JANUARY 2016 6

Food and Book now: Blood sugar: PLUS: CAM Hero

environment: Nutrigenomics prof the nutrigenomics Dr Kelley Nutrition
nutritional therapy Dr Ahmed El-Sohemy study that should and acupuncture

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and herbal medicine opens CAM Conference revolutionise for IBS Candida
hand in hand series in March nutrition research update

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e: info@targetpublishing.com with IBD is a unique individual, doing Crohns or colitis in their own, unique way.
www.targetpublishing.com But what a terrible indictment of allopathic medicine that a personalised
approach to treatment stimulated by the biggest ever genetic analysis of IBD sufferers is seen as
EDITOR: SIMON MARTIN, BSc (Hons)
e: simon.martin@cam-mag.com a new idea, a breakthrough. Heres the head of the renowned Cedars Sinai hospital in Los Angeles
commenting on the new Lancet study (see report, page 8):
CONTRIBUTING EDITORS: MIKE ASH, BSc
(Hons), DO, ND, F DipION; BEN BROWN, ND; Genetic research of this magnitude of sample size provides critical information about IBD
MIGUEL TORIBIO-MATEAS, MSc, BSc (Hons), that takes us farther down the road to providing personalised diagnosis and care to our patients
NMed PgDip, mBANT
with complex disorders, said Shlomo Melmed, MD, dean of the medical faculty. Individualising
SECTION EDITOR: REBECCA SMITH treatment approaches will help ensure we are getting the most appropriate treatment to the right
CAM STUDENT EDITOR: JUSTIN LUSTY patient at the correct time.
SALES DIRECTOR: RUTH GILMOUR Now why didnt we think of that?
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practitioners incorporated into everyday clinical practicewell, YEARS ago.
SALES EXECUTIVE: FIONA CHRISTODOULIDES
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CAM section editor Rebecca Smith reminds us in this issue (page 44) that cancer-curer Dr
t: 01279 810071 William Kelley introduced metabolic typing without the benefit of genomics in the 1960s. That
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e: lorraine.evans@targetpublishing.com probiotics and supplements we use.
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Stay with us: 2016 is going to be momentous.
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Some material may be speculative and/or not
in agreement with current medical practice.
Information in CAM is provided for professional
education and debate and is not intended to be used

Nutrigenomics prof kicks off our 2016

by non-medically qualified readers as a substitute
for, or basis of, medical treatment. Copyright of
articles remains with individual authors. All rights
reserved. No article may be reproduced in any form,
printed or electronically, without wriiten consent
of the author and publisher. Copying for use in
conference series
education or marketing requires permission of the Prof Ahmed El-Sohemy, PhD, is Canadas
author and publisher and is prohibited without that
permission. Articles may not be scanned for use Research Chair in Nutrigenomics (at the
on personal or commercial websites or CD-ROMs. University of Toronto) and serves on Health Canadas Science Advisory Board.
Published by Target Publishing Limited. Colour
reproduction & printing by The Magazine Printing He is committed to expanding the evidence base for the clinical application of genetics. Among
Company, Enfield, Middx. EN3 7NT www.magprint.
co.uk. 2016 Target Publishing Ltd. Produced on
his more than 100 peer-reviewed publications, he has studied the impact that provision of genetic
environmentally friendly chlorine free paper derived test results has on client compliance and that will be one of his three presentations at out March
from sustained forests. To protect our environment
papers used in this publication are produced by 19 event in collaboration with BANT. (Read more on page 16.)
mills that promote sustainably managed forests and
utilise Elementary Chlorine Free process to produce
fully recyclable material lin accordance with an
Environmental Management System conforming
with BS EN ISO 14001:2004. The Publishers cannot
accept any responsibility for the advertisements in
CAMs contributors Our thanks this month to:
this publication. Sally Duffin, BSc Nutritional founder and director of Integrative A4M Fellow and CAM contributing
Medicine, Nutrition Clinic Supervisor Health Education and PCI Europe: editor Miguel Toribio-Mateas,
and module leader for Clinical Practice www.parasitetesting.co.uk. MSc, BSc (Hons), NMed PgDip,
at Northern College of Acupuncture, In Practice section editor mBANT, chairman of BANT: www.
tutor at Nutrigold Ltd: www. Rebecca Smith, ASK, CMH, miguelmateas.com.
nutritioninyork.co.uk. CHyp, PNLP, SQHP: www. In Practice featured practitioner
Parasite expert Emma Lane, ND, Dip newportcomplementaryhealthclinic. Susse Wedel. MA, Dip CNM: www.
NT, CMTA, C.H.E.K IV, HLC3, PEA, RSA, co.uk. sussed-out.com.

JANUARY 2016 I cam-mag.com 3

 camcontents

in this issue
JANUARY 2016
Features
16 CAM Conferences
Booking opens for 2016
Nutrigenomics prof Dr Ahmed
El-Sohemy signed for March

18
40
Sushi or ice cream?
Parasites that heal: Blood sugar response
depends on your genes
what our old friends New nutrigenomics study from
can do for us the Weizmann Institute: could
it change the way nutrition
Worms can heal! Naturopath Emma Lane looks research is done?
at the research in gut diseases, multiple sclerosis,
allergies, inflammation and auto-immune disease
showing the benefits of parasites that co-evolved 28 CAM Case study
Sharing a client: how nutrition and
with our immune systems. acupuncture combine to help IBS

32 Hunting down Candida

Research update on the fungal
pathogen that thinks its part of us

22 44
Blinded by science: CAM Hero
practising nutrition as if Personalised nutrition in the
evidence mattered 1960s: Dr William Kelley,
metabolic typing and the
CAM contributing editor Miguel Toribio-Mateas, cancer cure that worked
BANT chairman, sets us up for the New Year
with a look at the professional backlash against
evidence-based scientism, and previews the
Regulars
launch of a new Functional Dietetics curriculum.
5 News
Functional Dietitian: BANT
launches bid to personalise
dietetics
Feeling full up? Its your gut

14
microbes, not you
Food and environment: Faecal transplant in a pill: new
probiotic is getting there
nutritional therapy and herbal
medicine hand in hand
10 CPD Dates
Meet naturopath, nutritionist and herbalist Susse
Wedel, whose practice in Ibiza emphasises the
interactions and relationships between us, our 12 New releases
Methylated B complex breaks
food and our environment. new ground
Alkalise if not now, when?

36 Listings

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Follow us on Twitter
@CAMmagUK
Want to be a Functional Dietitian?
BANT consults on a new curriculum
BANT has launched a full public consultation
on its curriculum framework for functional
dietetic practice.
If the process goes as planned, the first
Functional Dietitians could be in practice in the
next three years. And they will be registered
on the dietitians register of the Health and
Care Professions Council, alongside dietitian
members of the British Dietetic Association.
BANT will then seek grandparenting rights
to enable all current BANT/CNHC Registered
Nutritional Therapists to join the HCPC
Register of Dietitians.
The move by the British Association for
Applied Nutrition and Nutritional Therapy,
the UKs professional body for nutritional
therapists, will provide the public with
dietitians who are trained in the functional
medicine model and able to deliver
personalised nutrition.
It comes in response to a growing
dissatisfaction among public and professionals
alike, with the one size fits all approach to
nutrition currently on offer through the NHS,
and to spurious claims by some dietitians that
they are practising personalised nutrition.
BANT chairman Miguel Toribio-Mateas
commented: Why are we doing this?
The general public needs and is asking
for nutritional interventions that are
individualised and that work for them
Nutrigenomics
conference kicks
off our 2016 series
Canada Research Chair in Nutrigenomics Prof Ahmed El-Sohemy of the University of Toronto
leads off this years series of CAM Conferences in collaboration with BANT.
March 19 Individualised nutrition: diet and DNA unlocking the power of nutrigenomics,
conference follows the BANT annual meeting.
April 9 Detox the key to healthy ageing.
May 21 Feeding the gut: health through microbiome modulation.
September 10 Feeding the brain: nutrition for bullet-proof neuroimmunity.
November 5 Nutrition resolution: breaking the cycle of stress and chronic inflammation.
More conference details: page 16.
camnews
as unique people. They need the type of
interventions that a functional medicine model
can deliver.
Miguel expands on the news in his CAM
opinion piece on page 22. The idea is that,
following the three-month consultation
period, existing nutrition education providers
will develop education and training courses
to meet the HCPC entry level standards for
dietetics. Courses will be approved by the
HCPC.
Not sustainable
Says BANT: As the practice of dietetics
has widened outside of the NHS, so have
the professional and other organisations
involved in delivering nutrition and health care
proliferated. The British Dietetic Association
(BDA), trade union and professional
association, represents the dietetic
community working primarily in the NHS.
Professional registration has historically been
linked to the professions supplementary to
medicine working in the public sector. Current
evidence on the individualised requirements
of, and response to, diet now render the NHS
one-size-fits-all approach as outdated and not
sustainable. Up-to-date dietetic practice in the
post-genome era demands a new approach in
the delivery of care to all service users.
BANT is supported, it says, by two years of
legal investigation which have revealed that
many of the rules in place to protect the
practice of dietetics, are in fact myths:
A six-month placement in the NHS is NOT a
requirement to become a dietitian
HCPC registration does not require a
university degree
You do NOT need to be a member of the BDA
to practise as a dietitian.
As Miguel points out: Dietetics is not a
protected title; only dietitian is. The HCPC has
told us that there can be several professional
associations in one register, as is the case for
the podiatry and chiropody register, where
four professional associations happily coexist.
FAQ document from BANT is online at: http://bant.
org.uk/wp-content/uploads/2015/11/FUNCTIONAL_
DIETETICS_CURRICULUM_FRAMEWORK_FAQ.pdf.
Half of UK GPs ready
to resign
Almost half of GPs support mass resignation
from the NHS in protest at the current state of
general practice, a Pulse survey has revealed.
The survey of 922 GPs found that 49% are
willing to resign their NHS contracts to highlight
issues such as chronic underfunding, relentless
bureaucracy and the misrepresentation of
doctors, reports the GPs magazine.
GPs have been rapped over the knuckles
for their antibiotic prescribing, mental health
treatment and cancer diagnosis rates and
rewarded with pay cuts, a myriad of payment
problems and the brutal hand of the CQC,
commented Pulse editor Nigel Praities.
CQC is the UKs health care regulator the Care
Quality Commission, which conducts what have
come to be dreaded inspections of GP practices.
JANUARY 2016 I cam-mag.com 5
 camnews

Feeling full up? Its your gut microbes, not you

Dont want dessert? Dont get too proud of
yourself, the bacteria in your gut may be telling
you something. 20 minutes after a meal, gut
microbes produce proteins that can suppress
food intake in animals, reports a French study
published in Cell Metabolism (doi: 10.1016/j.
cmet.2015.10.017).
The researchers also show how these
proteins injected into mice and rats act on the
brain to reduce appetite, suggesting that gut
bacteria may help control when and how much
we eat.
The new evidence complements current
models of appetite control, which involve
hormones from the gut signalling to brain
circuits when were hungry or done eating. For
the first time, researchers found that bacterial
proteins produced by commensal E. coli after
theyve been satiated influenced the release
of gut-brain signals such as GLP-1 and PYY, as
Neurons (green) in the rat central amygdala activated
by E. coli proteins, surrounded by red nerve terminals.
(Picture: J. Breton, N. Lucas and D. Schapman.)
well as activate appetite-regulated neurons in
the brain.
There are so many studies now that
look at microbiota composition in different
pathological conditions, but they do not
explore the mechanisms behind these
associations, says senior study author Sergue
Fetissov of Rouen University and the nutrition,
gut and brain laboratory at INSERM, Frances
national research centre. Our study shows
that bacterial proteins from E. coli can be
involved in the same molecular pathways
that are used by the body to signal satiety,
and now we need to know how an altered gut
microbiome can affect this physiology.
Mealtime from the microbiomes
point of view
Mealtime brings an influx of nutrients to the
bacteria in the gut. In response, they divide
and replace any members lost in stools. The
study raises an interesting theory: since gut
microbes depend on us for a place to live, it is
to their advantage for populations to remain
stable. So it would make sense if they had a
way to communicate to the host when they
need more nutrients, promoting the host to
find food again.
Fetissov and colleagues found that after
20 minutes of consuming nutrients and
expanding numbers, E. coli bacteria from the
gut produce different kinds of proteins than
they did before their feeding. The 20-minute
mark seemed to coincide with the amount
of time it takes for a person to begin feeling
full or tired after a meal. Excited over this
discovery, the researcher began to profile the
bacterial proteins pre- and post-feeding.
Injections
They saw that injection of small doses of the
bacterial proteins produced after feeding
reduced food intake in both hungry and free-
fed rats and mice. Further analysis revealed
that full bacterial proteins stimulated the
release of peptide YY, a hormone associated
with satiety, while hungry bacterial
hormones did not. The opposite was true for
glucagon-like peptide-1 (GLP-1), a hormone
known to simulate insulin release.
The investigators next developed an assay
that could detect the presence of one of the
full bacterial proteins, called ClpB, in animal
blood. Although blood levels of the protein in
mice and rats detected 20 minutes after meal
consumption did not change, it correlated with
ClpB DNA production in the gut, suggesting
that it may link gut bacterial composition with
the host control of appetite. The researchers
also found that ClpB increased firing of
neurons that reduce appetite. The role of other
E.coli proteins in hunger and satiation, as well
as how proteins from other species of bacteria
may contribute, is still unknown.
We now think bacteria physiologically
participate in appetite regulation immediately
after nutrient provision by multiplying and
stimulating the release of satiety hormones
from the gut, Fetisov says. In addition, we
believe gut microbiota produce proteins that
can be present in the blood longer term and
modulate pathways in the brain.

Plus size oops: ads encourage women to eat more

Adverts featuring larger-size women
may be encouraging women to eat
more, according to US researchers.
In five studies, two marketing
professors found that cues
suggesting the acceptance of larger
body types resulted in greater
intended or actual consumption of
food and a reduced motivation to
engage in a healthier lifestyle.
They report their findings in
The (Ironic) Dove Effect: Usage
of Acceptance Cues for Larger
Body Types Increases Unhealthy
Behaviours (J Public Policy &
Marketing, doi: http://dx.doi.
org/10.1509/jppm.14.020).
Average weight is increasing in
the UK and US and advertisers also
encouraged by a backlash against
Victorias Secret stereotypes of the
perfect body have upped the use
of larger models in their campaigns.
Many of these ads claim that their
larger models possess realistic
body types, and many groups have
lauded these moves as beneficial
to promoting a healthy body
image in society. Thats not the end
result, say Lily Lin at Cal State and
Brent McFerran at Simon Fraser Ads featuring plus- or normal-size women in the famous Dove campaign may be
encouraging unhealthy diet and lifestyle habits, say researchers.
University, BC.
Being larger-bodied appears images are actually making it motivation to engage in healthy
to be contagious, thanks to more socially permissible to behaviours and [they] consume
the Dove Effect of the ads. The be overweight. Studies show greater portions of unhealthy food,
authors say that the realistic that Individuals exhibit lower they say.

