Lonza’s chemical network

Diketene and HCN derivatives, heterocycles

and basic chemicals catalog
Pharma&Biotech

Nutrition

Agriculture

MaterialsScience

PersonalCare
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Content
About Lonza 3
Introduction 4
Diketene / ketene derivatives 6
Esters 6
Arylides 7
Alkylamides 8
Pyrazolones 9
Dehydroacetic acid 9
Lonzamon monomers 10
Other diketene derivatives 10

HCN derivatives 12
Heterocycles 14
Basic chemicals 16
Others 17
Alphabetical index 18
About Lonza
Lonza is the global leader in the production and support of active phar-
maceutical ingredients both chemically and biotechnologically. Biophar-
maceuticals are one of the key growth drivers of the pharmaceutical and
biotechnology industries.
Lonza has strong capabilities in large and small molecules, peptides,
amino acids and niche bioproducts which play an important role in the
development of novel medicines and healthcare products. In addition,
Lonza is a leader in cell-based research, endotoxin detection and cell
therapy manufacturing. Furthermore, the company is a leading provider
of chemical and biotech ingredients to the nutrition, hygiene, preserva-
tion, agro and personal care markets.
3
From 1897 to the present day combining Swiss tradition with global
experience, the company has had an enterprising character, adapting
its offerings and services to the needs of customers and to changing
technologies. Throughout our history, we have maintained a strong
culture of performance, results and dependability that is valued by all
of our customers.
Lonza’s cracker in Visp is the back bone of a comprehensive fully back-
ward integrated chemical network. Our product portfolio consists of
HCN- and diketene derivatives as well as basic chemicals which are key
raw materials and intermediates for many sophisticated applications.
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Diketenes / ketenes
Diketene is a colorless liquid produced by dimerization of ketene. It is
a highly reactive building block which can be combined with numerous
other chemical compounds to make a wide range of products. Because
of its high energy content, transport of diketene is forbidden. It is pro-
cessed further at the site of manufacture. Lonza is one of the world’s
leading suppliers of diketene derivatives manufactured in its production
facility in Visp, Switzerland. Our diketene derivatives are used in the
pharmaceutical, vitamin, agrochemical and pigment industries. The
niche markets are in cosmetics, plasticizers, paints. The acetoacyl group
in diketene derivatives has a broad functionality which can be used
for the production of further products. Lonza’s most comprehensive
diketene product lines are those made with alcohols (aceto-acetic acid
and acrylate derivatives), aliphatic amines (alkylamides) and aromatic
amines (arylamides). Lonza uses some of these to produce further
components (pyrazolones, aminocrotonates, side chains).
The following summary provides an overview of the diketene derivative
product groups:
Diketene esters (acetoacetates): “Major” products such as methyl,
ethyl, isopropylester of acetoacetic acid are produced in a continuous
process and purified by distillation. “Minor” derivatives are produced
batchwise in stirred vessel reactors. The products are used mostly in
the dye, agrochemical, pharmaceutical and vitamin industries.
Arylamides: A large variety of arylamides are obtained by the reaction
of aromatic amines with diketene. Our most important products are AAA,
AAOT, AAMX, AAOA, and AAOC; others are made regularly or on special
request. These derivatives are used mainly in the production of azo
pigments; but also in the dye and agrochemical industries.
4
Alkylamides: Aliphatic amines react with diketene to result in alkyl-
amides. Major products such as monomethyl- or dimethylacetoacet-
amides are manufactured as aqueous solutions with continuous pro-
cesses; other derivatives and water-free compounds are produced with
batch processes. The (alkyl-) acetoacetamides are used principally in
the manufacture of insecticides. The derivatives are also deployed in
the pigment, pharmaceutical and polymer industries.
DHS / NaDHS: The catalytic dimerization of diketene yields dehydroacetic
acid (DHS), which is a solid material. The free acid can be neutralized
with sodium hydroxide and is available as the salt NaDHS or its monohy-
drate NaDHS-H2O. These products are used above all in the manufacture
of PVC stabilizers and as preservatives in the cosmetic industries.
Acrylic acid esters (acetoacetoxy monomers): Acetoacetoxyethyl meth-
acrylate (AAEMA), the most important product of this group, is made
in a multipurpose batch production plant. It is used as a copolymer for
coatings and adhesives in emulsion polymerization (waterborne disper-
sions) or solvent polymerization (high solids), and provides improved
mechanical and solvent resistance to water or organic solvents. It also
promotes adhesion to metallic, mineral and wood surfaces.
Other diketene derivatives: 4-Chloroacetoacetic acid ester is a highly
versatile diketene derivative. It can be used in syntheses of various
pharmaceutical intermediates.
Ketene: Lonza has the specific capability to perform a variety of reac-
tions with ketene. The production of ethyl 4, 4, 4-trifluoroacetoacetate
is one example for such a ketene reaction.
For more information about ketene / diketene chemistry and its various
derivatives, please ask for specific brochures and related literature or
send mail to diketene@lonza.com.
Hydrocyanic acid (HCN)
Hydrogen cyanide is a extremely poisonous colorless or pale-blue liquid
that undergoes a wide variety of reactions. Lonza has manufacturing
capabilities to offer a solution of hydrogen cyanide in water (hydrocy-
anic acid) and producing its derivatives. HCN is used in metallurgical
and photographic processes. Furthermore, HCN is a starting material
for cyanogen chloride, cyanoacetates, cyanohydrins, sodium cyanide,
chelating agents and many more. Cyanogen chloride is a functional
building block for other Lonza products like cyanuric chloride and malo-
nonitrile. The cyanohydrins, give access to a variety of useful organic
compounds including the monomer methyl methacrylate, amino acids
via the Strecker synthesis, and the chelating agents EDTA and NTA.

