Blood Component Therapy

Whole Blood

DESCRIPTION
Up to 510 ml total volume
450 ml blood + 63 ml anticoagulant/preservative

SHELF-LIFE
ACD 21D
CPDA 28D
SAGM 42D

Packed RBC

Contains RBC depleted of plasma

Same as WB

Platelet
Concentrate

Single donor unit: platelets prepared from 1 donor

Pooled unit: platelets prepared from 4 to 6 donor units

3-5 days

5.5x1010 platelets in 50ml plasma

4.4x1011 in apheresed platelets

Fresh Frozen
Plasma

Cryoprecipitate

1 unit of platelet concentrate/10 kg body weight: in a

60 or 70 kg adult, 4-6 single donor units containing at
least 240x109 platelets should raise the platelet count
by 20-40x109/L
Increment will be less if there is:
o Splenomegaly
o DIC
o Septicemia
Pack containing the plasma separated from one
whole blood donation within 6 hours of collection and
then rapidly frozen to -25C or colder
Contains normal plasma levels of stable clotting
factors, albumin and immunoglobulin
Also contains plasma proteins and all coagulation
proteins

Thawing FFP at 1-6C and recovering the

precipitated material
Contains >150 mg of fibrinogen, > 80 units of factor
VIII, significant amounts of vWF, and some
fibronectin and factor XII in less than 15 ml volume
Dosage: 1 unit/6kbw

Storage
At -25C or colder for up to 1 year
Before use, should be thawed in
the blood bank in water which is
between 30C to 37C. Higher
temperatures will destroy clotting
factors and proteins
Once thawed, should be
immediately transfused or stored
in a refrigerator at +2C to +6C,
not >24 hours

INDICATIONS
Actively bleeding patient (>2530% blood loss)
Exchange transfusion
Patients needing red cell
transfusion where red cell
concentrated or suspensions are
not available
1. Chronic anemias
2. Preoperative or predelivery
transfusion
3. Replacement of surgical blood
loss
4. Anemic patients in congestive
heart failure
5. Anemic patients with liver failure
6. Uremia
7. BM failure
In non-bleeding patients: With
platelet count <20,000 as a result
of chemotherapy, tumor invasion
or primary aplasia
Before surgery or invasive
procedure with platelet count
<50,000
Documented bleeding in patients
with count <50,000
Patients with documented
abnormal platelet function

Replacement of multiple
coagulation factor deficiencies:
e.g.
- Liver disease
- Warfarin (anticoagulant)
overdose
- Depletion of coagulation
factors in patients receiving
large volume transfusions
Disseminated intravascular
coagulation (DIC)
Thrombotic thrombocytopenia
purpura (TTP)

Von Willebrands disease

Hypofibrinogenemia
Hemophilia A
Factor XIII deficiency
Bleeding related to renal failure

CONTRAINDICATIONS
Chronic anemia
Incipient cardiac failure

ITP
TTP
DIC
Thrombocytopenia associated
with septicemia, until treatment
has commenced or in cases of
hypersplenism

Cryosupernate

o Contains Factors II, VII, IX, XI

o Dosage: 1 unit/10 kg daily dose

Hemophilia B patients
Liver disease