6 cam-mag.com I JANUARY 2016


Obesity biggest
threat to UK
women
Englands chief medical officer has
said that obesity is the biggest threat to
womens health and the health of future
generations.
Dame Sally Davies said that we should
make tackling obesity a national priority to
avert a growing health catastrophe.
Presenting her annual report, she
was backed by statistics showing that In
England in 2013, 56.4% of women aged
34-44 and 62% of women aged 45-54 were
classified as overweight or obese.
She warned that if the food industry
did not do more, it should face a sugar tax.
She told the BBC: I think it is inevitable
that manufacturing has to reformulate
and resize, that supermarkets and
others need to stop cheap promotions
on unhealthy food and putting unhealthy
food at the check-out, and limit advertising
dramatically.
I think were at a tipping point. If
industry wont deliver, then well have to
look at a sugar tax.
Autism: brains
blood supply
is weak, say
researchers
Evidence of autism may be found in the
composition and malfunction of the brains
blood vessels, a team of scientists at New
York University has found.
Their research sheds new light on the
causes of autism, focusing attention away
from neurological factors and instead on the
vascular system.
Our findings show that those afflicted
with autism have unstable blood vessels,
disrupting proper delivery of blood to the
brain, explains Prof Efrain Azmitia.
In a typical brain, blood vessels are
stable, thereby ensuring a stable distribution
of blood, he says. Whereas in the autism
brain, the cellular structure of blood vessels
continually fluctuates, which results in
circulation that is fluctuating and, ultimately,
neurologically limiting.
The study appears in the Journal of Autism
and Developmental Disorders (doi: 10.1007/
s10803-015-2672-6).
Fathers diet may alter childrens
appetite
Its not all maternal diet; at last dad is
getting a look-in. University of Copenhagen
scientists have made two startling
discoveries by uncovering a previously
unknown epigenetic mechanism in human
sperm cells.
One year after gastric-
bypass surgery,
researchers observed
an average of 4,000
structural changes to
sperm cell DNA
Researchers in Prof Romain Barrs
laboratory compared sperm cells from 13
lean men and ten obese men and discovered
that the sperm cells in lean and obese men,
respectively, possess different epigenetic
marks that could alter the next generations
appetite. (Cell Metabolism 2016 (in press),
doi: 10.1016/j.cmet.2015.11.004.)
A second major discovery was made as
researchers followed six men before and
one year after gastric-bypass surgery (as a
weight-loss intervention) to find out how the
surgery affected the epigenetic information
contained in their sperm cells. The
researchers observed an average of 4,000
structural changes to sperm cell DNA from
the time before the surgery, directly after,
and one year later.
We certainly need to further examine
the meaning of these differences; yet,
this is early evidence that sperm carries
information about a mans weight. And our
results imply that weight loss in fathers may
influence the eating behaviour of their future
children, says Barrs.
Epigenetic inspiration
Epidemiological observations revealed
that acute nutritional stress, for example
famine, in one generation can increase
the risk of developing diabetes in the
following generations, Barrs states. He
also referenced a study that showed that the
availability of food in a small Swedish village
during a time of famine correlated with
the risk of their grandchildren developing
cardiometabolic diseases.
The grandchildrens health was likely
influenced by their ancestors gametes
(sperm or egg), which carried specific
epigenetic marks chemical additions to
the protein that encloses the DNA, methyl
groups that change the structure of the DNA
once it is attached, or molecules also known
as small RNAs. Epigenetic marks can control
the expression of genes, which has also been
shown to affect the health of offspring in
insects and rodents.
Molecular carrier
In our study, we have identified the molecular
carrier in human gametes that may be
responsible for this effect, says Barrs.
By detecting differences in small RNA
expressions (where the function is not yet
determined) and DNA methylation patterns,
the researchers have proven that weight loss
can change the epigenetic information men
carry in their spermatozoa. In other words,
what is transmitted in the fathers sperm can
potentially affect the development of a future
embryo and, ultimately, it can shape the
childs physiology.
We did not expect to see such important
changes in epigenetic information due
to environmental pressure, says Barrs.
Discovering that lifestyle and environmental
factors, such as a persons nutritional state,
can shape the information in our gametes
and thereby modify the eating behaviour
of the next generation is, to my mind, an
important find, he adds.
Obesity
If we consider it in an obesity context, a
worldwide heritable metabolic disorder
which is sensitive to environmental
conditions (diet and physical activity), the
discovery that weight loss in fathers-to-be
potentially affects the eating behaviour of
their offspring is ground-breaking, he says.
Today, we know that children born to
obese fathers are predisposed to developing
obesity later in life, regardless of their
mothers weight. Its another critical piece
of information that informs us about the
very real need to look at the pre-conception
health of fathers says Ida Donkin, MD, one
of the lead authors., And its a message we
need to disseminate in society.
Disruption
The study disrupts the current assumption
that the only thing our gametes carry is
genetic information, and there is nothing we
can do about it.
Traits that we once thought were
inevitable could prove modifiable, and what
men do in life has implications not only for
their own health but also the health of their
children and even grandchildren.
JANUARY 2016 I cam-mag.com 7
 camnews
IBD an array of disorders with key genetic variations
Genetic variation in patients with
inflammatory bowel disease (IBD) appears
to play a major role in determining how sick
they will become and how they respond to
treatment.
The findings of an international study of
35,000 patients with the two most common
forms of the illness, Crohns disease and
ulcerative colitis, appears in The Lancet
(doi: 10.1016/S0140-6736(15)00465-1).
Investigators compared the clinical records
of IBD patients with data collected from
analysing their DNA in what is considered the
largest study of its kind.
The genetic information provided new
insights into the progression of IBD and
the rate at which the disease develops.
Researchers said the findings showed
that IBD actually may be an array of bowel
disorders.
This new research strongly suggests that
we are dealing a number of different diseases
hidden within Crohns disease and ulcerative
Vitamin D receptor
the key to myelin
regeneration
Multiple sclerosis patients continually lose the
insulating myelin sheath that wraps around
neurons and increases the speed of impulses
in the central nervous system. Whenever
neurons are demyelinated, OPCs migrate
toward these cells and differentiate into
mature, myelin-producing oligodendrocytes,
but this process becomes less and less effective
as people age. Vitamin D may hold the key to
prevention and treatment.
A nuclear receptor protein called
retinoid X receptor gamma (RXRgamma) is
known to promote OPC differentiation and
remyelination, but, because nuclear
receptors generally function in pairs, a
team of researchers, led by Dr Robin
Franklin at the University of Cambridge,
set out to identify RXRgammas binding
partners and investigate their possible role in
remyelination.
RXR bound to several nuclear receptors,
including VDR, in OPCs and mature
oligodendrocytes. Inhibiting VDR impaired
OPC differentiation and reduced the cells
ability to remyelinate axons ex vivo. In
contrast, Vitamin D, which binds and activates
VDR, boosted OPC differentiation.
Low vitamin D levels have been linked
to the onset of multiple sclerosis, and the
researchers findings suggest that the vitamin
8 cam-mag.com I JANUARY 2016
colitis, constituting a large spectrum of
inflammatory bowel disease, said Dermot
McGovern, MD, PhD, MRCP(UK), director of
Translational Medicine at Cedars-Sinai.
IBD is caused when the bodys immune
system attacks the gastrointestinal tract,
causing chronic and damaging inflammation.
The NHS estimates that IBD affects about
one person in every 250 in the UK. There are
around 146,000 people with ulcerative colitis
and 115,000 with Crohns disease in the UK.
IBD is usually diagnosed in people in their late
teens or early 20s, but can affect people of any
age, says the NHS.
Genetic analysis
Researchers found that genetic analysis could
potentially identify which patients might
benefit from earlier intervention with more
aggressive therapy.
We have very effective therapies for
IBD if we use them sooner in the disease,
especially for those patients who are at risk
In a control brain slice (left), most axons (red) have
regained a myelin sheath (green) eight days after
demyelination. But regeneration is impaired when VDR
is inhibited (right). (Pictures: De la Fuente et al, 2015.)
might also affect disease progression by
controlling myelin sheath regeneration,
a critical step to alleviate the diseases
symptoms that fails as patients age. (J Cell
Biology, doi: 10.1083/jcb.201505119.)
More than one in five people in the UK have
low levels of vitamin D, according to Public
Health England. In August last year, SACN
(the UKs independent scientific advisory
committee on nutrition) recommended in a
draft report to be confirmed this year that
everyone in Britain should boost their vitamin
D intake with supplements.
and SNPs may
determine vitamin D
levels
Certain genetic variations increase the risk of
having a lower level of vitamin D.
This finding from a PhD project from the
National Food Institute, Technical University
of Denmark, correlates with University of
Toronto work on vitamin C (by Prof Ahmed
for developing a serious form of illness, said
McGovern. We want to understand what
the important, singular, genetic signature is
for each individual patient because they may
respond to available therapies very differently,
even with the same IBD diagnosis.
Individualising treatment
Genetic research of this magnitude of sample
size provides critical information about
IBD that takes us farther down the road to
providing personalized diagnosis and care
to our patients with complex disorders, said
Shlomo Melmed, MD, executive vice president
of Academic Affairs and dean of the medical
faculty. Individualizing treatment approaches
will help ensure we are getting the most
appropriate treatment to the right patient at
the correct time.
McGovern pointed out that that genes
associated with IBD also are connected
to other autoimmune diseases, including
spondylitis and psoriasis.
El-Sohemy, who talks at the CAM Conference
in March).
Janna Nissen compared the effect of eating
vitamin D-fortified foods or receiving artificial
UVB irradiation during the winter months. The
fortified diet and artificial sunlight had less of
an effect on vitamin D status in people with
certain genetic variations. The results can be
used to identify people who are genetically
predisposed to having lower levels of vitamin
D, she says.
While vitamin D is essential to bone health,
studies have also linked adequate levels of
vitamin D with a lower risk of cardiovascular,
inflammatory and autoimmune diseases,
certain cancers and death and multiple
sclerosis. A University of Georgia researcher
has also found that low levels of vitamin D
may limit the effectiveness of HIV treatment
(Clinical Nutrition 2015, doi: 10.1016/j.
clnu.2015.08.007).
Two genes involved
The two genes CYP2R1 and GC influence the
level of vitamin D in a persons blood.
The results show that carriers of all
the genetic risk variants have the lowest
vitamin D levels in late summer, the largest
drop in vitamin D levels after eating
fortified bread and milk during winter, and
the smallest increase after artificial UVB
irradiation compared to carriers of fewer
or no genetic risk variants, Nissen
explains.
Source: Technical University of Denmark (DTU).
Faecal transplant in a pill? New spore probiotic designated
Breakthrough Therapy by FDA
A new generation drug for the potential
prevention of recurrent Clostridium difficile
infection is in a Phase 2 clinical trial and
has won the FDAs Breakthrough Therapy
designation reserved for a drug intended to
treat a serious or life-threatening disease
with preliminary clinical evidence that it
is a substantial improvement over existing
therapies.
Remarkably, the SER-109 pills from Seres
Therapeutics contain bacterial spores taken
from healthy donors. These spores may help
to bring back healthy bacteria into the gut,
say Seres of this ECOSPORTM trial. The study
doctors think that a healthier gut may help
prevent recurrent CDI, which is mostly caused
by antibiotic treatment.
Seres has now also launched a trial of the
first microbiome drug for ulcerative colitis.
CAM contributor Patty Carter of http://
biomeonboardawareness.com reports:
Finally, an IBD microbiome drug goes to
clinical trial.
Seres Therapeutics began its Phase 1b
placebo-controlled clinical trial on Dec 14
for SER-287, which is the first drug aimed at
the microbiome for a non-infectious, chronic
condition, ulcerative colitis (UC).
This is the first IBD microbiome drug
that actually targets the constituents of the
microbiome. This approach treats chronic
disease without suppressing the bodys
Flavonoid apigenin stimulates stem cells: has potential to treat
schizophrenia, depression, Alzheimers and Parkinsons
Apigenin, a substance found in parsley, thyme,
chamomile and red pepper, improves neuron
formation and strengthens the connections
between brain cells.
Previous experiments with animals had
already shown that substances from the
same chemical group as the apigenin, known
as flavonoids, positively affect memory and
learning. Many studies highlight the potential
of flavonoids to preserve and enhance brain
function. While the effectiveness of flavonoids
for brain health is not an entirely new concept,
this research is the first to show the positive
effects of apigegin directly on human cells and
the first to unraveling its mechanism.
Brazilian researchers from DOr Institute
for Research and Education (IDOR), Federal
University of Rio de Janeiro (UFRJ) and Federal
University of Bahia (UFBA) have demonstrated
that just by applying apigenin to human stem
cells in a dish they become neurons after 25
days an effect they would not see without
the substance. Moreover, the neurons that
Seres Therapeutics rationale: Breaking Unhealthy Microbial Networks By Establishing Healthy Microbiome
Communities.
immune response. Instead, specific strains of
bacteria are introduced that re-balance the
billions of different types of bacteria that are
in the digestive tract, which then increases
immunity and manages the disease. Instead
of being immunosuppressive, this treatment
targets the root cause of UC which is gut
dysbiosis.
Seres have other microbiome drugs in the
pipeline.
In addition to our CDI product candidates,
we are developing Ecobiotic drugs to treat
inflammatory bowel disease, including
ulcerative colitis, and various enteric
The neurons treated with apigenin (right) show more
formation of synapses (red) than the neurons that were
not treated. (Picture: Rehen et al.)
were formed made stronger and sophisticated
connections among themselves after being
treated with this natural compound.
Strong connections between neurons
are crucial for good brain function,
memory consolidation and learning, says
neuroscientist from IDOR and UFRJ Stevens
Rehen, leader author of the paper published
in Advances in Regenerative Biology (doi:
10.3402/arb.v2.29244).
pathogens, such as antibiotic-resistant
bacteria. We are also researching the use
of Ecobiotic drugs for the treatment of
metabolic diseases, such as non-insulin
dependent type 2 diabetes, other
inflammatory diseases, such as Crohns
disease, and infections related to antibiotic
use, cancer chemotherapy, and immune
suppression.
Ecobiotic drugs, they say, Are
combinations of selected microbes that may
catalyse a shift of the microbiome from a state
that supports disease to a state that supports
health.
Apigenin works by binding to oestrogen
receptors, which affect the development,
maturation, function, and plasticity of the
nervous system. This group of hormones
is known to delay the onset of psychiatric
and neurodegenerative disorders such as
schizophrenia, depression, Alzheimers
and Parkinsons disease. However, the use
of oestrogen-based therapies is limited by
the increased risk of oestrogen-dependent
tumours and cardiovascular problems.
Researchers believe apigenin can be used as
an alternative approach on future treatments
for neurodegenerative diseases as well as
in neuronal differentiation strategies in
laboratory.
We show a new path for new studies with
this substance, points out Rehen. Moreover,
flavonoids are present at high amounts in
some foods and we can speculate that a diet
rich in flavonoids may influence the formation
of neurons and the way they communicate
within the brain.
JANUARY 2016 I cam-mag.com 9
 camdates
Gut, thyroid, microbiome:
research into practice
Invivo Clinical is co-
sponsoring a re(FIND)
Health event on January 17
with Dr Michael Ruscio, DC,
(pictured) in London.
Thanks to the recent
explosion in microbiota
research, we are learning
that the gut has an immense
impact on every system of
the body. Understanding the
causes of gut dysfunction
and microbial imbalance is
crucial for optimum patient
outcomes. After healing
the gut, many conditions
improve, including
hypothyroid, arthritis,
pain, fatigue, weight gain,
insomnia and IBS.
But with the explosion
in research also comes
a misapplication of the
findings in clinical practice.
Which studies are relevant
for patient care, which need
further exploration, and
which are simply not useful
in creating an effective
treatment model?
Dr Ruscio will present his
recommendations on these
two topics:
Gut
The three most common
causes of GI dysfunction, and
their roots.
Ordering the right tests
and making the right
diagnosis while still being
cost-effective
Cutting-edge treatment
options straight from the
research.
Putting it all together
a clinical algorithm for
successful treatment.
Thyroid
The three types of thyroid
problems seen in patients,
and how to differentiate
between them.
When and how to treat
each type of thyroid issue.
The role of iodine in
thyroid treatment a
definitive guide based on
incontrovertible science.
Chiropractor and
functional medicine
practitioner Michael
Ruscio is a doctor, clinical
researcher, author and health
enthusiast. He is currently
performing two clinical trials
in the treatment of digestive
conditions.
Early Registration: 89, then 99
after the first 50 tickets are sold.
Full details and online booking:
https://re-findhealth.com/
michael-ruscio.
Naturopathic Nutrition Association
changes for 2016, puts CFS in the
spotlight for May conference
The Naturopathic Nutrition
Association (NNA) is gearing up
for 2016 with a new website, a
conference on chronic fatigue and new
membership benefits.
The organisation was founded in
2010 to meet the growing needs of
nutritional therapists who have a
naturopathic slant to practice, and
enables NTs to also register as NDs.
The NNA is a member of the General
Naturopathic Council (GNC) and
via the NNA many members join
(at no additional charge) the GNC
as an Associate Naturopath, adding
a further title and credentials to
their practice. On a voluntary basis,
members can also apply to either or
both the naturopathy or nutritional
therapy CNHC registers.
With membership continuing to
grow, there has been intense focus
by the management committee to
provide members with exactly what
they want from their professional
association. Caroline Peyton, Chair of
the NNA, says: Putting our members
first and the safety of the public have
always been our priorities. We listen
carefully to what members want and
we do not believe in moving away
from our naturopathic nutrition
principles. We believe it is this
approach that is drawing members to
us year-on-year and the message is
clearly spreading.
The NNA is launching a
new website this year, with a
comprehensive members area that
will include including recording CPD,
membership renewals, discussion
forum, and a document repository
for locating forms such as templates,
newsletters and seminar reviews.
member benefits. A fully searchable
Find a Practitioner page will be
available to help the public locate
members.
A recent new addition to
member benefits is access to the
Natural Medicines Comprehensive
Database considered to be the
most authoritative resource available
on dietary supplements, natural
medicines and interactions. Other
membership benefits include
discounts with CAM (24%), reduced
rate insurance and reduced price
seminars with respected companies.
One of our success stories has
been our mentoring scheme for
newly qualified or soon-to-graduate
practitioners, says Caroline. Now in
its fourth year and run by the popular
Cora Weekes, we offer this as a free
resource for the first session with a
small token payment for subsequent
sessions. A scheduled programme of
topics covered is detailed on the NNA
website, with excellent testimonials
from past mentees.
Light at the end of the
tunnel
After the success of the NNAs sell-out
full-day conference last summer, there
will be a larger conference, continuing
the naturopathic nutrition theme, to
be held on 7 May 7 in Central London,
with the theme Light at the end of the
Tunnel Naturopathic Techniques for
Chronic Fatigue.
www.nna-uk.com, or contact info@nna-uk.
com or call 01908 616543.

Detoxification and cellular renewal: plus cooking!

The unique combination of nutritional
therapist and chef Christine Bailey and CAM
Award-winning nutritional therapy educator
Antony Haynes delivers a timely one-day
workshop on January 17.
The Cookery Day aims to enable
you to discover the key foods and
nutrients to incorporate in your diet to
enhance your detoxification pathways,
how to remove toxins safely, signs and
symptoms of toxic overload, consequences
and links to long term chronic health
conditions and the importance of
supporting gut barrier health.
The day will include practical recipes
and meal planning solutions to help you
plan a cleansing programme with clients,
together with details of the most effective
supplements and nutrients to incorporate.
Christine has special
expertise in allergy free and
gluten-free cooking and was
awarded Coeliac Chef of the
Year 2008, as well as being
author of numerous recipe and health
books including the forthcoming Functional
Nutrition Cookbook (co-authored with
Lorraine Nicolle).
Antony Haynes is one of the
UKs most experienced NTs and
has evolved a successful general
practice using the functional
medicine principles and
practices to great effect. He brings real-life
examples to his presentations, explaining
how he arrives at clinical decisions.
* January 17, 10am-4pm; 96. The Avenue Cookery
School, Mission Hall, Walkers Place, London,
SW15. Booking: www.clinicaleducation.org/event/
detoxification-cellular-renewal.

10 cam-mag.com I JANUARY 2016

 camnew releases

Methylated B complex breaks new ground

A new methylated Super B-Complex from
Igennus breaks new ground with its unusual
combination of ingredients.
The new supplement includes
P5P methylcobalamin and [6S]-5-
methyltetrahydrofolate supplied as the patented
Quatrefolic, as well as other forms of nutrients
chosen for highest bioavailability.
[6S]-5-methyltetrahydrofolate is the reduced
and methylated form of folic acid (folate) and the
metabolically active methyl group donor required
for the conversion of homocysteine to methionine.
When presented with folic acid, the synthetic
form of folate used in some supplements,
the body has to reduce it enzymatically by
methylenetetrahydrofolate reductase (MTHFR)
for it to become biologically active. A SNP or
genetic mutation of MTHFR, means cells are
unable to convert folic acid to 6(S)-5-MTHF.
Supplementing with the downstream, active form
may be important for people with MTHFR SNPs. In
addition, and importantly, 6(S)-5-MTHF is also the
form which is transported across membranes into
peripheral tissues, particularly across the blood-
brain barrier.
Igennus have chosen dosages in line with
scientific evidence of amounts needed to
maintain healthy homocysteine levels. Elevated
homocysteine is a risk factor for heart disease
and disrupts neurotransmitter function,
affecting brain function and mood balance.
Key features:
Vitamin B complex tablets contain the most
active forms of ingredients formulated to
deliver maximum levels of key nutrients.
Quatrefolic provides the body-ready form of
folate, as [6S]-5-methyltetrahydrofolate (most
standard supplements contain folic acid).
The active form of riboflavin, riboflavin-5-
phosphate.
Vitamin B6 as pyridoxal-5-phosphate with
cofactor activity.
Vitamin B12 as methylcobalamin, for
enhanced uptake.
Offers support for a wide range of concerns:
heart health, nervous system support and
psychological and neurological function.
Supports energy levels and contributes to the
reduction of tiredness and fatigue.
Small, easy-to-swallow tablets.
RRP: 11.99 for 60 tablets, providing a one-month
supply at a daily dosage of two tablets.

If theres ever a time of year to

alkalise
Alkala is a little-known alkaliser
that has been a best-seller in
Germany and around the world
for more than 30 years, but
deserves more attention from UK
practitioners.
It is the original Sanum-
Kehlbeck product for alkalising
for health, developed as an
integral part of the Sanum therapy
system currently in use by more
than 30,000 doctors, dentists,
veterinary surgeons and natural
health practitioners in Germany.
Sanums range includes the
fungal isopathic remedies based
on the pioneering work of Prof Dr
Gnther Enderlein.
In a 2010 paper in the British
Journal of Nutrition (doi:10.1017/
S0007114509993047),
naturopathic physician Joe
Pizzorno, ND, and colleagues
asked the question, Diet-induced
acidosis: is it real and clinically
relevant?
Their conclusion: yes, it is not
just a weird natural health fad.
They explained: The lack of
consensus for both qualitative
and quantitative aspects of acid
base chemistry in physiological
systems as well as measurement
has caused considerable
confusion for both researchers
and clinicians. This confusion
has also complicated the search
for cause and effect and made
clinical application difficult and
controversial.
Nonetheless, the available
research makes a compelling
case that diet-induced acidosis Alkala contains very pure spoon, 48 pH test papers and a
is a real phenomenon, has sodium bicarbonate, potassium colour chart to monitor urine pH.
significant clinical relevance, may bicarbonate and sodium citrate Alkala N Powder 150g 9.40;
largely be prevented through to help buffer acids and maintain additional booklet of 48 pH indicator
test papers 4.50. Available exclusively
dietary changes, and should be a healthy pH balance. Each box to practitioners only from Helios: www.
recognised and treated. of Alkala contains a measuring helios.co.uk.