Basic chemicals
Beside ketene and HCN chemicals Lonza’s cracker related product port-
folio also offers a selective number of basic chemicals. The chemicals
can be used as starting materials and processed further to yield coat-
ings, colorants, adhesives, medicines, agrochemicals and more.

Icons

Pharma

Colorants

Agriculture

Polymers

Nutrition

Various

5
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Methyl acetoacetate (MAA) Ethyl acetoacetate (EAA)

Diketene /  Esters   C5H8O3   C5H10O3
ketene
derivatives

Molecular weight   116.12  130.14

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
  105-45-3
  99.0 %
  2 years
  –28°C
  170°C
  1.077
 Xi irritant
 drums, bulk
 not restricted
 141-97-9
 99.0 %
 2 years
 –43°C
 180°C
 1.03
 –
 drums, bulk
 not restricted

Isopropyl acetoacetate (IPAA) Isobutyl acetoacetate (AAisobutyl) t-Butyl acetoacetate (AA-t-butyl)

  C7H12O3   C8H14O3   C8H14O3

Molecular weight  144.17  158.20  158.20

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
 542-08-5
 98.5 %
 2 years
 –27°C
 185°C
 0.998
 Xi irritant
 drums, bulk
 not restricted
 7779-75-1
 98.0 %
 2 years
 –20.5°C
 205°C
 0.974
 –
 drums
 not restricted
 1694-31-1
 98.0 %
 2 years
 –38°C
 71°C / 15hPa
 0.970
 –
 drums
 not restricted

N-Benzyl-N-methyl-2-aminoethyl-
Benzyl acetoacetate (BAA) acetoacetate (AABME) Dodecyl acetoacetate (AAdodecyl)

  C11H12O3   C14H19NO3   C16H30O3

Molecular weight  192.22  249.31  270.42

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
 5396-89-4
 –
 2 years
 12°C
 275°C dec.
 1.114
 Xi irritant
 drums
 not restricted
 54527-65-0
 95.0 %
 8 months
 –
 175°C dec.
 1.067
 –
 drums
 not restricted
 52406-22-1
 96.0 %
 2–3 years
 –
 190°C /20 hPa
 0.914
 Xi irritant
 drums
 not restricted

6
 2-Methoxyethyl acetoacetate 4-Nitrobenzyl acetoacetate
Ethyl benzoylacetate-91 (BESethyl-91) (AAmethoxyethyl) (30 % in toluene) (PNBAA 30T)

  C11H12O3   C7H12O4   C11H11NO5

Molecular weight  192.22  160.16  237.21

CAS RN  94-02-0  22502-03-0  61312-84-3
Minimum assay  91.0 %  97.5 %  270-330 g/l
Minimum stability  2 years  2 years  9 months
Melting point ca.  –  –  –
Boiling point ca.  93°C / 10 Pa  118°C / 26hPa  –
Density g/cm3 (20°C)  –  1.091  –
EU labeling  –  T toxic  F, Xn; R11-38-48/20-63-65-67
Packaging  drums  drums  iron drums 56.25 kg, 187.5 kg
Transport information  not restricted  not restricted  UN 1993, 3, PG II

Acetoacetanilide (AAA) Acetoacetanilide, flakes (AAA,flakes)

Arylides   C10H11NO2   C10H11NO2

Molecular weight   177.20  177.20

CAS RN   102-01-2  102-01-2
Minimum assay   99.5 %  95.0 %
Minimum stability   2 years  9 months
Melting point ca.   83.0°C  62.0°C
Boiling point ca.   –  –
Density g/cm3 (20°C)   –  –
EU labeling  Xn harmful  Xn harmful
Packaging  paper bags, big bags  big bags
Transport information  not restricted  not restricted

Acetoacet-o-toluidide (AAOT) Acetoacet-m-xylidide (AAMX)

