Professional Documents
Culture Documents
Topic titles in bold reflect the videos in the Video Lectures page. The indented text below each title reflects the
Lesson Objectives for that topic, which are also available for reference in the Tutorial Notes. You will also find a
resource for a direct link to all of the figures mentioned throughout the course in the Tutorial Figures page.
Unit 1: Neuroanatomy
Differentiate the basic classes of cells found in the central nervous system (CNS).
Characterize the functional microanatomy of neurons (differentiate neuronal cell bodies, dendrites,
axons and synapses).
Describe the microanatomical composition of gray matter and white matter in the CNS.
Non-Neural Cells of the Central Nervous System (CNS)
Describe the basic classes of cells found in the central nervous system (CNS).
Describe the basic functions of the three types of glial cells found in the CNS.
Discuss position in various divisions of the central nervous system (CNS) using the following pairs
of direction terms: anterior/posterior; rostral/caudal; superior/inferior; dorsal/ventral; and medial/lateral
Demonstrate the three orthogonal planes that are used to section the CNS.
Lateral Surface of the Cerebral Hemispheres
Demonstrate the four paired lobes of the cerebral cortex and describe the boundaries of each.
Sketch the major features of each cerebral lobe, as seen from the lateral view, identifying major gyri
and sulci that characterize each lobe.
Medial Surface of the Cerebral Hemispheres
Demonstrate the four paired lobes of the cerebral cortex and describe the boundaries of each.
Sketch the major features of each cerebral lobe, as seen from the medial view, identifying major gyri
and sulci that characterize each lobe.
Finding the Central Sulcus
Recognize the central sulcus from its medial terminus in the paracentral lobule to its lateral terminus
central gyri that represent somatic motor control and somatic sensation for the contralateral leg, arm and
face.
Ventral Surface of the Cerebral Hemisphere
Describe the major features of the cerebral lobes, as seen from the ventral view, discussing major
gyri and sulci that characterize each lobe.
Recognize the major embryological subdivisions of the brain that are visible from the ventral view.
Fingers to Gyri
Identify the major blood vessels that comprise the anterior and posterior circulation of the brain.
Sketch the anastomotic ring of blood vessels (the circle of Willis) at the base of the brain.
Identify the major blood vessels that supply the spinal cord.
Describe the system of vessels for venous drainage of blood from the brain into the jugular veins.
Discuss the functions of the cranial nerves in terms of the sensory and motor signals conveyed by
each nerve.
Identify the major subdivisions of the brainstem and spinal cord, as seen in representative
transverse cross-sections.
Discuss the relationship between the cranial nerves and the corresponding cranial nerve nuclei.
Internal Anatomy of the Spinal Cord (3 parts)
Discuss the organization of gray matter in the spinal cord and the general functions associated with
the dorsal horn, ventral horn and intermediate gray matter.
Discuss the organization of white matter in the spinal cord and the general functions associated with
each column.
Ventricles
Describe the distribution of the ventricular spaces in the forebrain and brainstem.
Internal Capsule and Deep Gray Matter (3 parts)
Identify major white matter and gray matter structures that are apparent in sectional views of the
forebrain, including the structures listed in the chart and figures in this tutorial.
Describe and sketch the relations of the deep gray matter structures to the internal capsule in
coronal and axial sections of the forebrain.
Describe the distribution of the ventricular spaces in the forebrain and brainstem.
Describe the concept of electrochemical equilibrium and relate this concept to the resting
membrane potential of neurons.
Explain why the permeability of the neuronal plasma membrane at rest to K+, and the concentration
gradient of this ion across the neuronal plasma membrane, account for the resting membrane potential of
neurons.
Use the Nernst equation to predict the resting membrane potential of neurons given knowledge of
the concentration gradients of permeant ions.
Ionic Basis of the Action Potential (3 parts)
Use the Goldman (and Nernst) equations to predict the membrane potential of neurons given
knowledge of the concentration gradients of ions and their relative permeabilities across the neuronal
plasma membrane.
Describe the ionic basis of the action potential in terms of the voltage- and time-dependant changes
in ionic permeabilities that occur across the neuronal plasma membrane.
Describe the driving force for current flow across the plasma membrane.
With careful precision, relate the time course of changes in Na+ and K+ conductance to changes in
membrane potential during the action potential.
Molecular Mechanisms of Action Potential Generation (2 parts)
Describe the molecular properties of sodium and potassium channels that explain the voltage- and
time-dependent permeability changes underlying action potential generation.
Describe the molecular mechanisms for establishing chemical gradients for sodium and potassium
across the neuronal plasma membrane.
Propagation of Action Potentials
Describe the ionic basis of the action potential in terms of the voltage- and time-dependent changes
in ionic permeabilities that occur across the neuronal plasma membrane.
Characterize the advantages of myelination for the conduction of an action potential along an axon.
Synaptic Transmission (2 parts)
Compare and contrast the structural and functional similarities and differences between electrical
and chemical synapses.