12 cam-mag.com I JANUARY 2016

 inpractice
Food and environment:
nutritional therapy
and herbal medicine
hand in hand
How long did it take for you to
qualify?
I started out studying alongside
my full-time job in IT. After two
years, I left my job to concentrate
on studying nutritional therapy
and herbal medicine full-time. All
in all it took three years.
I continue to study and learn
each year. In the last few years
I have branched out within the
field of herbal medicine. I have
enjoyed wonderful courses,
including distilling Aromatic
Waters in Wales, making essential
oils in France, and learning the
application of Gemmotherapy.
Where do you practise?
I currently practise in both
London and Ibiza, although I
started my practice from several
multidisciplinary CAM centres in
central and east London, one of
which I still enjoy practising from
today. In London, my approach
is more functional medicine
based, but in Ibiza I integrate
the energetic aspects of plant
medicines into my practice more,
as I have access to grow and
harvest plants and make herbal
remedies.
Whats your main therapy/
modality and why?
I guess it would be naturopathy.
I love the freedom of using
different tools from my CAM box.
I like to use nutritional
therapy and herbal medicine
14 cam-mag.com I JANUARY 2016
I was always interested
in natural medicine and had
tried various short courses in
aromatherapy and massage over
the years, but it wasnt until I
came across a few naturopathic
medicine articles online
that I decided to enroll on a
naturopathic course.
How long have you been in
practice?
Since 2008/2009.
Who or what has been the
main influence/inspiration on
your practice?
Ive drawn inspiration from
numerous sources along the way
Name: Susse Wedel. and still do. Many of my course
Website: www.sussed-out.com. tutors were greatly enthusiastic
QualificatioNs: MA, Diplomas in Naturopathy, Nutritional and motivational, and I went on
Therapy, Herbal Medicine, Iridology, Behavioural Iridology, to do additional studying with
Colonic Hydrotherapy, First Line Therapy (FLT). some of them.
traiNiNg: College of Naturopathic Mecidine London for Ive always been fascinated by
naturopathy, herbal medicine, nutritional therapy and the water cure clinics of Central
iridology. Further training includes colonic hydrotherapy, Europe in the mid to late 1800s.
behavioural iridology and Ayurvedic medicine. The works of Dr Edward Bach, Dr
Bernard Jensen, Alfred Vogel and
Dr John Christopher have also
hand in hand. This I tend to do between us, our food and our guided my work.
by encouraging clients to enjoy environment, the level of impact
the therapeutic benefits of and sustainability. What conditions or types of
culinary herbs in their diet and as client do you see most?
herbal teas, and external herbal Why did you decide to become Coming from a banking
remedies. Where possible using a practitioner? environment and having my
herbs already in their gardens or After a ten-year career of practice based in the City gave me
growing on their kitchen sills. banking/IT in London, I began to a great insight into what stress
Ive noticed a strong movement feel increasingly unfulfilled and can do to the body and mind. So I
towards food as medicine in less connected to the industry and found myself working with cases
Ibiza; the interaction/relationship wanted to explore other options. of adrenal fatigue quite a bit,
especially for the first few years
of practice. Alongside dietary
changes, introducing stress
management techniques and
lifestyle changes often proved to
be the key in many cases.
In general though, I see a
wide variety of health concerns.
I have noticed a lot more cases
of auto-immune conditions,
especially in the last few years in
London. Ive gravitated over the
last three years to having more
of a particular interest in skin
conditions and environmental
health concerns and do quite a
bit of functional medicine testing
as a result.
What do you find the easiest
to treat? And why?
Clients who are willing to
learn how to improve their
health. Those who want to take
responsibility for their health
and are committed to take
the time to make the relevant
changes in their diet, lifestyles
and attitudes for the better, even
if it seems difficult at first.
What is your favourite type of
client?
Clients who challenge me!
Those who wish to learn about
preventative medicine.
Clients who want to
understand the root cause of
their ill-health and actively
develop long-term health
solutions.
What is the most challenging
type of symptoms/illness/
problem that you get
presented with?
There are times when clients are
sceptical about the usefulness of
CAM therapies when they come
to see you. Whether its due to a
previous bad experience, lack of
knowledge or media influence,
its up to you the practitioner to
The CAM Awards are hugely successful, but were aware they only reward and recognise a handful of practitioners and clinics each year. Meanwhile, we know that
CAM practitioners are quietly getting on with changing peoples lives, every day and we want to celebrate and share the inspiration. So weve re-vamped our
popular In Practice series. It is coordinated by regular CAM contributor Rebecca Smith, who runs a successful practice of her own, established 20 years ago. Contact
her direct to be part of the feature: rebecca@newportcomplementaryhealthclinic.co.uk, and follow her on Twitter: @NCHealthClinic.
educate and enlighten them.
No matter what the challenge
is, there are always steps that
can be taken to support a clients
health.
Im always reminded of the
onion strategy, especially for
more complicated cases: start
dealing with a layer at a time,
tackling the outside layers first.
What one thing is absolutely
essential to you in your
practice?
Really listen to your client and
understand their needs. Be
practical, realistic and positive.
And my iridology torch!
Do you enhance your business
with any projects outside of
your clinic?
As part of my practice I make
herbal medicines, including
tinctures, creams, essential oils
and aromatic waters. This takes
up quite a bit of my time, but is
also a passion.
Outside my practice, I have
started to make a range of
organic skincare, mostly for
family and friends, but hope to
expand it to the public at some
point over the next year or so.
I do contribute to articles for
magazines/websites when I get
the chance.
My partner is a POSE running
coach who uses movement
analysis with clients, so I am
hoping to start a new project
with him in London and Ibiza
to combine the wonderful
world of natural medicine
practice with physical exercise
and well-being.
Which CAM book has helped
or inspired you most, so far in
your career?
There are so many inspirational
books out there. Im always
diving in and out of them.
Im fond of the older
naturopathic and herbal books I
read during my earlier studies
including the works of Lindlahr,
together with The Healing Power
of Illness, by Dethlefsen and
Dahlke.
Not long after starting out
in practice I read Maurice
Messgus Of People and Plants,
and since then I have always
incorporated herbal hand and
foot baths into my practice!
I am currently reading The
Ringing Cedars series of books,
which starts with Anastasia by
Vladimir Megre.
Why do you do what
you do?
Because I get to exercise my
logical and creative sides.
Making a difference. Seeing
lasting change in clients: its
so motivating, it propels you
forwards.
I find its important to learn
how to be responsible for our
own health (mentally, physically,
emotionally) and that of the
environment that sustains us. Its
all connected.
If money, time and effort were
no object, what one thing
would you change about your
practice, or complementary
and alternative medicine in
general?
I would set up an organic herb
farm with an onsite integrated
health practice with CAM and
orthodox medical practitioners.
What piece of advice
would you give to newly
qualified CAM practitioners
who are just setting up a
business?
Invest in yourself! Look after
yourself physically, mentally,
emotionally it will reflect on
your practice well.
When you enjoy what you do
it will shine through, positively
impacting those you work with.
JANUARY 2016 I cam-mag.com 15
 camconferences

Up and running: booking opens

for 2016 CAM Conference series
A
fter a fantastic series of sell-out
events last year, CAM Conferences
in collaboration with BANT are
looking forward to another great
year of cutting-edge education as
booking opens for 2016.
The first conference of the year is on Saturday
March 19 at the Cavendish Conference Centre
in London, and will focus on nutrigenomics and
personalised nutrition. The conference takes place
after the BANT annual meeting, which will run from
9.30am11.30am (only available to BANT members).
Miguel Toribio-Mateas, chairman of BANT said:
The CAM Conferences in collaboration with BANT
are a priceless educational resource that enable
cross-disciplinary communication and learning.
With speakers ranging from professors from
some of the worlds most prestigious academic
institutions to clinicians with impressive success
track records in the treatment of complex diseases,
I believe no BANT member can afford to miss any of
these conferences.
Ive been very pleased to also see a growing
number of non-BANT member clinicians and
scientists from around the world attend our
conferences during 2015. Im really looking forward
to the next set of these stupendous events.
Last years conferences played host to an array of
world-class speakers, including Dr Dale Bredesen,
who will be back by popular demand. Dr Bredesen,
a world-renowned researcher in the field of
neurodegenerative diseases, will join twelve other
expert speakers in the 2016 series.
We had a record year for attendance in 2015,
and with 99% of delegates telling us they would
attend a CAM Conference again, 2016 is looking
to be another sell-out year. Places are expected to
go quickly, so delegates are encouraged to book as
soon as possible to avoid disappointment.
March: Individualised nutrition: diet and
DNA unlocking the power of nutrigenomics
For our kick-off event in
March, were welcoming
one of the worlds leading
nutrigenomic researchers.
You can read about his
research on how DNA
testing improves client
GolD SPoNSoR
compliance in our page 18
feature. Dr Ahmed El-Sohemy
(pictured) has also completed
original research on individual,
genetically-driven responses
to caffeine and cholesterol. His study on
vitamin C revealed that 1 of 7 of the young
Canadian adults had serum ascorbic acid
deficiency, and only 53% had adequate
serum ascorbic acid and led to research
suggesting that genetic variants might
explain the higher prevalence of inadequate
serum ascorbic acid in some individuals.
The presentations
Dr El-Sohemy will give three hour-long
presentations, followed by Q&A, focusing
on caffeine and vitamin C, inflammation
and metabolic syndrome, and how genetic
information can lead to behaviour change.
The speaker
Dr Ahmed El-Sohemy obtained his PhD from
the University of Toronto and completed
a postdoctoral fellowship at the Harvard
School of Public Health. He currently holds
a Canada Research Chair in Nutrigenomics
at the University of Toronto and serves on
Health Canadas Science Advisory Board.
Dr El-Sohemy has published in the top
scientific and medical journals, with more
than 100 peer-reviewed publications and
has given more than 150 invited talks
around the world. He is on the editorial
board of eight journals, and has served as an
expert reviewer for more than 30 different
scientific and medical journals and 12
research granting agencies. He has been a
member of international expert advisory
panels and the scientific advisory boards of
several organisations.
He is the founder of Nutrigenomix Inc.,
and serves as chief science officer. He is also
chairman of the companys International
Science Advisory Board, which consists
of key opinion leaders in the field of
nutrigenomics.
Booking for the 2016 CAM Conference series is
now open: just head to www.camconferences.
co.uk or call the team on 01279 810080 for more
information. Tickets are 92, with considerable
discounts available for students and members of
associations. A multiple booking discount is also
applied if you book more than one conference at
a time.
All delegates receive:
Education delivered by speakers internationally-
recognised in their specialist fields.
A delegate folder on arrival.
A free goody bag.
Free healthy refreshments and a gluten-free
buffet lunch.
Networking with more than 200 fellow
delegates and a range of exhibitors.
Free audio/video post-show downloads
CPD accreditation from BANT and the NNA
for every event.

Nutrigenomics conference kicks off our 2016 series

Canada Research Chair in Nutrigenomics Prof
Ahmed El-Sohemy of the University of Toronto
leads off this years series of CAM Conferences in
collaboration with BANT.
MArCh 19 Individualised nutrition: diet and
DNA unlocking the power of nutrigenomics,
conference follows the BANT annual meeting.
APRil 9 Detox the key to healthy ageing.
MAy 21 Feeding the gut: health through
microbiome modulation.
SEPTEmBER 10 Feeding the brain: nutrition
for bullet-proof neuroimmunity.
NovEmBER 5 Nutrition resolution: breaking
the cycle of stress and chronic inflammation.
n Book now by heading to
www.camconferences.co.uk or by calling
the team on 01279 810080.

16 cam-mag.com I JANUARY 2016

 @camconferences

cam 2016
conferences
in collaboration with

Book now
for the CAM Conferences 2016
Join us for 2016s most exciting education programme, with cutting-edge
themes and world-class speakers.

19 March 9 April 21 May

Individualised Nutrition: Detox - the key to Feeding the gut: health
Diet and DNA unlocking the healthy ageing through microbiome
power of Nutrigenomics modulation

10 September 5 November
Feeding the brain: Nutrition resolution:
nutrition for bullet-proof breaking the cycle of stress
neuroimmunity and chronic inammation

Book now on our brand new website www.camconferences.co.uk

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 cam nutrigenomics

Sushi or ice cream? Blood sugar

response depends on your genes
Which is more likely to raise blood sugar levels: sushi or ice cream?

A
ccording to a Weizmann Institute
of Science study reported in
the November 19 issue of the
high-impact journal Cell (doi:
http://dx.doi.org/10.1016/j.
cell.2015.11.001), the answer varies from
one person to another. The largest study of
its kind supports the need for personalised
dietary recommendations and might trigger a
revolution in nutrition research.
The study, which continuously monitored
blood sugar levels in 800 people for a week,
revealed that the bodily response to all foods
was highly individual.
The Personalized Nutrition Project (www.
personalnutrition.org), was conducted by the
groups of Prof Eran Segal of the Department of
Computer Science and Applied Mathematics
and Dr Eran Elinav of the Department of
Immunology. Prof Segal said: We chose to
focus on blood sugar because elevated levels
are a major risk factor for diabetes, obesity
and metabolic syndrome. The huge differences
that we found in the rise of blood sugar
levels among different people who consumed
identical meals highlights why personalised
eating choices are more likely to help people
stay healthy than universal dietary advice.
Indeed, the scientists found that different
people responded very differently to both

The modern era is marked by an unhealthy increase in body

weight across the world. Metabolic diseases are also on the rise,
with more and more cases of diabetes, hypertension, and heart
disease. General nutritional recommendations, published by
governmental agencies, are not effective for controlling these
rises in weight and disease. This is largely because different
people respond differently to food. Therefore, food choices that
are good for one person may not be good for another.
One source of such variability is our microbiome the collection
of 100 trillion germs and microbes that we carry around with us.
Each of us has a unique microbiome, which is affected by what
we eat, and in turn, affects our response to food. Our aim in the
Personalized Nutrition Project is to understand individual variation
and construct a truly personalized diet. The research was featured on the cover of the journal Cell.

Will this change everything?

Israel is unique in having a National Institute for Personalised Medicine, housed at the world-famous Weizmann Institute.
Now the latest research from Israel might, just might, be the final push that nutritional research needs to step out of the Stone Age. Especially
as it was featured on the front cover of Cell, one of the worlds leading journals.
Until now, nutrition researchers have just ignored everything we know about nutrigenetics, nutrigenomics and epigenetics. They carry on
regardless, trialling, testing and systematically reviewing diets and nutritional interventions as if one size fits all and disregarding, even, the
concept of biochemical individuality floated by Dr Roger Williams 60+ years ago.
Now we have the Weizmann Institute weighing in. It wasnt just the focus and scope of the research that was groundbreaking, but also
the manner of gathering information. They tracked blood sugar responses to more than 46,000 meals using embedded monitors. They
investigated changes in the microbiome. They recorded sleep and physical activity. And no wonky, three-day diet recalls here the 800
participants were hooked up to a smartphone app linked to the researchers central database, to record their food stats on the fly.
CAM comment: SIMON MARTIN

18 cam-mag.com I JANUARY 2016

simple and complex meals. For example, a
large number of the participants blood sugar
levels rose sharply after they consumed a
standardised glucose meal, but in many others,
blood glucose levels rose sharply after they ate
white bread, but not after glucose.
Our aim in this study was to ind factors
that underlie personalized blood glucose
responses to food, said Dr Elinav. We used
that information to develop personal dietary
recommendations that can help prevent and
treat obesity and diabetes, which are among
the most severe epidemics in human history.
The study was unique in its scale and in
the inclusion of the analysis of gut microbes,
collectively known as the microbiome,
which had recently been shown to play an
important role in human health and disease.
Study participants were outitted with small
monitors that continuously measured their
blood sugar levels and were asked to record
everything they ate, as well as such lifestyle
factors as sleep and physical activity. Overall,
the researchers assessed the responses of
Gene results motivate clients
R
esearchers from the University
of Toronto (U of T) report that
personalised dietary advice
based on a persons genetic
makeup improves eating habits
compared to current one-size-its-all
dietary recommendations.
We conducted the irst randomised
controlled trial to determine the impact
of disclosing DNA-based dietary advice on
eating habits, says Ahmed El-Sohemy, an
associate professor in nutritional sciences
at U of T and Canada Research Chair in
Nutrigenomics. We found that people who
receive DNA-based advice improve their diet
to a greater extent than those who receive
the standard dietary advice. Theyre also the
ones who need to change it the most.
Prof El-Sohemy will launch the 2016
series of CAM Conferences, having agreed
to present on March 19 following BANTs
annual meeting.
Prof El-Sohemy and colleagues collected
data on the intake of caffeine, sodium,
vitamin C and sugar from 138 healthy young
adults. The subjects were then randomised
into two different study groups one was
given DNA-based dietary advice for each
of the four dietary components of interest,
and the other group was given current
standard dietary advice for the same dietary
Well worth a visit: the consumer-
friendly full description of the study is at
www.personalnutrition.org.
different people to more than 46,000 meals.
Participants had strikingly different
responses to identical foods (see graphic,
below). In study participant number 445 (top),
blood sugar levels rose sharply after eating
components with no genetic information.
Changes in their dietary habits were
assessed after three and 12 months. The
researchers found that subjects who
received DNA-based dietary advice started
to show improvements to their diets after
three months and the changes became even
more apparent after 12 months.
Speciically, those who were informed that
they carried a version of a gene linked to salt
intake and high blood pressure signiicantly
reduced their sodium intake, in accordance
with the recommendation, compared to the
group that received the standard advice for
sodium intake.
No effects were observed for the other
components of the diet. However, most
subjects were already meeting the dietary
recommendations for the three other
components at the start of the study, and the
researchers believe this might explain why
no signiicant changes were seen in these
intakes.
This study addresses some notable
limitations in previous studies that
attempted to measure the impact of
disclosing genetic information on lifestyle
changes, says El-Sohemy. Previous studies
focused on disease risk prediction rather
than metabolic genes that affect speciic
components of the diet. This is the irst time
bananas, but not after cookies with the same
amount of calories. The opposite occurred in
participant 644 (bottom).
Taking these multiple factors into account,
the scientists generated an algorithm for
predicting individualised response to food
based on the persons lifestyle, medical
background, and the composition and function
of his or her microbiome. In a follow-up study
of another 100 volunteers, the algorithm
successfully predicted the rise in blood sugar
in response to different foods, demonstrating
that it could be applied to new participants. The
scientists were able to show that lifestyle also
mattered: the same food affected blood sugar
levels differently in the same person, depending,
for example, on whether its consumption had
been preceded by exercise or sleep.
In the inal stage of the study, the scientists
designed a dietary intervention based on their
algorithm; this was a test of their ability to
prescribe personal dietary recommendations
for lowering blood-glucose-level responses to
food. Volunteers were assigned a personalised
that the impact of
dietary advice based
on diet-related
genes with speciic
actionable advice
has been tested.
Prof Jos M.
Ordovs, Director See Prof Ahmed El-Sohemy
at the first CAM Conference
of Nutrition and of 2016 on March 19.
Genomics at
Tufts University, who was not involved
in the study, says personalised dietary
information not only increases compliance,
but also supports the long-term health of
patients. One of the major problems that
we have found regarding one-size-its-
all dietary recommendations is peoples
adherence to them, says Ordovs. This
work supports the notion that DNA-based
recommendations can be more beneicial for
the individual and, in addition, will increase
his or her compliance, which will increase
our ability of preventing chronic diseases
using dietary approaches.
Booking for the 2016 CAM Conferences in
collaboration with BANT is now open. Guarantee
your place today by booking online at www.
camconferences.co.uk or by calling 01279 810080.
JANUARY 2016 I cam-mag.com 19
 cam nutrigenomics
A video animation describing the study is available at www.youtube.com/watch?v=Ryc5M3Ciytg.
good diet for one week, and a bad diet
also personalised for another. Both good
and bad diets were designed to have the same
number of calories, but the diets differed
between participants. Thus, certain foods
in one persons good diet were part of
anothers bad diet. The good diets indeed
helped to keep blood sugar at steadily healthy
levels, whereas the bad diets often induced
spikes in glucose levels all within just one
week of intervention.
Moreover, as a result of the good diets, the
volunteers experienced consistent changes
in the composition of their gut microbes,
suggesting that the microbiome may be
influenced by the personalised diets while
also playing a role in participants blood sugar
responses.
The scientists are currently enrolling Israeli
volunteers for a longer-term follow-up dietary
intervention study that will focus on people
with consistently high blood sugar levels and
thus are at risk of developing diabetes with
the aim of preventing or delaying this disease.
How the
microbiome affects
blood glucose
The Weizmann scientists put it this way:
Insulin resistance is a state in which
the cells of our body do not respond to
insulin produced by the pancreas. As a
result, our body cannot lower the level of
glucose in our blood. A recent study (Koren
et al, doi: http://dx.doi.org/10.1016/j.
cell.2012.07.008), showed that insulin
resistance is associated with certain
communities of gut microbes in humans.
Transferring these communities to healthy
mice caused them to develop insulin
resistance as well.
Another study (Qin et al, doi: 10.1038/
nature11450) showed a strong association
between type 2 diabetes and a certain
fingerprint of gut microbes. Type 2
diabetes is a disease in which the pancreas
is exhausted by trying to supply more
and more insulin to an insulin resistant
body. Currently, about 300 million people
worldwide have type 2 diabetes, and
experts predict that this number will double
over the next 15 years.