  C11H13NO2   C12H15NO2
Pharma

Colorants

Agriculture
Molecular weight  191.23  205.26
CAS RN  93-68-5  97-36-9
Minimum assay  99.5 %  99.5 % Polymers
Minimum stability  2 years  2 years
Melting point ca.  103.5°C  89°C
Boiling point ca.  –  – Nutrition
Density g/cm3 (20°C)  –  –
EU labeling  Xn harmful  Xn harmful Various
Packaging  paper bags, big bags  paper bags, big bags
Transport information  not restricted  not restricted

7
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

Acetoacet-4-chloro-2,5-dimethoxy-
Acetoacet-o-chloroanilide (AAOC) Acetoacet-o-anisidide (AAOA) anilide (ASIRG)
Diketene /    C10H10ClNO2   C11H13NO3   C12H14ClNO4
ketene
derivatives

Molecular weight  211.65  207.23  271.70

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
 93-70-9
 99.5 %
 2 years
 103.5°C
 –
 –
 Xn harmful
 paper bags
 not restricted
 92-15-9
 99.5 %
 2 years
 83.5°C
 –
 –
 Xn harmful
 paper bags, big bags
 not restricted
 4433-79-8
 98.0 %
 2 years
 104°C
 –
 –
 Xn harmful
 paper bags
 not restricted

Acetoacet-5-chloro-2-methoxy- Potassium N-(acetoacetyl)

anilide (AAMOC) sulfanilate (AAsulfanil-K)

  C11H12ClNO3   C10H10KNO5S Alkylamides

Molecular weight  241.68  295.36 

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
 52793-11-0
 99.0 %
 2 years
 92°C
 –
 –
 –
 paper bags
 not restricted
 70321-85-6 
 96.0 % 
 2 years 
 >300°C 
 – 
 – 
 –
 paper bags, big bags
 not restricted

N,N-Dimethylacetoacetamide
N-Methylacetoacetamide (MMAA) (DMAA-80) N,N-Diethylacetoacetamide (DEAA)

  C5H9NO2   C6H11NO2   C8H15NO2

Molecular weight  115.13  129.16  157.21

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
 20306-75-6
 70.0 %
 2 months
 –
 110°C
 1.078
 –
 drums, bulk
 not restricted
 2044-64-6
 80.0 %
 6 months
 –
 106°C
 1.060
 –
 drums, bulk
 not restricted
 2235-46-3
 98.0 %
 3 months
 –
 213°C
 0.995
 –
 drums, bulk
 not restricted

8
 Acetoacetamide (AAmid) 3-Methyl-5-pyrazolone (MP)

  C4H7NO2 Pyrazolones   C4H6N2O

Molecular weight  101.11  98.11

CAS RN  5977-14-0  108-26-9
Minimum assay  98.5 %  99.0 %
Minimum stability  18 months  2 years
Melting point ca.  52°C  217°C
Boiling point ca.  –  –
Density g/cm3 (20°C)  –  –
EU labeling  – –
Packaging  paper bags drums
Transport information  not restricted not restricted

3,5-Dimethylpyrazole (DMP) Dehydroacetic acid (DHS)

  C5H8N2 Dehydroacetic acid   C8H8O4

Molecular weight 96.13  168.15

CAS RN 67-51-6  520-45-6
Minimum assay 99.0 %  99.0 %
Minimum stability 3 years  2 years
Melting point ca. 107°C  109°C
Boiling point ca. 218°C  –
Density g/cm3 (20°C) –  –
EU labeling – Xn harmful
Packaging drums paper bags
Transport information not restricted not restricted

Dehydroacetic acid, sodium salt Dehydroacetic acid, sodium salt

(NaDHS) monohydrate (NaDHS-H2O)

  C8H7O4Na   C8H9O5Na
Pharma

Colorants

Agriculture
Molecular weight 190.13 208.15
CAS RN 4418-26-2 64039-28-7
Minimum assay 99.0 % 98.0 % Polymers
Minimum stability 2 years 2 years
Melting point ca. – 109°C
Boiling point ca. – – Nutrition
Density g/cm3 (20°C) – –
EU labeling Xn harmful Xn harmful Various
Packaging drums drums
Transport information not restricted not restricted

9
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog

2-(Acetoacetoxy) ethylmetha­crylate Propane-1.1.1-triyltrimethyl tris

(AAEMA) (acetoacetate) (AATMP)
Diketene /  Lonzamon monomers   C10H14O5   C18H26O9
ketene
derivatives

Molecular weight  214.21 386.4

CAS RN  21282-97-3 22208-25-9
Minimum assay  95.0 % 92.0 %
Minimum stability  1 year 2 years
Melting point ca.  –60°C –30°C
Boiling point ca.  100°C / 1hPa 300°C
Density g/cm3 (20°C)  1.122 –
EU labeling Xi irritant –
Packaging drums drums
Transport information not restricted not restricted

Squaric acid (QS) Diethyl squarate (QS, diethyl)