Describe the sequence of events responsible for the transmission of a neural impulse from one
neuron to the next via a chemical synapse.
Name the major small molecule neurotransmitters and neuropeptides in the CNS and briefly state
the function of each.
Account for the factors that determine the effect of neurotransmitters on postsynaptic neurons.
Neurotransmitters Receptors (3 parts)
Discuss the means by which ligand-gated ion channels affect the membrane potential of
postsynaptic neurons.
Compare and contrast the structure and function of ligand-gated ion channels and metabotropic (Gprotein coupled) receptors.
Discuss the properties of the NMDA receptor for glutamate and why it is important for synaptic
plasticity.
Account for the factors that determine the effect of neurotransmitters on postsynaptic neurons.
Synaptic Integration
Discuss the concepts, excitatory postsynaptic potential (EPSP) and inhibitory postsynaptic
potential (IPSP), defining them in terms of the reversal potential for the postsynaptic current and the
threshold for generating an action potential.
Discuss the role of AMPA and NMDA subtypes of glutamate receptors in the induction and
maintenance of LTP.
Discuss the molecular basis of LTD in the cerebral cortex and cerebellar cortex.
Synaptic Plasticity: STDP
Discuss the importance of the timing of the postsynaptic response, relative to presynaptic activity,
for synaptic plasticity.
Synaptic Plasticity: Hebb's Postulate
State Hebbs postulate and discuss its relevance for neural plasticity.
Account for the generation of action potentials in peripheral axons in response to somatic sensory
stimulation.
Identify and characterize the major sensory endings that mediate sensations elicited by touch,
Characterize the mapping of the body (somatotopy) in the primary somatic sensory cortex.
Discuss the distribution of somatic sensory signals to higher-order processing centers in the parietal
lobe, motor centers, emotional centers and memory centers in the brain.
Mechanosensory Pathways (3 parts)
Characterize the organization of the dorsal-column medial lemniscal system from peripheral nerve
cerebral cortex.
Characterize the organization of the neural pathways that mediate unconscious proprioception
(proper proprioception) from peripheral nerve ending to cerebellum (the spinocerebellar pathway).
Recognize components of the spinocerebellar pathway in the spinal cord and brainstem.
Describe two categories of pain sensation (first and second pain) and explain the neural basis of
each.
Characterize the neural mechanisms for the feedback modulation of nociceptive processing.
Characterize the neural mechanisms for the feedforward modulation of nociceptive processing.
Discuss the affective dimensions of pain and identify the neural systems that are involved in pain
affect (suffering).
Pain Pathways (2 parts)
Characterize the organization of the anterolateral system from peripheral nerve ending to cerebral
o
cortex.
Recognize components of the anterolateral system in the spinal cord, brainstem, thalamus and
cerebral cortex.
Characterize the organization of the trigeminal pain & temperature (spinal trigeminal) system from
Describe the factors and neural mechanisms that account for the focusing of an image on the
o
retina.
o
Identify the five neuronal cell types of the retina and state the roles of each in retinal processing.
Discuss the responses of retinal ganglion cells to the onset and offset of light and the relevance of
their receptive fields for the detection of light and shadow.
Visual Systems: Central Visual Processing (3 parts)
Describe the distribution of the axons of retinal ganglion cells to major processing centers in the
forebrain and brainstem.
Describe the distribution of the axons of retinal ganglion cells to major processing centers in the
forebrain and brainstem.
Discuss the topographic representation of visual space in the primary visual cortex (V1) and its
anatomical basis in the organization of visual projections.
Discuss the distribution and functions of parietal and temporal extrastriate visual pathways.
Visual Systems: Visual Field Deficits
Describe the distribution of the axons of retinal ganglion cells to major processing centers in the
forebrain and brainstem.
Discuss the topographic representation of visual space in the primary visual cortex (V1) and its
anatomical basis in the organization of visual projections.
Characterize, using appropriate clinical terms, the visual field deficits associated to damage or
disease along the central visual pathways.
Visual System: Pupillary Light Reflex
Describe the distribution of the axons of retinal ganglion cells to major processing centers in the
forebrain and brainstem.
Describe the biomechanics of sensory transduction in the middle and inner ear, including the
tonotopy of the basilar membrane.
Describe the biomechanics of sensory transduction in the vestibular labyrinth, including the
biophysics of hair cell sensory transduction.
Vestibular System: Central Processing (4 parts)
Discuss the general somatotopic organization of motor neurons in the ventral horn of the spinal
o
cord.
o
Characterize the motor unit and discuss different types of motor units.
LMNC: Segmental Reflexes (4 parts)
Discuss the critical components of the myotatic reflex and how they interact to monitor and adjust
muscle length.
Discuss the critical components of the Golgi tendon reflex and how they interact to monitor and
adjust the force of muscle contraction.
Discuss the critical components of the flexion/crossed-extension reflex and how they interact to
withdraw a limb from a harmful stimulus.
