Hematology

1. Which of the following changes is likely to be seen in bone marrow cells from a case of
chronic myeloid leukemia?
a) Part of chromosome 9 is present on chromosome 22
b) Part of chromosome 22 is present on chromosome 9
c) Part of chromosome 22 is present on chromosome 9 and part of chromosome 9 is
present on chromosome 22
d) Chromosome 22 is absent.
Ans:……

2. A person with gastric cancer undergoes gastrectomy (removal of stomach). He is likely to

suffer from which of the following types of anemia.

a) Microcytic hypochromic anemia

b) Hemolytic anemia
c) Macrocytic anemia
d) Normocytic Normochromic anemia
Ans:…

3. A 16-year old boy develops ecchymotic spots on his body. He gives history of developing
fever about 2 weeks ago, that lasted for 5 days. His platelet count was reported as normal. His
platelet count is likely to be in range of

A 1,50,000 – 4,50,000/mm3
B 50,000 – 75,000/mm3
C 4,500 – 11,000/mm3
D 4.5 million – 5.5 million/mm3
Ans:……

4. A 30- year old man develops enlarged lymph nodes on his neck that did not respond to
conventional antibiotic therapy. A lymph node biopsy was done and it showed many binucleate cells
with owl-eye nuclei. This man is likely to be having

A Tubercular lymphadenitis
B Hodgkin’s lymphoma
C Metastasis of squamous cell carcinoma
D Non-Hodgkin’s lymphoma
Ans:…
5. A 13-year-old boy has enlarged lymph nodes of the posterior cervical group. As no response
was obtained after adequate antibiotic therapy, a lymph node biopsy was done. It was reported as
Burkitt’s lymphoma. Which of the following viruses has been implicated in its causation?

A. Human papilloma virus

B. Epstein Barr virus
C. Human immunodeficiency virus
D. Human T cell leukemia virus
Ans:…………

6. A 55-year-old man presented to the hospital complaining of pain in abdomen. On

examination, he had marked spleenomegaly. His WBC counts were 74,000/cmm with presence of
many immature leukocytes. The cells were positive for Philadelphia chromosome. This patient is
likely to be suffering from

A Hodgkins disease
B Chronic lymphatic leukemia
C Severe pyogenic infection
D Chronic myeloid leukemia
Ans:……..

7. An 11-year old child with hemoglobin level of 7.5 gm/dl showed presence of microcytic
hypochromic RBCs. He was prescribed iron supplements. His reticulocyte count after one
week of therapy was 4.0 %. This indicates that:

A The patient is showing accelerated erythropoeisis.

B Patient is unresponsive to iron therapy.
C Erythropoeisis is depressed.
D Patient is having aplastic anemia
Ans:……
8. A 55-year-old man presented to the hospital with large spleenomegaly. On investigation, his
peripheral blood revealed a total WBC count of 1,78,000/cmm with presence of 40%
neutrophils, 36% myelocytes, 10% metamyelocytes and 2% blast cells. Most likely
diagnosis in his case is

A Acute myeloid leukemia

B Chronic myeloid leukemia
C Chronic myeloid leukemia with blast transformation
D Chronic lymphoid leukemia
Ans:…..
9. An 8-year-old child develops swelling in the mandibular bone since last 8 months. No other
lymph node enlargement was seen. A biopsy was done and it revealed a type of lymphoma
in which ‘starry sky’ appearance is seen. Most likely diagnosis is
 A Hodgkins lymphoma, lymphocytic predominant
B Hodgkin’s lymphoma, nodular sclerosis
C Burkitt’s lymphoma
D Non-Hodgkins lymphoma, small lymphocytic.

10. Which of the following statements about the molecule hemoglobin is FALSE

A Breakdown of this molecule yields bilirubin

B The molecule can combine with carbon monoxide
C Decreased synthesis of this molecule produces anemia
D Amino acids are not seen in this molecule
Ans:…..

