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NIPAGIN M Page 1
SECTION 1. IDENTIFICATION
Combustible dust
Precautionary statements :
Prevention:
P264 Wash skin thoroughly after handling.
P210 Keep away from heat, hot surfaces, sparks, open flames
and other ignition sources. No smoking.
P233 Keep container tightly closed.
P243 Take precautionary measures against static discharge.
Response:
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water
for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
P337 + P313 If eye irritation persists: Get medical advice/
attention.
SAFETY DATA SHEET
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Other hazards
None known.
Chemical nature :
CAS-No. : 99-76-3
Hazardous components
Chemical name CAS-No. Concentration (% w/w)
Methyl paraben 99-76-3 100
In case of skin contact : Wash thoroughly with soap and water for 15 minutes. If skin
irritation occurs, seek medical attention.
In case of eye contact : Hold eyelids apart and flush eyes with plenty of water for at
least 15 minutes. Get medical attention.
Most important symptoms : The possible symptoms known are those derived from the
and effects, both acute and labelling (see section 2).
delayed No additional symptoms are known.
NIPAGIN M Page 3
Dry powder
Specific hazards during : In case of fires, hazardous combustion gases are formed:
firefighting Carbon monoxide (CO)
Carbon dioxide (CO2)
Further information : Exercise caution when fighting any chemical fire. Use NIOSH
approved self-contained breathing apparatus and full
protective clothing.
Environmental precautions : If the product contaminates rivers and lakes or drains inform
respective authorities.
Do not empty into drains.
Methods and materials for : Keep in suitable, closed containers for disposal.
containment and cleaning up Take up mechanically
NIPAGIN M Page 4
Hand protection
Remarks : Chemical resistant gloves (butyl rubber, nitrile rubber,
polyvinyl alcohol). However, please note that PVA degrades
in water.
Skin and body protection : Protective clothing to minimize skin contact should be worn.
Chemically resistant safety shoes. Wash contaminated
clothing with soap and water and dry before reuse. Safety
showers and eyewash stations should be provided in all
areas where this material is handled.
Colour : white
Odour : odourless
SAFETY DATA SHEET
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pH : 7 (20 °C)
Concentration: 1 g/l
Burning number : 1
Does not catch fire
Solubility(ies)
Water solubility : approx. 1.88 g/l (20 °C)
Method: OECD Test Guideline 105
NIPAGIN M Page 6
Viscosity
Viscosity, dynamic : Not applicable
Possibility of hazardous : The product is not a dust explosion risk as supplied; however
reactions the build-up of fine dust can lead to a risk of dust explosions.
not known
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Components:
Methyl paraben:
Acute oral toxicity : LD50 (Rat, male): 2,100 mg/kg
Method: OECD Test Guideline 401
Skin corrosion/irritation
Product:
Species: Rabbit
Method: Other
Result: No skin irritation
Components:
Methyl paraben:
Species: Rabbit
Method: Other
Result: No skin irritation
Components:
Methyl paraben:
Species: Rabbit
Result: No eye irritation
Method: Other
NIPAGIN M Page 8
Components:
Methyl paraben:
Test Type: Maurer optimisation test
Species: Guinea pig
Method: OECD Test Guideline 406
Result: Not a skin sensitizer.
Germ cell mutagenicity - : In vitro tests did not show mutagenic effects
Assessment
Components:
Methyl paraben:
Genotoxicity in vitro : Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
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Germ cell mutagenicity - : In vitro tests did not show mutagenic effects
Assessment
Carcinogenicity
Product:
Species: Rat, (male and female)
Exposure time: 52 weeks
Frequency of Treatment: twice weekly
3.5 mg/kg bw/day
Method: Other
Result: negative
Components:
Methyl paraben:
Species: Rat, (male and female)
Exposure time: 52 weeks
Frequency of Treatment: twice weekly
3.5 mg/kg bw/day
Method: Other
Result: negative
NIPAGIN M Page 10
Reproductive toxicity
Product:
Effects on fertility : Test Type: Fertility
Species: Rat, male
Application Route: oral (feed)
Dose: 100, 1000, 10000 ppm
General Toxicity - Parent: NOAEL: 1,000 ppm
Method: Other
Components:
Methyl paraben:
Effects on fertility : Test Type: Fertility
Species: Rat, male
Application Route: oral (feed)
Dose: 100, 1000, 10000 ppm
General Toxicity - Parent: NOAEL: 1,000 ppm
Method: Other
Components:
Methyl paraben:
Remarks: no data available
SAFETY DATA SHEET
NIPAGIN M Page 11
Components:
Methyl paraben:
Remarks: no data available
Components:
Methyl paraben:
Species: Rat, male and female
NOAEL: >= 250 mg/kg
Application Route: oral (gavage)
Exposure time: 28 d
Number of exposures: daily
Dose: 50, 250, 1000 mg/kg/day
Method: Other
Aspiration toxicity
Product:
no data available
Components:
Methyl paraben:
no data available
NIPAGIN M Page 12
Further information
Product:
Remarks: Inhalation of dust causes slight irritation of the respiratory tract.