LMNC: Central Pattern Generation
Describe central pattern generators and their significance for locomotion and other rhythmic
behavior.
LMNC: Lower Motor Neuron Syndrome
Discuss the neural centers that give rise to lateral and medial descending projections to lower motor
neurons.
Discuss the organization of the motor cortex and its contributions to the control of volitional
movement.
Characterize the representation of the body in the motor cortex and compare it to the representation
of the body in the primary somatic sensory cortex.
Discuss the neural centers that give rise to lateral and medial descending projections to lower motor
neurons.
Discuss the organization of the motor cortex and its contributions to the control of volitional
movement.
UMNC: Brainstem
Discuss the neural centers that give rise to medial descending projections from the brainstem to
lower motor neurons.
UMNC: Emotional Motor System
Identify the major components of the basal ganglia, including the parts of the dorsal motor stream
and ventral limbic stream.
Discuss the role of the basal ganglia in the initiation and suppression of behavior.
Describe the principle of disinhibition and explain how it applies to the circuitry and functions of the
basal ganglia.
Discuss the critical role of dopamine in facilitating the function of basal ganglia circuitry.
Modulation of Movement by the Cerebellum (6 parts)
Describe the circuitry involved in the main excitatory loop and inhibitory side-loop through the
cerebellum.
Discuss the means by which circuitry in the cerebellum aid to increase the success of volitional
motor performance.
Describe the clinical signs and symptoms associated with cerebellar damage.
Eye Movements (6 parts)
Discuss the five major types of eye movements and indicate the functional purpose of each.
Discuss the neural circuits responsible for making a saccadic eye movement.
Discuss the roles of the frontal eye fields and the superior colliculus in directed gaze toward an
object of interest in the visual field.
Corticospinal and Corticobulbar Pathways (2 parts)
Characterize the organization of the corticospinal pathway from cortex to lower motor circuits in the
spinal cord.
Characterize the organization of the corticobulbar pathway from cortex to lower motor circuits in the
brainstem.
Sketch the corticospinal and corticobulbar pathways from cortex to lower motor circuits for volitional
movement.
Visceral Motor System: Functional Anatomical Divisions (5 parts)
Describe the anatomical organization of the sympathetic and parasympathetic divisions of the
visceral motor system, including the sources of preganglionic innervation and the location of postganglionic
visceral motor neurons.
Characterize the major functions of the sympathetic and parasympathetic divisions of the visceral
motor system.
Identify and discuss the neural centers in the CNS that regulate the outflow of activity in the
preganglionic fibers of the visceral motor system.
VMS: Hypothalamus (2 parts)
Describe the organization of the hypothalamus and identify several functions associated with key
hypothalamic nuclei.
VMS: Micturition
Discuss the interplay among the sympathetic and parasympathetic divisions of the visceral motor
system and the volitional somatic motor system in the control of micturition (urination; voiding urine).
Identify each of the major subdivisions of the adult nervous system, and relate them to their
embryological precursors and associated ventricular spaces.
Early Brain Development(6 parts)
State the significance of induction for the initial development of the CNS.
Discuss the factors that guide migrating neuroblasts to their final destinations in the developing gray
matter structures of the CNS.
Characterize the cellular mechanisms that influence the differentiation of neurons and glia in the
o
CNS.
Discuss the major classes of molecular signals that guide axonal growth.
Discuss the significance of genetic specification, self-organization and sensory experience for the
postnatal development.
State Hebbs postulate and discuss its relevance for neural plasticity in developing and recovering
o
brains.
The Changing Brain Across the Lifespan: Development, Repair and Regeneration(5 parts)
Discuss the neurobiological basis for changes in gray matter and while matter volume in the
developing human brain throughout childhood.
Discuss the mechanisms of plasticity in adult sensorimotor maps following peripheral injury.
Discuss the mechanisms of plasticity in adult neural circuits following central injury.
Unit 6: Cognition
Overview of the Associational Cortex (2 parts)
Characterize the behaviors and corresponding neural processes that contribute to cognition.
Discuss the major similarities and differences in the organization of primary cortex and
associational cortex.
Associational Cortex of the Parietal Lobe (2 parts)
Discuss the major functions that are localized to the associational cortex of the parietal lobe.
Associational Cortex of the Temporal Lobe (5 parts)
Discuss the major functions that are localized to the associational cortex of the temporal lobe.
Differentiate categories of human memory and discuss the relevant neuroanatomical systems.
Discuss dementia and relate its associated cognitive signs to associational cortex.
Associational Cortex of the Frontal Lobe (2 parts)
Discuss the major functions that are localized to the associational cortex of the frontal lobe.
Sleep and Wakefulness (6 parts)
Discuss the underlying neural systems that account for circadian rhythmicity.
Describe the functional states of the thalamocortical projection neurons in non-REM sleep and
waking states.
Overview of the Limbic Brain
Discuss the localization of the amygdala and the hippocampus in the medial temporal lobe.
Differentiate the role of the amygdala and the orbital-medial prefrontal cortex in emotion.