11. A 13-year girl complaining of increasing tiredness on investigation was found to be anemic.
Her peripheral blood smear showed presence of macrocytes and her bone marrow examination
revealed megaloblastic maturation. Megaloblasts result from impaired synthesis of

A. DNA
B. RNA
C. Beta globin chains
D. G 6 PD enzyme
Ans …….

12. A 10-year-old boy develops swelling on mandible that on excision was histologically
reported as Burkitt’s lymphoma. If this tumour was to be further investigated, it may reveal
presence of

A. Caseating granulomas
B. Reed Sternberg cells
C. Epstein Barr virus integrated into the tumour cell genome
D. Human papilloma virus within cytoplasm of the tumour cells
Ans ……
A 13-year girl complaining of increasing tiredness was found to be anemic. Her PBS shows
presence of macrocytes. Bone marrow examination revealed megaloblastic maturation.
Megaloblasts result from impaired synthesis of
a) DNA
b) RNA
c) Β -globin chains
d) G 6 PD enzyme

A WBC (having lobed nucleus and fine cytoplasmic granules staining purple with Leishman stain)
that provides an important defense against infection by ingesting and killing bacteria is called:
a) Basophil
 b) Monocyte
c) Neutrophil
d) Phagocyte
e) Cytokine

Poor prognostic indicator in ALL ?

A) Age < 2 years
B) TLC 4000 - 10,000
C) Presence of testicular involvement at presentation
D) Presence of Blasts in peripheral smear
Answer: A) Age < 2 years

ABO antigens are not found in ?

A) CSF
B) Plasma
C) Saliva
D) Semen
Answer: A) CSF

ABO incompatibility is not seen with ?

A) FFP
B) Packed RBCs
C) Platelet concentrate
D) Cryoprecipitate
Answer: C) Platelet concentrate

A 34-year-old previously healthy woman notes that she has bruises form on her arms and legs with
just minor trauma. Physical examination reveals areas of purpura from 1 to 3 cm in size over her
trunk and extremities, but no swelling, warmth, or erythema. Peripheral pulses are all palpable and
full. Her blood pressure is 110/70 mm Hg. An ultrasound examination of her lower extremities with
Doppler flow measurement reveals no evidence for thrombosis. Laboratory findings include serum
urea nitrogen of 16 mg/dL, LDH 300 U/L, total protein 6.9 g/dL, albumin 5.3 g/dL, alkaline
phosphatase 50 U/L, AST 40 U/L, and ALT 20 U/L. Which of the following additional laboratory
findings is most likely to be present in this patient?
a) Hyperglycemia
b) Hypercholesterolemia
c) Lactic acidosis
d) Thrombocytopenia
e) Hypoprothrombinemia
f) Anemia
A 16-year old boy develops ecchymotic spots on his body. He gives history of developing fever
about 2 weeks ago, that lasted for 5 days. His platelet count was reported as normal. His platelet
count is likely to be in range of

a) 1,50,000 – 4,50,000/mm3
b) 50,000 – 75,000/mm3
c) 4,500 – 11,000/mm3
d) 4.5 million – 5.5 million/mm3

A 55-year-old man presented to the hospital complaining of pain in abdomen. On

examination, he had marked spleenomegaly. His WBC counts were 74,000/cmm with
presence of many immature leukocytes. The cells were positive for Philadelphia
chromosome. This patient is likely to be suffering from

a) Hodgkins disease
b) Chronic lymphatic leukemia
c) Severe pyogenic infection
d) Chronic myeloid leukemia

A 55-year-old man presented to the hospital with large spleenomegaly. On investigation, his
peripheral blood revealed a total WBC count of 1,78,000/cmm with presence of 40% neutrophils,
36% myelocytes, 10% metamyelocytes and 2% blast cells. Most likely diagnosis in his case is

a) Acute myeloid leukemia

b) Chronic myeloid leukemia
c) Chronic myeloid leukemia with blast transformation
d) Chronic lymphoid leukemia

Which of the following statements about the molecule hemoglobin is FALSE

a) Breakdown of this molecule yields bilirubin

b) The molecule can combine with carbon monoxide
c) Decreased synthesis of this molecule produces anemia
d) Amino acids are not present in this molecule

Gross splenomegaly is a striking feature of which ONE of the following?

a) Acute lymphoblastic leukaemia.
b) Acute monoblastic leukaemia.
c) Acute myeloblastic leukaemia.
d) Acute myelomonocytic leukaemia.
e) Acute granulocytic anaemia.
Which of the following is the marker for granulocytic sarcoma?
a) CD 10
b) CD 13
c) CD 30
d) CD 33 √

Which of the following is seen in Burkitt’s lymphoma?

a) t(8:14) √
b) t(15:17)
c) t(X:18)
d) t(11:14)

The common age group in which patients develop CLL is

a. Before 10 years
b. 10 to 20 years
c. 30 to 40 years
d. 50-70 years