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NUR 471 Neuro and Mental Health 1

NUR 471 Neuro and Mental Health 1


NUR 471 Neuro and Mental Health 1
NUR 471 Neuro and Mental Health 1

NUR 471 Family Nurse Practitioner I


Spring 2012

Neurological and Mental Health Problems in Children

Common Problems
A. Cerebral palsy
B. Developmental delays and mental retardation
1. Micro/macroencephalopathy
2. Craniosynotosis
3. Down Syndrome
C. Spina bifida
D. Seizure disorders
E. Febrile seizures
F. Meningitis
G. Brain lesions
H. Reyes syndrome
I. Hypotonia: Muscular Dystrophy
J. Headaches
K. ADD/ADHD
L. Depression/suicide
M. Anxiety (added)
N. Bullying
O. Autism
P. Sleep Disorders

Associated Readings:
Burns et al. (2009). Pediatric Primary Care. Read Chapters 15, 16, 27, 1125-1133.
Chiocca. (2011). Advanced Pediatric Assessment. Read Chapters 22 & 24.
Hay et al. (2011). Current Diagnosis & Treatment Pediatrics. Read Chapters 6 (171-182,
common disorders listed above) & 23 (696-706, common disorders listed above).

Optional resource on neurological exam of newborns with videos!


http://library.med.utah.edu/pedineurologicexam/html/newborn_n.html#01
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Cerebral Palsy

Non-progressive disorder of movement

Caused by injury to the CNS

Incidence: 1-3 live birth per 1000

Brain lesion is static but manifestation changes over several years due to developing nervous system

Mental retardation 26% (mild), 27% (severe)


Microcephalic

Definitive diagnosis of cerebral palsy should not be made until 1 year of age (changing findings)

Diagnosis- based on 4 out 6 major motor areas:

Posture

Oral motor functioning

Visual-motor functioning

Tone

Evolution of primitive reflexes

Muscle-stretch reflexes; hyperreflexia


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Levine (Poster) Criteria for Diagnosing Cerebral Palsy

P posturing and abnormal movement pattern

O oropharyngeal problems

S strabismus

T tone, increased or decreased in muscles

E evolution response, persistent primitive reflexes/ failure to develop protective response

R reflexes, deep tendon reflex increase, plantar reflexes up-going

Types of Cerebral Palsy

Hemiparesis

Spastic Diplegia/ Quadriplegia; 75%

Dystonic-Athetoid (Extrapyramidal)

Hypotonic

Ataxic; 15%

Mixed
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Management Issues in CP

Nutrition (FTT common due to oral motor problems) - assess/educate parents re: eating difficulties/
appropriate techniques

Constipation common (stool softeners/ regular bowel regime)

Drooling skin breakdown/ social issue

Seizures 50%

Orthopedic issues muscle relaxants

Safety issues high risk for injury

Multi-disciplinary management

Micro/Macrocephaly

Average head circumference at birth: 2 cm greater than chest circumference (about 35cm)

Head growth faster in premature infants than term infants

Microcephaly 2 standard deviations below the mean (or 2 nd percentile for age and gender)

Macrocephaly 2 standard deviation above the mean

Refers to brain size

Causes of Micro/Macrocephaly

Infections
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Drugs

Anoxia

Heredity

Chromosomal

Malformations

Trauma

Perinatal metabolic/endocrine imbalances

Malnutrition

Perinatal maternal illness

Management:

Microcephaly no treatments or medications are indicated

Counseling for parents

Genetic evaluation and counseling

Routine follow-up with neurologist

Macrocephaly dependent on cause

Monitor for ICP and immediately seek medical attention - teach parents to monitor

o Infants bulging fontanels, vomiting, drowsiness, seizures

o Older child - headache, blurred vision, behavior changes, decreased level of consciousness,
vomiting, seizures)
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Monitor head circumference (document parents head circumference) and fontanel size

Chromosomal evaluation

Craniosynotosis

Premature fusion of the cranial sutures, usually beginning in utero

Sagittal suture most common (50%)