Personalised medicine is being hijacked by

the pharmaceutical industry
Gene testing is being hijacked by
BigPharma, who see it as a way of
personalising drugs.
On the face of it, a Good Idea.
Orthodox medics see this as a way
of minimising side-effects and
identifying patients who really
will benefit from a drug. The move
to use gene testing in this way is
being sold as Precision Medicine.
In the US, President Obama
this year announced the Precision
Medicine Initiative. The White
House played up the more holistic
aspects of the Initiative, saying:
The future of precision medicine
will enable health care providers
to tailor treatment and prevention
strategies to peoples unique
characteristics, including their
genome sequence, microbiome
composition, health history,
lifestyle, and diet. To get there,
we need to incorporate many
different types of data, from
metabolomics (the chemicals
in the body at a certain point
in time), the microbiome (the
collection of microorganisms in
20 cam-mag.com I JANUARY 2016
or on the body), and data about
the patient collected by health
care providers and the patients
themselves.
However, the President himself
revealed where the emphasis will
really be:
Doctors have always recognised
that every patient is unique, and
doctors have always tried to tailor
their treatments as best they can to
individuals. You can match a blood
transfusion to a blood type that
was an important discovery. What
if matching a cancer cure to our
genetic code was just as easy, just
as standard? What if figuring out
the right dose of medicine was as
simple as taking our temperature?
The President called for $215
million in fiscal year 2016 to
support the Initiative, which
includes several components
with efforts from across the
federal government. Of this
total proposed budget, $130
million was allocated to the
National Institutes for Health to
build a database of the genetic
information from one million
people; and next largest slice of
the budget ($70 million) has gone
to the National Cancer Institute
to lead efforts in cancer genomics
matching drugs precisely to
cancer patients in a continuation
of the failed war on cancer.
Imprecision medicine
Commentators have been quick
to point out that the dawn of
precision medicine does point
to the fact that what is passing
for evidence-based, science-led
practice is at the moment clearly
qualifying for the description
imprecision medicine, and
the pharmaceutical industry is
leading it by the nose.
Recent figures show that for
every person they do help, the ten
highest-earning drugs in the US
fail to improve from three to 24
people.
Or, as Prof Nicholas Schork
puts it in a recent opinion piece
in Nature:The top ten highest-
grossing drugs in the United
blue = helped by the prescription;
red = not helped.
States help between 1 in 25
and 1 in 4 of the people who
take them. (Nature 2015, doi:
10.1038/520609a.)
As an example, above is part of
a Nature graphic on the top ten,
second best-selling drug:
Nexium, Crestor and Seroquel
(bipolar disorder), combined for
$10.6 BILLION in sales last year
for AstraZeneca, the UKs second-
largest drugmaker, according to
Bloomberg Business. Crestor, a
statin, is number four in the best-
seller list and is estimated to fail
to help 19 people for every person
it benefits.
Prof Schork is director of human
biology at the J. Craig Venter
Institute, and professor at the
University of California, San Diego,
and at the Translational Genomics
Research Institute. For some
drugs, such as statins routinely
used to lower cholesterol as few
as 1 in 50 may benefit, he says.
SM
 cam opinion

Blinded by science: practising

nutrition as if evidence mattered
CAM contributing editor Miguel Toribio MaTeas, BANT chairman, sets us up for the New Year with
a look at the professional backlash against evidence-based scientism, and previews the launch of a
new Functional Dietetics curriculum.

I
f you are a social media user, particularly
a Twitter fan, you may have noticed a
growing trend Ive spotted in the last few
months. Increasing numbers of frustrated
healthcare professionals, including
medical doctors and dietitians, have publicly
raised their concerns about a group of very
vocal members of their own professions for
whom science and evidence are the most
valuable part of human learning.
This latter group of serial tweeters are
keen to let the world know that they believe
in the universal applicability of the scientific
method, and that empirical science constitutes
the most authoritative worldview. They take
this to the point where theyre quite happy
to exclude any other viewpoints, particularly
those that cannot be confirmed by large scale
randomised controlled trials which have then
been included in a systematic review.
Any piece of scientific and clinical
knowledge that doesnt make it to the tiny top
of this evidence-based medicine pyramid is
simply not accepted as true, hence the current
conflicts in the interpretation of evidence.
Only last month I had an interesting, mildly
heated Twitter debate on detoxification
with a well-known dietetics professor. He
is quite obviously a highly intelligent man,
but couldnt agree with me that inducing the
activity of detoxification enzymes by means
of nutritional substrates (food, nutritional
supplements etc.) was necessary at all. He
just didnt see the point, nor the clinical
applicability, of engaging in any kind of
induction (or inhibition) of detoxification
enzymes. controlled trial thats long enough and thats
In fact, it took a few tweets for him to even run on enough human participants for it to be
acknowledge the existence of the biological included in a systematic review can easily end
reality that is the enzymatic detoxification up costing a quarter of a million pounds. No
system. That only came about after I provided wonder there are hardly any RCTs on the use
a link to a paper published in the BioMed of food and food supplements as medicines
Central journal BMC Genomics. (See screen for the treatment of various conditions.
shot opposite). Theres no money to be made from foods and
Just taking a look at the evidence-based natural products that cant be patented, so the
medicine pyramid (below), one realises funding for this research is simply not there.
that the model is ill-fitted for any non- But the lack of good evidence according
pharmacological intervention. A randomised to this model does NOT mean the evidence

22 cam-mag.com I JANUARY 2016

we see in clinic with our clients every day is
worthless or irrelevant.
A few weeks after this exchange, the
TV programme Doctor in The House is
aired during prime time on BBC1. In an
unprecedented move, a GP actually stays
with a family for a few days and does the
Functional Medicine thing on them, putting
them at the centre of the picture and engaging
them in drugless processes that see them
experience huge improvements in glycaemic
control markers such as HbA1c, fasting
insulin and glucose, and reversal of diabetic
neuropathy.
In one of the programmes, a woman
loses two stone in a short space of time just
by implementing simple changes to her
diet which are along the lines of the BANT
Wellness Guidelines (featured in Octobers
CAM), ie reduced carbohydrate intake, higher
protein, no junk food. Shortly after the first
programme of the series, the British Dietetic UK Science Advisory Committee on Nutrition and other evidence-based authorities have not acknowledged that fructose is
Association published a statement headlined part of the obesogenic environment, as identified by BANT.

BDA alarmed by controversial and potentially

dangerous advice in BBCs Doctor in the who now have the power to do so thanks to and departments, has failed to acknowledge
House. social media. More and more people whove fructose as a contributing factor to the current
In their statement the BDA said that apart improved their health based on nutrition obesogenic environment at all. In fact, the
from the advice to reduce refined carbs and interventions, some self-directed, some Sugar Reduction Summit, which took place
sugar, many of the other recommendations working with a professional, are expressing in December at the Royal Society of Medicine,
made by Dr Rangan Chatterjee lack evidence their views and questioning the inclusion and completely ignored fructose, too.
from scientific research base [sic]. exclusion criteria of so-called called evidence- The most incredible of trends is that Ive
I really dont get the idea that these based medicine. seen more and more members of the British
recommendations are not based on evidence. Dietetic Association and the Association for
Did the BDA ask the 5ft 2 lady who initially Evidence-based? Nutrition talk about personalised nutrition
was 19 stone and who lost five stone during Another evidence-based shambles that and about individualising care. In fact, theyre
the process, going from being diagnosed type has been attracting widespread attention is using that argument to dismiss those who are
2 diabetic to being given the glycaemic all that evidence-based authorities seem to sharing their success using lower carbohydrate
clear within four months where the evidence have developed a blind spot about fructose. diets, telling them that their approach is not
was? Or the guy who reversed his diabetic SACN, the UK Science Advisory Committee evidence based. Same old chestnut.
neuropathy which impeded him feeling the on Nutrition that advises Public Health For someone whos sharing on Twitter
tips of his fingers? Or indeed the child who England and other government agencies how theyve lost seven stone and controlled
suffered from eczema who benefitted from a
probiotic-based intervention? The health of
all these people improved during the time the
series was filmed, and continued to improved
thereafter, but this doesnt constitute good
enough evidence. Instead, Dr Chatterjees
recommendations are classed as dangerous.
The BDA statement also claimed, amazingly,
that dietitians are the only qualified health
professionals that specifically assess, diagnose
and treat diet and nutrition problems at an
individual and wider public health level.
Uniquely, dietitians use the most up-to-date
public health and scientific research on food,
health and disease, which they translate into
practical guidance to enable people to make
appropriate lifestyle and food choices.
No wonder such ludicrous statements
from the BDA are questioned by individuals

