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Anemia Disease
Etiology 1. Chronic blood 1. Chronic 1. Idiopathic (50% 1. Folate deficiency
loss inflammation 70%) - Celiac disease
- PUD - Autoimmune - Alcoholism
- Hookworm diseases 2. Drugs - Drug inhibition
(Ancyclostoma - (Rheumatoid - Pregnancy / lactation
Duodenale, arthritis) 3. Chemical agents
Necator - Infections 2. Vitamin B12 deficiency
Americanus) (Tuberculosis (TB)) 4. Infection (EBV, - Pernicious anemia
- Polyps / colorectal - Crohn disease CMV, HCV) - Gastritis
cancer - Gastric bypass
- Menorrhagia 2. Alcoholism 5. Whole body - Fish tapeworm
- Pregnancy ionizing radiation - Malnutrition
3. Malignancy - Pregnancy, lactation
2. Decreased intake 6. Pregnancy
3. Decreased 7. Thymoma
absorption
- Celiac sprue 8. Paroxysmal
- Gastric surgery nocturnal
- Atrophic gastritis hemoglobinuria
- Achlorhydria
4. Intravascular
Hemolysis
- Microangiopathic
hemolytic anemia
Paroxysmal
nocturnal
hemoglobinuria
Hemoglobin
synthesis become
low resulting in
anemia.
RBC Morphology - From normocytic Normocytic to Normocytic - Megaloblasts with high RBC
normochromic Microcytic (in hypoplastic distribution width (RDW) is
anemia to setting of high
microcytic Rheumatoid - Macro-ovalocytosis,
hypochromic RBCs Arthritis and Anisocytosis, and
Crohns disease) Poikilocytosis
- Increased red cell
distribution width
(RDW) -
anisopoikilocytosis
Laboratory findings - Decreased serum - Decreased serum - Pancytopenia - Decreased serum vitamin
iron iron (anemia, B12 and folic acid
- Decreased iron % - Decreased iron % thrombocytopenia, - Increased serum
saturation saturation and leukopenia) homocysteine and
- Decreased serum -Reticulocytopenia methylmalonic acid (95%
ferritin cases)
- Increased TIBC - Increased or - Hypocellular bone - Howell-Jolly bodies
- Increased serum normal serum marrow replaced by (residual fragments of the
free erythrocyte ferritin large adipose cells nucleus)
protoporphyrin - Decreased serum with scattered - Reticulocytopenia
(FEP) transferrin, lymphocytes in - Hypersegmented
typically low to between from bone neutrophils
normal marrow examination - Pancytopenia
- Decreased TIBC (Neutropenia,
- Increased serum thrombocytopenia)
free erythrocyte - Oval macrocytes
protoporphyrin - Megaloblastic nucleated
(FEP) cell with primitive open
- Low reticulocyte chromatin pattern