More common in boys

Results in skull/craniofacial deformities

Increased intercranial pressure

Cause chromosomal or unknown etiology

Goal is to ensure normal brain growth

Surgery is usually treatment of choice

Down Syndrome
Common chromosomal abnormality; 1/800 to 1/1000 live births
Involves multiple anomalies due to partial or complete (84%) trisomy of chromosome 21
Prenatal diagnosis by amniocentesis offered to women over 35 years
Most born to women under age 35
Genetic counseling and chromosome analysis of parents (especially with translocation of 21)
Interdisciplinary team management is key

Diagnostic Features
Facial; up-slanted palpebral fissures, small nose with low nasal bridge, inner epicanthal folds, flat
facial profile, Brushfield spots (speckling of iris), open mouth, tongue protruding, small ears
Flat occiput
Short neck, excess skin on posterior neck
Hypotonia
Hyper-flexibility of joints
Limbs; wide space between first and second toe, single palmar crease, short wide hands
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Small stature, immature gait

Associated Developmental and Medical problems


Variable global delay
Mid-moderate mental retardation (IQ 45-90)
40-60% with cardiac problems ASD, VSD, TOF, PDA
12% with GI problems Hirschsprung Disease, imperforate anus, duodenal atresia
Jaundice when newborn
Orthopedic problems atlantoaxial instability, late hip dislocation
Ophthalmologic problems refractive errors, myopia, congenital cataracts, strabismus
incidence of OM, chronic sinusitis, hearing loss (70-80%), hypothyroidism, leukemia

Management considerations
Medical through physical evaluation
o Consider X-rays if indicated for orthopedic problems, echocardiogram, TSH, vision and
hearing screening
Educational IEP, teachers aide in classroom
Psychological social skills training, behavioral therapy consult
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Spina Bifida and Myelomeningocele

Most frequent serious congenital malformation

Multifactorial cause (incidence 1 in 1000 live births)

Folic acid supplementation is protective

Neural tube defect present at birth

Level of lesion in spinal cord determines childs potential for mobility

75% of lesions occur in lumbosacral area

Scoliosis develops with higher level lesions

Foot deformities occur early due to innervation of ankle dorsiflexors and weak plantar flexors

Care Issues with Spina Bifida

Monitor growth & development

Skin breakdown due to decreased sensation

Safety prone to injury due to w/c or braces and decreased mobility

Bowel and bladder management assess bladder program; constipation is common and can cause
shunt malfunction or UTIs

Latex allergy is common in those with spina bifida

Multidisciplinary management
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Seizure Disorder

Definition: Abnormal brain functioning caused by abrupt, uncontrolled, repetitive discharges of


cortical neurons with the brain

Incidence: Approximately 3.5 to 5% of children have a seizure by 15 years of age

Only 1% with seizures have epilepsy (recurrent seizures)

50% occur in children under 10 years

Appx. of childhood seizures are idiopathic

Common Etiology

Neonate: hypoxia, CNS bleed, infection

Infants: infection, dehydration, fever, CNS trauma, inborn errors of metabolism

Children and Adolescent: head trauma, fever, tumor, toxin ingestion, non-adherence or inadequate
dose of anticonvulsant med, street drugs esp. cocaine, breath-holding spells

Classification of Seizures:

Generalized Seizures (arise from both cerebral hemispheres)

Nonconvulsive

o Typical absence seizures petit mal

o Atypical absence seizures onset gradual

Convulsive

o Tonic abrupt increase in muscle tone

o Atonic abrupt decrease in muscle tone

o Clonic repetitive muscle jerking


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o Tonic-Clonic classic grand mal seizure

o Myoclonic brief, shock-like muscle contractions

Partial Seizures (focal onset)

Simple does not impair consciousness


o Symptoms bases on lobe affected such as temporal (emotional sensations, smell,
taste), frontal (strange movements), parietal (strange sensations), occipital (visual
sensations)
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Complex focal onset seizure that does involve the loss or impairment of consciousness