Ecotoxicity
Product:
Toxicity to fish : LC50 (Oryzias latipes (Orange-red killifish)): 59.5 mg/l
Exposure time: 96 h
Test Type: semi-static test
Method: OECD Test Guideline 203
Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): 11.2 mg/l
aquatic invertebrates Exposure time: 48 h
Test Type: static test
Method: ISO 6341
Toxicity to daphnia and other : NOEC (Daphnia magna (Water flea)): 0.2 mg/l
aquatic invertebrates End point: Reproduction rate
(Chronic toxicity) Exposure time: 21 d
Test Type: semi-static test
Method: OECD Test Guideline 211
Ecotoxicology Assessment
Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects.
Components:
Methyl paraben:
Toxicity to fish : LC50 (Oryzias latipes (Orange-red killifish)): 59.5 mg/l
SAFETY DATA SHEET
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Exposure time: 96 h
Test Type: semi-static test
Method: OECD Test Guideline 203
Toxicity to daphnia and other : EC50 (Daphnia magna (Water flea)): 11.2 mg/l
aquatic invertebrates Exposure time: 48 h
Test Type: static test
Method: ISO 6341
Toxicity to daphnia and other : NOEC (Daphnia magna (Water flea)): 0.2 mg/l
aquatic invertebrates End point: Reproduction rate
(Chronic toxicity) Exposure time: 21 d
Test Type: semi-static test
Method: OECD Test Guideline 211
Ecotoxicology Assessment
Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects.
NIPAGIN M Page 14
Components:
Methyl paraben:
Biodegradability : Inoculum: activated sludge, domestic, non-adapted
Carbon dioxide (CO2)
Result: Readily biodegradable.
Biodegradation: 89 %
Exposure time: 28 d
Method: OECD Test Guideline 301B
Bioaccumulative potential
Product:
Bioaccumulation : Remarks: Due to the low logPow bioaccumulation is not
expected
Components:
Methyl paraben:
Bioaccumulation : Remarks: Due to the distribution coefficient n-octanol/water,
accumulation in organisms is not expected.
Mobility in soil
Product:
Distribution among : Remarks: Based upon the calculated log Koc, adsorption to
environmental compartments the soil phase is not expected.
Components:
Methyl paraben:
Distribution among : Koc: 280
environmental compartments
Method: estimated
Additional ecological : The product should not be allowed to enter drains, water
information courses or the soil.
Components:
Methyl paraben:
Results of PBT and vPvB : The substance is not identified as a PBT or as a vPvB
assessment substance.
SAFETY DATA SHEET
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Disposal methods
RCRA - Resource : No -- Not as sold.
Conservation and Recovery
Authorization Act
Waste Code : NONE
SARA 313 : This product does not contain any toxic chemical listed under
Section 313 of the Emergency Planning and Community
Right-To-Know Act of 1986.
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Further information
Full text of other abbreviations
AICS - Australian Inventory of Chemical Substances; ASTM - American Society for the Testing of
Materials; bw - Body weight; CERCLA - Comprehensive Environmental Response,
Compensation, and Liability Act; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN -
Standard of the German Institute for Standardisation; DOT - Department of Transportation; DSL -
Domestic Substances List (Canada); ECx - Concentration associated with x% response; EHS -
Extremely Hazardous Substance; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; ERG - Emergency Response Guide;
GHS - Globally Harmonized System; GLP - Good Laboratory Practice; HMIS - Hazardous
Materials Identification System; IARC - International Agency for Research on Cancer; IATA -
International Air Transport Association; IBC - International Code for the Construction and
Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory
concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing
Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO -
International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO -
International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory; LC50
- Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test
population (Median Lethal Dose); MARPOL - International Convention for the Prevention of
Pollution from Ships; MSHA - Mine Safety and Health Administration; n.o.s. - Not Otherwise
Specified; NFPA - National Fire Protection Association; NO(A)EC - No Observed (Adverse) Effect
Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect
Loading Rate; NTP - National Toxicology Program; NZIoC - New Zealand Inventory of Chemicals;
OECD - Organization for Economic Co-operation and Development; OPPTS - Office of Chemical
Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS
- Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; RCRA - Resource Conservation and Recovery Act; REACH - Regulation
(EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration,
Evaluation, Authorisation and Restriction of Chemicals; RQ - Reportable Quantity; SADT - Self-
Accelerating Decomposition Temperature; SARA - Superfund Amendments and Reauthorization
Act; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TSCA - Toxic
Substances Control Act (United States); UN - United Nations; UNRTDG - United Nations
Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very
Bioaccumulative
This information corresponds to the present state of our knowledge and is intended as a general
description of our products and their possible applications. Clariant makes no warranties, express
or implied, as to the information’s accuracy, adequacy, sufficiency or freedom from defect and
assumes no liability in connection with any use of this information. Any user of this product is
responsible for determining the suitability of Clariant's products for its particular application. NO
SAFETY DATA SHEET
NIPAGIN M Page 17
US / EN