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PharmaNote Volume 27, Issue 5 February 2012
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PharmaNote Volume 27, Issue 5 February 2012
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PharmaNote Volume 27, Issue 5 February 2012
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PharmaNote Volume 27, Issue 5 February 2012
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PharmaNote Volume 27, Issue 5 February 2012
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ȋͶȌǤͳͲ ǡ
ϐǡǦ
ϐǦ
ϐ
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-‐ȋȌ
ĔĘĆėęĆēĎē
͵ͺͶ ȋ
ȂȌ
ζͶͲΨǤʹ͵
ʹͷ
͵ǡͳͷʹ
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Ȃǡ ͳͷͲͷͲǡǤ
ζͶͲΨǡ
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ͷͲȋȌǤʹͳ ͷͲǤ
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ͳǤͳ͵ǢͻͷΨͲǤͻͷ-‐ͳǤ͵ͷǢαͲǤͳȌȋͶȌǤǡ
ͷͲȋαͲǤͻͲǢ
ϐ
ͻͷΨͲǤͺʹ-‐ͲǤͻͻǢαͲǤͲʹȌǤ
ȋαͳǤʹͷǢ ͳͷͲ
Ǧ
ͻͷΨͲǤͻͺ-‐ͳǤͷͲǢαͲǤͲͺȌǡ
ȋαͳǤͲͶǢͻͷΨͲǤͻͶ-‐ͳǤͳǢαͲǤͶͷȌǡ ͷͲȋαͲȉͺͺǢͻͷΨͲǤͻȂ
ȋαͲǤͻʹǢͻͷΨ ͲǤͻǢαͲǤͲͳͳȌǤ
ͲǤͺ-‐ͳǤͲͺǢαͲǤ͵ʹȌȋͷȌǤ
-‐
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ȋαͲǤͻͷǢͻͷΨͲǤͺͺȂͳǤͲ͵Ǣ
ȋδͲǤͲͲͳȌǤʹͳǦ αͲǤʹͶȌǤǡǦ
ϐ
-‐ϐ-‐
ȋαͲǤͶͶȌǤʹʹ
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ʹͳǡ
ͳͷͲ
ϐ
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ȋȌͷͶ
εͷͲ
δ͵ͷΨǤʹʹͺͲΨǦ ėćĊĘĆėęĆēĎē
ȋαͶͶͳȌ
ϐ
Ȁʹ
ϐ
δ͵ͷΨǤǦ
ȋ-‐Ȍͳͳ
ͷͲ
Ǧ ȋ̺Ȍ
ͷͲǤ
ǡ ηͶͷΨȋ
-‐
ǡ
Ǧ
Ȍǡ
ȋαͳǤͳ͵ǢͻͷΨͲǤͻͻȂ ǡ
ǡ
ͳǤʹͺǢαͲǤͲͻȌȋͶȌǤǡ ǡǤ
Ͷǡͳʹͺ
-‐ͳǤʹͺ
ͳǤͳͲ ͵ͲͲǡ
Ǧ
-‐Ǥ Ǥ
ͷ
ϐ
ʹ-‐Ͷ
Ǣ
ʹʹǤ
ȋαͳǤͳͻǢͻͷΨͲǤͻͻȂͳǤͶ͵ǢαͲǤͲʹȌȋ͵Ȍ ϐ
Ȁ-‐ȋαͳǤͲ͵ȋͲǤͺͻȂͳǤͳͺȌǢ
-‐
ȋαͳǤͲͲǢ
PharmaNote Volume 27, Issue 5 February 2012
ͻͷΨͲǤͺͺ-‐ͳǤͳͶǢαͲǤͻͺȌȋͶȌǦ
ȋ
ʹͲͲͳ
ȋαͲǤͻͷǢ ȌǤ
ǤʹͲͲͷʹͲǢͶȋȌǣͳ-‐ͺʹǤ
ͻͷΨͲǤͺͷ-‐ͳǤͲͺǢαͲǤͶͶȌȋͷȌǤͳͳ ͶǤ
ǡ-‐ǡ
ǡǤ
ʹͲͲͺǣ
ȋαͲǤͻͷǢͻͷΨ
ʹͲͲͺ
Ǥ
ȋͲǤͺ-‐ͳǤͲͷȌǢαͲǤ͵ͷȌǤ-‐ǯϐǦ
ȋ Ȍ
-‐
ȋȌǤ
ǤʹͲͲͺ
ǢͳͲȋͳͲȌǣͻ͵͵-‐ͺͻǤ
ǡͳͲ ͷǤ
ȋȌȏ
ȐǤ
Ǧ
ǢʹͲͳͳǡǡǤ
ϐ Ǥ
Ǥ
ȋ
Ȍȏ
ȐǤǦ
ǢʹͲͳͳǡǡǤ
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ȋȌȏ
ȐǤ-‐
ǢʹͲͳͳǡǡǤ
ĎċċĊėĊēĈĊĘćĊęĜĊĊēĘĎē
ͺǤ
ȋȌȏ
ȐǤ
ǢʹͲͳͳǡǡǤ
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ǡǤ-‐-‐
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ʹͲͳͳ-‐
Ǣͳȋ͵-‐ͶȌǣ͵ͺ-‐ͷǤ
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ǡǡǡǤ
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-‐
-‐
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Ǣ͵ʹȋͻ͵ͺȌǣ-‐ͺͳǤ
ʹͲ-‐Ȁ ͳͳǤ
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ͶǢ͵ͷͻȋʹ͵ȌǣʹͶͷ-‐Ǥ
ǡʹʹǡʹͳʹ͵Ǧ ͳʹǤ
ǡǡ
ǡǤǡǡ
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ǡ ͳͲǢ͵ͷͺȋͳͷȌǣͳͷͶ-‐ͷͻǤ
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Ǣ͵Ͷͷȋʹ͵Ȍǣͳ-‐ͷǤ
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-‐ ͳͷǤ
ǤǤǤ-‐ ǣ
