Laporan hasil penelitian

Efektivitas atorvastatin terhadap penurunan profil lipid pada pasien hiperkolesterolemia

Tujuan Umum : Mengetahui Efektivitas atorvastatin terhadap penurunan profil lipid pada pasien
hiperkolesterolemia
Tujuan Khusus :
1. Mengetahui karakteristik pasien hiperkolesterolemia
2. Mengetahui efek samping pemberian obat atorvastatin
3. Mengetahui kadar profil lipid pasien hiperkolesterolemia sebelum mendapatkan
atorvastatin 40 dan 60 mg
4. Mengetahui kadar profil lipid pasien hiperkolesterolemia setelah mendapatkan
atorvastatin 40 dan 60 mg
5. Membandingkan kadar profil lipid pasien hiperkolesterolemia sebelum dan setelah
mendapatkan atorvastatin 40 dan 60 mg
6. Mengetahui efektivitas atorvastatin 40 dan 60 mg terhadap penurunan profil lipid

Desain studi : Eksperimental

Analisis data :
1. Analisis deskriptif untuk mengetahui distribusi frekuensi karakteristik (umur, JK,
pendidikan, Sosek) pasien hiperkolesterolemia dan distribusi frekuensi profil lipid
2. Uji homogenisitas
3. Uji normalitas
4. Analisis analitik untuk membandingkan kadar profil lipid pasien hiperkolesterolemia
sebelum dan setelah mendapatkan atorvastatin 40 dan 60 mg digunakan uji Paired T-Test
bila distribusi normal, bila tidak berdistribusi normal digunakan uji wilcoxon.
5. Untuk mengetahui perbedaan profil lipid setelah pemberian atorvastatin 40 dan 60 mg
menggunakan uji independent T-Test bila data berdistribusi normal, bila data tidak
berdistribusi normal digunakan uji Mann-whitney.
Crosstabs

Notes

Output Created 12-DEC-2017 14:00:14

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA
PENELITIAN ATOR.sav
Active Dataset DataSet1
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data
156
File
Missing Value Handling Definition of Missing User-defined missing values are treated
as missing.
Cases Used Statistics for each table are based on all
the cases with valid data in the specified
range(s) for all variables in each table.
Syntax CROSSTABS
/TABLES=JK Pddk efek_samping BY
KLP
/FORMAT=AVALUE TABLES
/CELLS=COUNT COLUMN
/COUNT ROUND CELL.
Resources Processor Time 00:00:00.02

Elapsed Time 00:00:00.02

Dimensions Requested 2

Cells Available 174734

Case Processing Summary

Cases
Valid Missing Total
 N Percent N Percent N Percent

Jenis Kelamin * Kelompok

156 100.0% 0 0.0% 156 100.0%
Perlakuan
Pendidikan * Kelompok
156 100.0% 0 0.0% 156 100.0%
Perlakuan
Efek samping * Kelompok
156 100.0% 0 0.0% 156 100.0%
Perlakuan

Jenis Kelamin * Kelompok Perlakuan Crosstabulation

Kelompok Perlakuan

Ator 40 mg Ator 60 mg Total

Jenis Kelamin Laki-laki Count 33 46 79

% within Kelompok Perlakuan 42.3% 59.0% 50.6%

Perempuan Count 45 32 77

% within Kelompok Perlakuan 57.7% 41.0% 49.4%

Total Count 78 78 156

% within Kelompok Perlakuan 100.0% 100.0% 100.0%

Pendidikan * Kelompok Perlakuan Crosstabulation

Kelompok Perlakuan

Ator 40 mg Ator 60 mg Total

Pendidikan SD Count 5 3 8

% within Kelompok Perlakuan 6.4% 3.8% 5.1%

SMP Count 18 10 28

% within Kelompok Perlakuan 23.1% 12.8% 17.9%

SMA Count 28 27 55

% within Kelompok Perlakuan 35.9% 34.6% 35.3%

S1 Count 24 33 57

% within Kelompok Perlakuan 30.8% 42.3% 36.5%

S2 Count 3 5 8

% within Kelompok Perlakuan 3.8% 6.4% 5.1%

Total Count 78 78 156
% within Kelompok Perlakuan 100.0% 100.0% 100.0%
 Efek samping * Kelompok Perlakuan Crosstabulation