Other diketene / ketene   C4H2O4   C8H10O4

derivatives

Molecular weight  114.06 170.17

CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
 2892-51-5 5231-87-8
 98.5 % 98.0 %
 2 years 12 months
 293°C 4–8°C (solidification)
 – 95°C / 0.1 hPa
 1.82 1.15
– T toxic; R21-25-36/37/38-42-43
drums iron drums
not restricted UN 2810, 6.1, PG III

Diacetoacet-1,4-phenylenediamide Diacetoacet-2,5-dimethyl-1,4-
Diacetoacet-o-tolidide (DiAA-o-tolidid) (DiAAphen) phenylenediamide (DiAA DM)

  C22H24N2O4   C14H16N2O4   C16H20N2O4

Molecular weight 380.45 276.29 304.38

CAS RN 91-96-3 24731-73-5 24304-50-5
Minimum assay 98.0 % 98.5 % 98.0 %
Minimum stability 2 years 2 years 2 years
Melting point ca. 206°C 171°C 232°C
Boiling point ca. – – –
Density g/cm3 (20°C) – – –
EU labeling – – –
Packaging bag-in-box, drums paper bags paper bags
Transport information not restricted not restricted not restricted

10
 Diacetoacet-2-chloro-5-methyl-1,4- Diacetoacet-2,5-dichloro-1,4-
phenylenediamide (DiAA MC) pheny­lene­diamide (DiAA DC) Methyl 3-aminocrotonate (ACMe)

  C15H17ClN2O4   C14H14Cl2N2O4   C5H9NO2

Molecular weight 324.77 345.18 115.13

CAS RN 41131-65-1 42487-09-2 14205-39-1
Minimum assay 97.0 % 97.0 % 98.0 %
Minimum stability 5 years 5 years –
Melting point ca. 192°C 197°C 81°C
Boiling point ca. – – 112°C / 55hPa
Density g/cm3 (20°C) – – –
EU labeling – – Xi irritant
Packaging paper bags paper bags drums
Transport information not restricted not restricted not restricted

1,4-Butyleneglycolbis Thiodiglycolbis
(3-amino­crotonate) (BGAC) Diketene-acetone adduct (DAA) (3-aminocrotonate) (TGAC)

  C12H20N2O4   C7H10O3   C12H20N2O4S

Molecular weight 256.30 142.16 288.37

CAS RN 14205-47-1 5394-63-8 13560-49-1
Minimum assay 96.0 % 93.0 % 96.0 %
Minimum stability 2 years 3 months 2 years
Melting point ca. 146°C 12°C 88°C
Boiling point ca. – 66°C / 3mbar –
Density g/cm3 (20°C) – 1.094 –
EU labeling – F flammable N environment
Packaging bag-in-box drums fibre container
Transport information not restricted UN-No.: 1993, 3, PG II UN-No.: 3077, 9, PG III

2,5-Dimethyl-2,4-dihydro-
pyrazol-3-on (DMPO) Ethyl 4-chloroacetoacetate (CAAEt)

  C5H8N2O   C6H9ClO3
Pharma

Colorants

Agriculture
Molecular weight  112.13 164.59
CAS RN  2749-59-9 638-07-3
Minimum assay  >98.0 % 97.0 % Polymers
Minimum stability  – 1 year
Melting point ca.  117–118°C –8.5°C
Boiling point ca.  105–115°C / 8 hPa 220°C Nutrition
Density g/cm3 (20°C)  1.14 1.212
EU labeling  Xi irritant T toxic, N environment Various
Packaging  – drums
Transport information  not restricted UN-No.: 2922, 8, PG II

11
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Diketene /    C6H7F3O3
ketene
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
HCN
derivatives
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Ethyl 4,4,4-trifluoroacetoacetate Methyl 3,3-dimethoxypropanoate
(ETFAA) (PRSMe,DM)
  C6H12O4
184.12  148.16
372-31-6  7424-91-1
98.0 %  98.0 %
6 months  12 months
–39°C  <–65°C
131°C  77°C / 26 mbar
1.2586  1.06
Xn harmful  –
drums  –
not restricted  not restricted
Methyl 4-methyl-3-oxopentanoate
(OPMe, 4-methyl)
  C7H12O3
144.17
42558-54-3
98.0  %
12 months
–75°C
192°C
1.01
– Various
drum or iso-container
not restricted
Adenine Cyanuric chloride A (CC A)
  C5H5N5   C3Cl3N3
 135.13  184.41
 73-24-5  108-77-0
 98.0–102.0 %  99.5 %
 2 years  6 months
 360°C  145.0–147.0°C
 –  193°C / 1013 hPa
 –  –
 –  –
 drums  bags in box
 not restricted  not restricted
12
(E)-Methyl 3-methoxyacrylate
(E-MMA)
  C5H8O3
 116.12
 34846-90-7, 5788-17-0 (linear structure)
 ≥98.0 %
 2 years
 2–3°C
 95°C / 100 hPa
 1.07
 –
 –
 not restricted
Pharma
Colorants
Agriculture
Polymers
Nutrition
Cyanuric chloride AS (CC AS)
  C3Cl3N3
 184.41
 108-77-0
 99.5 %
 6 months
 145.0–147.0°C
 193°C / 1013 hPa
 –
 –
 big bags
 not restricted
 2-Methoxyethyl cyanoacetate
Allyl cyanoacetate (CNESallyl) Butyl cyanoacetate (CNESbutyl) (CNES methoxyet)