JANUARY 2016 I cam-mag.com 23

 cam opinion
their Type 2 diabetes with a Paleo type of
diet, its a bit of a slap in the face to be told
that theyre not evidence-based and that
their approach is dangerous. These people
feel better than theyve done for years, yet
well-respected healthcare professionals are
telling them theyre wrong and that they
should eat according to the UK governments
NHS-approved EatWell Plate making sure
to include plenty of carbohydrates in their
diet because they are necessary. Theyre
even being told theyre part of a cult, and
are being accused of having a single-minded
viewpoint on nutrition, yet the accusers
themselves show very little flexibility in their
worldviews.
Personalised vs individualised
A perfect example of how shockingly
confusing their message to the outside world
is comes from the BDA factsheet on Type 2
diabetes. It states this factsheet is for people
with diabetes only, then proceeds to provide
the reader with information based on the
EatWell Plate, ie a one-size-fits-all. Would you
ask a type 2 diabetic to eat according to the
EatWell Plate, with up to 50% refined carbs,
and even a little slice of cake and a can of
coke? Hm.
It seems science is actually showing that
more and more real evidence supports
the approach taken by BANT Nutritional
Therapists for years. And it also seems that
growing numbers of healthcare professionals
and the general public alike are realising that
this is the case. People need interventions that
work and scientists dont want to be seen to
be on the wrong side of science. So as the tide
changes, those who now want to say weve
done personalised nutrition all along are
either going to have to admit they were wrong
to start with, or admit we were right. They
simply cannot have their cake and eat it, even
if a slice of it is allowed on the EatWell Plate.
Thats why last month BANT launched
a full public consultation on its curriculum
framework for Functional Dietetic Practice to
meet the registration standards of the Health
and Care Professions Council (HCPC). This
is the same HCPC, by the way, who in 2006
wrote to BANT, the Association for Nutrition
and the BDA, recommending that we should
all work together as a cohesive community
of nutrition health experts. BANT would like
us all to work together, but any time weve
tried to build bridges weve been dismissed
on the grounds that we lack evidence for
our approach, the same approach that sees
people lose weight and reverse their type 2
diabetes on primetime TV, but that apparently
is dangerous and not based on evidence
24 cam-mag.com I JANUARY 2016
from the scientific research base. Thats the
evidence published daily in hundreds of
scientific papers from reputable research
centres worldwide; if it doesnt quite make
it to the tip of the EBM pyramid, this weight
of scientific evidence is ignored and/or
classed as irrelevant by those claiming to be
uniquely able to assess it.
The Functional Dietetics consultation runs
for three months to 24 February 2016. For
two years BANT has collected data, delivered
to the BANT council through the efforts of
a highly specialised law firm, that debunks
myths such as you need to complete a six-
month placement in the NHS to become a
dietitian, or you need to complete a degree
course at a university to be HCPC registered.
Another gem is that the HCPC has confirmed
that you dont need to be a member of the
BDA to be a dietitian. Another myth busted.
The BDA is simply a registrant professional
association for those practising dietetics
(which, incidentally, is not a protected title,
only Dietitian is). There can be several
professional associations in one register, as
is the case for the podiatry and chiropody
register, where four professional associations
happily coexist.
The HCPC has clarified (in writing) all of
these statements, and BANT has published
this and other facts in a FAQ document that
is key to the consultation and I recommend
everyone interested reads carefully. Its
enlightening. (http://bant.org.uk/wp-content/
uploads/2015/11/FUNCTIONAL_DIETETICS_
CURRICULUM_FRAMEWORK_FAQ.pdf)
As Chair of BANT I am excited to see a
tangible opportunity in front of us the ability
for training providers to develop courses
that build upon the proposed curriculum
framework in functional dietetics. This means
that the first Functional Dietitians may be
out practising in a little longer than three
years. BANT will then need to continue the
negotiations with the HCPC in order to get
grandparenting rights for all current BANT/
CNHC Registered Nutritional Therapists to
join the HCPC Register of Dietitians.
Why are we doing this? The general
public needs and is asking for nutritional
interventions that are individualised and that
work for them as unique people. They need
the type of interventions that a functional
medicine model can deliver. Im proud of
BANT Council for the incredible amount
of work thats gone into producing the
framework, and look forward to a very exciting
2016, with potentially life-changing turns for
the nutritional therapy profession. cam
About the author
Miguel Toribio-MaTeas is a Registered
Nutritional Therapist (BSc Hons Nutritional
Medicine) and published author, with a
specialism in healthy ageing. He has a
Fellowship in Anti-Ageing, Regenerative and Functional
Medicine with the American Academy of Anti-Aging
Medicine (A4M) and has passed board certification
exams in metabolic and nutritional medicine in the USA.
Miguel is completing an MSc in Clinical Neuroscience at
Roehampton University, working with neuroimmunologist
Dr Francisco Holgado-Molina on the assessment of
the impact of nutrients (CoQ10, serine, vitamin C) and
signalling molecules (NADH) on mitochondrial activity,
DNA replication and cell fate/apoptosis of murine neural
stem cells. His background includes more than 15 years
in scientific, technical and medical research publishing,
and postgraduate studies in systems complexity and
international business. Miguel is well-known for his
active voluntary role with the British Association for
Applied Nutrition and Nutritional Therapy (BANT). He
is the UK Head of Clinical Nutrition for Cenegenics, the
world number one personalised age management clinic.
Additionally, Miguel has advisory and educational roles
with Vitae Natural Nutrition and keeps developing his own
age management range. More about Miguel at https://
miguelmateas.com.
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 cam case study
Sharing a client: how
nutrition and acupuncture
combine to help IBS
York-based nutritional therapist Sally Duffin frequently shares clients with Tiziana BerTinoTTi,
a highly qualified TCM acupuncturist. They find that clients thrive by experiencing both modalities
of treatment and they have particular success with chronic digestive complaints, pain and fatigue
issues. Here Sally shares a typical case history.
T
he client is a 23-year-
old woman who is
coming in because of
fatigue and IBS, with
constipation, pain,
wind, bloating and abdominal
discomfort.
As therapists we are taught
the advantages of cross-referring
clients to other practitioners;
however this doesnt always work
out in practice, as patients may
struggle to afford more than one
therapy simultaneously, or feel
unable to cope with more than
one technique at a time.
When collaborative working
does happen, the results can be
enlightening and empowering for
both client and therapists.
Tiziana and I began cross-
referring clients to each other
several years ago while based
at the same multi-disciplinary
clinic. We recognised the need for
a team work approach to holistic
health, with foods, supplements,
energy medicine and physical/
manipulative therapies each
having their place in supporting a
client on their health journey.
This case history documents
the progress one shared client
made while following a functional
nutrition plan and receiving
Traditional Chinese Medicine
(TCM) acupuncture treatments
for digestive health.
Health history
Our client had been experiencing
low energy and IBS symptoms
of constipation, pain, wind and
28 cam-mag.com I JANUARY 2016
abdominal discomfort for roughly
eight years since the age of 15,
when her parents separated.
Around this time she also suffered
a bad cold and cough virus and
had never felt well since.
She took a food intolerance
ELISA test during her teens and
discovered gluten sensitivity:
cutting this out of her diet did
initially make a considerable
difference to both bowel
movements and bloating, but the
benefits were not sustained.
A few months before starting
her treatments, the client moved
house; this depleted her energy
levels even further and worsened
her IBS. She was aware of her
tendency to hold on to stress in
her stomach, and of not finding
time for relaxation. Due to low
energy levels she was no longer
enjoying regular exercise; this in
turn was worsening her IBS.
Her diet was typically very
good, with plenty of home-
prepared meals, fresh vegetables,
wholegrains and regular fluid
intake of water and herb teas.
Eastern and Western
interpretations of the
case
From the TCM acupuncture point
of view, the client had a mixture
of patterns of disharmony, with
stress and chronic tension being
key contributing factors. Tizianas
approach was multi-faceted and
also used her advanced training
in auricular acupuncture. She
focused primarily on calming the
clients mind and sympathetic
nervous system while improving
the flow of stagnated Qi through
her digestive system and liver.
Several ear and body points
were used to Calm the Shen (ie
calm the mind), including Shen
Men, Point Zero, Sympathetic
and YinTang. This combination of
body and auricular acupuncture
had a profound impact on the
clients parasympathetic nervous
system, allowing her to deeply
relax and engage in healing.
The disposition towards stress
and worry was also reflected in
her pulse and tongue diagnosis
which highlighted liver Qi
stagnation with heat. Various
points such as the 4 Gates were
used to promote the flow of
liver Qi.
The clients abdomen often
felt cold to the touch, a sensation
which tied in with Kid and Sp
Yang positions on her pulse being
fine, deep and deficient. Moxa
and needling were used to warm
and tonify Qi and Yang in her core
and digestive organs: the needles
conducted the warmth from the
moxa, helping it penetrate deeply
into her system.
The nutritional therapy
approach was based on the
functional medicine 4 Rs
for digestive health: Remove,
Replace, Reinoculate and Repair
alongside support for her
nervous system with specific
nutrients and simple deep
breathing relaxation techniques.
Similarities between
the Western and Eastern
interpretations are visible:
nutritionally supporting the
parasympathetic nervous system
and its influence on the gut/brain
axis equates to Calming the Shen,
while reducing inflammation
and enhancing digestion
and elimination parallels the
acupuncture effects of promoting
Liver Qi and warming and
tonifying the digestive organs.
Functional testing
The client was keen to take
another food intolerance test as
she felt new food sensitivities
had developed. The test
highlighted multiple food
reactions, the strongest being
to cows milk, cranberry, oats,
pea and egg white. Other animal
milks were also quite strongly
reactive, alongside several nuts
and grains. The presence of
multiple reactions suggested
compromised gut integrity and
emphasised the importance of
Repair and Rebalancing.
A comprehensive food plan
was devised focusing on as much
variety and interest as possible
and including warming, cooked
foods that are easy to digest. Food
sources of magnesium, B vitamins,
essential fats, zinc and vitamins A
and D were highlighted to ensure
optimal dietary intake of nutrients
to support digestive repair, energy
production and stress handling.
Contrasting
recommendations
The client had an early start to her
working day and had gotten in the
habit of drinking a protein powder
and soya milk smoothie for
breakfast. At first I recommended
she continue enjoying a smoothie,
but make it herself with nut
milk, ground flaxseeds, berries
and greens such as spinach. As
a stand-alone recommendation
this seemed fine, but Tiziana had
identified patterns of cold and
stagnation in her digestive system
which were not conducive with
such a cold breakfast! She switched
to a more warming breakfast and
enjoyed buckwheat porridge with
ground seeds, almond butter and
cooked apple instead.
Supplements
This client was already taking
several supplements, including
various fibre products. Some
contained oats and other food
extracts which she reacted to.
We replaced them with just
two products to begin with: a
multi-strain comprehensive high
strength probiotic supplement,
and a capsule blend of digestive
herbs including ginger, fennel,
clove, peppermint, papaya
and cardamom for their anti-
spasmodic, anti-inflammatory and
carminative properties.
Client progress
A few weeks after starting the
nutrition plan and acupuncture
treatments, our client went on
holiday to America. She was
initially apprehensive about the
trip, but after some careful forward
planning, coped well with the
eating plan and enjoyed a wide
range of fresh salads, vegetables,
meats and fish, while avoiding the
majority of trigger foods.
At her three-month nutrition
consultation, the client reported
consistent improvements in her
sleep, energy levels, constipation,
pain and bloating. She was
enjoying regular high intensity
exercise again and had changed
her routine to make time for
regular relaxation in the evening.
These improvements had steadily
accumulated, interrupted only
briefly by a mild upset in bowel
function caused by changes to her
routine and body clock following
the flight home from America.
The acupuncture sessions quickly
resolved this imbalance and
relieved her symptoms.
Maintaining well-
being
The client now supplements
with a magnesium citrate and
B vitamin formula to provide
ongoing support for energy
levels and dealing with stress,
and continues to enjoy monthly
acupuncture treatments to
maintain her well-being and
digestive comfort. In her own
words, she now feels much more
energised and empowered! After
many years of discomfort I can
now enjoy life to the full!
Benefits of working
together
Collaborating on clients has given
us both a broader insight into each
others modality. There is deep
respect for the others approach
and a shared motivation and
interest in helping the client. From
our experience of co-working,
the benefits of sharing a case
can really come into play when a
barrier to progress crops up. The
missing element in ones own
practice for example knowledge
of nutrition, therapeutic exercise
or bio-energetics can be provided
by the other practitioner, thereby
sustaining the clients progress and
momentum.
JANUARY 2016 I cam-mag.com
About the
practitioners
Sally Duffin, BSc
Nutritional Medicine,
CNHC Reg, mBANT,
began working in the
health food industry in
1999 and qualified as
a nutritional therapist
in 2009, after six years part-time
study. She runs a busy practice in York,
offering one-to-one consultations
and workshops, and enjoys writing
health and nutrition articles for various
websites and publications. Sally is
committed to supporting students of
nutrition: she is the Nutrition Clinic
Supervisor and Module Leader for
Clinical Practice at Northern College
of Acupuncture and a tutor in the
Education Team at Nutrigold Ltd, the
independent naturopathic nutritional
supplement company.
www.nutritioninyork.co.uk.
Tiziana BerTinoTTi:
BHSc Acupuncture,
PGCert Chinese Herbal
Medicine, Adv Dip
Acupuncture, Dip
Bowen Therapy, MBAcC,
BA Hons, and PGCE,
qualified through a four-year full-time
course in Traditional Chinese medicine
at the Australian College of Natural
medicine, Brisbane, Australia. She
graduated with the Bachelor of |Health
Science Acupuncture, with the
award for Most Outstanding Student
Practitioner of Acupuncture in her
year. She worked as a practitioner of
Chinese medicine in various clinics in
Brisbane as well as on a cruise ship as
the official Resident Acupuncturist at
Sea, before returning to England to
set up m practice at York Traditional
Acupuncture. Within the Acupuncture
for Childbirth Team (ACT), Yorkshire
(www.actyorkshire.org.uk), she
specialises in treating morning
sickness, in preparing the body for
labour, turning a breech baby, inducing
labour and in post-natal care.
www.yorktraditionalacupuncture.
co.uk.
29
 cam case study
Acupuncture impacts same
biologic pathways as pain drugs
Described as providing the strongest
evidence to date on the mechanism of this
ancient Chinese therapy in chronic stress,
Georgetown University Medical Center
(GUMC) researchers have discovered that in
rats, acupuncture appears to impact the same
biologic pathways ramped up by pain and
stress the same pathways targeted by human
pharmaceuticals.
The benefits of acupuncture are well-
known by those who use it, but such proof
is anecdotal. This research, the culmination
of a number of studies, demonstrates how
acupuncture might work in the human body
to reduce stress and pain, and, potentially,
depression, says the studys senor
investigator, physiologist Prof Ladan Eshkevari,
PhD, CRNA, LAc, associate professor in the
department of nursing and the department of
pharmacology and physiology at GUMC.
We have now found a potential mechanism,
and at this point in our research, we need to
test human participants in a blinded, placebo-
controlled clinical study the same technique
we used to study the behavioural effects of
acupuncture in rats, says Eshkevari, a nurse
anaesthetist and licensed acupuncturist. The
team published the results in Endocrinology
(2015, doi: 10.1210/EN.2015-1018).
Eshkevari and her team found that applying
the technique with electroacupuncture to
a single but powerful acupuncture point
stomach meridian point 36 (St36) blunts
activity in the hypothalamus pituitary adrenal
(HPA) axis, the chronic stress pathway that is
also associated with chronic pain, the immune
system, mood and emotions. Tuning down the
HPA axis via acupuncture reduced production
of stress hormones, secreted by the pathway,
that are involved in the chronic stress response.
Some antidepressants and anti-anxiety
drugs exert their therapeutic effects on these
same mechanisms, Eshkevari says.
She has already shown that pre-treatment
with acupuncture prevents increases in HPA
hormones caused by cold-induced painful
stress in rats, and that the beneficial effects
were long lasting.
Placebo and sham
Her series of studies uses four different groups
in rats: three stress group of animals a
group that received acupuncture through
electroacupuncture (a device that ensures
equitable distribution of electro stimulation);
those that received sham acupuncture
(delivered in an area that is not an acupuncture
point); and a third, placebo group that did not
receive any acupuncture. The stress groups
were compared to a fourth group of animals
that served as controls, with no exposure to
stress or acupuncture.
The first study mimicked the benefit
experienced by individuals who have
Found: Prof Ladan
Eshkevari and team
have uncovered a new,
potential mechanism for
acupunctures effects on
pain and stress.
acupuncture regularly, while the new study
looked at the benefit of acupuncture during a
stressful event which is how acupuncture is
most often utilised clinically, Eshkevari says.
They indeed found that electroacupuncture
delivered at St36 minutes after chronic painful
cold exposure was as effective in preventing
elevation of stress hormones as it was with
pretreatment with acupuncture.
The new study also used a drug to block
acupunctures manipulation of the HPA system,
and found that production of stress hormones
equalised in all treatment groups. This
confirmed that electroacupuncture does affect
the HPA system, she says.
Behavioural and protein analyses indicated
that acupuncture appears to prevent
stress-induced release of hormones, as well
as decrease depression and anxiety-like
behaviour in the rats. This is the first report
linking the effects of electroacupuncture at
St36 to chronic stress induced depressive and
anxious behavior in animals, Eshkevari says.
This work provides a framework for future
clinical studies on the benefit of acupuncture,
both before or during chronic stressful events,
she says.

York trial shows long-term benefits of acupuncture,

Alexander Technique for chronic neck pain
A large-scale investigation by
researchers at the University
of York found that the use
of Alexander Technique or
acupuncture can significantly
relieve chronic neck pain.
Chronic neck pain is a difficult
condition to treat, and previous
research shows that single
interventions generally do not
provide long-term benefits.
After evaluating the benefits
of Alexander Technique or
acupuncture, the researchers
from the Department of Health
Sciences at York concluded that
both interventions reduced pain
and associated disability over a
12-month period when compared
with usual care alone.
The study, published in Annals
of Internal Medicine (2015, doi:
10.7326/M15-0667), recruited
517 patients from GP practices
in Leeds, Manchester, Sheffield
and York. Participants were
randomly placed in three groups:
one group was offered up to 20
half-hour lessons with teachers
from the Society of Teachers of
the Alexander Technique plus
usual care; another received up
to 12 sessions of 50 minutes of
acupuncture based on traditional
Chinese medical theory with
practitioners of the British
Acupuncture Council, plus usual
care; and the third and final group
received usual care alone.
The interventions were
delivered within the first four to
five months. In all three groups,
usual care over the 12 months
included prescribed medications
and visits to GPs, physiotherapists
and other healthcare
professionals.
The research showed that at
12 months, pain was reduced
by 32% for those receiving
acupuncture and 31% for
those undertaking Alexander
Technique lessons, where 25%
is a clinically relevant reduction.
When comparing Alexander
lessons or acupuncture with
usual care alone, these reductions
were found to be statistically
significant. Moreover, patients in
these two groups were found to
be better able to cope or reduce
their pain levels without resorting
to medication.
Dr Hugh MacPherson, a
Senior Research Fellow in the
Department of Health Sciences at
York, said: Our key finding is that
there are significant reductions
in neck pain associated with
Alexander Technique lessons and
acupuncture at 12 months. This
is an important finding because
for the first time we now have
clear evidence that these two
interventions provide longer-term
benefits for chronic neck pain.

30 cam-mag.com I JANUARY 2016

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 cam candida update
Coconut oil
can control
overgrowth
of a fungal
pathogen
in GI tract
A
new inter-disciplinary study
led by researchers at Tufts
University has found that coconut
oil effectively controlled the
overgrowth of Candida albicans in
mice. In humans, high levels of Candida in the
gastrointestinal tract can lead to bloodstream
infections, including invasive candidiasis.
The research, published in mSphere, has
given strong backing to the CAM approach of
using dietary approaches as an alternative to
antifungal drugs in order to tackle Candida
(2015, doi: 10.1128/mSphere.00020-15).
Although we always tend to think
of Candida as a yeast that turns into a
fungal pathogen at the drop of a sugar
cube, researchers see it as part of the
gastrointestinal tracts normal lora, where
32 cam-mag.com I JANUARY 2016
it is well-regulated by the immune system.
When the immune system is compromised,
however, the fungus can spread beyond
the GI tract and cause disease. Systemic
infections caused by Candida can lead to
invasive candidiasis, which is one of the most
common blood infections among hospitalised
patients, cutting a swathe through anyone
immunocompromised, including premature
infants and older adults.
Antifungal drugs can be used to decrease
and control Candida in the gut and prevent
it from spreading to the bloodstream, but
repeated use of antifungal drugs can lead to
drug resistant-strains of fungal pathogens. In
order to prevent infections caused by Candida,
the amount of Candida in the gastrointestinal
tract needs to be reduced.
The team, led by microbiologist Prof
Carol Kumamoto and nutrition scientist Dr
Alice Lichtenstein, investigated the effects
of three different dietary fats on the amount
of Candida in the mouse gut: coconut oil,
beef tallow and soybean oil. A control group
of mice were fed a standard diet for mice.
Coconut oil was selected based on previous
studies that found that the fat had antifungal
properties in the laboratory setting.
Coconut oil even reduced fungal
colonisation when mice were switched from
beef tallow to coconut oil, or when mice were
fed both beef tallow and coconut oil at the
same time. These indings suggest that adding
coconut oil to a patients existing diet might
control the growth of Candida in the gut, and
possibly decrease the risk of fungal infections

caused by Candida, said Kumamoto.
Food can be a powerful ally in reducing
the risk of disease, said Alice H Lichtenstein,
DSc, director of the Cardiovascular Nutrition
Laboratory at the Jean Mayer USDA Human
Nutrition Research Centre on Ageing at Tufts.
This study marks a first step in understanding
how life-threatening yeast infections in
susceptible individuals might be reduced
through the short-term and targeted use of a
specific type of fat.
We want to give clinicians a treatment
option that might limit the need for antifungal
drugs. If we can use coconut oil as a safe, dietary
alternative, we could decrease the amount of
antifungal drugs used, reserving antifungal
drugs for critical situations, said first author
Kearney Gunsalus, PhD.
Profile of a Candida-hunter
We think that
Candida thinks its
part of the body
While studying the
opportunistic fungal
pathogen Candida
albicans, Tufts Carol
Kumamoto (pictured) and her team made
a stunning discovery: the fungus has an
identity crisis.
We think that Candida thinks its part
of the [human] body, says the associate
professor of microbiology at the Tufts
School of Medicine. The body is where it
spends its whole life. So we think its learned
everything about being in the body, including
the idea that if you can sense contact with
other cells or matrix, this provides important
information that tells you where you are, and
therefore, what you ought to do.
All jokes about the fungus among us
aside, Kumamoto calls the discovery very
significant, noting that it helps explain how
the fungus changes when it afflicts a host.
And thats the real crisis at hand.
In the body, if [Candida] were to invade,
it would be surrounded by tissue, and this
is something it would be able to sense and
figure out Oh, here I am, Kumamoto
explains.
Twenty years ago when she first came
to Tufts, Kumamoto studied the largely
non-pathogenic bacteria E. coli. Though
she focused on that for about 12 years,
Kumamoto simultaneously became very
fascinated by Candida, which eventually
became her labs entire research focus.
My decision to work on a pathogenic
organism came out of the really strong
interest of our department as a whole in
infectious diseases, she says.
What captivates Kumamoto is
Candidas transition point, its mysterious
transformation from harmless to harmful.
She is working to pinpoint the genetic shifts
that occur during this change.
Basically, everybody has this organism,
and its not doing anything, explains
Kumamoto. But if a person were to become
immunocompromised lets say they have
AIDS then, this organism can cause infection.
Shes also interested in the ways that
change manifests itself. Candida is a
yeast, she says. If you were to grow it in
a laboratory and look at it, it looks just like
bakers yeast. But if you look at Candida
thats causing disease in somebody, it looks
really different. It forms long filaments if
you have a mouldy piece of bread, you can
see those threads, and it looks like that. So
when Candida starts to invade, what are the
triggers that cause it to form these filaments,
and what are the molecular events that are
taking place?
Kumamoto has found that Candidas
change in appearance reflects the newly
pathogenic organisms purpose. Those
threads will be drawn into the tissues of
the host, so [the new form] is a way that
the organism can get from wherever it is to
the bloodstream, where it can disseminate
throughout the body, becoming life-
threatening. Unfortunately, that point is
reached often in hospitals when patients are
already hospitalised and possibly immune-
suppressed due to treatment.
A new awareness
Kumamoto hopes her research will provide
a way to prevent Candida from seizing
on these patients immunocompromised
conditions. The idea is to understand
whats going on at a molecular level during
the invasion, with the hope that you could
design a new therapy that could maybe even
prevent it from happening in the first place,
she says.
But Kumamoto is well aware that even if
such a therapy were developed, her work
would not yet be complete. Drug resistance
in pathogenic species is becoming a big
problem with fungal pathogens, she says.
So were doing molecular studies trying
to identify genes and figure out what the
process is that allows them to be resistant.
In a 2011 paper she explained the
link more of a vicious cycle between
Candida and inflammation. Results from
animal experiments suggest that Candida
colonization delays healing of inflammatory
lesions and that inflammation promotes
colonisation.
These effects may create a vicious
cycle in which low-level inflammation
promotes fungal colonization and fungal
colonisation promotes further inflammation.
Both inflammatory bowel disease and
gastrointestinal Candida colonisation are
associated with elevated levels of the pro-
inflammatory cytokine IL-17. Therefore,
effects on IL-17 levels may underlie the
ability of Candida colonisation to enhance
inflammation. Because Candida is a frequent
coloniser, these effects have the potential to
impact many people.(Curr Opin Microbiol,
doi: 10.1016/j.mib.2011.07.015.)
JANUARY 2016 I cam-mag.com 33
 cam candida update
Undecenoic acid: powerful
against Candida but treat
the underlying dysfunction
10-undecenoic acid, derived from castor bean oil, is finding favour among
practitioners as a potent and non-toxic anti-Candida intervention.
One of those recommending it is microbiology researcher Kiran Krishnan,
Chief Scientific Officer at Physicians Exclusive and one of the driving
forces behind a new approach to probiotics associated with the new
MegaSporeBiotic products.
He confirmed that he and his team have used 10-undecenoic acid with
success to bring down Candida flare-ups. However he says:
One of the misconceptions about Candida is that it is a classical infection.
What people dont realise is that there are more than 200 different strains of
Candida that naturally exist in us and on us. Usually, if Candida is overgrown
its a symptom of other issues that are suppressing the immune system and
the microbiome.
Candida overgrows when the immune system is dysfunctional and the
microbiome is experiencing dysbiosis. In many cases it is heavy metal toxicity,
liver function issues, thyroid or adrenal issues etc. Even with antifungal
treatment, in many people Candida is quite recurrent, because the original,
underlying cause is not addressed.
He adds: I think the topic of Candida being a symptom of another issue
is a overlooked by most practitioners and instead the Candida itself is
aggressively treated, often without success
www.gomegaspore.com.
34 cam-mag.com I JANUARY 2016
Cystic fibrosis researchers
discover how Candida
defends against bacteria
Researchers at the University of Toronto examined
fungi in the mucus of patients with cystic fibrosis and
discovered how Candida albicans has evolved to defend
itself against neighbouring bacteria.
Fungi have a staggering impact on human health,
infecting billions of people around the world and
killing 1.5 million every year thats in the range of
tuberculosis and malaria, says Prof Leah Cowen,
University of Toronto Molecular Genetics professor
and Canada Research Chair in Microbial Genomics and
Infectious Disease. And yet, they are underappreciated
and not well understood.
For this study (PLOS Pathogens, 2015. DOI: 10.1371/
journal.ppat.1005308), researchers analyzed 89 mucus
samples from 28 cystic fibrosis patients, using both
high-throughput genetic sequencing as well as culture-
based analysis. Candida albicans was predictably
prevalent.
What surprised the researchers, however, was
that some of this fungi began shifting into its stringy
shape without any environmental cue usually this
transformation (called filamentation) doesnt happen
spontaneously, but is triggered by the presence of
certain substances, such as blood. To see if there could
be a genetic explanation, the researchers sequenced
the genomes of these samples and found a common
denominator. All but one had genetic mutations in a
gene known to repress the change shape called NRG1.
Genetic brake
This was a smoking gun, says Cowen. This gene
makes a protein that stops filamentation like a brake.
Because of these genetic mutations, the fungi lost this
brake and were not able to stop these long strings from
forming.
To find out why certain strains of this fungus would
have developed this genetic variation, researchers
looked to neighbouring bacteria. As part of an ongoing
battle between microbes, certain bacteria, which are
also found in cystic fibrosis patients, secrete molecules
preventing the fungus from changing into its stringy
shape. The researchers tried exposing the mutated
fungus to these bacterial rivals. Instead of responding
to the bacterial signals, the fungus kept to its stringy
form. The researchers believe these fungi have evolved
to counter the tactics of their bacterial rivals.
We think the interaction between bacteria and
fungus drove this, says Cowen. Usually losing control
isnt a very good thing, but in this case it may be a great
defense mechanism for Candida. These fungi have
essentially learned to ignore the bacteria.
Cowen is continuing research into the impact of
fungal pathogens in cystic fibrosis patients, who are
unable to clear microbes from their airways and suffer
reduced lung function as a result. There is no cure
for this fatal genetic disease. She is also seeking to
better understand the role of fungi in variety of other
conditions.

