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Surgical pathology
Topic: adrenal gland tumors
Adrenal myelolipoma mixture of mature Not clearely understood unknown Asymptomatic composed of macroscopic fat and
(benign) adipose tissue and When large: Symptoms include pain in mature hematopoietic tissue,
hematopoietic marrow the abdomen or flank, blood in the urine, resembling bone marrow.
and is notable for its a palpable lump or high blood pressure.
occasional large size. There is a mixture of normal
adrenal tissue, fat, and a full
trilineage maturation of the three
major blood-
forming elements: myeloid (white
blood cell forming), erythroid (red
blood cell forming),
and megakaryocytic (platelet
forming) lines
Adrenal cysts predisposing factors for adrenal When it becomes large it can impinge near by When large: significant for poorly controlled revealed bloody proteinaceous
pseudocysts that occur as a noted to occur from birth pseudocysts include trauma, structure in the retroperitoneal area such as kidney hypertension, chronic back pain, arthritis, fluid with hypocellularity and no
result of degenerative to 80 years of age, with a infection, anoxia in infants, palpitations, and anxiety disorder. malignancy.
changes in benign adrenal peak incidence in the hemorrhagic diathesis, vascular
tumors or resolution of third to sixth decades of aneurysm, or embolism with
haemorrhage they represent life; subsequent infarction.
remnants of an underlying
vascular lesion.
Pheochromocytomas more frequent in part of hereditary syndromes, Associated to medical syndromes with genetic Hypertension, sustained or episodic, is the key
women than in men. such as MEN types 2A and 2B defect and produces a tumor that secretes high symptom.
associated with von Hippel- amounts of catecholamines, asymptomatic hypertension
They occur at any age, Lindau disease, mostly norepinephrine, plus epinephrine to a symptomatic hypertension resistant to
including infancy, but neurofibromatosis type 1 and lesser extent antihypertensive therapy
are uncommon after 60 McCune-Albright syndrome. malignant
years of age. hypertension (e.g., encephalopathy,
Rare Catecholamine-
Secreting Tumors of papilledema, proteinuria),
80% are unilateral, myocardial infarction or aortic dissection
Chromaffin Cells of the encapsulated, spongy, reddish
10% are bilateral and paroxysms of convulsions, anxiety or
Adrenal Medulla masses, with prominent central
10% occur in extra- hyperventilation. scars, haemorrhage and foci of
adrenal locations; 10%
(malignant) cystic degeneration
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Transcribed by: John Velasco - #makingEAC-SMgreatAgain #batch2019 Taste and see that the LORD is good; blessed is the one who takes refuge in him.- Psalm 34:8
Patho 2 TOPIC: adrenal gland tumors
The HSRs represent amplification of N-myc; this scant cytoplasm, discloses a firm,
Neuroblastomas are abnormality is key in determining the Spinal cord compression may lead to gait irregular, nontender mass.
the most common solid aggressiveness of neuroblastoma. disturbance and sphincter dysfunction.
extracranial neoplasms The cut surface is soft and friable,
of childhood, accounting Severe diarrhea may be caused in tumors with a variegated maroon color.
for up to 10% of all secreting vasoactive intestinal peptide Areas of necrosis, hemorrhage,
childhood cancers and calcification and cystic change are
15% of cancer deaths in The urine contains increased amounts of often present.
children. norepinephrine, VMA,
homovanillic acid (HVA) and dopamine. Homer Wright rosettes
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Transcribed by: John Velasco - #makingEAC-SMgreatAgain #batch2019 Taste and see that the LORD is good; blessed is the one who takes refuge in him.- Psalm 34:8