Kelompok Perlakuan

Ator 40 mg Ator 60 mg Total

Efek samping Tidak ada Count 56 44 100

% within Kelompok Perlakuan 71.8% 56.4% 64.1%

Mual Count 5 20 25

% within Kelompok Perlakuan 6.4% 25.6% 16.0%

Perut Kembung Count 2 2 4

% within Kelompok Perlakuan 2.6% 2.6% 2.6%

Mual dan Perut Kembung Count 9 1 10

% within Kelompok Perlakuan 11.5% 1.3% 6.4%

Mual, Perut Kembung dan Count 1 2 3

Atralgia % within Kelompok Perlakuan 1.3% 2.6% 1.9%

Mialgia Count 1 0 1

% within Kelompok Perlakuan 1.3% 0.0% 0.6%

Mual, diare dan konstipasi Count 0 4 4

% within Kelompok Perlakuan 0.0% 5.1% 2.6%

Atralgia Count 1 0 1

% within Kelompok Perlakuan 1.3% 0.0% 0.6%

Diare, konstipasi dan Count 1 0 1

flatulence % within Kelompok Perlakuan 1.3% 0.0% 0.6%

Konstipasi Count 2 0 2

% within Kelompok Perlakuan 2.6% 0.0% 1.3%

13.00 Count 0 4 4

% within Kelompok Perlakuan 0.0% 5.1% 2.6%

14.00 Count 0 1 1

% within Kelompok Perlakuan 0.0% 1.3% 0.6%

Total Count 78 78 156

% within Kelompok Perlakuan 100.0% 100.0% 100.0%

T-Test
 Notes

Output Created 12-DEC-2017 14:02:57

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA PENELITIAN
ATOR.sav
Active Dataset DataSet1
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data File 156
Missing Value Handling Definition of Missing User defined missing values are treated as
missing.
Cases Used Statistics for each analysis are based on the
cases with no missing or out-of-range data
for any variable in the analysis.
Syntax T-TEST GROUPS=KLP(1 2)
/MISSING=ANALYSIS
/VARIABLES=TotalKolesterolpratest
Trigliseridpratest HDLpratest LDLpratest
/CRITERIA=CI(.95).
Resources Processor Time 00:00:00.05

Elapsed Time 00:00:00.05

Group Statistics

Kelompok Perlakuan N Mean Std. Deviation Std. Error Mean

Total Kolesterol pre test Ator 40 mg 78 241.538 31.1322 3.5250

Ator 60 mg 78 249.038 35.3026 3.9972

Trigliserid pre test Ator 40 mg 78 143.731 57.9323 6.5595
Ator 60 mg 78 191.705 64.9238 7.3512
HDL pre test Ator 40 mg 78 44.718 19.0882 2.1613
Ator 60 mg 78 43.679 11.0071 1.2463
LDL pre test Ator 40 mg 78 159.769 37.6963 4.2683

Ator 60 mg 78 156.846 37.3906 4.2336

 Independent Samples Test

Levene's Test
for Equality of
Variances t-test for Equality of Means

95% Confidence

Sig. Interval of the

(2- Mean Std. Error Difference

F Sig. t df tailed) Difference Difference Lower Upper

Total Equal
- -
Kolesterol variances 1.113 .293 154 .161 -7.5000 5.3295 3.0284
1.407 18.0284
pre test assumed

Equal
- -
variances not 151.629 .161 -7.5000 5.3295 3.0297
1.407 18.0297
assumed
Trigliserid Equal
- - -
pre test variances 1.482 .225 154 .000 -47.9744 9.8523
4.869 67.4374 28.5113
assumed
Equal
- - -
variances not 152.043 .000 -47.9744 9.8523
4.869 67.4394 28.5093
assumed
HDL pre Equal
test variances 4.098 .045 .416 154 .678 1.0385 2.4949 -3.8902 5.9671
assumed
Equal
variances not .416 123.109 .678 1.0385 2.4949 -3.9000 5.9769
assumed
LDL pre test Equal
variances .102 .749 .486 154 .628 2.9231 6.0118 -8.9532 14.7993
assumed

