Professional Documents
Culture Documents
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A. ELISA
B. Precipitation
C. Hapten inhibition
D. Opsonization
E. Ouchterlony
20. Which cell populations are BEST characterized by the ability to display high-affinity
surface receptors for IgE?
A. Eosinophils, Mast cells, and T cells
B. Basophils and splenocytes, and B cells
C. Macrophages, Neutrophils, and T cells
D. Basophils, Mast cells, and Eosinophils
E. Neutrophils, Eosinophils, and Macrophages
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21. Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T Cells are
induced to secrete cytokines following the highly specific binding between the T cell
receptor (TCR) and the MHC/antigen peptide complex. Which of the following
statements is FALSE regarding MHC-specific T cell activation?
A. The TCR interacts with MHC Class II molecules and a peptide antigen of
approximately 12-25 amino residues.
B. gamma-delta T cells require co-stimulation through binding of the CD4 with the
Fc receptor on the antigen presenting cell.
C. Cytotoxic T lymphocytes recognize antigen presented on infected target cells. f
D. Adhesion molecules aid in the interaction of T helper lymphocytes with antigen
presenting cells.
E. All of the above are true.
22. All of the following affect the antigen-binding region of immunoglobulins EXCEPT:
A. Insertion of nucleotides at the D-J junction by terminal deoxynucleotide transferase
B. Isotype switching
C. Random selection of V, D and J gene segments,
D. Pairing of different heavy and light chain V regions
E. Somatic mutation
23. A Type IV hypersensitivity reaction is characterized by:
A. Neutrophil infiltrate
B. Participation by complement
C. T lymphocyte infiltration
D. Cytotoxic antibody
E. None of the above
24. Cells of the reticuloendothelial system (RES) contribute to immunity against
microorganisms by all of the following means EXCEPT:
A. Intracellular killing of pathogens
B. Recruitment of inflammatory cells
C. Synthesis and secretion of antibodies
D. Presentation of antigen
E Cytokine production
25. C3b is involved in all of the following EXCEPT:
A. Covalent attachment to bacteria
B. Altering vascular permeability
C. Enhancement of humoral immune responses
D. Formation of C5 convertase
E. Opsonization and ptiagocytosis of bacterial pathogens
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26. A large body of immunologic, epidemiologic and genetic data indicates that tissue injury
in multiple sclerosis (MS) results from an abnormal immune response to one or more
myelin antigens. Susceptibility may be mediated by the class II MHC genes
themselves, related to the known function of these molecules in the normal immune
response. Regarding the organization of human MHC genes, which is TRUE:
A. The class II region consists of HLA-A, HLA-D, and HLA-C loci.
E. The class II region is subdivided into HLA-DP, HLA-DQ and HLA-DR.
C. The class Ill region encodes for HLA-C.
D. The class III region encodes for Beta-2-Microglobulin.
E. All of the above are false.
27. A 13 year old teenager stung by a bee experiences immediate respiratory distress followed by
unconsciousness. The underlying mechanism is mediated most likely by.
A. IgA antibody
B. Complement C3a
C. IgM antibody
D. Sensitized T cells
E. IgE antibody
28. Regarding T cell receptor (TCR) gene rearrangement events:
A. If the gamma and delta chain genes do not rearrange successfully, then the
alpha chain genes begin to rearrange.
B. The gamma and delta chain genes rearrange simultaneously
C. If the alpha and beta chain genes do not rearrange successfully, then the delta
chain genes begin to rearrange.
D. The alpha and beta chain genes rearrange simultaneously
E. The TCR genes of mature T cells are all in the germ line configuration.
29. Which statement is TRUE regarding immunoglobulin genes and expression?
A. A single B Dell can express multiple kappa and lambda light chains
simultaneously.
B. The kappa locus undergoes rearrangement first, followed by the lambda and
heavy chain loci.
C. The kappa and lambda light chain loci utilize the same set of V and J gene
segments.
D. The transition from membrane-bound IgG1 to secreted IgG1 expression involves
DNA rearrangement.E. Lack of the surrogate light chain protein lambda-5 can arrest B Cell development
and result in immunodeficiency.
30. The MHC Class III genes:
A. Encode complement components
B. Encode Beta-2-Microglobulin
C. Encode proteins structurally similar to Class II molecule
D. Encode proteins structurally similar to Class I molecules.
E. Encode interleukin-1 beta and lymphophilin.
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ANSWERS:
1.
A
2.
C
3.
B
4.
C
5.
C
6.
E
7.
C
8.
D
9.
E
10.
B
11.
C
12.
C
13.
A
14.
C
15.
A
16.
E
17.
D
18.
A
19.
E
20.
D
21.
B
22.
B
23.
C
24.
C
25.
B
26.
B
27.
E
28.
A
29.
E
30.
A
31.
A
32.
B
33.
D
34.
E
35.
C
36.
E
37.
C
38.
A
39.
E
40.
A
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