnerandadi Kashayam, Maharasnadi
Kashayam, Rasna Panchakam Kashayam, Rasna
5 FEB -2010
Sapthakam (Along with the Chitrakadi gulika / yogaraja
/ Simhanada/ Rasnadi guggulu)
Dose : Varies (20ml BD)
2. Along with these Aushadhas patient can adopt the
Swedana also
3. If the patient is showing the Vatarakta Lakshanas then
go for the Kashayas mentioned in Vatarakta
Shodhana Chikitsa: If the patient gets proper Bala after
the intake of the medicine, he can go for the Shodhana
chikitsa.
1. Ksharavasthi to remove the deep seated Amatwa
(Usually Vasti Containing the Chincha rasa, Jaggery,
Gomutra and Saindhava is given)
2. Then Go for the Snehapana and Virechana. Snehapana
can be done with Thiktaka Ghrita followed by Virechana
with Trivruth churna or any other suitable preparations
3. Niruha Vasti with Erandadi or Dasamooladi Kashyam
can be given
4. Anuvasana Vasti can be given but the condition of the
patient should be accessed that the taila is not at all
increasing the Ama.
5. Abhyanga and Kayaseka (Taila – According to the
conditions. Preferably Kottamchukkadi )
Vatarakta Chikitsa: 1st Diagnose Avastha of Vatarakta.
If it is Uthana Vatarakta, then Kushtavat chikitsa should
be given. Then the Amavastha and Niraamaavastha
should be accessed. If Amatwa then go for the
Amaharachikitsa like Langhana Deepana, and pachana.
After that go for the Vatarakta chikitsa. The Above
mentioned Kashayas can be given in the same dose with
Kaishora guggulu or Yogaraja guggulu. Lepa can also be
given in the same prescription.
Lepa – Dasangalepa (Available and preferable) Taila for
Application after clearing Amavastha – Pinda tailam is
preffered
If Severe Rakta dooshita Lakshanas observed
then Rakta shodhaka kashayas like Manjshtadi Kashayam
can be given. Other medicines which are having the same
action can also be given. Sodhana chikitsa can be adopted
once the patient got the relief from the Lakshanas or if
the patient is not at all getting the relief.
 Newsletter of ARMARC
production of Ama, and the Vata which is vitiated
combines with Ama, inturn lodges into the Sandhis causing
the Amavata. Now it is clear that the pathology is very
similar and thus proves that the Sandhigata vata can not
be a separate entity in case of Amavata. But it is clear
that the Amavata patient are also a patient of also having
the Lakshans of Sandhigatavata but not vice versa.
Similarly if the conditions are favourable to
Raktha prakopa then the disease will be manifesting in
the form of Vatarakta with the involvement of Raktavrutha
Vata. So the Vatarakta patients are also having the
Lakshanas of sandhigata vata.
Why generally bigger joints are affecting first in
Amavata and Smaller joints in Vatarakta?
We all know that the Ama is having more Pichilata
and Gurutwa compared to Rakta. If we consider a test
tube as a joints of the body, its top portion can be
correlated to bigger joints and bottom portion as smaller
joints. Put the Butter into it, it may not reach the bottom
easily. Because it may get stuck in the middle or upper
part of the test tube. If goes on filling, it reaches bottom.
Like that Ama reaches the smaller joints last. Butter can
stuck in the middle of the test tube also. It indicates that
Amavata can also manifest where ever it is lodged.
If you are putting the blood to the test tube, blood
reaches the bottom very easily and from bottom it starts
filling till to the upper part, which is exactly opposite to
the previous experiment. It is due to the more dravatwa
of rakta compared to the butter. So the bigger joints first
affects generally in Amavata and Smaller joints are
affected in Vatarakta. But they can manifest according to
the place where they lodges.
Amavata = Rheumatoid arthritis ?
Better don’t compare any of the diseases
to the modern. Why because it may not fulfill the crieteria
of Ayurvedic Vyadhis. It is better to compare Mordern
with Ayurveda if it is necessary. All patients with RA+ve
and even RA-ve (Sero negative arthriris) patient also come
under the Amavata.
6 FEB-2010
Sodhana Chikitsa:
1. Snehapana with Tiktaka ghrita, then Virechana.
2. Rakta mokshana (Preferably Siravyadha or Jalouka).
3. Ksheeravasthi – It can also be given in case of
Amavata where Ama got cleared completely and if the
signs and symptoms of Vatarakta are seen.
4. Niruha Vasti with Erandadi or Dasamooladi kashya
can be given.
5. Anuvasana Vasti can be given.
6. Kayaseka or Abhyanga with Pinda tailam preferably.
Shamana after the Sodhana (Both for Amavata and
Vatarakta)
1. According to the condition above mentioned kashayas
are used.
2. Arishtas – Pitta shamaka-Vata shamaka-Rakta
shodhaka.
3. Ghritas – Thiktaka Ghritha.
4. Rasayanas – according to condition (Eg.
Chyavaprasha).
Sandhigatha Vata chikitsa: Here the Amahara
Chikitsa and Rakta shodhaka procedures are not
necessary because the Ama and Rakta are not involved
in it. Usulally in OPD base, we can try with
Samanoushadhis like the above said Vatahara kashayas
mentioned for the Amavata and Vatarakta. Application
with the oils are necessary (Kottam chukkadi tailam is
preffered). According to the severity the oil can be
changed (Depends on Vaidyas).
Sodhana chikitsa includes: 1. Snehapana – with Guggulu
thikthaka Ghritham.
2. Virechana – with Trivrit lehya or churna
3. Vasti – it is the most preferable Sodhana,Niruha Vasti
done with Dasamoolam or Erandadi Kashayam. Sneha
vasti with Dhanwantaram tailam is preffered.
Ksheeravasti also beneficial.
4. Swedana – Patrapinda sweda, Navarakkizhi.
Kayaseka Usually Abhyanga and swedana procedures
are done before the Sodhana procedures. If the patient
doesn’t got the relief, he has to undergo for the Sodhana
to get a good result.
Shamana Aushadha includes the above
Kashayas. Guggulu Thiktaka Ghritha can be given 1 tsp
once a day at bed time. Application of oil can be done
with preferable one.
************
 Newsletter of ARMARC 7 FEB -2010
Formulation Profile (Series-A/13) Herbal Drug Profile (Series-A/14)
Guduchyadi Kwatha Brihad Gokshura
Prof: D.K.Mishra M.D (Ay) 1. Prof. M.Vidyasagar 2. Prof. K.S.Sanjay
Dr.Mahesh.M.Madaalageri Nagaraja R. 3. Dr. Hari Venkatesh 4. Dr. Prashant Kumar Jha
(Ref: B.R. 5/156. P.No 57)
Kwatha: Acharya Sharangadhara mentioned detail

