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Culture Documents
puberty with painful, deep-seated, infamed lesions in the apocrine gland-bearing areas of the body, most
commonly the axillary, inguinal, and anogenital regions.
Epidemiology
Genitofemoral lesions are more prevalent in women, whereas axillary involvement does not demonstrate a
gender predilection.
Etiology
Adnexal structures
HS was thought to represent a primary disorder of apocrine glands, and was also referred to as apocrinitis.
Genetic factors
A family history of HS may be elicited in 26% of patients. Several studies have not demonstrated HLA
associations.
Associated diseases
The coexistence of HS and Crohn disease, particularly with perianal involvement has been associated with a
more fulminant course
Obesity
Obesity is unlikely to be a causal factor in HS but is often regarded as an exacerbating factor.
Bacterial infection
The role of bacterial infection in HS is unclear. It is believed that the pathogenic role is similar in acne. Bacterial
involvement is thought to occur secondarily. The bacteria can be found such as Staphylococcus aureus and
Streptococcus.
Smoking
The use of tobacco products is more common in HS patients than in healthy controls. It is postulated that
smoking affects polymorphonuclear cell chemotaxis.