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5. Myelofibrosis
6. Granulomatous Infections
- In the Myelophthisic Thombocytopenia,
extramedullary hematopoiesis is evident the
cellular precursors are present in the peripheral
blood.
2. Abnormal Distribution
- Spleen is responsible in platelet sequestration and
destruction and making it one of the organ
responsible for thrombocytopenia.
- Hypersplenism rapid removal or destruction of
the thrombocytes even they are not yet old or
damaged. This conditions is the primary cause of
thrombocytopenia in Gauchers Disease,
Sarcoidosis, and Felty Syndrome.
- Splenomegaly there is more platelet
sequestration of the spleen which now caused the
thrombocytopenia. The spleen sequesters 50
90% instead of the normal 20%.
- The spleen contains the larger fragments of
megakaryocytes called the megathrombocytes or
large platelets, and younger thrombocytes which
are more effective in hemostasis.
3. Increase Destruction
- Platelets are lost or destroyed in the circulation
Can be divided into two:
3.1. Non-immune Mediated Destruction
3.2. Immune Mediated Destruction
3.1. Non-immune Mediated Destruction
Can be divided into two:
3.1.1. Increased Consumption
3.1.2. Miscellaneous Conditions
3.1.1. Increased Consumption
Disease associated:
3.1.1.1. Hemolytic Uremic Syndrome
3.1.1.2. Thrombotic Thrombocytopenic Purpura
3.1.1.3. Disseminated Intravascular Coagulation
3.1.1.1. Hemolytic Uremic Syndrome
- Occurs more often in children less than 8 years of
age.
- Occasionally occurs in adults with predisposing
conditions associated with endothelial cell damage.
- Endothelial damage can be caused by viral
infections, hypertension, hypoxia, and autoimmune
complexes.
- Using Western blot assay inorder to detect the
autoantibodies against cryptic endothelial antigens.
- Thrombi formation is primarily intraglomerular
with renal dysfunction proteinuria, and hematuria.