descriptions about preparing the Kwatha in general. The

coarsely powdered drug with 16 times, 8 times, 4 times

water as the case may be of the herb very hard, hard/

medium or soft respectively is to be boiled with mild heat

up to 1/4 part of the residual water.

Mouth of the vessel should be kept open and

steam – vapour should be allowed to evaporate. If lid is Botanical Name: Pedalium murex Linn
Family: Pedaliaceea
kept on the mouth of the vessel at the time of Kwatha -
Habitat: Throughout the plains of India
the boiling process – the Kwatha becomes improper in English: Caltrops (bigger var.)
action i.e. difficult to digest (Durjara). Ayurvedic: Brihatgokshura, Kshouraka, Trikantaka,
Gokantaka, Swaadukantaka, Bhakshantaka
Ingredients:
Unani: Khaar-e-khasak Kalaan, Gokharu Kalaan
Guduchi- 20gms, Nimbatwak-20gms
Siddha/Tamil: Peru-neranji, Annaineringi
Dhanyaka-20gms, Padmaka-20gms, Habit: It is a glabrous annual undershrub, around 6-15
Rakta chandana- 20gms, inches in height. Leaves are 2-4 inch long, irregularly
Water- 1600 ml. toothed or almost lobed on 0.5-1.5 inch long petiole.
Procedure: Pedicels are axillar, solitary, short, biglandular at the base.
Calyx is 5-partite. Corolla is yellow with round funnel-
All drugs are taken and weighed. Coarse powder
shaped lobes, around 1 inch long. Stamens are 4 in
was prepared and boiled with 16 parts of water (1600ml)
number, didynamous and included. Ovary is bi-celled
& reduced it to 1/4th (400 ml) with 2 ovules in each. Capsule is hard, indehiscent. The
Uses : Jwara, rasayana etc. upper portion is pyramidal-ovoid with 4 patent spines
Dose : 8 tola from its base. Seeds are 2-1 in each cell, pendulous,
Colour : Orange oblong with black testa.
Action: Fruit is used for spermatorrhoea, nocturnal
Odour : Unpleasant
emissions, menstrual irregularities, puerperal diseases,
Taste : Bitter
genitourinary disorders, difficult micturition, chronic
Consistency : Liquid cystitis, renal calculus. Root is antibilious.
pH : 4.64 The stem and fruits contain flavonoids pedalitin
 Newsletter of ARMARC 8 FEB-2010
and its glucoside (pedaliin), diometin, dinatin and its