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is pre-treated with calcium, magnesium
and potassium, which it will exchange with
the toxic metal. In terms of effect, 6oz of
nano-scale Zeolite is equivalent to 1000kg
of Micro Zeolite, making ACZ Nano 1000s
of times more effective than other Zeolite
powders. www.resultsrna.co.uk
Amazing Grass Chocolate
Raw Reserve Greens &
Protein
Amazing Grass Chocolate Raw Reserve Greens
& Protein is a blend of AFAs (blue green
algae), spirulina, chlorella, and sea vegetables
from the coast of Maine, like kelp and sea
lettuce, combined with nutrient-dense cereal
grasses and 25 billion probiotics at the time
of bottling. And with the addition of organic
maca, burdock root, ginger, aloe vera, cayenne
and organic flax and chia seed, Chocolate
Protein Raw Reserve is a nutritious, vegan
way to introduce free-radical fighting plants
and herbs to the diet, plus 14 grams of non-soy
plant-based protein. All Amazing Grass products are raw, vegan
GMO- and gluten- free, and USDA and Ecocert certified organic.
Also available in Vanilla flavour. For more information call
08450 725 825 or visit www.kinetic4health.co.uk
Bio-Kult Canda confronts
candida
Bio-Kult Canda is a scientifically
developed seven strain probiotic
that is proven to survive the
high acidity of the stomach and
reinforce the gut microflora,
helping to prevent Candida from
finding binding sites in the gut to
grow. These bacteria lower the
gut pH so that Candida cannot
thrive, as it prefers a more
alkaline environment. It also
contains garlic and grapefruit
seed extract, well known
for their naturally powerful
properties. Canda does not
need to be refrigerated and can
be taken alongside antibiotics, by babies, when pregnant, by
vegetarians and as part of a healthy diet. www.bio-kult.com
JANUARY 2016 I cam-mag.com 35
 camclassified
products
A-Z NUTRITIONAL HEALTH
SOLUTIONS
THE REALLY HEALTHY COMPANY
LTD
1 Larch Court, Royal Oak Yard
Bermondsey Street
London SE1 3GB
Tel: 020 8480 1000
Email: sales@healthy.co.uk
www.healthy.co.uk
We supply a specialist range
of effective therapeutic food
supplements, including natural
immunomodulators, detoxifiers,
antioxidants, anti-inflammatories
and green superfoods providing
practitioners with effective tools
for their clients. Products include:
Biobran MGN-3; the full range of
Premier Research Labs products; the
Medpro range including Prostasol,
Imupros, I3C and Prostectan,
which together with Biobran
are used in the Pfeifer protocols;
Natto NKCP for a healthy vascular
system; organic Klamath Blue
Green Algae, Spirulina and Chlorella
combinations; AlphaGuard, for
complete antioxidant support;
AlphaCurcumin, a super-absorbable
curcumin complex; AlphaProst, for
full prostate support; and Flowease,
pollen extract for urinary support.
HERBAL REMEDIES
HELIOS HOMEOPATHY LTD
97 Camden Road, Tunbridge Wells,
Kent TN1 2QR
Tel: 01892 537254
8 New Row, Covent Garden
London WC2N 4LJ
Tel 0207 379 7434
www.helios.co.uk
Celebrating 28 years as one of
the UKs leading homeopathic
pharmacies, Helios remedies are
prepared by hand to traditional
methods. We employ qualified
homeopaths throughout, providing
a unique working environment with
a high level of expertise both for
remedy preparation and customer
advice. In addition, we manufacture
a range of remedies, kits and creams
available at trade prices for re-sale
through clinics, pharmacies and
health stores.
36 cam-mag.com I JANUARY 2016
NUTRITIONAL SUPPLEMENTS
HEALTHAID LTD
HealthAid House, Marlborough Hill,
Harrow Middlesex HA1 1UD
Tel: 0208 4263400
Fax: 0208 4263450
Email: sales@healthaid.co.uk
www.HealthAid.co.uk
HealthAid is one of UKs premier
manufacturers of nutritionally balanced
supplements. The range comprises
of Vitamin, Mineral, Herbs, Essential
aromatherapy oils and natural Bodycare
products. Established over 30 years
ago, with an extensive product portfolio
of 500 products. Providing nutritional
health solutions to meet the demands
of a modern lifestyle. HealthAid is
dedicated to supplying products
of the finest quality that have been
comprehensively researched, using
unique and innovative formulations,
which contains high grade quality
ingredients, produced to GMP
standards, supported by across-the-
board distribution network, with
experienced sales, marketing and
technical expertise. Call 0208 4263400
for an information pack
NUTRI ADVANCED LTD
Meridian House, Botany Business
Park, Macclesfield Road, Whaley
Bridge, High Peak SK23 7DQ
Tel: 0800 212 742
Fax: 0800 371 731
Email: info@nutri.co.uk
www.nutri.co.uk
Nutri Advanced has been providing effective
nutritional supplements and exceptional
support to healthcare professionals for over
30 years. We supply over 130 specialist
products to thousands of practitioners and
their patients. Our most notable products
include Eskimo-3, our incredibly pure and
stable omega-3 fish oil from sustainable
sources, and our MegaMag range, high
strength magnesium formulas. We also
work closely with Metagenics, the worlds
largest manufacturer of practitioner
supplements. Nutri are industry leaders in
education and provide a comprehensive
educational programme each year, including
live seminars with some of the leading
names in functional medicine, webinars and
interactive training. Our team of qualified
Nutritionists who form our technical
helpline, unbeatable customer service and
quality assured products all set Nutri aside
from competitors. Call us to receive your free
practitioner introductory pack.
NUTRIVITAL
Petersfield
Hampshire GU31 4JD
Tel: 01730 233414
enquiries@nutrivital.co.uk
www.nutrivital.co.uk
The NutriVital range consists of
around 90 products to neatly span the
needs of your practice, and includes
excipient-free capsules, liquid herbals
and homeopathic complexes. Our
formulations emphasise the best
nutrient-forms and use no animal
products.
We offer you the highest standards
of service, with same-day dispatch for
web and phone orders placed before
3pm.
Among our best-loved products
are the Paragon cleansing formula
and our highly-regarded B-complex.
More than just a product supplier,
NutriVital is also a thriving clinical
practice and provides support and
training to help you bring together
the benefits of nutrition and energy
medicine.
Please call for samples or a
practitioner pack.
REVIVE ACTIVE PRODUCTS
Unit 5/6 Kilkerrin Park 3, Liosban
Industrial Estate, Tuam Road, Galway,
Ireland
Tel: 0800 901 2152
www.reviveactive.com
Winners - Beauty Short List Award 2014
for Best Health Breakthrough Nutritional
Product. Galway Natural Health Company
was established in January 2011 by Daithi
OConnor and Liam Salmon with a combined
50+ years in Management, Pharmaceutical
and Medical Devices Industries. Revive
Active was formulated by Liam and Daithi
in conjunction with a team of doctors and
scientists. It is a revolutionary Health
Food Supplement containing a powerful
combination of Amino Acids, Vitamins and
Minerals. It is conveniently packed in single
dose sachets which dissolves easily in water
or juice. Revive Active promotes normal
heart function, Immune system support and
Natural Sustained Energy with Co Enzyme
Q10 and B Complex Vitamins. Also available
Revive Active Krill Oil.
VITABIOTICS LTD
1 Apsley Way, London, NW2 7HF
Tel: 020 8955 2600
Fax: 020 8955 2602
Email: customerservices@vitabiotics.com
www.vitabiotics.com
Vitabiotics is the UKs fastest growing major
vitamin supplement manufacturer, as well as
being the overall number 1 VMS Company
by value sales in the UK. Vitabiotics also
exports to over 100 countries worldwide
and are regularly used and recommended
by health practitioners. Vitabiotics has been
manufacturing leading consumer healthcare
products for over 40 years and have created
a unique portfolio of products at the forefront
of scientific developments in key sectors,
including life stage nutrition and womens
health. Vitabiotics has been recognised for its
pioneering work by becoming the first and
only vitamin business to receive a coveted
Queens Award for Enterprise in Innovation.
All products are designed to provide
maximum efficacy by supporting the human
body in its own natural processes. The
Vitabiotics range includes market leading
brands including Perfectil, Osteocare,
Menopace and Pregnacare. The formulations
are based on solid scientific research, proven
in clinical trials conducted in the UK and
are manufactured under pharmaceutical
quality control. In addition Vitabiotics works
closely with some of the UKs best known
and most trusted healthcare organisations
and charities including the Royal College of
Midwives, National Osteoporosis Society and
the National Childbirth Trust (NCT).
PRACTITIONER SUPPLIES
BIOCARE
Lakeside, 180 Lifford Lane, Kings Norton,
Birmingham, West Midlands B30 3NU
Tel: 0121 433 3727
Fax: 0121 433 8705
Email: customerservice@biocare.co.uk
www.biocare.co.uk
BioCare - the leading producer of
innovative and high quality nutritional
supplements in the UK. The BioCare
range offers over 220 products formulated
using unique manufacturing processes
such as emulsification, micellisation,
microencapsulation and freeze-drying to
maximise nutrient integrity, absorption
and bio-availability. BioCare supplements
are the preferred choice of nutrition
practitioners, health professionals and
retailers with a professional interest in
nutrition. Formulations are based on current
medical, scientific and nutritional research
backed up by many years experience in
naturopathic and nutritional practice.
BioCare has an ongoing commitment to
education and holds regular practitioner
seminars around the UK and in the Republic
of Ireland.

