First Call With Ms.

Mudd
● Huge open field,
● Allergy treatment- many forms of oral immunotherapy,
● Paper-
● Next thing to do: take the broad food allergy treatment-
○ Overview?- where come, next step, where going
○ Look at one topic-> oral immunotherapy?
○ Read more papers
○ Patch- limited studies, commercial product, company that is doing study, own
data and not inclined to published b/c different goals, lot of data but not published
● Oral, Sublingual
○ Lot on oral- focus on this one, what is coming
■ Questions, on dosage, time, stopping does, timing of dose,
● Can send articles
○ Impact rating- important
○ Journal of Allergy and clinical immunology
○ Journal of allergy and clinical immunology in practice
● NExt STep
○ Broaden reading
● Perspective:
○ What point
● Interview: ways to go
● Runs research facility- people that lays hands on kids while doing research
○ Clinical coordinator
● Other researcher- Dr. Wood, where is this going
● Very clinical- ask Dr. Silber, impact
● CHalenge the number of sensitivity-
○ Make ton of IgE- but not related to sensitivity
○ Cannot look at IgE- and equate them to a
 ○ Much more
○ S
● Skin test- small amount of allergen
○ Dendritic cells , mast cell is sensitized to recog the IgE and get a response.
● IgE- mediated allergy
○ Skin test not necessarily equate
○ Skin test= no way to measure and
● Both test have a false positive
● Sensitization vs Allergy
● Only way to prove allergy- a double blind placebo challenge
○ Gold standard
○ Food challenge- establish that the people are truly allergic
○ Standardize- threshold
○ Reacted to different amount,
■ Significant?
■ Based on way to start

11/17
specify peanut allergies
OIT
if we must specify
envi
PRESENTATION
Presentation is best match: talk about the up to date methods
Not specific topic:

12/10
Approach
Overview
Where we are Now- feasibility and
Overview OIT
Chronological
Start, now, where are we going 2005-2017
Preducing a paper would be difficult for publish
Informational panpelt- audience is so small

Chronological overview:

Survey across Not drilling deep

Watch progress of the science
Apply differently

Run by Sasser
Come up with thesis statement that and just how to organize and the approach works
thesis is title- get specific but find a starting point.

a) can you induce desentizatlion in very allergic- yes

b) stop dosing everyday and retain to desentisation- no
c) Trying to answer- What is decent what is tolerance —> need to answer to get a good dose

Don’t know what id different about some kids- not simple there is no correlation between any of
the test
Different in immunolofy
Don’t know at

Clinical trials:
everyone has symptoms
out of nowhere
not risk free

Have to be able to say that you can tolerate

3 groups:
can get to design but lose it fast no sticking
build decent
can’t tolerate at all

on paper: look the same but something is very different

At this point

induce tolerance- can we figure out at a cellular level

apply clinically
who is the treatment app

rapid vs long term

mostlu a combination
in research world- keep them for the
go up every hour
get below threshold but as far as you can go
you can manage the symp
very labor intensive
harder ot do

dose at home
initial dose very small and get to a measurable at the office
and then send home with the dose
xolare- binds the free IgE in blood stream- finds the mast cells, and the iGe and bemuses and
attena
inactivates the Ige and it

challegnes - makes a ton of IgE- in 1000s cannot accommodate all Ige

you half it iwht dollar injected

3 shots- sig cost

Feb 6th 2:30

Let know how much editing- organization, tell

Rough Draft ->

her perspective: stay organized, use outline, come back and look at gaps, over write
the format is correct, a little difficult to apply: no data, it would be slightly mismatch

Intro: thesis

Prevention versus treatment:

Public health perspective: prevention- ideal, absence of prevention- response- cure, treatment,
damage is done- maximize what is done
These are the priorities: address this
Ideally prevention- but we are not there
Cannot prevent, so cure- do a treatment regime: the problem is gone we are not there yet, a
treatment- our only option.

Introduce this concept early- where reader should acknowledge: after quality of life
Absence of prevention and cure: development of treatment
prevents confusion
focus the reader

Conclusion
be a wrap up, until there is a cure, or prevention. We are much further along than
Identifying triggere and prevent
We are beyond this and it is important to acknowledge
Future goals

Meta analysis
Check for this
approaches of immunotherapy
Look at different treatments
look at outcome

Look at a specific approach and

Focus a lot of background
DO diligence of background
Firgure out what other people have done
Do things well
What I am doing a literature review

Do need data analysis- look at several peanut projects and assess and compare the outcomes
compares methods, if not let know

Most of feb she will be out

Timing Mar 1- Mar 7 she is gone