Published on: 27 Mar 2014

Antibiotics: Dosage, Indications and Tissue Penetration

Indication And Dosage
Beta-Lactams and Beta-Lactam Plus Beta Lactamase Inhibitors
Amoxicillin

Ampicillin

Ampicillin Sulbactam

Amoxicillin Clavulanic Acid

Cefpodoxime

Cefixime

Cefuroxime

Ceftriaxone

Quinolones
Ciprofloxacin

Norfloxacin

Levofloxacin

Moxifloxacin

Gemifloxacin

Macrolides
Erythromycin

Azithromycin

Clarithromycin

Tissue Penetration
Cephalosporins
Cepodoxime

The Tissue Penetration of Cefpodoxime was approximately 2-fold higher than that of cefixime (tissue
AUC 15.4 mg.h/L for cefpodoxime vs. 7.3 mg.h/L for cefixime)

AUC= Area under curve

International Journal of Antimicrobial Agents 2002; 19:285-290,
J Antimicrob Chemother. 2002; 50:19-22.
Cefixime

International Journal of Antimicrobial Agents 2002; 19:285-290

Cefuroxime

Pharmacotherapy 1983;3:82-100
Penicillin
Piperacillin

International Journal of Antimicrobial Agents 2002; 19 :285-290

Amoxicillin

J. Chemother 1990; 2 (3): 171-7

Antimicrobial Agents and Chemotherapy 1995; 39(1): 94-98
Infection 1982; 10 (Suppl 2): S108-12
Quinolones
Gemifloxacin

International Journal of Antimicrobial Agents 2002; 19 :285-290

Levofloxacin

International Journal of Antimicrobial Agents 2002; 19 :285-290

Moxifloxacin

International Journal of Antimicrobial Agents 2002; 19 :285-290

Macrolides

Infectious Diseases in Clinical Practice 1994; 3: 405-410

Clarithromycin

Infectious Diseases in Clinical Practice 1994; 3: 405-410

J. Antimicrob. Chemother..1991; 27: 61-65
Roxithromycin

Infectious Diseases in Clinical Practice 1994; 3: 405-410

J. Antimicrob. Chemother..1991; 27: 61-65
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