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A. NUCLEAR
1. Hypersegmentation (≥ 6 lobes)
a. Hereditary
• autosomal dominant
b. Acquired
• Megaloblastic anemia
2. Hyposegmentation
nez” shape
• Autosomal dominant
B. CYTOPLASM
b. Auer Rods
c. Chediak-Higashi Inclusion
d. May-Hegglin Inclusion
• Pale blue inclusion derived from RNA (confused with Dohle Bodies)
• May Hegglin Anomaly – autosomal dominant; associated with thrombocytopenia and GIANT PLATELETs.
e. Dohle Bodies
• Aggregates of free ribosomes of rough ER seen in severe infections and toxic states.
• Single multiple blue inclusions
f. Toxic granules
g. Toxic Vacuoles
C. FUNCTION
a. Job’s Syndrome
a. LE Cell
b. Tart Cell
E. LYMPHOCYTE ABNORMALITIES
• Type II
– Associated with IM
– “Ballerina-skirt” appearance
• Type III
– Vacuolated
Seen in:
• Pressure in wedge smear preparation; usually the remedy is the addition of BOVINE ALBUMIN.
• Chronic Lymphocytic Leukemia (CLL) where in there is an increase in Smudge cell.
c. Hairy Cells
d. Sezary Cells
a. Flame Cell
b. Russel Bodies
• Individual globules of Ig
d. Dutcher’s Bodies
• Intranuclear protein inclusions
HISTIOCYTES
a. Gaucher’s Disease
b. Niemann-Pick
• Deficient SPHINGOMYELINASE
• Accumulation of sphingomyelin
• FAOMY cytoplasm
c. Tay-Sach’s
• Deficient HEXOAMINIDASE A
• Accumulation of glycolipid and ganglioside
• Vacuolated cytoplasm
d. Sandhoff