Both types of partial seizures may present with motor signs (clonic jerking), sensory symptoms
(tingling, distortions of smell or vision), autonomic signs (pallor, diaphoresis), or psychic sxs
(fear, hallucinations)

Status epilepticus: Prolonged seizure for > 30 minutes

History

High-risk screening by 5 questions: Born prematurely, family history of seizures, personal history
of seizures, head injury with loss of consciousness for 30 minutes or more, CNS infection
(meningitis, encephalitis)

Characteristics of seizure

Loss of consciousness

Presence of an aura; visual, auditory, sensations

Abnormal eye movements

Precipitating events

Post-ictal state

Head injury

Incontinence

Cyanosis

Hx of seizures, medication, underlying illness

Management
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Complete physical/neurologic exam

Blood chemistry (serum glucose, lytes, Ca, BUN, CBC with diff)

Lead screen

Toxicology on blood and urine in teens

Liver function tests

EEG; may need to do serial EEGs (sleep-deprived)

MRI (for focal seizures, adolescent with 1st seizure)

Dont routinely change from Trade to Generic brand drug; increase risk of seizure

Referral/consultation

o May not treat 1st seizure

o Some seizures in children resolve with aging

o Trial off medication if > 5 years seizure free

o No driving until 6 months seizure fee


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Monitoring/Education

Routine monitoring of lab related to anticonvulsant medications (levels, CBC, LFTs as indicated)

Dental hygiene/gum hyperplasia if on Dilantin

Emphasize need to never abruptly discontinue meds

Educate regarding seizure precautions and safety issues (ie. shower versus bath, no swimming
alone, biking, mowing, pregnancy)

Febrile Seizures

Occurs in approximately 2% of children; most common childhood seizure

Highest incidence between 6-18 months (range 3 months-5 years)

Risk increases with:

o Family hx of seizures

o Maternal smoking during pregnancy

o Prematurity

o Day care > 20 hours per week

o Frequent infections in the 1st year of life

Triggered by rapid rise in temperature to at least 39 degrees during the early course of an illness

A febrile seizure that occurs after the 1st 24 hours of fever is most likely due to significant
infection

Most are generalized seizures (tonic-clonic)

Duration: 50% last < 5 minutes; 75 % last < 20 minutes; 2-3% last longer than 30 minutes

Recurrence risk 30%, < 1year-old 50%


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Increased risk of epilepsy


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Management

Controlling fever (rectal acetaminophen, sponging)

Monitoring for any sign of meningitis esp in children under 2 yrs

Monitoring for other infections (UTIs, throat) with UA, CBC, strep screen

Lorazepam used for status epilepticus due to less resp. depression

Prophylaxis with anticonvulsant if: family member has hx of nonfebrile seizures; duration > 15
min; > 1 seizure in 24 hrs; prior hx of abnormal neuro exam

Reassure parents/of nature of seizures

Seizure precaution education

Referral if uncertain of diagnosis or cause of recurrence

Meningitis

Most common pathogens: Strep pneumoniae and Neisseria meningitidis (2 mo to 12 yrs)

Aseptic meningitis (acute inflammation of meninges) most often viral

Incidence: increased during winter and spring

More common in males/age 2 mos to 2 years

Risk factors: varicella inf., URI, insect bites, without Hib or MMR vaccinations, head trauma,
day-care

Sxs: irritability, fever, lethargy, nuchal rigidity, confusion, severe headache


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Brain Lesions

Most common brain tumors:

o Astrocytoma

o Medullablastoma

o Ependymoma

2nd most common childhood malignancy

Incidence: 3 per 100,000 under 15yrs

Sxs: headaches, neuromuscular changes, behavioral changes, vomiting, seizures, papilledema


cranial neuropathy, VS changes

Care of children with brain tumors

Txs: surgery, chemotherapy, radiation

Monitor nutrition

Immunizations

Sleep

Safety

Vision/hearing/dental screening

Discipline advise parents to use other strategies than spanking

Normal activity as possible

Reyes Syndrome
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Encephalopathy and non-inflammatory fatty infiltration of liver and kidney

