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Bioprocess modelling presents a challenging subject, which requires a meticulous

modelling strategy. During the modelling process, experimental data form a key
ingredient during structure characterization and parameter estimation. Accurate system
identification can only be guaranteed if the experimental data contain sufficient
information on the process dynamics. In this respect, sufficient effort should be spent on
optimal experiment design in order to maximize the information that can be extracted
from data, particularly because experimental data generation for bioprocesses is usually
a time-consuming, labour-intensive and costly job. This paper reviews the modelling
cycle of bioprocesses, emphasizing the need for careful experimental data collection.
The concepts of optimal experiment design for parameter estimation are outlined in
particular. Application of this methodology is illustrated for a case study involving the
optimal estimation of two model parameters describing temperature dependence of
microbial growth kinetics.

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