BIO-PATHICA LTD
PO Box 217, Ashford, Kent TN23 6ZU
Telephone: 01233 636678
Email: products@biopathica.co.uk
www.biopathica.com
Formed in 1996, Bio Pathica Ltd
are Sole Distributors and Importers
for The Anti Homotoxic Remedies
manufactured by HEEL GmbH in Baden
Baden Germany. They also import and
solely distribute synergistic products
such as Probiotics from WASA Medicals
in Sweden - Spirulina, Chlorella and a
range of Natural Skincare Products from
Sanatur in Germany. In addition they
use a manufacturing pharmacy to have
homoeopathic products manufactured
on an individual basis. All of these
products can be effectively used by
professionals in all fields of Medicine,
Veterinary and Dental Practice. The
business is run with Customer Service
and Satisfaction as its main objective.
Supplies are generally despatched within
24hrs of receiving an order. The supply
of products is limited to Practitioners
and Professionals only. In association
with Bio Pathica - The International
Academy for Homotoxicology offer
a free online Introductory Course in
Homotoxicology. For more course details
visit www.iah-online.com
CYTOPLAN LIMITED
Unit 8 Hanley Workshops,
Hanley Road, Hanley Swan,
Worcestershire WR8 0DX
Tel: 01684 310099
Fax: 01684 312000
www.cytoplan.co.uk
Cytoplan An exclusive practitioner-
dedicated company specialising in a
unique range of food-based products
which are exceptionally bio-effective. The
founding principle of Cytoplan is to base
product development on the increasing
awareness through science that nature
know best. This means we seek to create
natural products that optimise support
for the many body systems, as we believe
completely in the bodys wonderful self
healing ability when properly supported.
We are currently working with scientists
and Doctors in the development of
wholefood, phytonutrient and detox
formulae at the cutting edge of the most
recent scientific research. Cytoplan
products are conceived by common
sense, grounded in science and proven
with results. Our products are for those
who are serious about health, trust that
nature holds the key to real health and
want a company they can believe in.
HADLEY WOOD HEALTHCARE LTD
28 Crescent West
Hadley Wood
Barnet
Herts. EN4 0EJ
Tel: 0208 449 1113
Fax: 0208 449 2113
Email: info@hhcproducts.co.uk
www.hhcproducts.co.uk
Supplying practitioners with
specialist products has been our
mission for over 20 years. During this
time we have introduced high quality
product ranges from well known
brands such as Acidophilus Pearls,
Enzymatic Therapy, Natures Way, ITI,
Natural Factors as well as specialist
products like Dr Shamsuddins IP6
with Inositol formula, Phytogen,
ST-Repair and Organic Red Yeast.
We actively support the individual
practitioner and small independent
business through our no minimum
order policy and friendly one to
one telephone support and product
advice service where needed. If you
are looking for a fresh range for clinic
or business lets chat. Please call and
talk to one of our practitioner and
trade account team today!
HEALTH INTERLINK LTD
Interlink House, 22 Digby Drive,
Leicester Road Industrial Estate,
Melton Mowbray, Leicestershire
LE13 0RQ
Tel: 01664 562454
Fax: 01664 563561
Email: info@health-interlink.com
www.health-interlink.com
Importers and distributors of
the highest quality nutritional
and herbal formulations since
1994. Our aim has always been to
provide our clients with the purest
most innovative and bio-available
products available. We are the UK
distributor for Thorne Research Inc.
the most respected manufacturer
of truly pure nutritional and herbal
formulations in the world - Jarrow
Formulas who have developed an
exceptional variety of economically
priced quality products - Garden of
Life specialising in complete whole
food nutrition. Our pricing policy,
discount structure, practitioner
preference and loyalty schemes and
patient direct prescription service
are second to none. Our bespoke test
kit service for Applied Kinesiologists
is extremely popular and continues
to expand daily.
camclassified
HIGHER NATURE
Burwash Common,
East Sussex, TN19 7LX
Orders: Freephone 0808 178 8614
Nutritional Advice: 0870 066 4458
Fax: 0870 066 4010
Email: trade@highernature.com
www.highernature.com/practitioner
Higher Nature is an innovative,
independently owned UK company with a
long, outstanding reputation as pioneers
in nutrition. With an extensive range of
supplements, beauty products and health
foods, all developed for optimum health,
we are renowned for quality, integrity,
expert advice and excellent service.
All of our products are developed and
formulated by an experienced team of
nutrition specialists. Our Kids, Young
Adults, Mind Matters, True Food, Aeterna
Gold, Performax Sports and Omega
Excellence ranges are some of the most
advanced available. Our online education
academy, www.highernatureacademy.
com , offers free CPD accredited nutrition
information to suit all levels . And why
not register your practice for free on our
nutritional database, www.nutripeople.
com and sign up to receive all the latest
research as well.
LAMBERTS HEALTHCARE LTD
1 Lamberts Road, Tunbridge Wells,
Kent TN2 3EH
Tel: 01892 554313
Fax: 01892 515863
Email: ordering@lambertshealthcare.
co.uk
www.lambertshealthcare.co.uk
Lamberts has been supplying nutritional
and herbal supplements for over 25 years.
We are the leading experts in nutrition,
producing the highest quality products in
some of the most modern and technically
advanced factories in Europe. These operate
to stringent pharmaceutical standards of
Good Manufacturing Practice (GMP) and
are approved by the UK Department of
Health, Medicines and Healthcare Products
Regulatory Agency (MHRA). Lamberts
philosophy of healthcare is all about sound
science we only develop products that are
at the relevant potency, based on an in-depth
understanding of the latest nutritional
research. And we have a range of over 150
products including vitamins, minerals, amino
acids, digestive aids, essential fatty acids
and herbs, as well as specialist formulas. We
also provide training and support to many
practitioners, including one-to-one training
and seminars which are recognised for CPD
hours by the British Association for Applied
Nutrition & Nutritional Therapy (BANT)
and the Naturopathic Nutrition Association
(NNA). For further information or to receive
a practitioner pack, please call us on 01892
554313.
PHARMA NORD (UK) LTD
Telford Court,
Morpeth, NE61 2DB
Tel: 01670 534900
Fax: 01670 534903
Email: uksales@pharmanord.co.uk
www.pharmanord.co.uk
Pharma Nord is one of Europes largest
manufacturers of preventative nutrition
and dietary supplements. The company
develops, manufactures and markets
scientifically well founded dietary
supplements based on optimal bio-
availability, safety and documentation.
Pharma Nords research database
contains more than 8,000 scientific
studies - including a large number of
studies conducted with Pharma Nords
own preparations. The database is the
cornerstone of product development
and the entire product range without
exception are manufactured in
accordance with the current GMP (Good
Manufacturing Practice) guidelines. All
Pharma Nord products are blister packed
to ensure the active ingredients are not
exposed to the atmosphere and maintain
100% of their efficacy over time. Technical
support and training is available via a team
of experts which includes BANT accredited
nutritionists. Pharma Nords customer
service team is available to answer your
calls and queries, Mon-Fri, 9am-5pm and
if you order before 2pm Pharma Nord
guarantees shipment that same day.
RIO TRADING COMPANY LTD
Unit 2, Centenary Estate, Hughes
Road, Brighton. BN2 4AW
Tel: 01273 570987
Fax: 01273 691226
Email: info@riohealth.co.uk
www.riohealth.co.uk
Rio Trading is a supplier and
distributor of natural products from
around the world, specialising in
a wide range of whole plant South
American botanicals, including Pau
dArco (Lapacho), Suma (Pfaffia) and
Rosa Mosqueta (Rosehip seed oil).
The Rio Amazon collection consists
of botanical extracts and superfoods
including Maca, Graviola (soursop),
Quebra Pedra and the award-
winning organic skincare range Rio
Rosa Mosqueta. Rio Trading is the UK
distributor for Silidyn, Green Magma,
Epigenar and Nutramedix.
JANUARY 2016 I cam-mag.com 37
 camclassified
SOLGAR VITAMIN & HERB
Aldbury, Tring, Hertfordshire HP23
5PT
Tel: 01442 890355
Fax: 01442 890366
marketinguk@solgar.com
www.solgar.co.uk
Since 1947 in the USA, Solgar
has been dedicated to innovative
research and development and
state-of-the-art manufacturing
of nutritional supplements to
the highest standards. Today,
Solgars guiding principles remain
unchanged. With an in-house
laboratory and stringent quality
control procedures, Solgars gold
label is recognised as the ultimate
symbol of quality and potency
worldwide. Solgar Vitamins award-
winning range of more than 450
nutritional supplements is backed
by comprehensive distribution,
customer care, sales, technical and
strategic marketing support.
THE NATURAL DISPENSARY LTD
26 Church Street, Stroud,
Gloucestershire GL5 1JL
Tel : 01453 757792
Fax : 01453 751402
Contact: Michael Hill
Email: enquiries@naturaldispensary.
co.uk
www.naturaldispensary.co.uk
The Natural Dispensary is a
Nutritional Supplement Mail Order
Company, dedicated to Practitioners
and their Clients. With over 10,000
Practitioner prescribed products
under one roof, our aim is to provide
an efficient One Stop Service. As
a registered Practitioner, you can
benefit from favourable Practitioner
prices and only one account to
manage. Both you and your Clients
can save time and effort, as well as
postage and packaging, by buying
different brands of supplements from
only one distributor. Registration and
ordering are available via website,
telephone, fax or email and delivery is
direct to your clinic or Clients. Please
get in touch, we are here to help.
38 cam-mag.com I JANUARY 2016
BIOENERGETIC SYSTEMS
QEST INTERNATIONAL LTD
Worcester House, 4 Dragon Street,
Petersfield, Hampshire GU31 4JD
Tel: +44 (0) 1730 237248
info@qest4.eu
www.qest4bioresonance.com
Qest4 is the latest innovation
in bioresonance technology,
helping you to complete a swift
and comprehensive bio-energetic
evaluation for your clients.
Qest International brings 20
years experience working with
energetic testing systems, and is
the UK and European distributor
and training provider for Qest4 and
Asyra technology.
We hold regular demonstrations,
training and workshops for
practitioners in the UK and in other
European centres.
So, to find out how the Qest4
can grow and transform your
natural health practice by achieving
quicker insight and faster results
for your clients, please give us a call.
PROBIOTICS
BIO-KULT PROBIOTICS
(PROTEXIN)
Lopen Head, Somerset, TA13 5JH
Tel: 01460 243230
Fax:01460 249543
Email: info@bio-kult.com
www.bio-kult.com
Bio-Kult and Bio-Kult Canda
are manufactured by probiotic
specialists Protexin. Bio-Kult is a
unique, multi-strain probiotic with
14 strains of beneficial bacteria,
expertly formulated to help maintain
healthy digestive and immune
systems.
Bio-Kult Canda is a probiotic
supplement with grapefruit seed
extract and garlic - taken daily it can
help strengthen the bodys natural
defenses against Candida. Protexin
is dedicated to ongoing research
and development and has 20 years
experience of manufacturing a broad
range of probiotic supplements.
Bio-Kult is available to the public
through health food stores; health
practitioners can contact Protexin
directly.
services
ASSOCIATIONS
BRITISH ASSOCIATION FOR
APPLIED NUTRITION AND
NUTRITIONAL THERAPY (BANT)
27 Old Gloucester Street, London
WC1N 3XX
Tel: 0870 606 1284
www.bant.org.uk
BANT is the largest non-profit body
representing Nutritional Therapy (NT).
This highly regarded professional body
welcomes members who seek to provide
the highest level of practice. Membership
benefits: Competitive BANT insurance
scheme Free Online access to the
Comprehensive Database and the Natural
Standard Database Code of Ethics and
Practice CNHC aligned Free listing in
the easy access online directory Free
webinars for CPD Mandatory CPD for
members in a bid to improve standards
and credibility of the profession Access
to PR, Marketing and Business Toolkits
Discounted CAM conferencesBANT
recognised CPD events, jobs and classifieds
Regular emails on key professional
information Consumer focused graphics,
posters and leaflets Monthly online
magazine. Access to contacts for your
local and regional media Regional support
groups Clinical Supervision Programme
Opportunities to contribute to shaping
the future of the industry BANT Council
working closely with official regulatory
bodies. If you are serious about nutritional
therapy join us today.
CThA - COMPLEMENTARY
THERAPISTS ASSOCIATION
598-608 Chiswick High Road, 2nd
Floor Chiswick Gate, London, W4 5RT
Tel: 0845 202 2941
Fax: 0844 779 8898
Email: info@ctha.com
www.ctha.com
The Complementary Therapists
Association (CThA) is the leading
organisation representing
Complementary Therapists in UK and
Ireland. As CThA members Therapists
receive a quarterly Magazine, with
the latest information on Exhibitions
and Seminars. Free membership of
the UKs largest online directory of
Complementary and Beauty Therapists,
www.embodyforyou.com
Members have access to Local Groups &
Forums giving then the opportunity to
meet with like minded Professionals.
Access to Discounted Rates on Insurance.
CRANIOSACRAL THERAPY
EDUCATIONAL TRUST
78 York Street, London W1H 1DP
Tel/fax: 07000 785778
Email: info@cranio.co.uk
www.cranio.co.uk
Course Director: Michael Kern D.O.,
R.C.S.T., N.D. author of Wisdom In The
Body The Craniosacral Approach To
Essential Health.
The Craniosacral Therapy Educational Trust
has been providing practitioner trainings
in Craniosacral Therapy since 1989 and
is established as a school of excellence
offering in-depth courses in a clear and
accessible way. This two-year part time
training is presented by a team of highly
experienced teachers in a supportive and
creative environment. An emphasis is placed
on developing practical skills that work
with the essential factors that govern our
health, and supporting our innate capacity
for health. Courses start each Autumn and
are fully accredited by the Craniosacral
Therapy Association and the International
Affiliation of Biodynamic Trainings. Also,
regular introductory weekends. Plus
Living Anatomy - an experiential eight-
weekend foundation course in Anatomy and
Physiology starting each January.
THE BELMONT HYPNOTHERAPY
CENTRE
Belmont Centre, 46 Belmont Road,
Ramsgate, Kent, CT11 7QG
Tel: 01843 587929
Email: belmontcentre@btconnect.com
www.belmont-centre.co.uk
There are many misconceptions about
hypnosis, however, there is nothing magical
or mystical about the practice of hypnosis.
Hypnosis is a natural state, achieved in
deep levels of relaxation, during which it is
possible to communicate directly with the
subconscious mind. When people are in this
hypnotic state, it is possible to instruct the
subconscious to bring about the behavioral
changes needed, whether it is to quit smoking
or to source why you are feeling the way
you are. All who train with Jean Murton and
her students learn to deal with their own
problems as well as gaining the skill and
confidence to help others to over come any
psychosomatic issue that have reduced or
even destroyed the quality of their lives. For
more information call 01843 587929 or visit
www.belmont-centre.co.uk or email
Belmontcentre@btconnect.com
Condensed courses designed to offer
professional qualifications; schedule sessions
which are arranged to accommodate your
existing commitments.

INDEPENDENT PROFESSIONAL
THERAPISTS INTERNATIONAL
PO Box 106, Retford DN22 1WN
Tel: 01777 700383/703177
Fax: 01777 869429
Email: mail@iptiuk.com
www.iptiuk.com
IPTI is an association that has
been providing insurance cover for
therapists since 1982. Membership
and insurance is available for
practitioners of Alternative/
Complementary Therapies, Beauty
Therapists, Hairdressers and
Fitness Professionals. The IPTI
policy includes Malpractice &
Professional Liability, Public Liability
and Products Liability all in one
package, at a very competitive price.
The policy can offer cover up to 5
million indemnity and can also cover
for working abroad. The teaching
of workshops and practitioner level
courses is also covered under the
policy. Students may also join IPTI
and all members receive copies
of our chatty and informative
newsletter.
DISTRIBUTOR
KINETIC NATURAL PRODUCTS
DISTRIBUTOR
1 Central Park, Central Way, London
NW10 7FY
Contact: Alexander Barani
Tel: +44 (0)845 072 5825
Fax: +44 (0)845 072 5826
Email: sales@kinetic4health.co.uk
www.kinetic4health.co.uk
Kinetic supplies ethical and
specialised herbal and dietary
supplement brands to the natural
products industry. Leading dietary
supplements and herbal brands
include; Natures Answer, pioneers in
standardised and non-standardised
alcohol-free and low-alcohol liquid
herbal extracts, liquid nutritional
supplements, and superfoods and
oral care products; Renew life,
specialist products for digestive
care and detoxification; Emergen-C
from Alcer No1 selling effervescent
vitamin C supplement, Terra Nova,
holistic yet scientifically based
enhanced nutritional supplements;
Nutiva the No 1 leading organic &
coconut food brand and Organic
Food Bar probably the best raw bar
on the market.
NAP4EU LTD
14 North Parade, Penzance,
Cornwall TR18 4SL
Tel: 01259 743 255
Fax: 01259 743 002
info@right4eu.com
www.right4eu.com
NAP4EU Limited is the EU
distributor of products manufactured
in the USA by North American
Pharmacal Inc. These products are
created by Dr. Peter DAdamo N.D.
who is the author of The Blood Type
Diet, The Genotype Diet and other
publications on Nutrigenomics.
NAP4EU sells diagnostic test kits, a
variety of educational materials and
the worlds first truly individualised
food supplements and cosmetics.
We are all unique biochemical
individuals and we need to profile
our nutrition accordingly in order
to optimise the health potential
inherent in our genetic makeup.
Blood type is a valuable genetic
marker, and functions as the gateway
to our immune system and metabolic
needs. Nutrition is the ultimate
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New Vistas Healthcare is Irelands
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JANUARY 2016 I cam-mag.com 39
 cam gut health
Parasites that heal:
what our old friends
can do for us
In our third article examining the health implications of parasite infections, naturopath EMMA LANE
looks at some of the research around the positive effects of these fascinating hitchhikers.
W
hile there is no doubt that
parasites can cause serious
health problems, it is now
understood that as a result
of the hosts protective
response, some worms can actually help the
human immune system. The evidence for
this is so strong that over the past few years
a number of studies have tested worms for
clinical benefits.
During the past ten years, studies have
found that certain helminth infections protect
against the development of allergic diseases.
(A helminth is a parasitic worm.) Several
clinical trials investigated the effects of
deliberate exposure to parasites like porcine
whipworm (Trichuris suis) (Summers, 2003,
2005) or hookworm (Necator americanus)
to develop helminth therapies (Feary,
2010). They proved to be a safe option to
control aberrant inflammation. The goal of
researchers is now to identify the parasite-
derived immunomodulatory molecules
responsible for the protective effects.
One of the earliest insights was from
researcher John Turton, who in 1976 noted
the absence of his own normally pronounced
hay fever attacks during two summers in
which he was infected with hookworms;
he wrote a paper for The Lancet describing
his experience. He had deliberately infected
himself in order to rear larvae for his own
research (Turton, 1976).
A University of Nottingham study involving
parasites (Scrivener et al, 2001) focused
on hookworm and asthma; in America,
scientists have explored whipworms effects
on ulcerative colitis and Crohns disease
(Summers et al, 2005, 2003). At the University
of Cambridge, a study examined how the
tropical worm which causes the parasitic
disease bilharzia could modulate type 1
diabetes (Zaccone et al, 2010). All the studies
40 cam-mag.com I JANUARY 2016
showed positive outcomes and suggest that
worms and other organisms, through our
evolutionary history, have developed a role in
driving our immune systems.
Wilson and colleagues, in a 2005 study,
showed that worms in the gut can keep
allergies at bay. They found that mice infected
with the helminth H. polygyrus activated
regulatory T-cells in the gut. These T-reg cells
were dispatched to the lungs, where they
dampen the immune response to inhaled
allergens. The study reported significantly
reduced airway inflammation in the infected
mice (Wilson, 2005).
A 2007 study showed beneficial
immunomodulation in humans with multiple
sclerosis when they were infected with
helminths (Correale, 2007).
Effects on IBD
In 2010, scientists at the University of
California, San Francisco published a
comprehensive cellular and molecular
analysis of changes in the intestinal mucosa
of a patient with irritable bowel disease.
Active colitis was associated with T-helper
cells producing IL-17 and expression of
pro-inflammatory genes such as IL-17 and IL-
13RA2. However, during parasitic colonisation
with the human whipworm T. trichiura, the
colitis remitted and there was a decrease in
IL-17-producing cells and a dramatic increase
in IL-22-producing cells. They also saw a
relative reduction in pro-inflammatory gene
expression (Broadhurst, 2010).
Researchers are excited that parasites, and
their secreted products, could be used to treat
inflammatory diseases. Consequently, live
helminths are currently employed in at least
15 clinical trials in efforts to alleviate allergic
and autoimmune disorders. (See the 2013
review by Khan and Fallon in the International
Journal for Parasitology).
Bacteria and worms from healthy people
and animals have been transplanted to
stimulate a healing response in unhealthy
organisms especially in regards to
inflammatory diseases. A study published by
Duke University in April this year added new
insight into parasites and their potential. (Pi,
2015).
The researchers hypothesised that
enhancing biodiversity in laboratory rats,
including treating the rats with worms,
would suppress their immune systems. But
the results were the opposite. They found
enhanced, rather than suppressed, immune
function and increased biodiversity. The
findings add to the growing understanding of
the complex environment in the digestive tract
and its role in maintaining health.
Senior author William Parker, PhD, said the
study suggests that biome enrichment might
serve as an immune trainer to improve
immune function and overall health: In our
clean environment, rats and by extension
humans, are not doing well. We are potentially
seeing a decreased ability to respond to
dangerous antigens while, at the same time,
we respond to things that we shouldnt,
causing allergies and autoimmune problems.
This work demonstrates we all may really
need better biodiversity introduced back in
the system.
The hygiene hypothesis that our over-
clean environment is causing allergies has
been expanded. There are now good reasons
to think that a whole range of autoimmune
disorders are a result of our diminished
exposure to organisms like helminths.
Prof Graham Rook, from the Centre for
Clinical Microbiology, University College
London, developed the old friends version
of the hygiene hypothesis in 2003. He
said: The rise in allergies and inflammatory
diseases seems at least partly due to gradually
 The rise in allergies and inflammatory diseases
seems at least partly due to gradually losing contact
with the range of microbes our immune systems
evolved with, way back in the Stone Age. Only now
are we seeing the consequences of this, doubtless
also driven by genetic predisposition and a range of
factors in our modern lifestyle - from different diets
and pollution to stress and inactivity. Prof Graham Rook,
Centre for Clinical Microbiology, University College London.

losing contact with the range of microbes our
immune systems evolved with, way back in
the Stone Age. Only now are we seeing the
consequences of this, doubtless also driven by
genetic predisposition and a range of factors
in our modern lifestyle from different diets
and pollution to stress and inactivity. It seems
that some people now have inadequately
regulated immune systems that are less able
to cope with these other factors.
Rook suggests that the old friends include
commensal organisms (the normal microbiota
of the skin, gut and respiratory tract of
humans) and some potentially pathogenic
organisms such as helminths (worms), which
can establish chronic infections. These latter
have to be tolerated, because attempts by the
immune system to eliminate infections that it
cannot remove only leads to pointless tissue-
damaging inlammation.
Prof Rook said that it now looks more
and more likely that the development of
our regulatory immune system depends on
molecules that are encoded not in the genome
of the human, but in the genome of some other
organism we lived with throughout history.
(Rook GA. 2010).
Scientists are now suggesting that we
need constant exposure to a diverse range of
old friends, not just speciic microbes. The
most likely explanation of this need for daily
exposure to microbes, particularly in early life,
is because they interact with the regulatory
systems which keep our immune systems in
balance. Without this our immune systems
may overreact, react inappropriately, or fail to
switch off completely when no longer needed,
which is an underlying cause of these diseases.
Prof Jan Bradley, a parasitologist from the
University of Nottingham, said: If you dissect
any free-living organism it has worms. Its full
of them, in its blood, in its guts, everywhere.
Prof Bradley continues: It is only in the last
50 years in Britain that humans have been free
of worms. In the past we would have eaten
our own sewage through contaminated water
systems or spreading it on crops. Even getting
bitten a lot by insects would help to keep a
healthy amount of worms in our system. We
have evolved to have worms. Worms can have
unpleasant consequences but also maybe
theres a positive side that we can exploit in
new therapies for allergies.
In 2014, Prof Bill Gause, Rutgers New Jersey
Medical School, and colleagues showed that
intestinal helminth infection may indirectly
affect inlammation by inluencing the
composition of the intestinal microbiome.
Studies suggest that intestinal helminth-
induced responses have potent systemic
effects on the immune system, raising the
possibility that whole parasites, or speciic
molecules produced by them, may be an
important resource for the development
of future immunotherapies to control
inlammatory diseases (Mishra, 2014).
Cross-talk with the microbiome
While it appears some worms can actually help
the immune system of their hosts, very little
was known about how worms interact with
the hosts immune system. However a new
study from the Ecole Polytechnique Fdrale
de Lausanne (EPFL) shows that these effects go
through the guts bacteria (Zaiss M, 2015).

