Professional Documents
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Hemodiafiltration
Martin K. Kuhlmann, MD
Vivantes Klinikum im Friedrichshain
Berlin, Germany
Martin.kuhlmann@vivantes.de
MPO-study:
Overall no clinical benefit of high-flux HD
was observed in this RCT. However,
diabetic patients and patients with base
line serum albumin levels < 4 g/L
benefitted significantly from high-flux HD
Locatelli F et al: JASN 20:645, 2009
High-Flux Dialysis
HDF
Hemodiafiltration [HDF]*
Acetate-free biofiltration
* Note: HDF is not currently approved by the FDA in the US
Basics of online-Hemodiafiltration
-In HDF, diffusive and convective dialysis modalities are
combined. Diffusion occurs along the transmembrane
concentration gradient between plasma and dialysate, while
convective transport is obtained by filtering, through a highflux dialyzer, amounts of plasma water considerably in excess
of those required to manage interdialytic weight gain.
-Fluid balance is maintained by simultaneously infusing online
generated sterile substitution fluid directly into the patients
bloodstream.
-Fluid can be substituted before (pre-dilution), within (middilution), or after the dialyzer (post-dilution).
-Clearance of middle- and large molecular-weight substances is
substantially greater during HDF than during high-flux HD.
diffusion
clearance
urea
(ml/min)
(ml/min)
200
100
clearance
vitamin B12
10%
10%
clearance
inulin
(ml/min)
200
200
100
100
50%
50%
120%
120%
0
60 90 UF rate
30
0
(ml/min)
Calculated values
0
0
30
60
90
0
UF rate 0
(ml/min)
30
60
90 UF rate
(ml/min)
510
300
blood
ultrapure
dialysis
fluid
Classical HDF
On-line HDF
with 50 ml/min
ultrafiltration rate
with 90 ml/min
ultrafiltration rate
300
300
blood
500
550
ultrapure
dialysis
fluid
blood
ultrapure
dialysis
fluid
420
500
40
290 ml/min
510
290
substitution
fluid from bags
Filter
290
500
80
Prescription:
Target convective volume (CV): 24 L per treatment
Treatment time (t): 240 min
Blood flow rate (Qb): 400 ml/min
Then:
Ultrafiltration rate (UFR) = CV/t = 100 ml/min
Filtration fraction = UFR/Qb = 100/400 = 25 % of Qb
Meta-analyses
Wang F et al. Am J Kidney Dis 2014; 63: 968
Susantitaphong et al. Nephrol Dial Transplant 2013; 28: 2859
DOPPS shows survival advantage for pts on highefficiency HDF (convective volume > 15 L per Tx)
CV > 15 L/Tx
1 outcome
2 outcome
All-cause mortality
Cardiovascular events
Meta-analysis:
Convective vs. diffusive dialysis modalities
Convective therapy
Hemofiltration (n=274)
High-flux HD (n=3,204)
Hemodiafiltration (n=1,288)
Duration of follow-up
7-12 months (n=377)
>12 months (n=4,389)
Study Quality
Fair (n=452)
Good (n=4,314)
Schiffl (2007)
OK (2011)
Grotteman (2012)
Maduell (2013)
Overall (I2=41.7%, p=0.16)
All-cause mortality
HDF
Locatelli (1996)
Wizemann (2001)
Schiffl (2007)
OK (2011)
Grotteman (2012)
Maduell (2013)
Subtotal (I2=58.6%, p=0.03)
HF
Beerenhout (2005)
Santoro (2008)
Alvestrand (2011)
Subtotal (I2=0.0%, p=0.54)
HDF or HF
Locatelli (2010)
Subtotal (I2=.., p=.)
Overall (I2=38.3%, p=0.10)
Lin (2001)
Schiffl (2007)
Maduell (2013)
Subtotal (I2=86.1%, p=0.001)
HF
Santoro (2008)
Subtotal
HDF or HF
Locatelli (2010)
Subtotal
Overall (I2=76.7%, p=0.002)
online-HDF: Conclusion
-ol-HDF may increase removal of middle molecules and phosphate; however,
no clincial trial has shown an effect of HDF on blood levels of commonly
measured middle molecules
-Both, CONTRAST and the Turkish HDF study did not show survival benefits
for HDF vs. conventional HD. In post-hoc analysis survival benefits for pts
treated with high volume ol-HDF (CV > 17.5 22 L/Tx) were observed in
both trials
-ESHOL demonstrates better outcomes for high-volume ol-HDF (CV > 22 L/Tx)
vs. high-flux HD including a dose-effect relation
-Two meta-analyses were unable to show significant survival benefits for olHDF vs. conventional HD; Further studies will be required to test the
hypothesis that high-volume HDF is superior to high-flux HD
-An individual patient data meta-analysis of all ol-HDF RCTs is currently being
conducted to examine the effects of body size-adjusted HDF-dosing on
outcome.
-ol-HDF is safe with no increased risk for infection and associates with
increased hemodynamic stability; ol-HDF may be slightly more costly than
HD (+ 3%)
-Current recommendations for HDF-dosing include an achieved CV > 22 L/Tx