Equal
variances not .486 153.990 .628 2.9231 6.0118 -8.9532 14.7993
assumed

T-Test
 Notes

Output Created 12-DEC-2017 14:02:57

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA PENELITIAN
ATOR.sav
Active Dataset DataSet1
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data File 156
Missing Value Handling Definition of Missing User defined missing values are treated as
missing.
Cases Used Statistics for each analysis are based on the
cases with no missing or out-of-range data
for any variable in the analysis.
Syntax T-TEST GROUPS=KLP(1 2)
/MISSING=ANALYSIS
/VARIABLES=TotalKolesterolpratest
Trigliseridpratest HDLpratest LDLpratest
/CRITERIA=CI(.95).
Resources Processor Time 00:00:00.05

Elapsed Time 00:00:00.05

Group Statistics

Kelompok Perlakuan N Mean Std. Deviation Std. Error Mean

Total Kolesterol pre test Ator 40 mg 78 241.538 31.1322 3.5250

Ator 60 mg 78 249.038 35.3026 3.9972

Trigliserid pre test Ator 40 mg 78 143.731 57.9323 6.5595
Ator 60 mg 78 191.705 64.9238 7.3512
HDL pre test Ator 40 mg 78 44.718 19.0882 2.1613
Ator 60 mg 78 43.679 11.0071 1.2463
LDL pre test Ator 40 mg 78 159.769 37.6963 4.2683
Ator 60 mg 78 156.846 37.3906 4.2336
 Independent Samples Test

Levene's Test
for Equality of
Variances t-test for Equality of Means

95% Confidence

Sig. Interval of the

(2- Mean Std. Error Difference

F Sig. t df tailed) Difference Difference Lower Upper

Total Equal
- -
Kolesterol variances 1.113 .293 154 .161 -7.5000 5.3295 3.0284
1.407 18.0284
pre test assumed

Equal
- -
variances not 151.629 .161 -7.5000 5.3295 3.0297
1.407 18.0297
assumed
Trigliserid Equal
- - -
pre test variances 1.482 .225 154 .000 -47.9744 9.8523
4.869 67.4374 28.5113
assumed
Equal
- - -
variances not 152.043 .000 -47.9744 9.8523
4.869 67.4394 28.5093
assumed
HDL pre Equal
test variances 4.098 .045 .416 154 .678 1.0385 2.4949 -3.8902 5.9671
assumed
Equal
variances not .416 123.109 .678 1.0385 2.4949 -3.9000 5.9769
assumed
LDL pre test Equal
variances .102 .749 .486 154 .628 2.9231 6.0118 -8.9532 14.7993
assumed

Equal
variances not .486 153.990 .628 2.9231 6.0118 -8.9532 14.7993
assumed
NPar Tests

Notes

Output Created 12-DEC-2017 14:10:36

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA
PENELITIAN ATOR.sav
Active Dataset DataSet1
Filter KLP = 1 (FILTER)
Weight <none>
Split File <none>
N of Rows in Working Data
78
File
Missing Value Handling Definition of Missing User-defined missing values are treated
as missing.
Cases Used Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.
Syntax NPAR TESTS
/WILCOXON=TotalKolesterolpratest
WITH TotalKolesterolposttest (PAIRED)
/STATISTICS DESCRIPTIVES
/MISSING ANALYSIS.
Resources Processor Time 00:00:00.02

Elapsed Time 00:00:00.02

Number of Cases Alloweda 112347

a. Based on availability of workspace memory.

Descriptive Statistics

N Mean Std. Deviation Minimum Maximum

Total Kolesterol pre test 78 241.538 31.1322 202.0 328.0

Total Kolesterol post test 78 170.282 43.8385 92.0 250.0
Wilcoxon Signed Ranks Test

Ranks

N Mean Rank Sum of Ranks

Total Kolesterol post test - Negative Ranks 78a 39.50 3081.00

Total Kolesterol pre test Positive Ranks 0b .00 .00

Ties 0c

Total 78

a. Total Kolesterol post test < Total Kolesterol pre test

b. Total Kolesterol post test > Total Kolesterol pre test
c. Total Kolesterol post test = Total Kolesterol pre test

Test Statisticsa

Total Kolesterol
post test - Total
Kolesterol pre
test

Z -7.674b
Asymp. Sig. (2-tailed) .000

a. Wilcoxon Signed Ranks Test

b. Based on positive ranks.