Associated with epidemics of influenza A & B, and chicken pox and medicating with aspirin for
viral illness (predisposes to developing Reyes syndrome)

Sxs: protracted vomiting; confusion; combative behavior; agitation; stupor; coma

Management: supportive care, monitoring ICP, vit K or fresh frozen plasma, educate parents
regarding no aspirin products

Muscular Dystrophy

Duchenne and Becker Muscular dystrophy (most common types) - genetically determined

Progressive disorder affecting muscles of upper extremities, chest wall and heart

Clinical onset: appx 3 yrs old, with rapid progression

Sxs: hx of clumsiness; trips and falls easily; muscular looking calves; delayed motor
development; inability to keep up with peers when running, mental impairment (30%), scoliosis
-Gower maneuver - pushes off ones own upper legs to get up from seated position

Headaches
Optional resource Migraine headache article http://www.aafp.org/afp/2009/1215/p1445.html
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Majority of HAs due to nonorganic causes (Tension, allergies, sinus infections, migraines 5-15%)

Frequent complaint; 37% by age 7, 69% by age 14

More common in girls

Young children (less than 5 years of age) esp with specific complaints are likely to have organic
etiology

Increased risk: stressful home/school environments; family hx of HA; parent with mental health
problem; recent major life crisis; use of drugs or ETOH

Hx/Exam:

o Ask about associated sxs

o Vital signs (esp temp and B/P)

o Complete Neurologic exam

o Assessment of TMJ/dental exam

o Visual acuity/last vision exam by optometrist

o Thorough HEENT exam

o Skin inspection for rashes and/or lesions

Headache Warning Signs Indicators of Organic Etiology

New onset (less than 3 months)

Child less than 3 years old


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Headaches associated with diplopia/papilledema

Awakens child in middle of night, worse when lying down

Pain present upon arising but improves as day progresses, or occipital pain (common with
tumors)

Bruit in temporal areas

Positive neurologic finding/seizures/N/V

Increase in frequency/severity over a few weeks

Exacerbated by position changes, straining, coughing

Petechiae/ecchymosis

Post trauma

Headache Differential Dx:

Acute generalized: fever, infection; trauma

Acute localized: sinusitis, otitis, dental, TMJ, cocaine use

Acute recurrent: migraine, cluster, post seizure

Chronic progressive: tumor, brain abscess, subdural, hematoma, hemorrhage, vasculitis

Chronic nonprogressive (tension headache): muscle contraction, malingering, post concussion,


depression, anxiety, adjustment reaction

Management

Medicate at onset of headache. Reassurance is important.

Headache diary if frequent, including diet.


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Acetaminophen: if sxs infrequent or not severe (15mg/kg/dose) for non-migraine

Acute migraine attacks

o Ibuprofen: when acetaminophen not providing good relief or if migraine or menses


related HA (5-10mg/kg/dose) q 6-8 hrs

o Abortive for migraines (if has aura): sumatriptan po 50 mg children 6-12 yrs; 100mg if
over 12 yrs

Migraine Prophylaxis

o Beta-blockers, propranolol 40-80 mg BID initially

o Sleep

o Stress reduction

o Dietary management

With comorbid depression - Zoloft 50 mg per day

Also used but not recommended in migraine clinical guideline;

o Fiorinal (butalbital, aspirin, caffeine) 1-2 caps q 4 hrs if ibuprofen not effective, use
sparingly (for adolescents)

o Amitriptyline (for adolescents) 25-50mg q HS

ADHD - Attention Deficit Hyperactivity Disorder (ADHD and ADD )

Most commonly diagnosed behavioral problem

o Is it under-diagnosed or over-diagnosed?

o Does every inattentive child have ADD or ADHD?


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One of five most common chronic disorders of childhood

Prevalence for school age children 3-5%; 4.5 million 5 to 17 year-olds

3 Basic Symptoms of ADHD

o Inattention (pays attention too many things),

o Impulsivity,

o Hyperactivity

M>F

o Teachers expect more of boys

o Boys more hyperactive/impulsive so diagnosed earlier


o Girls more inattention so often diagnosed in Middle school

Clear genetic influences (twin studies), believed to be due to;

o Low norepinephrine (inattention, distractability) and,

o Low dopamine (impulsivity, behavior problems).