  C6H7NO2   C7H11NO2   C6H9NO3

Molecular weight  125.13  141.17  143.14

CAS RN  13361-32-5  5459-58-5  10258-54-5
Minimum assay  99.0 %  99.0 % ≥99.0 %
Minimum stability  2 years  2 years  2 years
Melting point ca.  –40°C  –  –
Boiling point ca.  89–90°C / 5 hPa  109.0°C / 13.0 hPa  257°C / 1000 hPa
Density g/cm3 (20°C)  –  0.998–1.002  –
EU labeling  T toxic; R25  –  –
Packaging  drums 200 kg  drums 200 kg  iron drums 200 kg, container
Transport information  UN 3276, 6.1, PG III  not restricted  not restricted

Malononitrile (85 % in methanol)

Chlorosulfonyl isocyanate (CSI) Malononitrile (MDN) (MDN)

  CClNO3S   C3H2N2   C3H2N2 ; CH4O

Molecular weight  141.53  66.06  98.11

CAS RN  1189-71-5  109-77-3  109-77-3
Minimum assay  99.0–100.3 %  99.0 %  83.5–86.5 %
Minimum stability  12 months  18 months  2.5 months
Melting point ca.  –  – 19.5°C
Boiling point ca.  1060°C  218–219°C  –
Density g/cm3 (20°C)  1.626  1.0494 (35°C)  1.011 (35°C)
EU labeling  C corrosive; R14-20/21/22-34  T toxic, N environment; R23/24/25-50/53  T,N; R10-23/24/25-39/23/24/25-50/53
Packaging  drums  drums  drums, rail tank wagon
Transport information  UN 3264, 8, PG I  UN 2647, 6.1, PG ll  UN 2929, 6.1 (3), PG ll

3-Aminocrotononitrile (Diacetonitril) Sodium dicyanamide (Na-dicyanamide) 1,1,3,3-Tetramethylguanidine (TMG)

  C4H6N2   C2N3Na   C5H13N3

Molecular weight  82.11  89.03  115.18

CAS RN  1118-61-2  1934-75-4  80-70-6
Minimum assay  96.0 %  ≥97.0 %  99.0 %
Minimum stability  8 months  2 years  1 year
Melting point ca.  40–67°C  >260°C  –
Boiling point ca.  –  –  162°C / 1013 hPa
Density g/cm3 (20°C)  0.9520 (77°C)  –  0.92
EU labeling  –  –  –
Packaging  drums  drums, BB packaging on request  drums, bulk
Transport information  not restricted  not restricted  not restricted

13
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Heterocycles
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Akolidine 10
(Pyridine, alkyl derivatives)
  All akolidines contain the following components:
 –
 68391-11-7
 –
 –
 –
– 
 0.978–0.990
 –
 iron drum, bulk
 not restricted
2-Amino-4,6-dimethoxypyrimidine
(ADMP)
  C6H9N3O2
 155.16
 36315-01-2
 98.0–101.0 %
 2 years
 96–98°C
 –
 –
 –
 drums
 not restricted
5-Ethyl-2-methylpyridine (MEP)
  C8H11N
 121.18
 104-90-5
 –
 1 year
 –70.9°C
 178.3°C
 0.918–0.921
– 
 iron drum 180 kg
 not restricted
Akolidine 11
(Pyridine, alkyl derivatives)
 –
 68391-11-7
 –
 –
 –
– 
 1.018–1.034
 –
 iron drum, bulk
 not restricted
2-Chloro-4,6-dimethoxypyrimidine
(DMP, 2-Chlor)
  C6H7ClN2O2
 174.59
 13223-25-1
 98.0–100.3 %
 2 years
 102–104°C
 –
 –
 –
 drums
 not restricted
6-Hydroxynicotinic acid (NS,6-Hydroxy)
  C6H5NO3
 139.11
 5006-66-6
97.5–100.3 %
 2–3 years
 314 –316°C
 –
 –
– 
 drums
 not restricted
14
Akolidine 12
(Pyridine, alkyl derivatives)
 –
 68391-11-7
 –
 –
 –
–
 1.024–1.038
 –
 iron drum, bulk
 not restricted
2-(5-Ethyl-2-pyridyl)ethanol
(PRD-2-etol, 5-Et)
  C9H13NO
 151.21
 5223-06-3
95.0 %
 2 years
 45°C 
 147–149°C
 1.042
 –
 iron drum 200 kg
 not restricted
Sodium nicotinate (NS-Na)
  C6H4NNaO2
 145.09
 54-86-4
 99.0–100.3 %
 3 years
 410°C
 –
 –
–
 drums
 not restricted
 Niacin min. 99.5 % (NS fg) Niacinamide USP (NSA USP) Meta™ metaldehyde (META tc)