NPar Tests

Notes

Output Created 12-DEC-2017 14:16:00

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA
PENELITIAN ATOR.sav
Active Dataset DataSet1
Filter KLP = 2 (FILTER)
Weight <none>
Split File <none>
N of Rows in Working Data
78
File
Missing Value Handling Definition of Missing User-defined missing values are treated
as missing.
Cases Used Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.
Syntax NPAR TESTS
/WILCOXON=TotalKolesterolpratest
WITH TotalKolesterolposttest (PAIRED)
/STATISTICS DESCRIPTIVES
/MISSING ANALYSIS.
Resources Processor Time 00:00:00.05

Elapsed Time 00:00:00.03

Number of Cases Alloweda 112347

a. Based on availability of workspace memory.

Descriptive Statistics

N Mean Std. Deviation Minimum Maximum

Total Kolesterol pre test 78 249.038 35.3026 200.0 371.0

Total Kolesterol post test 78 179.231 27.2062 112.0 266.0

Wilcoxon Signed Ranks Test

Ranks

N Mean Rank Sum of Ranks

Total Kolesterol post test - Negative Ranks 78a 39.50 3081.00
Total Kolesterol pre test Positive Ranks 0b .00 .00

Ties 0c

Total 78

a. Total Kolesterol post test < Total Kolesterol pre test

b. Total Kolesterol post test > Total Kolesterol pre test
c. Total Kolesterol post test = Total Kolesterol pre test

Test Statisticsa

Total Kolesterol
post test - Total
Kolesterol pre
test

Z -7.673b
Asymp. Sig. (2-tailed) .000

a. Wilcoxon Signed Ranks Test

b. Based on positive ranks.

NPar Tests

Notes

Output Created 12-DEC-2017 14:18:24

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA
PENELITIAN ATOR.sav
Active Dataset DataSet1
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data
156
File
Missing Value Handling Definition of Missing User-defined missing values are treated
as missing.
Cases Used Statistics for each test are based on all
cases with valid data for the variable(s)
used in that test.
Syntax NPAR TESTS
/M-W= TotalKolesterolposttest BY
KLP(1 2)
/MISSING ANALYSIS.
Resources Processor Time 00:00:00.03

Elapsed Time 00:00:00.05

Number of Cases Alloweda 112347

a. Based on availability of workspace memory.

Mann-Whitney Test

Ranks

Kelompok Perlakuan N Mean Rank Sum of Ranks

Total Kolesterol post test Ator 40 mg 78 76.03 5930.00

Ator 60 mg 78 80.97 6316.00

Total 156

Test Statisticsa

Total Kolesterol
post test

Mann-Whitney U 2849.000
Wilcoxon W 5930.000
Z -.684
Asymp. Sig. (2-tailed) .494

a. Grouping Variable: Kelompok Perlakuan

Tidak ada perbedaan pada pemberian ator 40 dan 60 karna p>0.05

T-Test

Notes

Output Created 12-DEC-2017 14:19:43

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA PENELITIAN
ATOR.sav
Active Dataset DataSet1
Filter <none>
Weight <none>
Split File <none>
N of Rows in Working Data File 156
Missing Value Handling Definition of Missing User defined missing values are treated as
missing.
Cases Used Statistics for each analysis are based on the
cases with no missing or out-of-range data
for any variable in the analysis.
Syntax T-TEST GROUPS=KLP(1 2)
/MISSING=ANALYSIS
/VARIABLES=TotalKolesterolposttest
/CRITERIA=CI(.95).
Resources Processor Time 00:00:00.02

Elapsed Time 00:00:00.01

Group Statistics

Kelompok Perlakuan N Mean Std. Deviation Std. Error Mean

Total Kolesterol post test Ator 40 mg 78 170.282 43.8385 4.9637

Ator 60 mg 78 179.231 27.2062 3.0805

Independent Samples Test

 Levene's Test
for Equality of
Variances t-test for Equality of Means

95% Confidence

Sig. Interval of the

(2- Mean Std. Error Difference

F Sig. t df tailed) Difference Difference Lower Upper

Total Equal
- -
Kolesterol post variances 22.108 .000 154 .128 -8.9487 5.8419 2.5919
1.532 20.4894
test assumed

