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Departments of Surgery, and 1Hemathology, LAUTECH College of Health Sciences, PMB 4400, Osogbo, Osun State, 2Department of
Statistics, University of Ilorin, Ilorin Kwara State, 3Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin Kwara
State, Nigeria
Correspondence to: Dr.Moses L Adeoti, Email:adeoti7449@yahoo.com
Abstract
BACKGROUND: There is an indication of the possibility of the direct or indirect influence of trace element in the development and prevention
of malignant diseases, the contribution of the trace elements in the etiology of breast cancer has been under scrutiny. AIMS: The aim of this
study was to determine the serum concentration of trace element in serum of female patients with breast cancer in comparison with healthy
controls. SETTINGS: Breast Clinic of the Department of Surgery LAUTECH University teaching hospital Osogbo, in southwestern Nigeria.
MATERIALS AND METHODS: A crosssectional age matched controlled prospective study wherein the venous blood sample of 30patients
with breast cancer and 30 healthy volunteers as controls were analyzed using atomic absorption spectrophotometry. The collected data were
analyzed using statistical package for the social sciences (SPSS Inc) 16. RESULT: The mean serum concentration of the copper, zinc and
selenium were 95.34.9ug/dl and 65.215ug/dl, 62.715.7ug/dl and 93.57.2 ug/dl, 45.04.6ug/l and 76.48.9 ug/l in the two groups
respectively. The concentrations of copper and copperzinc ratio(C/Z) were significantly higher in the cancer bearing group compared to the
controls(C/Z 1.60.5 against 0.700.14 the P <0.01). The concentration of zinc and selenium in the venous blood of the breast cancer
patients showed inverse relationship while that of the control showed a direct relationship(0.03 against 0.09). In the breast cancer patients
the correlation of copper and zinc, copper and selenium and zinc and selenium showed inverse relationships, none of the relationships was
statistically significant. CONCLUSION: We found a significant association between the serum concentration of trace elements and breast cancer.
Key Words: Copper, female breast cancer, Nigeria, Osogbo, selenium, zinc
Introduction
Trace elements are micronutrients that are part of
our daily diets, they are required in minute quantity,
but are very important in many different biological
processes, [1,2] such as function of structural nutrients,
normal healing, metabolism of genetic materials for growth
and differentiation, programmed cell death and necrosis,
protection against oxidative injuries and antiinflammatory
and anticarcinogenesis effect.[3] On the other hand, some
are also involved in undesirable events in vivo,[1] such as
participation in carcinogenesis and sustenance of cancerous
cells in which lead, copper, chromium and zinc have been
implicated. Some of the specific desirable anticarcinogenetic
activities of trace elements include the role of selenium
in prevention of oxidative stress through its activity in
glutathione and super oxide dismutase and activation of
p53 a tumor suppressor gene and the role of zinc in the
application of brakes in the cell cycle and induction of
apoptosis.
The invivo utilization of trace elements is complex and
not completely understood. [2] They have redundancy of
function because the same element may incite both positive
and negative events depending upon its concentration and
interaction with other trace elements.[1,2,4,5]
The concentration of trace elements in body fluids and
tissues are influenced by sex and age, the dietary intake,
uptake in the gastrointestinal tract, storage, excretion and
the presence or absence of disease state. These numerous
influencing factors raise the question, of which is the
appropriate tissue for estimating the bioactivity of these
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DOI:
10.4103/0019-509X.175573
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Adeoti, etal.: Some trace elements in breast cancer patients in Osogbo, Nigeria
Cancer
Control
1
4
7
9
5
4
0
30
1
5
5
11
5
2
1
30
47.36.8
46.56.8
3135
3640
4145
4650
5155
5660
6165
Total
Mean age(years)
P=0.678
Copper (ug/dl)
Zinc (ug/dl)
Selenium (ug/l)
95.34.9
65.215
62.715.7
93,57.2
45.04.6
76.48.9
P<0.01
P<0.01
P<0.01
Cancer
Control
Copper/zinc ratio
Copper/selenium ratio
1.60.5
0.700.14
2.10.27
0.870.2
P<0.01
P<0.01
Cancer
Control
Breast cancer
patients
Controls
Pvalue
Pvalue
0.252
0.2
0.196
0.3
0.137
0.4
0.178
0.3
0.039
0.8
0.134
0.5
107
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Adeoti, etal.: Some trace elements in breast cancer patients in Osogbo, Nigeria
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Adeoti, etal.: Some trace elements in breast cancer patients in Osogbo, Nigeria
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