Clear environmental influences; maternal tobacco&/or alcohol use, fetal distress, low birth weight

Big controversy due to increased use of stimulants in 1990s

80% have comorbid conditions; ODD (35%), OCD CD (30-50%), mood disorders (15-70%), anxiety
disorders (25%), substance abuse, and may precede development of Tourettes
2011 AAP guidelines cover age 4-18
http://pediatrics.aappublications.org/content/128/5/1007.full.pdf+html
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ADHD Hyperactive/Impulsive Criteria

Fidgets hands or feet or squirms in seat

Leaves seat in classroom

Runs about or climbs excessively

Difficulty playing quietly

On the go or driven by a motor

Talks excessively

Blurts out answers

Difficulty waiting turn

Interrupts or intrudes on others

ADHD Inattentive Criteria

Makes careless mistakes

Difficulty sustaining attention

Does not seem to listen

Does not follow through

Difficulty organizing tasks

Avoids tasks that require mental effort

Loses necessary items


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Easily distracted

Forgetful

ADHD evaluation

Symptoms before age 7; difficult to diagnose before age 4

DSM IV criteria

o Symptoms present for at least 6 months

o 2 settings (home, daycare, school, work)


o Evidence of social, academic &/or occupational impairment
o At least 6 inattention symptoms and/or hyperactivity/impulsivity symptoms
o Some hyperactivity/impulsivity symptoms must have been present before 7 years-old

Symptoms are not better accounted for by another mental illness

Information must be obtained directly from parent and teachers (Conners)

History; DSM-IV criteria, family history


Physical exam; complete history, growth, neurological, auditory/visual screening
Consider testing; CBC, lead, TSH, neurodevelopmental, psychoeducational
Differential diagnosis: see Burns pg. 328
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Treatment for ADHD

Behavioral (positive reinforcement, time-out, token economy, response cost) 1 st line

Medication, 2nd line starting at age 4

o Stimulants: methylphenidate (Ritalin), methylphenidate extended release (Concerta,


Ritalin SR, Metadate ER, Methylin), amphetamine/dextroamphetamine (Adderall)

o Non-stimulant: atomoxetine (Strattera), Pemoline, Guanfecine, clonidine (for aggression,


tics, controversial for sleep problems- off label, need baseline ECG, important SEs &
Contraindications).

o If one stimulant does not work at the highest feasible dose, try another

o Parent education on side effects crucial

Dietary considerations; monitor weight

Close follow-up is important for successful management including input of school (family
support, nutrition, sleep, academic performance, psychological functioning)

Depression and Suicide

Rate of depression increases with age; 1-3% before puberty, 8% adolescent, nearly adult rate by at 15
(lifetime risk 10-25% women; 5-12% men)
Depression rate higher for females starting at puberty 5:1, equal rate before puberty
50% do not seek treatment
Most treated in primary care
Often comorbid with ADHD, conduct disorders, anxiety disorders, eating disorders, substance abuse
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Suicide is the 2nd leading cause of death for 15-19 year olds

o For each suicide, approximately 100-200 attempts

o Medical examiners under report 25-50%

o 1 in 5 (19%) high school students consider attempting suicide

Behavioral Warning Signs

Changes in appetite or weight

Changes in behavior

Changes in school performance

Helplessness/Hopelessness

Loss of energy

Loss of interest in activities/withdrawal

Morbid ideation

Substance abuse

Myths of Youth Suicide

Most youth suicides occur unexpectedly without warning signs

Youth who talk about suicide do not attempt or commit suicide

Most youth who try suicide fully intend to die

Educating youth about suicide leads to increased suicide attempts


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Many suicide threats or attempts should not be taken seriously

Youth suicide occurs only among poor individuals

Only a counselor can help a suicidal youth

How can primary providers help prevent suicide?