PRINTED MATTER/BOOK POST

derivatives.
The fruits contain nonacosane, tritriacontane,

RNI Regd No. KARENG/2002/7924

triacontanoic acid, sitosterol-beta-D-glucoside, rubusic
acid, luteolin as major constituents.
Leaves and fruits yield phenolic acids which
include caffeic, protocatechuic, p-coumaric and ferulic
acids. Flowers gave dinatin, quercetin and quercetin-7-
glucoside.
Aqueous extract of the fruit is reported to produce
in vitro inhibitory effect on crystallization in urinary
lithiasis.
The solubility of uric acid in aqueous extract is
reported to be 45% more than in water alone.
The plant extracts exhibit diuretic activity.
Dosage: Fruit, root—3–5 g powder; 50–100 ml.
decoction (CCRAS)
New Reseacrhes In Medical Science
• Patients with chronic obstructive pulmonary disease
(COPD) are at an increased risk for developing
depression.
• A mother’s exposure to bisphenol A may increase
the odds that her children will develop asthma, says
a new study.
• Researchers in California have found that a hormone
responsible for the body’s stress response is also
linked to the growth of insulin-producing cells in the
pancreas.
For All Pharmacopoeial Analysis, Standardization
of Single as well as Compound Drugs, with
Spectrophotometer, Flame Photomeneter, Photo-
micrograph etc. at nominal charges Contact:
Dr. Prashant Kumar Jha CIPR, DIM, PGDEE, M.Sc., Ph.D.
Quality Control Laboratories, ALN Rao Me-
morial Medical College, Koppa
Your Suggestions and Queries are invited.
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Student(Rs. 50), Individual(Rs. 100), Institution(Rs.
150)
Patron (Rs. 1000)
OVERSEAS
USD 10
Membership fees, which includes an annual
subscription to the newsletter, may be sent by
MO, DD or Crossed Cheque addressed to Princi-
pal, ALN Rao Memorial Ayurvedic Medical Col-
lege, Koppa, Chikmagalur Dt. Karnataka - 577 126.
On receipt of the fees, each member will be
issued a receipt and a membership card, both
of which should be preserved carefully. The
receipt number and the membership number
should be referred to in all transactions. The
membership is to be renewed each year and
the new receipt number noted on the member-
ship card by each member. On producing the
card, special discount can be availed on
ARMARC publications.
Note: All the original scientific papers are invited
from the works of scientific field. Mail (Post/E-
mail) us.
Aroor Ravi Memorial Ayurvedic Research Centre
Patron
Honourable A. Ramesh Rao

Editor: Prof (Dr.) M.Vidyasagar & Co-Editor: Dr.Prashant kumar Jha

Research Co-ordinator Dr. Mahesh.M.Madalageri
Printed and Published by ARMARC on behalf of Honourable A. Ramesh Rao, Koppa, Chikmagalur Dt., Karnataka - 577126, India
(No. KARENG/2002/7924, RNI, New Delhi)
email: armarc_koppa@yahoo.com, prashantjha19@rediffmail.com URL:www.alnrmamc.com