JANUARY 2016 I cam-mag.com 41

 cam gut health
The EPFL laboratory has shown that
the anti-inflammatory activity of intestinal
helminths involves cross-talk with the
microbiome. The researchers looked at the
effects of helminths that infect pigs. After
chronic infection with the helminths, they
discovered that the animals metabolism had
been changed drastically: specifically, they
produced increased levels of short-chain
fatty acids. These SCFAs produced by the
microbiome can activate a family of receptors
that in turn influence the immune system.
The receptors are also known to contribute
to certain functions and malfunctions of the
colon, and are even involved in modulating
allergic airway disease.
The same results were found when they
monitored cells in the immune system of
mice that had been infected with a helminth.
Further testing showed that these acted on the
same receptors to influence specific immune
cells. In short, the researchers uncovered
a clear link between worm infection, the
microbiome and the immune system.
The work highlights the microbiome as a
new pathway through which helminths could
influence the immune function of the host.
Prof Nicola Harris of EPFL said: Its not the
whole story, but it opens up an additional,
intriguing way to explain, and perhaps exploit,
the strategy with which intestinal worms
communicate with the hosts immune system.
A review published in Nature showed
there is increasing evidence that intestinal
helminths can control harmful inflammatory
responses and promote homeostasis by
triggering systemic immune responses
(Maizels 2003). Induction of separable
components of immunity by helminths, which
includes type 2 and immune regulatory
responses, can both contribute toward
the reduction in harmful type 1 immune
responses that drive certain inflammatory
diseases. Despite inducing type 2 responses,
intestinal helminths may also down-regulate
harmful type 2 immune responses, including
allergic responses.
In conclusion
In conclusion, it seems that our declining
exposure to helminths and increasing
bacterial dysbiosis, alongside the overuse of
antibiotics and poor dietary choices, have all
contributed to the rising incidence of immune
and metabolic inflammatory disorders in
industrialised countries.
Parasites can be friends or foes; however
what is very clear is that we need to make
better lifestyle choices on a daily basis in
order to create a more desirable balance in
42 cam-mag.com I JANUARY 2016
Whipworm and autism: one
boys symptoms disappear
Stuart Johnson, an American father of a
severely autistic child, has made a significant
connection between the eggs of the
whipworm and autism.
His son, Lawrence, displayed many typical
autistic behaviours, such as no interaction
with other children, fixations, poor impulse
control and self-abusive behaviour. As he
matured, his agitation, anxiety and self-
abusive behaviours became more severe,
and he also had a number of severe allergies.
Stuart observed that the autistic behaviours
improved when his son had a fever or cold.
Equally, his behaviours would become more
severe when his seasonal allergies were at
their worst.
The tipping point came when his son went
to summer camp. Instead of having to collect
him after a day or two, the boys behaviour
improved to such an extent that he was able
to stay for the whole week. When he collected
Lawrence, he found his sons legs were
covered in Chigger bites, which cause a very
powerful immune response in humans. His
autistic behaviour was significantly reduced,
but returned once the bites healed.
our health and environment. It may also be wise
to show respect towards parasites. We are only
at the very beginning of our understanding of
their potential benefits for humans, however
when there is a parasitic overgrowth that is
causing negative symptoms for the individual it
must be addressed appropriately.
In the next and last article in the series
we will take a close look at when and how to
appropriately address parasites when they are
causing challenges to a persons health and
wellbeing. cam
References online at www.cam-mag.com/references.
This set Stuart on a path of research
that led to a number of studies relating to
ulcerative colitis and Crohns disease, all of
which involved introducing helminths in the
form of porcine whipworm eggs (Trichuris
suis ova, or TSO) to patients.
Researchers thought that TSO could
down-regulate the human immune
response, which Stuart felt was the reason
why his sons behaviour changed with the
Chigger bites and when he was unwell with
fevers.
After discussion with Dr Eric Hollander,
Director of the Seaver and New York Autism
Center of Excellence and Chair of the
Department of Psychiatry at Mount Sinai
Medical Center in New York, Lawrence was
treated with TSO ova. After eight weeks
on a dose of 2500 ova bi-weekly, they saw
significant improvements in Lawrences
behaviour. After ten weeks the symptoms had
disappeared. The treatment has continued,
with no re-occurrence of symptoms.
Additionally Lawrences nut allergy and
seasonal allergies have disappeared.
http://autismtso.com.
About the author
Emma LanE, ND, Dip NT, CMTA, C.H.E.K IV,
HLC3, PEA, RSA, has more than 25 years
experience in the industry, working as a
naturopath, naturopathic nutritionist and
functional medicine practitioner. Emma has two busy
practices in the north of England and central London,
and is also the founder and director of Integrative Health
Education and PCI Europe. Emma regularly lectures
around the world and is passionate about sharing her
knowledge with other practitioners. She works closely
with Dr Omar Amin, a world-renowned professor of
parasitology. For more information about parasite testing
go to www.parasitetesting.co.uk. The World of Parasites,
Fungus and Bacteria course taught by Emma Lane: www.
integrativehealtheducation.co.uk.
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DECEMBER 2015 6 NOVEMBER 2015 6

Nutrigenomics Whats wrong with How to prevent See faces light up Mucosal Parasites on Missing E: Dysbiosis:
and pyrroluria: nutrition research? breast cancer: because someone immunology: the brain? why we a therapeutic
a pathway to the What we can learn get in early and understands! new truths about What accidents and need more In target in

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case unlocked and media headlines metabolism Practice moments the gut have in common syndrome colitis
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 cam hero

Personalised nutrition in the 1960s:

Dr William Kelly, metabolic typing and
the cancer cure that worked
When it comes to the effective alternative treatments that we use day in, day
out, we truly do stand on the shoulders of giants. But many newbies to the
CAM world dont know the history. We didnt get where we are today without
immense sacrifices being made by the pioneers, Knowing our roots matters.
CAM section editor REBECCA SMITH remembers CAM Hero Dr William Kelley,
the man who had personalised nutrition down back in the 1960s.

D
r William Donald
Kelley, DDS, MD, who
died ten years ago,
was an American
orthodontist who,
with a deep interest in medicine,
had studied in its many areas
since he was a child. Described
by the late Dr Nicholas Gonzalez
as an extraordinary brilliant
man, Kelley was a pioneer in
research relating to nutrition and
CAM methods to treat cancer,
beginning in the 1960s.
Through a long process over
many years, Kelley worked
out the relationship between
enzymes, minerals, co-enzymes
and proper detoxification
methods. And realised the
importance of this against cancer.
Kelley described cancer as
single disease, caused by a lack
of certain enzymes. He had his
own research and also used some
of Dr Max Gersons ideas in using
vitamins, minerals, pancreatic
enzymes, coffee enemas, prayer
and osteopathic manipulation in
his treatment regimes.
Pancreatic cancer
In the early 1960s, Kelley
himself faced news from his
own physician that he was soon
to die from a fast-spreading
pancreatic cancer He was told to
go home and prepare for death.
His mother travelled to live
with him and was said to rescue
him by removing all junk food,
sweets and cookies from his diet,
to which he admitted he was
addicted. They were replaced
with fresh produce, grains and
mostly raw fruits and vegetables.
In three months, Kelley was
back at work and he started to
realise that diet and cancer were
connected.
His new regime made him
healthier, but he still had cancer.
Reading one of Gersons books
led him to the research of John
Beard, an early 20th century
embryologist who had made
the connection between cancer
cells and pancreatic enzymes.
He proposed in 1906 that
pancreatic proteolytic digestive
enzymes represent the bodys
main defence against cancer, and
that enzyme therapy would be
useful as a treatment for all types
of cancer, explained Gonzalez,
who later reviewed Beards work
in the light of modern molecular
biology. ( In The Trophoblast
and the Origins of Cancer: One
solution to the medical enigma
of our time, written with Linda
Isaacs, MD).
To test the research, Kelley
took heavy doses of pancreatic
enzymes. He realised that he was
killing the cancer cells, but due
to the toxins the cancer released
upon death, he had Herxheimer
(healing crisis) reactions, which
made him feel very unwell. He
started using coffee enemas as a
way of detoxing his overworked
liver.
Kelleys road back to health
was a long trial and error process.
When he began to attract people
also failed by conventional
medicine, he started them on
the same diet regime that had
worked for him. One of these was
his then wife, but she got sicker
on his vegetarian diet; only when
he put his dogma to one side and
put her on good quality meat, did
she get better.
Kelley was man enough to
realise that he hadnt yet got the
answer. One diet didnt fit all,
no matter how many pancreatic
digestive enzymes you threw in.
More meticulous observation
and research followed, out of
which came his realisation that
people could be categorised
into different metabolic types.
This related to their particular
balance, or imbalance, in the
sympathetic and parasympathetic
nervous system.
Ten types
In One Answer to Cancer,
published in 1962, Kelley
proposes ten basic metabolic
types, which could be subdivided
into three groups:
Group A, which includes the
Sympathetic Dominant Metabolic
Types: one, four, and six these
are people best suited to a
vegetarian diet;
Group B, which includes the
Parasympathetic Dominant
Metabolic Types: two, five, and
seven, which Kelley called the
carnivore types; and
Group C, which includes
the Balanced Sympathetic/
Parasympathetic Metabolic
Dr William Kelly: pioneered
the enzyme and nutritional
treatment of cancer.
Types: three, eight, nine and ten,
who can handle a mix of foods.
Kelley was a fan of Dr Roger
Williams, the scientist who
came up with the concept of
biochemical individuality in the
1950s, but where Kelley went
with his study of types was far
beyond Williams and not only
remarkable in its own right, but
way ahead of discoveries to do
with genes and SNPs.
For each type, Kelley had not
only worked out what basic
diet they needed, but whether
it should be raw or cooked,
what nutritional supplements
they should take and he
recommended a lot and what
their mental, physical and
behavioural characteristics
would be.
Kelley wrote: Individuals are
classified into ten basic types,
which are named Metabolic
Types One through Ten. By
classifying each person into their
own proper type, it is possible
to determine accurately what
vitamins, minerals, foods and
other supplements would best
support his or her own body
chemistry. Equally important,
it is possible to know what
supplements and foods they
should not have. With the
knowledge of these factors, it
is possible to design a program

44 cam-mag.com I JANUARY 2016

that has the fullest potential.
All people fall into one of the
metabolic types, that is to say
they fall into one of the basic
ways the body functions. Each
persons body takes in food,
water and air. How a person
uses these raw materials to
maintain life differs from one
person to another. This function
of maintaining life is called
metabolism and is normally
defined as the sum total of all the
chemical reactions occurring in
the body.
Identifying a persons
metabolic type was not a quick
and easy matter. CAM editor
Simon Martin met Dr Kelley in
the 1970s, interviewing him for
a long feature in Heres Health
magazine, the first time Kelley
had been profiled in the UK.
Simon recalls:
Dr Kelley knew more about
nutrition and the human body
back then, than most of us
today. Kelley could pretty much
pinpoint your metabolic type
just by looking at you and asking
you a few innocent-sounding
questions, but the process
was resolutely scientific. If
you wanted to find out your
metabolic type, you were handed
a ring-bound manual the size of
a small telephone directory. That
was stuffed with hundreds of
questions that took around four
hours to answer. That then went
off to be marked and, if you were
lucky, you would have a metabolic
typing counsellor to guide you
through what was then required
in terms of diet and lifestyle, and
then you would be sent massive
amounts of supplements to take.
Personalised nutrition, sorted,
more than 40 years ago.
Ignored
Having cured himself in 1964
from his own metastatic
pancreatic cancer, having
helped other people heal from
supposedly terminal diseases,
having published One Answer to
Cancer, and having desperately
tried to get the medical and
cancer establishment interested
in running trials of his treatment,
Before the storm: Dr William Kelley (right) and a young medical student who was to become
Dr Nicholas Gonzalez, pictured in 1982; Dr Kelley very happy that finally his protocol was being
seriously investigated. (Picture from One Man Alone.)
you can guess what happened
next. First he was ignored, then
he was aggressively targeted.
At one point he was
investigated by undercover
officials posing as patients.
Soon after, the American Cancer
Society listed Kelleys therapy
protocols on their unproven
methods blacklist, where sadly,
yet unsurprisingly, it remains to
this day.
Despite the opposition,
patients continued to turn to
Kelley, often when all else had
failed and they were already
so weak from rounds of
chemotherapy and surgery that
there was little a nutrition-based
protocol could do for them.
One such was iconic actor Steve
McQueen, who consulted him in
the 1980s after being diagnosed
with an inoperable cancer of the
lung. McQueen did not follow
Kelleys regime strictly, but
nonetheless his tumour stopped
growing after eight weeks and he
started to put on weight. Kelley
claimed the actor was cured,
but McQueen went on to have
surgery under the pressure of his
medics, and died soon after.
Although Kelley remained
popular with many patients with
terminal cancer, McQueens death
sparked a vicious national media
assault on the cancer quack.
Bitter and broken, he quit
practising after 20 years, having
curing thousands of people, and
with documented cases to prove
it.
Kelleys protocols and his
metabolic typing not only
remain alive and popular with
the general public, thanks to
a bunch of websites who have
kept his original material
available (including a self-test
version of the metabolic typing
questionnaire), but are being
practised successfully in the CAM
world too, largely due to the late
Dr Nicolas Gonzalez, MD, who
ironically was originally involved
in a bid to debunk Kelley.
Gonzalez first met Kelley in
1981 after his second year at
medical school; an event, he said,
that changed my life forever. He
knew at once his approach (to
curing cancer with nutrition) was
what I wanted to study. In a CAM
magazine interview (November
2007), Dr Gonzalez remembers
wondering if Kelley was crazy or
brilliant, or crazy and brilliant.
He knew he was extraordinary.
Gonzalez looked into Kelleys
work at the urging of his then
supervisor and mentor, Dr
Robert Good, then president of
Sloane Kettering Hospital and
acknowledged as the father of
modern immunology. A summer
project turned into a five-year
study.
I went through 10,000 of
Kelleys records, interviewed
1,300 of his patients.
Unfortunately, no one believed
that anybody could reverse
cancer with nutrition. But clearly
Kelley was doing that, said
Gonzalez.
Alive for grandchildren
One case was a woman
with metastatic pancreatic
adenocarcinoma whose diagnosis
was confirmed at the Mayo Clinic.
She had biopsy-proven liver
metastases. Talking at the time
of the interview, Gonzalez told us
that she was still alive, 25 years
on, was well, and enjoying her
grandchildren. If she had been
treated with orthodox medicine
and survived even five years, the
academics would have held a
Press conference, and she would
have been on the cover of Time
magazine. But because some
crazy dentist who used coffee
enemas treated her successfully,
she just passed into oblivion in
terms of the orthodox medical
community.
Dr Gonzalez saw that he had
no option but to stand by his
findings (Dr Good distanced
himself from the results). As an
advocate of Dr Kelleys cancer
protocols which he developed
over the years Dr Gonzalez was
himself subject to investigation
and slander. His official clinical
trial of the enzyme treatment of
JANUARY 2016 I cam-mag.com 45
 cam hero
cancer was deliberately sabotaged (a story
documented in his 2012 book What Went
Wrong).
CAM reported (in February 2009): A
pilot study on his (Gonzalez) nutritional
programme for the treatment of pancreatic
cancer produced what have been called
the most positive data ever seen on the
fast-moving cancer for which orthodox
medicine has nothing to offer. The USAs
National Cancer Institute awarded $1.4
million for a controlled clinical study
comparing the Gonzalez protocol with
chemotherapy. However, after eight
years of work, Gonzalez is still unable to
produce results, and there are now two
investigations being run after what appear
to be deliberate attempts to sabotage
the results or to alter them to show
chemotherapy in a better light.
Kelley had his dentistry licence
suspended, was investigated by undercover
agents, spent a short time in jail, was
hounded by the national media. and
inally gave up practice. The situation has
not changed; CAM practitioners are still
enduring the batterings from the medical
establishment. As Nicholas Gonzalez said
in 2009: The idea that the academic
establishment is ready to welcome
well-meaning, well-intentioned, serious
alternative practitioners who are doing
serious research, just isnt happening...its
going to take a major nuclear explosion to
change the way they think.
Dr Gonzalez died unexpectedly last year.
His work and the legacy of Dr William
Kelley is being carried on at his New York
clinic by his colleague Dr Linda Isaacs. cam
Resources
The original self-test book has been
republished by Kettle Moraine, Ltd, and
is only available from them via http://
thebookshelf.us/the-books/dr-kelleys-
self-test.
One Answer to Cancer, the original,
is online at http://www.drkelley.com/
CANLIVER55.html#_Toc434239934.
You can nd details of two brilliant
books by Dr Nicholas Gonzalez:
One Man Alone: an investigation of
nutrition, cancer and William Donald
dr-gonzalez.com.
Kelley and What Went Wrong, at www.
Victory over Cancer is available from www.drkelley.
info.
About the
author
REBECCA SMITH has been in practice
25 years and is co-owner of Newport
Complementary Health Clinic in Shropshire. As a
Wellbeing Coach, she uses Systematic Kinesiology,
nutrition, hypnotherapy, and NLP (neuro-linguistic
programming), in which she also trains. She is
Section Editor of CAMs In Practice pages.
www.newportcomplementaryhealthclinic.co.uk.
46 cam-mag.com I JANUARY 2016
camresearch
JOINT HEALTH
Body clock study
gives new hope for
osteoarthritis
A University of Manchester biologist has for
the irst time established that the painful
and debilitating symptoms endured by
osteoarthritis sufferers are intrinsically linked
to the human body clock.
Dr Qing-Jun Meng, Senior Research Fellow
for Arthritis Research UK, has discovered
that body clocks within cartilage cells
chondrocytes control thousands of genes
which segregate different biological activities at
different times of the day.
The body clock, he realised, controls the
equilibrium between when chondrocyte
cells are repaired during rest and when they
are worn down through activity. As we age,
he suggests our cartilage cell body clocks
deteriorate, making the repair function
insuficient and that could contribute to
osteoarthritis.
Now we have identiied a link between the
human body clock and osteoarthritis, this could
unlock the prospect of drugs which reset the
body clock mechanism, says Meng. But there
are other body clock related approaches which
can help osteoarthritis sufferers: eating and
exercising at set regular times each day is also
something we think is a good idea.
Using heat pads that approximate body
temperature changes in cartilage tissue which
are too governed by the body clock is also
potentially useful.
His indings are published in the Journal of
Clinical Investigation (doi: 10.1172/JCI82755).
Dr Mengs team examined three types of human
cartilage under the microscope: normal, mildly
affected by osteoarthritis and severely affected.
As the osteoarthritis became more severe, the
number of cells that express BMAL1 a protein
which controls the body clock became fewer
and fewer.
Eating and exercising at
set regular times each day
is also something we think
is a good idea. Using heat
pads that approximate body
temperature changes in
cartilage tissue which are too
governed by the body clock
is also potentially useful.
Osteoarthritis and the body clock: researcher Dr Qing Jun
Meng. (Picture: University of Manchester.)
In ageing, he found similar reduction of
BMAL1 in chondrocytes, which coincided with
the reduced amplitude of the body clock (up
to 40% weaker in older mice), supporting the
theory that ageing, at least partially through
dysregulation of the chondrocyte clocks, is a
major risk factor for osteoarthritis.
Chronic inlammation is another factor
which can increase the risk of contracting the
disease, according to Dr Meng.
And in an American study on mice he
participated in earlier in the year, weekly
reversal of the light dark cycle, a condition that
simulated rotating shift work or severe jet lag,
could also disrupt the body clock making the
disease more of a risk.
Prof Ray Boot-Handford commented: This
study, delivered by an international team led
by Dr Meng, demonstrates the important role
the body clock plays in keeping our joints
healthy. The indings open up new avenues for
understanding and developing treatments for
osteoarthritis.
Stephen Simpson, director of research and
programmes at Arthritis Research UK said:
Many people with arthritis ind that their
symptoms get worse at certain times of the day
and the results of this interesting and exciting
study reveal a likely biological basis to this
effect.
It is important to understand the role that
the bodys circadian rhythm (our inbuilt body
clock) has in maintaining healthy joint tissue
and how disruptions to this process could
contribute to the development of osteoarthritis.
An exciting prospect is that it may be possible
to use this new information to improve
treatments and pain relief for the millions of
people affected by this debilitating condition.