  C6H5NO2   C6H6N2O   C8H16O4

Molecular weight  123.11  122.13  176.21

CAS RN  59-67-6  98-92-0  108-62-3
Minimum assay  99.5–100.3 % 99.0–101.0 % 98.0–99.8 %
Minimum stability  3 years  3 years  3 years (10°C)
Melting point ca.  234.0–237.0°C  128.0–131.0°C  246°C
Boiling point ca.  –  –  –
Density g/cm3 (20°C)  –  –  –
EU labeling  –  –  –
Packaging  paper bags, big bags  bag-in-box 20 kg  bag-in-box 25 kg
Transport information  not restricted  not restricted  not restricted

Paraldehyde (PARA) 2-Picoline (Picoline,2) 4-Picoline (Picoline,4)

  C6H12O3   C6H7N   C5H7N

Molecular weight  132.16  93.13  93.13

CAS RN  123-63-7  109-06-8  108-89-4
Minimum assay 99.5 %  99.0 %  >98.0 %
Minimum stability  60 days  2 years  –
Melting point ca.  –  –66.8°C  3.6°C
Boiling point ca.  –  125–130°C  145.4°C
Density g/cm3 (20°C)  0.993–0.997 kg/l (20°C)  –  0.954
EU labeling  –  –  T toxic; R10, R20/22, R24, R36/37/38
Packaging  iron drum 200 kg, bulk  iron drum 180 kg, bulk  –
Transport information  not restricted  not restricted  not restricted

4,6-Dimethoxy-2-[(phenoxy-
Pyrimidine (<0.5 % water) carbonyl)amino]pyrimidine
(Pyrimidine W<0.5) (ADMP-carbamat)

  C4H4N2   C13H13N3O4
Pharma

Colorants

Agriculture
Molecular weight  80.09  275.26
CAS RN  289-95-2  89392-03-0
Minimum assay  98.5–100.0 %  97.0–101.0 % Polymers
Minimum stability  2 years  2 years
Melting point ca.  20–22°C  120–122°C
Boiling point ca.  122–24°C  > 250°C Nutrition
Density g/cm3 (20°C)  1.016  –
EU labeling  –  – Various
Packaging  drums  drums
Transport information  not restricted  not restricted

15
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Basic
chemicals
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Molecular weight
CAS RN
Minimum assay
Minimum stability
Melting point ca.
Boiling point ca.
Density g/cm3 (20°C)
EU labeling
Packaging
Transport information
Acetaldehyde (AcAl)
  C2H4O
 44.05
 75-07-0
 99.5 %
 1 year
 –123.5°C
 21°C
 0.784–0.786 kg/l (15°C)
 –
 drums, bulk
 not restricted
Ammonia techn. (Ammonia tc)
  NH3
 17.03
 7664-41-7
 99.8 %
 2 years
 –
 33.4°C / 1013 hPa
 0.609
 –
 rail tanker
 not restricted
Nitrosylsulfuric acid 40 % (SS,Nitrosyl 40)
  HNO5S
 127.08
 7782-78-7
 39.5–40.5 %
 2 years
 –12 – –3°C
 333°C
 1.893
 –
 rail tanker
 not restricted
Acetic acid (glacial) (ES 99) Acetic anhydride (ESanhydrid)
  C2H4O2   C4H6O3
 60.05  102.09
 64-19-7  108-24-7
 99.5–100.0 %  99.5 %
 2 years  2 years
 15.8–16.3°C  –73°C
 113–115°C / 933 hPa  –
 1.050 g/ml (20°C)  1.0820
 –  –
 drum 200 kg, bulk  drums 200 kg, rail tanker
 not restricted  not restricted
Ammonia aqueous (Ammonia 24)
approx. 24.5–24.9 % chemically pure Nitric acid 65 %
  NH3   HNO3
 17.03  63.01
 1336-21-6  7697-37-2
 24.5–24.9 %  65.0–65.5 %
 2 years  –
 –  –33°C
 –  121°C / 1013 hPa
 0.9150–0.9110 g/ml (15°C)  –
 –  –
 drums, road and rail tanker  rail tanker
 not restricted  not restricted
Malonic acid (MA)
  C3H4O4
 104.06
 141-82-2
 99 %
 1 year
 134°C (Mettler)
 –
 –
 Xi irritant; R36
 bags
 not restricted
16
 2,6-Diethyl-4-methylaniline (DEMA) 2,6-Diisopropylaniline (DIPA) 4,4-Dimethoxy-butan-2-one (DMB)
Others   C11H17N   C12H19N   C6H12O3

