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Chemistry
Course Structure
Central University of Karnataka, Gulbarga.
Semester-I
CY-01
CY-02
CY-03
CY-04
CYL-05
CYL-06
No. of credits = 19
Inorganic Chemistry I
Organic Chemistry I
Physical Chemistry I
Separation Science and Instrumentation
Inorganic Chemistry Lab
Organic Chemistry Lab
Semester-II
CY-07
CY-08
CY-09
CY-10
CYL-11
CYL-12
No. of credits = 19
Inorganic Chemistry II
Organic Chemistry II
Physical Chemistry II
Chemistry of Life
Physical Chemistry Lab
Computational Chemistry Lab
Semester-III
CY-13
CY-14
CY-15
CY-16
CY-17
CY-18
CY-19
4 credits
4 credits
4 credits
3 credits
2 credits
2 credits
No. of credits = 20
Semester-IV
CYP-20
CYP-21
CYP-22
CY-23
4 credits
4 credits
4 credits
3 credits
2 credits
2 credits
3 credits
3 credits
3 credits
3 credits
3 credits
3 credits
2 credits
No. of credits = 20
Research Proposal
Research Project
Comprehensive viva
Personality development/Seminar
To achieve M.Sc. degree students needs to fulfill 78 credits
2 credits
14 credits
2 credits
2 credits
4. Smith, M. B., March J., (Latest Ed.) Marchs Advanced Organic Chemistry,
Unit
II-Reagents
in
organic
synthesis:
Lithiumdiisopropylamide(LDA),
DicyclohexylCarbodiimide(DCC),
1,3-Dithiane
(Umpolung
reagent),
Trimethylsilyliodide, Gilmans reagent, Bakers yeast, DDQ, Prevost Hydroxylation,
Wilkinsons catalyst,
Phase transfer catalysts: Quaternary ammonium and
Phosphonium salts, Crown ethers, Merifield resin, Ziegler-Natta catalyst, Lawson
reagents, K-selecteride Sodium cyanoborohydride, 9-BBN, IBX, Manganese dioxide,
Ceric ammonium nitrate, Tebbe reagent, use of Os, Ru reagents.
Unit III-Rearrangements in organic synthesis: Pinacol-pinacolone, WagnerMeerwein, Demjanov, Benzil-Benzillic acid, Favorskii, Neber, Beckmann, Hofmann
Curtius, Schmidt, Baeyer-Villiger,Claisen, Cope, Smiles and SommeletHauser
rearrangements, Arndt-Eister syntheses.
Unit IV-Named reactions in organic synthesis: Mukaiyama aldol reaction,
Mitsunobu reaction, Sharpless epoxidation, Julia-Lythgoe olefination, BuchwaldHartwig coupling, Shapiro reaction, Stork-enamine reaction Aza-Cope, Aza-Wittig
reaction. Ugi reaction, RobinsonGabriel synthesis, Strecker amino acid synthesis,
VilsmeierHaack
reaction,
WohlZiegler reaction,
Baylis-Hillman
reaction,
Chichibabin reaction, Barton reaction, Biginelli reaction.
Unit V-Pericyclic reactions: Thermal and photochemical pericyclic reactions,
Conrotation and disrotation; Electrocyclic closure and opening in 4n and 4n+2
systems. Woodward-Hoffmann selection rules for electrocyclic reactions.
Explanation for the mechanism of electrocyclic reactions and examples.
Cycloaddition reactions: Suprafacial and antarafacial interactions. 2 + 2 and 4 +
2 cycloadditions; Cycloreversions. Diels-Alder reaction, Woodward-Hoffmann
selection rules for cycloaddition reactions and examples. Mechanism by orbital
symmetry correlation diagrams, Fukui Frontier Molecular Orbital (FMO) theory. Endoexo selectivity in Diels-Alder reaction and its explanation by FMO theory.
Sigmatropic reactions: mechanism of sigmatropic reactions, Cope and Claisen
rearrangements.
Reference books:
UNIT I-Basic Chemical Kinetics Molecularity, order and rate of reactions, Arrehenius
theory - Complex reactions: reversible, pre-equilibrium,consecutive, chain and
photochemical, oscillatory reactions, enzyme kinetics - Lindenmann's theory of unimolecular reactions - laser flash photolysis, flow techniques and relaxation methods.
UNIT II-Molecular reaction dynamics collision and activated complex theory,
comparison of results with Eyring and Arrhenius equations - reactive collisions,
molecular beam experiments, introduction to potential energy surfaces: treatment
of H2 + H reaction ionic reactions: salt effect.
UNIT III-Surface phenomena Growth and structure of surface, surface defects,
kinetics of surface adsorption: Langmuir and BET isotherms.