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ǡǡ
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-‐
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ͳͺǤ
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ǡǤ
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ǣ-‐Ǧ
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ǤʹͲͲ͵Ǣ͵ʹȋͻ͵ͺȌǣͷͻ-‐Ǥ
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Ǧ ͳͻǤ
ǡ
ǡǡ
ǡǤ͵
ǡǤ
-‐
Ǧ
-‐
-‐ǣ-‐ǤǦ
ĊċĊėĊēĈĊĘ
ʹͲͲ͵Ǣ͵ʹǣȂͳǤ
ʹͲǤ
ǡ
ǡǡǦ
ͳǤ
ǡ
ǡǤ
Ǧ Ǥ
Ǥ
-‐
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-‐-‐ʹͲͳͳǣ
-‐
-‐ǣ-‐
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ǤʹͲͳͳ ͳǢͳʹ͵ȋͶȌǣͳͺ-‐ʹͲͻǤ
Ǥ
ʹͲͲ͵Ǣ͵ʹǣʹȂǤ
ʹǤ
ǡǡ
ǡǤǦ ʹͳǤ
ǡ-‐ǡǡ ǡǤ
Ǧ
-‐-‐
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ͳͻͻͳʹͲͲͺǤ
ǤʹͲͳͲ-‐
Ǣͳ
ǣ-‐-‐
ȋͻȌǣͳ-‐ͻǤ
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ǤʹͲͲͲǢ͵ͷͷȋͻʹͳͷȌǣͳͷͺʹ-‐Ǥ
͵Ǥ
ǤȀʹͲͲͷ ʹʹǤ
ǡ
Ǣ
ǣ
Ǥ
Ǥ
Ȁ
-‐
Ǧ
PharmaNote Volume 27, Issue 5 February 2012
ǣǤ
ͳͲΨ
ǡʹͲΨǦ
Ǥ
ǤʹͲͲʹǢ͵Ͳȋͻ͵͵ͷȌǣͷʹ-‐ͲǤ
-‐Ǥ
ʹ͵Ǥ
ǡ
ǡ
ǡǤ ϐ
ȋͲǤͻͻȌǢ
-‐-‐
Ǧ ͳʹͲǤǡͶͲǡͳʹ
ȋȌǣǡ-‐ ȋͳǤͲȌǡ
ͳͲǡͲͶͻ
Ǥ
ǤʹͲͲͻʹͺǢ͵ͶȋͻͲͶȌǣͳͺͶͲ-‐ͺǤ
ȋ
ʹͶǤ
ǡ-‐ǡ
ǡǤ
-‐ȋȌ
ͳǤ͵ͳȌȋȌǤ͵Ǥ
-‐Ǥ
ǤʹͲͲͺǢͳͲ ǡ
-‐
ȋͻȌǣͺͻͻ-‐ͻͲǤ
ǡ
Ǥ
CLINICAL TRIAL UPDATE
ǡ
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ͳȄ
-‐-‐Ǥ
ǣ-‐
ǣϐȋȌ
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ȋȌ
(YHQWUDWHSHUSHUVRQ-\HDUVRIIROORZ-XS
ȋȌȋȌ
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Ǧ ǀĞŶƚ ^ WůĂĐĞďŽ
ϐǦ
EŽŶĨĂƚĂůD/ ϰ͘ϭ ϱ͘ϭ
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dŽƚĂůsǀĞŶƚƐ ϭϮ͘ϴ ϭϰ͘ϭ
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sDŽƌƚĂůŝƚLJ ϯ͘ϵ ϰ͘Ϭ
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-‐ǡ
ůů-‐ĐĂƵƐĞŵŽƌƚĂůŝƚLJ ϭϭ͘Ϭ ϭϭ͘ϳ
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ͳͲͲͲ
Ǧ dŽƚĂůůĞĞĚŝŶŐ ϯϲ͘Ϭ Ϯϭ͘Ϯ
ȋȌǡ
EŽŶƚƌŝǀŝĂůůĞĞĚŝŶŐ ϵ͘ϳ ϳ͘ϰ
-‐ǡ
ȋǤǤ
ǡǡǡ
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^͗ĂƐƉŝƌŝŶ͖s͗ĐĂƌĚŝŽǀĂƐĐƵůĂƌĚŝƐĞĂƐĞ
Ȍǡ
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ǡǡǡǤ
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ȐǤ
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ͳͲʹǡʹͳ
ͲͲǡͲͲͲ
-‐-‐Ǥ
ǢǦ The PharmaNote is Published by:
ǤϐǦ The Department of Pharmacy
Services, UF Family Practice Medical
Dz
Group, Departments of Community
Ǥdz
ǡ
ǡ
Health and Family Medicine and
ǡ Pharmacotherapy and Translational
Ȁǡ-‐ϐǤ
Research
Ǧ University of Florida
ȋȌ
ǡ
-‐
-‐ǢʹǦ
Ǥ John G. Gums Editor
ȋȌ
PharmD, FCCP
ȋȌ
ǡ
Ǧ R. Whit Curry, MD Associate Editor
Ǥ
ʹͳͻǦ Eric Dietrich Assistant Editor
ͲͲǡͲͲͲ-‐-‐ǢͳͷͶͲ PharmD
ϐ-‐ͷͻʹ
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PharmaNote Volume 27, Issue 5 February 2012