Equal
variances - -
128.651 .128 -8.9487 5.8419 2.6100
not 1.532 20.5074
assumed

Trigliserida
T-Test

Notes

Output Created 12-DEC-2017 14:36:42

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA PENELITIAN
ATOR.sav
Active Dataset DataSet1
Filter KLP = 1 (FILTER)
Weight <none>
Split File <none>
N of Rows in Working Data File 78
Missing Value Handling Definition of Missing User defined missing values are treated as
missing.
Cases Used Statistics for each analysis are based on
the cases with no missing or out-of-range
data for any variable in the analysis.
Syntax T-TEST PAIRS=Trigliseridpratest WITH
Trigliseridposttest (PAIRED)
/CRITERIA=CI(.9500)
/MISSING=ANALYSIS.
Resources Processor Time 00:00:00.02

Elapsed Time 00:00:00.03

Paired Samples Statistics

Mean N Std. Deviation Std. Error Mean

Pair 1 Trigliserid pre test 143.731 78 57.9323 6.5595

Trigliserid post test 125.282 78 45.2436 5.1228

Paired Samples Correlations

N Correlation Sig.

Pair 1 Trigliserid pre test & Trigliserid

78 .715 .000
post test

Paired Samples Test

Paired Differences

95% Confidence
Interval of the

Std. Std. Error Difference Sig. (2-

Mean Deviation Mean Lower Upper t df tailed)
Pair Trigliserid pre test
1 - Trigliserid post 18.4487 40.6766 4.6057 9.2776 27.6199 4.006 77 .000
test

LDL 40 mg

Wilcoxon Signed Ranks Test

 Ranks

N Mean Rank Sum of Ranks

LDL post test - LDL pre test Negative Ranks 76a 39.45 2998.00

Positive Ranks 1b 5.00 5.00

Ties 1c

Total 78

a. LDL post test < LDL pre test

b. LDL post test > LDL pre test
c. LDL post test = LDL pre test

Test Statisticsa

LDL post test -

LDL pre test

Z -7.599b
Asymp. Sig. (2-tailed) .000

a. Wilcoxon Signed Ranks Test

b. Based on positive ranks.

TGA 60 mg

Wilcoxon Signed Ranks Test

Ranks

N Mean Rank Sum of Ranks

Trigliserid post test - Negative Ranks 73a 40.42 2951.00

Trigliserid pre test Positive Ranks 5b 26.00 130.00

Ties 0c

Total 78

a. Trigliserid post test < Trigliserid pre test

b. Trigliserid post test > Trigliserid pre test
c. Trigliserid post test = Trigliserid pre test
 Test Statisticsa

Trigliserid post
test - Trigliserid
pre test

Z -7.026b
Asymp. Sig. (2-tailed) .000

a. Wilcoxon Signed Ranks Test

b. Based on positive ranks.

LDL 60 mg

T-Test

Notes

Output Created 12-DEC-2017 14:41:14

Comments
Input Data D:\DOKTER MUDA\8. IKM IKK\DATA
PRAKTIKUM COASS\DATA PENELITIAN
ATOR.sav
Active Dataset DataSet1
Filter KLP = 2 (FILTER)
Weight <none>
Split File <none>
N of Rows in Working Data File 78
Missing Value Handling Definition of Missing User defined missing values are treated as
missing.
Cases Used Statistics for each analysis are based on
the cases with no missing or out-of-range
data for any variable in the analysis.
Syntax T-TEST PAIRS=LDLpratest WITH
LDLposttest (PAIRED)
/CRITERIA=CI(.9500)
/MISSING=ANALYSIS.
Resources Processor Time 00:00:00.03

Elapsed Time 00:00:00.03

Paired Samples Statistics

Mean N Std. Deviation Std. Error Mean

Pair 1 LDL pre test 156.846 78 37.3906 4.2336

LDL post test 105.103 78 26.6963 3.0228

Paired Samples Correlations

N Correlation Sig.

Pair 1 LDL pre test & LDL post test 78 .441 .000

Paired Samples Test

Paired Differences

95% Confidence
Interval of the

Std. Std. Error Difference Sig. (2-

Mean Deviation Mean Lower Upper t df tailed)

Pair LDL pre test - LDL

51.7436 35.0682 3.9707 43.8369 59.6502 13.031 77 .000
1 post test