UNIT IV-Equilibrium electrochemistry Activities in electrolytic solutions, mean
activity coefficient, Debye-Huckel treatment of dilute electrolyte solutions, origin of
electrode potential, half cellpotential, electrochemical cell, Nernst equation,
thermodynamics of electrochemical cell
UNIT V-Dynamic electrochemistry Electrical double layer - electrode kinetics: rate
of charge transfer, current density, Butler- Volmer equation - introduction to
polarography, cyclic voltammetry - theory of corrosion and inhibition of corrosion.
Reference books:
1. K. J. Laidler, Chemical Kinetics, 3rd Edn., HarperInternational, 1987.
2. G. D. Billing & K. V.Mikkelson, Molecular dynamics and chemical kinetics, John
Wiley, 1996.
3. J.I. Sheinfield, J.S. Francisco, W. L. Hasse, Chemical kinetics & dynamics, Prientice
Hall, 1998.
4.
A. J.Bard & L. R. Faulkner, Electrochemical Methods, Fundamental and
Applications, JohnWiley, 1980.
5. Bockris & Reddy, Electrochemistry, Vol. 1& 2, Plenum, 1973
6. H. V. Keer Solid State Chemistry, Wiley Eastern, 1993.
7. A. K. Cheetam & P. Day, Solid State Chemistry Techniques, Oxford, 1987.
Reference books:
1. Voet, D.; Voet, J. G. (2010), Biochemistry, 4th Edition, John Wiley
2. Nelson D. L.; Cox, M. M. (2008), Lehninger Principles of Biochemistry, 5th Edition,
W. H. Freeman and CBS Publishers, New Delhi
3. Berg, J. M.; Tymoczko J. L.; Stryer L. (2012), Biochemistry , 7th Edition W. H.
Freeman and company.
4. Cantor C. R.; Schimmel, P. R. Biophysical Chemistry Part I & II.
5. Freifelder, D. Physical Biochemistry
Reference books:
1. Practical physical chemistry, A. Findary, T.A. kitchner ( Longmans, Green
and Co.)
2. Experiments in Physical Chemistry, J.M. Wilson, K.J. Newcombe, A.r. Denko.
R.M.W. richett ( Pergamon Press)
Reference books:
1. Practical physical chemistry, A. Findary, T.A. kitchner ( Longmans, Green
and Co.)
2. Experiments in Physical Chemistry, J.M. Wilson, K.J. Newcombe, A.r. Denko.
R.M.W. richett ( Pergamon Press)
types of ions and fragmentations, even electron rule, nitrogen rule, isotope
abundance, McLafferty rearrangement.
Reference books:
1. P. W. Atkins, Physical Chemistry, Oxford, London, 7th edition,2006.
2. D. L. Pavia, G. M. Lampman and G. S. Kriz, Introduction to Spectroscopy
2Edn, Saunders
3. Banwell, Molecular Spectroscopy, Tata McGraw Hill, 1998.
4. A. Carrington and Machlachlon, Magnetic Resonance, Harper & Row, 1967.
5. G. M. Barrow, Introduction to Molecular Spectroscopy, McGraw Hill, 1964.
6. D. H. Williams and I. Fleming, Spectroscopic methods in organic chemistry,
Tata McGraw Hill, 1998.
edition, UK.
7. Coyle, J. D. (1991) Introduction to organic photochemistry, Wiley.
8. Halton, B.; Coxon J. M. (2011) Organic Photochemistry, Cambridge
University Press.
: Medicinal Chemistry
Credit Hours-3
(Elective-1)
Books:
1. Gupta, S. (2005). Research methodology and statistical techniques,Deep
and Deep Publications (p) Ltd.New Delhi.
2. Kothari, C. R. (2008.) Research methodology(s), New Age International (p)
Limited.New Delhi
Medicinal Chemistry Practicals:
i) Synthesis of an antihypertensive drug-propranolol
ii) Synthesis of Diltiazem (a calcium channel blocker)
condensation, a key step in its synthesis
iii) Preparation of Paracetomol and its characterization
via
Darzen
Books:
1. Vogel, A.I. (1996). Text book of practical organic chemistry, Pearson, 5th
edition, UK.
2. Adams, R.; Johnson, J.R.; Wilcox, C.F. (1970). Laboratory Experiments in
Organic Chemistry, The Macmilan Limited, London.
3. Mann and Saunders. (2009). Practical organic chemistry, Pearson, 4th edition,
UK.
4. Pasto, D.P., Johnson, C., Miller, M. (1992). Experiments and Techniques in
Organic Chemistry, Prentice Hall, 1st edition, US.
5. Roberts, R.M.; Gilbert, J.C.; Rodewald, L.B.; Wingrove, A.S. (1969). An
introduction to Modern Experimental Organic Chemistry, Ranehart and
Winston Inc., New York.