Molecular weight  163.26  177.29  132.16

CAS RN  24544-08-9  24544-04-5  5436-21-5
Minimum assay  >98.0 %  92.0 %  >92.0 %
Minimum stability  1 year  1 year  2 years
Melting point ca. –12°C – –7°C –45°C  –83 – –81°C
Boiling point ca.  –  257°C / 1013 mbar  169–71°C
Density g/cm3 (20°C)  0.945  0.940  0.9977
EU labeling  Xn harmful; R21/22  R52/53  –
Packaging  steel drums, bulk  iron drum 180 kg, bulk  drums, bulk
Transport information  not restricted  not restricted  not restricted

Valeronitrile (VN)

  C5H9N
Pharma

Colorants

Agriculture
Molecular weight  83.13
CAS RN  110-59-8
Minimum assay  99.5 % Polymers
Minimum stability  2 years
Melting point ca.  –
Boiling point ca.  139–141°C / 1013 hPa Nutrition
Density g/cm3 (20°C)  0.7990
EU labeling  – Various
Packaging  drums, bulk
Transport information  not restricted

17
Diketene and HCN derivatives, heterocycles
and basic chemicals catalog
Alphabetical index
Page Product Abbreviation
A D
6
1 Acetaldehyde AcAl
16 Acetic acid (glacial) ES 99
16 Acetic anhydride ESanhydrid
9 Acetoacetamide AAamid
7 Acetoacetanilide AAA
8 Acetoacet-4-chloro-2,5-dimethoxyanilide ASIRG
8 Acetoacet-5-chloro-2-methoxyanilide AAMOC
7 Acetoacet-m-xylidide AAMX
8 Acetoacet-o-anisidide AAOA
8 Acetoacet-o-chloroanilide AAOC
7 Acetoacet-o-toluidide AAOT
10 2-(Acetoacetoxy)ethyl methacrylate AAEMA
12 Adenine Adenine
14 Akolidine 10 Akolidine 10
14 Akolidine 11 Akolidine 11
14 Akolidine 12 Akolidine 12
13 Allyl cyanoacetate CNESallyl
14 2-Amino-4,6-dimethoxypyrimidine ADMP
13 3-Aminocrotononitrile Diacetonitril
16 Ammonia aqueous approx. 24.5–24.9 % chemically pure Ammonia 24
10 Ammonia techn. Ammonia tc
B 7 Ethyl benzoylacetate BESethyl
6 Benzyl acetoacetate BAA
6 N-Benzyl-N-methyl-2-aminoethylacetoacetate AABME
13 Butyl cyanoacetate CNESbutyl
6 t-Butyl cyanoacetate AA-t-butyl
11 1,4-Butyleneglycolbis(3-aminocrotonate) BGAC
C 14 6-Hydroxynicotinic acid NS,6-Hydroxy
4
1 2-Chloro-4,6-dimethoxypyrimidine DMP, 2-Chlor
13 Chlorosulfonyl isocyanate CSI
12 Cyanuric chloride A CC A
12 Cyanuric chloride AS CC AS
18
Page Product Abbreviation
9 Dehydroacetic acid DHS
9 Dehydroacetic acid sodium salt monohydrate NaDHS-H2O
9 Dehydroacetic acid sodium salt NaDHS
11 Diacetoacet-2-chloro-5-methyl-1,4-phenylenediamide DiAA MC
11 Diacetoacet-2,5-dichloro-1,4-phenylenediamide DiAA DC
10 Diacetoacet-2,5-dimethyl-1,4-phenylenediamide DiAA DM
10 Diacetoacet-1,4-phenylenediamide DiAAphen
10 Diacetoacet-o-tolidide DiAA-o-tolidid
8 N,N-Diethylacetoacetamide DEAA
10 Diethyl squarate QS, diethyl
16 2,6-Diethyl-4-methylaniline DEMA
11 Diketene-acetone adduct DAA
16 2,6-Diisopropylaniline DIPA
16 4,4-Dimethoxy-butan-2-one DMB
15 4,6-Dimethoxy-2-[(phenoxy-carbonyl)amino]pyrimidine (ADMP-carbamat)
8 N,N-Dimethylacetoacetamide DMAA
11 2,5-Dimethyl-2,4-dihydro-pyrazol-3-on DMPO
9 3,5-Dimethylpyrazole DMP
6 Dodecyl acetoacetate AAdodecyl
E
6 Ethyl acetoacetate EAA
11 Ethyl 4-chloroacetoacetate CAAEt
14 5-Ethyl-2-methylpyridine MEP
14 2-(5-Ethyl-2-pyridyl)ethanol PRD-2-etol, 5-Et
12 Ethyl 4,4,4-trifluoroacetoacetate ETFAA
H
I
6 Isobutyl acetoacetate AAisobutyl
6 Isopropyl acetoacetate IPAA
M
6
1 Malonic acid MA
13 Malononitrile (85 % in methanol) MDN
13 Malononitrile MDN
15 Meta™ metaldehyde META tc
7 2-Methoxyethyl acetoacetate AAmethoxyethyl
13 2-Methoxyethyl cyanoacetate CNES methoxyet
9 3-Methyl-5-pyrazolone MP
12 Methyl 3,3-dimethoxypropanoate PRSMe,DM
11 Methyl 3-aminocrotonate ACMe
12 (E)-Methyl 3-methoxyacrylate E-MMA
12 Methyl 4-methyl-3-oxopentanoate OPMe, 4-methyl
8 N-Methylacetoacetamide MMAA
6 Methyl acetoacetate MAA
Page Product Abbreviation

