Professional Documents
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Acknowledgments
American Heart Association Clinical Research Program Award
12CRP8870004
Thank you to Dr. Joe Schwartz for guidance with analyses.
No conflicts of interest to disclose
costs
Third leading cause of disability in high-income countries
Affects approximately 840 million people worldwide 1
Unknown underlying pathophysiology
Possible role for vitamin D deficiency?
2N
Engl J Med
2007;357:266-81
May stimulate
neurotrophins, which
regulate neuronal
development
N Engl J Med
2007;357:266-81
Methods
Electronic databases searched through May 2012 (MEDLINE,
N
629
7358
639
Mean
age,
years Female
72.8
73.1
74.3
0%
58.8%
46.6%
Low
vitamin
D
Length
Definition
Type of
of
of low
vitamin D followvitamin D assessment
up
Site
GDS
5.2%
25(OH)D
<50 nmol/L
18.0%
25(OH)D
<37.4
nmol/L
CIA
1 year
USA
ICD-9 codes
via chart
review
31.0%
25(OH)D
<31.7
nmol/L
RIA
6 years
Italy
CES-D
16
RIA
4 years
Hong
Kong
Depression
measure/
definition
8
Conclusions
Vitamin D deficiency is associated with an increased risk of
Thank you
Epilogue