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Hemopoiesis:
Erythropoiesis & Leukopoiesis
Hemopoiesis
• hemopoiesis = the production of blood, especially its
formed elements
3 to 5 days to complete
Erythrocytes / Red Blood Corpuscles
Capillary
wall
Erythrocytes
7 µm
• principal function
Beta
– globular proteins // four chains Alpha
HC C C CH
Alpha Beta
– 5% CO2 in blood is bound to (a)
globin moiety
CH3 CH CH2
hemoglobin HC C C CH
C N C
CH3 C C CH3
N Fe2+ N
CH2 C C CH CH2
– Which form has the greatest CH2
C N C
HC C C CH
affinity for oxygen? COOH
C C
– Why? CH2 CH3
CH2
COOH
(b)
Factors That Influence O2 Transport
• Vitamin C
Erythrocytes
Small intestine
circulate for
120 days
Expired erythrocytes
break up in liver and spleen
Cell fragments
phagocytized
Hemoglobin
degraded
Heme Globin
• Iron-deficiency anemia
Leukopoiesis
Leukocytes (WBCs)
B lymphocyte
B prolymphocyte
T prolymphocyte T lymphocyte
Lymphocytic Lymphoblast
CFU
NK prolymphocyte NK cell
Types of Leukocytes
• Granulocytes // these cells stain // known as the
“NEBs”
– neutrophils (60-70
– eosinophils (2-4%)
– basophils (<1%)
– lymphocytes (25-33%)
– monocytes (3-8%)
Lymphocyte 10 µm Monocyte 10 µm
Granulocyte Functions
• Neutrophils
– 60-70% of WBC
• Eosinophils
Lymphocytes
Monocytes
Platelets
Monocyte
Neutrophils
Lymphocyte
Erythrocytes
(a)
(b) 75 µm
Complete Blood Count
• Hematocrit
• Hemoglobin concentration
• Total count for RBCs,
reticulocytes, WBCs, and
platelets
• Differential WBC count
• RBC size and hemoglobin
concentration per RBC