N
5
1 Niacin min. 99.5 % NS fg
15 Niacinamide USP NSA USP
16 Nitric acid 65 %
7 4-Nitrobenzyl acetoacetate (30 % in toluene) PNBAA 30T
16 Nitrosylsulfuric acid 40 %  SS,Nitrosyl 40

P
5
1 Paraldehyde PARA
15 2-Picoline Picoine,2
15 4-Picoline Picoline,4
8 Potassium N-(acetoacetyl)sulfanilate AAsulfanil-K
10 Propane-1,1,1-triyltrimethyl tris(acetoacetate) AATMP
15 Pyrimidine (<0.5 % water) Pyrimidine W<0.5

S
3
1 Sodium dicyanamide Na-dicyanamide
14 Sodium nicotinate NS-Na
10 Squaric acid QS

T
3
1 1,1,3,3-Tetramethylguanidine TMG
11 Thiodiglycolbis(3-aminocrotonate) TGAC

V
16 Valeronitrile VN
www.lonza.com
Administration /
technical service
Switzerland
Lonza Ltd
Muenchensteinerstrasse 38
4002 Basel
Tel + 41 61 316 81 11
contact@lonza.com
USA
Lonza Inc.
90 Boroline Road
Allendale, NJ 07401
Tel +1 201 316 9200
contact.allendale@lonza.com
Sales offices
Europe Asia
Lonza Benelux BV Lonza Guangzhou Ltd
Aluminiumstraat 1 39, Jinhui Road
PO Box 3148 Haizhu District
NL-4823 AL Breda CN-Guangzhou 510288
Tel +31 76 542 51 00 Tel +86 20 8433 8998
contact.nl@lonza.com contact.cn@lonza.com
Lonza Biotec sro Lonza Japan Ltd
Okruzní 134 Kyowa Shinkawa Bldg 8F
CZ-281 61 Kouřím 2-20-8, Shinkawa, Chuo-ku
Tel +42 0321 738 654 JP-Tokyo 104-0033
contact.cz@lonza.com Tel +81 3 5566 0612
contact.jp@lonza.com
Lonza France Sàrl
55, rue Aristide Briand
FR-92309 Levallois-Perret Cedex
Tel +33 1 40 89 99 00
contact.fr@lonza.com
Lonza Cologne GmbH
Nattermannallee 1
DE-50829 Köln
Tel + 49 221 99 1990
info.cologne@lonza.com
Lonza Ltd Representation Office
Dunaház III. lépcsöház II. em 2
Boráros tér 7
HU-1095 Budapest IX
Tel +36 1 215 94 19
contact.hu@lonza.com
Lonza Ltd Representation Office
ul. Smolenskiego 4 m 15
PL-01-698 Warsaw
Tel +48 22 833 87 45
contact.pl@lonza.com
Lonza Ibérica S.A.U. (Unipersonal)
Vía Augusta, n° 18, 2a Pta, izda
ES-08006 Barcelona
Tel +34 93 238 54 60
contact.es@lonza.com
Lonza Biologics plc
Suite 3, Building A
The Courtyard
Severn Drive
The information contained herein is believed to be correct
Tewkesbury Business Park and corresponds to the latest state of scientific and technical
GB-Tewkesbury GL20 8GD knowledge. However, no warranty is made, either expressed
Tel +44 1684 292 728 or implied, regarding its accuracy or the results to be obtained
contact.uk@lonza.com from the use of such information. Some products may not be
available in all markets or for every type of application. Any
user must make his own determination and satisfy himself
that the products supplied by Lonza Group Ltd and the informa-
tion and recommendations given by Lonza Group Ltd are (i)
suitable for intended process or purpose, (ii) in compliance
with environmental, health and safety regulations, and (iii)
will not infringe any third party’s intellectual property rights.
© 2011 Lonza Ltd