General screening includes:

o Pt/Fam hx of psychiatric disorders

o Pt/Fam hx of previous suicide attempts

o Hx of substance abuse

o Brief mental status exam

Ask directly about suicidal ideation, physical and sexual abuse

Actively listen to patient

Know your referral options!


o Treatment usually psychotherapy and in moderate to severe depression medication

Anxiety Disorders
Prevalence Social Anxiety Disorder (3-13%), Generalized Anxiety Disorder (3-8&), Panic Disorder
(6%), Obsessive Compulsive Disorder (2-4%), Phobias (2-9%); others with unknown prevalence
include Separation Anxiety Disorder, PTSD, Selective Mutism
Illness of secrecy need to ask about especially in quiet patient
Course - onset frequently in childhood, recover, chronic & untreated anxiety in childhood increases
adult risk 2-3X, leads to depression and alcoholism in adulthood
Differential diagnosis endocrine, infectious, neurological, drug/toxim, psychosis, affective,
ADHD/ADD
Often co-morbid with depression, ADHD, other anxiety disorders
SSRIs best studied, TCAs and BZ also used
CBT works
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Clinical practice guidelines -


http://www.aacap.org/cs/root/member_information/practice_information/practice_parameters/practice
_parameters
Resources www.childanxiety.net/, www.adaa.org/, www.aacap.org/.

Bullying

Physical, verbal, relational, electronic (triad of bully, bullied, bystander)

Autism Spectrum Disorders (ASD)

Optional resources Autism Training Program http://www.cdc.gov/ncbddd/actearly/act/class.html


Epidemiology Prevalence is 1 in 110 in U.S. (CDC, 2009), M>F 4-5:1, 10-25% with
identified etiology
Developmental screening at 9, 18 & 30 months important early warning signs!
ASD includes Autistic Disorder (AD), Rett Disorder, Childhood Disintegrative Disorder,
Aspergers Disorder, Pervasive Developmental Disorder Not Otherwise Specified (PDD-
NOS)
ASD Core Deficits (deviant relative to developmental level)
o Socialization giving, showing, social smiles, gestures, eye contact
o Communication absent spoken language and/or imaginative play
o Repetitive/stereotypic behavior rigidity, routines, perseverations
Sensory integration dysfunction (visual, auditory, tactile, gustatory, olfactory)
Average age of diagnosis > 3 years for AD, > 4 years with PDD, > 5 years for Aspergers
disorder

Medical evaluation should include dysmorphology exam, TSH, lead level, CMP (AA,
hypoglycemia), EEG, MRI

Clinical evaluations and therapy (if indicated) should include hearing, speech/language,
occupational, sensory, psychological

Earlier behavioral intervention beneficial with low risk of harm

o Address specific difficulties such as speech with best evidence therapy


Pharmacology may be useful in management of selected symptoms, significant adverse
effects-should be prescribed by providers with high volume of ASDs.
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o Atypical psychotics may be useful with aberrant behaviors (reserve aggression or risk of
self-injury), SEs

o SSRIs no benefit with repetitive behaviors


o Secretin not useful
Disturbed sleep may be due to serotonin (high anxiety, fear and arousal) & dopamine
abnormalities (muscle twitching ), late and low Melatonin release, circadian rhythm
dysynchrony
Educational plan and family support key

Common Sleep Disorders


Significant impact on physical, emotional and educational development

Common sleep disorders by age


Infant confusional arousals, insomnia, sleep-disordered breathing (SDB-sleep apnea
and others).
Preschool sleep terrors, nightmares, sleep enuresis, insomnia, restless legs syndrome
(RLS), periodic limb movement disorder (PLMD), SDB.
Grade school sleep walking, nightmares, sleep enuresis, insomnia, RLS, PLMD, SDB.
Adolescent insomnia, RLS, PLMD, SDB , delayed sleep phase syndrome, narcolepsy.

As part of a well visit screen use BEARS:

Bedtime problems,

Excessive daytime sleepiness,

Awakenings during the night,

Regularity and duration of sleep,

Sleep disordered breathing.

Optional resource PowerPoint presentation on children and sleep.

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