Abstract

We have conducted a study on the impact of the solid dispersion systems of caffeine, PEG
6000, and HPMC towards its dissolution profile. terhadap profil disolusi. Solid dispersion systems
were prepared with dissolution of various amount in grams of caffeine, PEG 6000, and HPMC ,
with a ratio of (1;0,5;0,5) as F5, (1;0,75;0,25) as F6, and (1;0,25;0,75) as F7. Sebagai pembanding
dibuat campuran fisika dengan komposisi yang sama dengan penamaan formula (F2, F3, F4).
Panjang gelombang Kafein murni dalam medium aquadest yaitu 273 nm. Uji disolusi yang
digunakan metode dayung dalam medium disolusi 900 ml larutan aquadest, suhu 37 0,5 0c dan
kecepatan 100 rpm. Hasil disolusi dispersi padat pada menit ke 60 (F5) 82,83%, (F6) 68,34%, (F7)
90,34%. Hasil disolusi campuran fisik pada menit ke 60 (F2) 68,34%, (F3) 64,19%, (F4) 71,60%.
Serbuk sistem dispersi padat dan campuran fisik dievaluasi sifat-sifat fisikokimia meliputi analisa
dengan SEM, Spektrokopi FT-IR dan profil disolusi. Hasil analisa dengan Spektrokopi FT-IR
menunjukkan tidak terjadi interaksi kimia antara Kafein murni, HPMC, dan PEG 6000 dalam
serbuk dispersi padat. Pada uji SEM hasil penelitian memperlihatkan bahwa sistem dispersi padat
Kafein, HPMC, dan PEG 6000 dapat memperbaiki sifat fisikokimia dan dapat meningkatkan profil
disolusi kafein dibandingkan dengan serbuk campuran fisik dengan hasil disolusi tertinggi
ditunjukkan oleh dispersi padat formula 7 (90, 34%).

Abstract

We have conducted a study on the impact of the solid dispersion systems of mefenamic acid,
Kollidon CL and PEG 4000 towards its dissolution rate. Solid dispersion systems were prepared
with dissolution of various amount in grams of mefenamic acid, Kollidon CL and PEG 4000, with a
ratio of (1:0,5:0,5) as DP1, (1:0,75:0,25) as DP2, and (1:0,25:0,75) as DP3. Physically similar
compositions were created as comparisons, which were named (CF1, CF2, CF3). The wave length
of pure mefenamic acid in phosphate buffer is 284 nm. Dissolution were tested using paddle
method in 900 ml of aquadest,with a temparature of 37 0,50c and speed of 100 rpm as the
medium. The solid dissolution in the 60th minute are : DP1 (79,48 %), DP2 (90,55 %), DP3
(67,46). The solid dissolution of the comparison compounds on the 60th minute are CF1 (49,60
%), CF2 (56,27 %), CF3 (42,98 %). The powder from the solid dispersions and physical
compounds are evaluated for their physicochemical properties using SEM, Spectrocopy FT-IR and
dissolution profile. Spectrocopy FT-IR showed no chemical interaction between pure mefenamic
acid, PEG 4000, and Kollidon CL in the solid dispersion powder. SEM analysis showed that the
solid dispersion systems of mefenamic acid, Kollidon CL, and PEG 4000 can repair the
physicochemical properties and increase the dissolution profile of pure mefenamic acid, with the
highest dissolution showed by DP2 (90, 55%).